• Title/Summary/Keyword: IL-17R

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Postoperative radiation therapy following the incomplete resection of a non-small cell lung cancer

  • Park, Jaehyeon;Song, Si Yeol;Kim, Su Ssan;Kim, Sang-We;Kim, Woo Sung;Park, Seung-Il;Kim, Dong Kwan;Kim, Yong-Hee;Park, Jongmoo;Lee, Sang-Wook;Kim, Jong Hoon;Ahn, Seung Do;Choi, Eun Kyung
    • Radiation Oncology Journal
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    • v.32 no.2
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    • pp.70-76
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    • 2014
  • Purpose: To review the results of postoperative radiation therapy (PORT) for residual non-small cell lung cancer (NSCLC) following surgical resection and evaluate multiple clinicopathologic prognostic factors. Materials and Methods: A total of 58 patients, who completed scheduled PORT for positive resection margin, among 658 patients treated with PORT from January 2001 to November 2011 were retrospectively analyzed. Radiation therapy was started at 4 to 6 weeks after surgery. Chemotherapy was also administered to 35 patients, either sequentially or concurrently with PORT. Results: The median age of patients was 63 years (range, 40 to 82 years). The postoperative pathological stage I NSCLC was diagnosed in 10 (17.2%), stage II in 18 (31.0%), and stage III in 30 patients (51.7%). Squamous cell carcinoma was identified in 43, adenocarcinoma in 10, large cell in 1, others in 4 patients. Microscopic residual disease (R1) was diagnosed in 55 patients (94.8%), and the remaining three patients were diagnosed with gross residual disease (R2). The median dose of PORT was 59.4 Gy (range, 50.0 to 64.8 Gy). Chemotherapy was administered to 35 patients (60%), and the median follow-up time was 22.0 months (range, 6.0 to 84.0 months). The 3-year locoregional relapse-free survival and distant metastasis-free survival rates were 82.1% and 52.9%, respectively. The median overall survival was 23.8 months (range, 6.0 to 84.1 months), and the 3-year overall survival rate was 58.2%. Chemotherapy did not influence the failure pattern or survival outcome. Conclusion: PORT is an effective modality for improving local tumor control in incompletely resected NSCLC patients. Major failure pattern was distant metastasis despite chemotherapy.

A Study on the Activities of Daily Living, Self-efficacy and the Health Promoting Behavior in Stroke Patients (뇌졸중 환자의 일상생활동작 수행능력, 자기효능감 및 건강증진행위에 관한 연구)

  • Park, Seon-Il;Cho, Bok-Hee
    • The Korean Journal of Rehabilitation Nursing
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    • v.7 no.2
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    • pp.149-158
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    • 2004
  • Purpose: The purpose of this study to analyze the relationship the activities of daily living(ADL), self-efficacy, and health promoting behaviors. Method: The research was a descriptive survey study. The subjects of this study were 115 hospitalized stroke patients to two General hospitals and one Oriental treatment hospital in G. Metropolitan. Data was collected through questionnaires from December 1st, 2003 to January 30th, 2004. The survey instruments used in the study Shah, Vanclay and Cooper's MBI(11 items), and Sherer and Maddux's self-efficacy(10 items), Walker, Sechrist, and Pender's HPLP(23 items) was developed by the researcher. The obtain data were analyzed with an SPSS 10.0 program using frequency, percentage, Cronbach's alpha, t-test, ANOVA, Duncan test, and Pearson's correlation coefficient. Result: The results were as follows; The level of ADL the score was 50.5, self-efficacy 40.4, and health promoting behavior 54.6. There were significant differences of ADL by general and disease related characteristics as follows : for monthly income(F=2.72, p= .048), duration of stroke(F=7.98, p= .001), number of attack(F=5.21, p= .007), operation (F=17.88, p= .000). There were significant differences of self-efficacy by general and disease related characteristics as follows : for monthly income(F=4.83, p= .003), number of attack (F= 6.20, p=. 003), operation(F=4.03, p= .047). There were significant differences of health promoti ng behaviors by general and disease-related characteristics as follows : for aphasia(F=4.24, p=.042). There were significant correlated between ADL and self-efficacy(r= .698, p=.000), self- efficacy and health promoting behavior(r=.398, p= .000), ADL and health promoting behavior(r= .235, p= .011). Conclusion: As a result, There was a significant correlation between ADL, self-efficacy and health promoting behaviors. There will be considered useful nursing intervention effect to progress, support health promoting behavior of stroke patients.

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Effects of Peduncle Cutting on Yield and Crude Saponin Content in Anemarrhena asphodeloides Bunge (화경제거가 지모의 수량 및 조사포닌함량에 미치는 영향)

  • Han, Seung-Ho;Choi, Byung-Jun;Shin, Cheol-Woo;Son, Seok-Young;Park, Sang-Il
    • Korean Journal of Medicinal Crop Science
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    • v.9 no.1
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    • pp.55-61
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    • 2001
  • In this study, effects of wiling peduncle on production yield and crude saponin content in Anemarrhena asphodeloides Bunge were investigation. The peduncle cutting were conduct on May 30, June 15, June 30, non-cutting of seed propagation type and young plant propagation type in Anemarrhena asphodeloides Bunge. The highest rhizome yield was 276.9g/plant on May 30, cutting puduncle in seed propagation type. The rhizome yield at seed propagation type was increased about 40.8%, compared to that at non-cutting. Crude saponin content in rhizome was 7.50% on May 30, cutting puduncle in seed propagation type. The crude saponin content at seed propagation type was increased about 32.2%, compared to that at non-cutting.

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Effect of β-glucan on immune parameters in the Manila clam Ruditapes philippinarum (β-glucan이 바지락의 면역력에 미치는 영향)

  • Nam, Ki-Woong;Park, Kyung-il
    • The Korean Journal of Malacology
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    • v.31 no.2
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    • pp.123-127
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    • 2015
  • ${\beta}$-Glucan is a polysaccharide that is widely used as an adductive in fish feed to facilitate immune stimulation. This study aimed to investigate the effect of ${\beta}$-glucan on immune responses in the Manila clam Ruditapes philippinarum. For this purpose, three groups of R. philippinarum were exposed to 0%, 0.1%, or 1% ${\beta}$-glucan in sea water for 1 hr/day for 2 weeks using an immersion method. Thereafter, two immune parameters-phagocytic rate and antibacterial activity-were measured. R. philippinarum exposed to 1% ${\beta}$-glucan showed an approximate 30% significant increase in phagocytic rate. In addition, ${\beta}$-glucan significantly limited the growth of the pathogenic bacteria Vibrio tapetis, V. parahaemolyticus, and V. ordalii. Moreover, the mortality rates of ${\beta}$-glucan-treated clams decreased during a 17-day experiment. Our study suggests that treatment with ${\beta}$-glucan significantly increases the immune responses in R. philippinarum, and that immersion is a simple and effective method for immune stimulation in this species.

ANALYSIS OF THE LiF:Mg,Cu,Si TL AND THE LiF:Mg,Cu,P TL GLOW CURVES BY USING GENERAL APPROXIMATION PLUS MODEL

  • Chang, In-Su;Lee, Jung-Il;Kim, Jang-Lyul;Oh, Mi-Ae;Chung, Ki-Soo
    • Journal of Radiation Protection and Research
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    • v.34 no.4
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    • pp.155-164
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    • 2009
  • In this paper, we used computerized glow curve deconvolution (CGCD) software with several models for the simulation of a TL glow curve which was used for analysis. By using the general approximation plus model, parameters values of the glow curve were analyzed and compared with the other models parameters (general approximation, mixed order kinetics, general order kinetics). The LiF:Mg,Cu,Si and the LiF:Mg,Cu,P material were used for the glow curve analysis. And we based on figure of merits (FOM) which was the goodness of the fitting that was monitored through the value between analysis model and TLD materials. The ideal value of FOM is 0 which represents a perfect fit. The main glow peak makes the most effect of radiation dose assessment of TLD materials. The main peak of the LiF:Mg,Cu,Si materials has a intensity rate 80.76% of the whole TL glow intensity, and that of LiF:Mg,Cu,P materials has a intensity rate 68.07% of the whole TL glow intensity. The activation energy of LiF:Mg,Cu,Si was analyzed as 2.39 eV by result of the general approximation plus(GAP) model. In the case of mixed order kinetics (MOK), the activation energy was analyzed as 2.29 eV. The activation energy was analyzed as 2.38 eV by the general order kinetics (GOK) model. In the case of LiF:Mg,Cu,P TLD, the activation energy was analyzed as 2.39 eV by result of the GAP model. In the case of MOK, the activation energy was analyzed as 2.55 eV. The activation energy was analyzed as 2.51 eV by the GOK model. The R value means different ratio of retrapping-recombination. The R value of LiF:Mg,Cu,Si TLD main peak analyzed as $1.12\times10^{-6}$ and $\alpha$ value analyzed as $1.0\times10^{-3}$. The R of LiF:Mg,Cu,P TLD analyzed as $7.91\times10^{-4}$, the $\alpha$ value means different ratio of initial thermally trapped electron density-initial trapped electron density (include thermally disconnected trap electrons density). The $\alpha$ value was analyzed as $9.17\times10^{-1}$ which was the difference from LiF:Mg,Cu,Si TLD. The deep trap electron density of LiF:Mg,Cu,Si was higher than the deep trap electron density of LiF:Mg,Cu,P.

Acute Respiratory Failure Treated with Veno-venous Extracorporeal Membrane Oxygenation (정-정맥 체외막형산소화요법을 이용한 급성호흡부전의 치료)

  • Kim, Hyoung-Soo;Han, Sang-Jin;Hong, Kyung-Soon;Yoon, Duck-Hyoung;Lee, Chang-Youl;Lee, Myung-Goo;Hong, Won-Ki;Lee, Sun-Hee;Kim, Kun-Il;Lee, Hee-Sung;Cho, Sung-Woo
    • Tuberculosis and Respiratory Diseases
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    • v.68 no.2
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    • pp.62-66
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    • 2010
  • Background: Extracorporeal membrane oxygenation (ECMO) during severe acute respiratory failure helps to recover the pulmonary function. This study evaluated our experience with veno-venous ECMO in adult patients with acute respiratory failure. Methods: From January 2007 to July 2009, ECMO was used on 54 patients. Of these 54 patients, 7 were placed on veno-venous ECMO for acute respiratory failure. The indications of ECMO were based on the lung dysfunction measured as a $PaO_2/FiO_2$ ratio <100 mm Hg on $FiO_2$ of 1.0, or an arterial blood gas pH <7.25 due to hypercapnia despite the optimal treatment. $EBS^{(R)}$, $Bio-pump^{(R)}$, and Centrifugal Rotaflow $pump^{(R)}$ were used and all cannulations were performed percutaneously via both femoral veins. When the lung function was improved, an attempt was made to wean on ECMO at moderate ventilator settings followed by decannulation. Results: Five of the 7 patients were male and the mean age was $46.3{\pm}18.3$. The causes of acute respiratory failure were 3 cases of pneumonia, 2 near-drownings, 1 pulmonary hemorrhage due to acute hepatic failure and 1 mercury vapor poisoning. The mean support time of ECMO was $17.3{\pm}13.7$ days. Of the 7 patients implanted with ECMO, 5 patients (71%) were weaned off ECMO and 3 patients (43%) survived to hospital discharge after a mean 89.6 hospital days. Conclusion: The early use of ECMO for acute respiratory failure in adults due to any cause is a good therapeutic option for those unresponsive to the optimal conventional treatments.

Synthesis of Binuclear Bismacrocyclic Iron(II) Complex by the Aerobic Oxidation of Iron(II) Complex of 1,4,8,11-Tetraazacyclotetradecane

  • Myunghyun Paik Suh;Gee-Yeon Kong;Il-Soon Kim
    • Bulletin of the Korean Chemical Society
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    • v.14 no.4
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    • pp.439-444
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    • 1993
  • The aerobic oxidation of the Fe(II) complex of 1,4,8,11-tetraazacyclotetradecane, [Fe(cyclam)$(CH_3CN)_2](ClO_4)_2$, in MeCN in the presence of a few drops of $HClO_4$ leads to low spin Fe(III) species [Fe(cyclam)$(CH_3CN)_2](ClO_4)_3$. The Fe(III) cyclam complex is further oxidized in the air in the presence of a trace of water to produce the deep green binuclear bismacrocyclic Fe(II) complex $[Fe_2(C_{20}H_{36}N_8)(CH_3CN)_4](ClO_4)_4{\cdot}2CH_3CN$. The Fe(II) ions of the complex are six-coordinated and the bismacrocyclic ligand is extensively unsaturated. $[Fe_2(C_{20}H_{36}N_8)(CH_3CN)_4](ClO_4)_4{\cdot}2CH_3CN$ crystallizes in the monoclinic space group $P2_1/n$ with a= 13.099 (1) ${\AA}$, b= 10.930 (1) ${\AA}$, c= 17.859 (1) ${\AA}$, ${\beta}$= 95.315 $(7)^{\circ}$, and Z= 2. The structure was solved by heavy atom methods and refined anisotropically to R values of R= 0.0633 and $R_w$= 0.0702 for 1819 observed reflections with F > $4{\sigma}$ (F) measured with Mo K${\alpha}$ radiation on a CAD-4 diffractometer. The two macrocyclic units are coupled through the bridgehead carbons of ${\beta}$-diimitie moieties by a double bond. The double bonds in each macrocycle unit are localized. The average bond distances of $Fe(II)-N_{imine}$, $Fe(II)-N_{amine}$, and $Fe(II)-N_{MeCN}$ are 1.890 (5), 2.001 (5), and 1.925 (6) ${\AA}$, respectively. The complex is diamagnetic, containing two low spin Fe(II) ions in the molecule. The complex shows extremely intense charge transfer band in the near infrared at 868 nm with ${\varepsilon}$= 25,000 $M^{-1}cm^{-1}$. The complex shows a one-electron oxidation wave at +0.83 volts and two one-electron reduction waves at -0.43 and-0.72 volts vs. Ag/AgCl reference electrode. The complex reacts with carbon monoxide in $MeNO_2$ to form carbonyl adducts, whose $v_{CO}$ value (2010 $cm^{-1}$) indicates the ${\pi}$-accepting property of the present bismacrocyclic ligand.

Effect of Aging Treatment on the Mechanical Properties of Mg-6Al-xZn(x=0,1,2) Alloys Fabr~catedb y Squeeze Casting (용탕단조법에 의해 제조된 Mg-6AI-xZn(x0,1,2)합금의 기계적 성질에 미치는 시효처리의 영향)

  • Gang, Min-Cheol;Yun, Il-Seong;Kim, Gyeong-Hyeon;Kim, In-Bae
    • Korean Journal of Materials Research
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    • v.7 no.2
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    • pp.129-135
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    • 1997
  • This study has investigated the effects of aging treatment on thc nlechanical propcrries of blg-iiAl-x%nix - 0.1.2) alloys fabricated by the squeeze castmg process. The microstructurcs of as-squeeze cast were composed of pro eurectic $\alpha$ magnesium solid solution, super saturated $\alpha$ solid solution and $\beta(Mg_{17}AI_{12}$) compund. Agcd at both $200^{\circ}C$ and $240^{\circ}C$, Mg--6AixZn alloys showed the peak hardness due to the formation of $\beta(Mg_{17}AI_{12}$) precipitates. The tiiscontinuous precipitates of the lamella r\.pe are predominant at $200^{\circ}C$ aging tredrment. tvhilc. the finely dispersed continu ous precipitates were major type at $240^{\circ}C$ treatment. Mg-- GAI-xZn a1loi.s fabricated hy the squeeze casting process had the hetter combination of tensile strength and elongation compared to the conventionally cast alloys. As increascci zinc: contents. the tensile strength was increased 11y the soiid solutirin strengthening effect of zinc,.

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Clinical Efficacy of Clozapine in Refractory Schizophrenia (불응성 정신분열증환자의 Clozapine 치료효과)

  • Lee, Min-Soo;Jung, In-Kwa;Kwak, Dong-Il
    • Korean Journal of Biological Psychiatry
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    • v.2 no.1
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    • pp.131-139
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    • 1995
  • Clozapine, on atypical antipsychotic drug, has been estimated to be a major improvement in the treatment-refractory schizophrenic patients. We evaluated the clozapine efficacy in the treatment of schizophrenic patients who are refractory to classic neuroleptics. The patients were assigned in a prospective, open, comparative trial for 12 weeks. Following an dose titration, 33 inpatients with treatment-refractory schizophrenia diagnosed according to DSM-III-R were given a clozapine(N=17, approximate 300-600mg/day) or haloperidol(N=16, approximate 20-30 mg/day) for 12 weeks. The clinical state was assessed before treatment, and 1st, 4th, 8th and 12th week during treatment using Brief Psychiatric Rating Scale(BPRS) and Positive and Negative Syndrome Scale(PANSS). Assessment of side effects were mode weekly using Simpson-Angus Scale for Extrapyramidal Side Effects and Adverse Events-Somatic Symptoms. Clozapine produces significant improvement than haloperidol on the BPRS and PANSS scores. 77% (13/17) of the clozapine-treated patients were categorized as responders, who showed at least 20% decrease in total BPRS scores, compared with 31% (5/16) of haloperidol-treated patients. Extrapyramidal side effects occurred in only one patient in clozapine group, but nine patients in haloperidol group. Salivation, sleepiness, constipation and hypotension were most frequent adverse effects observed in clozapine group. There was no significant changes in total WBC and neutrophil during clozapine treatment. These findings suggest that clozapine is on effective antipsychotic drug for the Korean treatment-refractory schizophrenic patients, who are nonresponsive to or unable to tolerate classcal antipsychotic drugs due to extrapyramidal side effects.

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Characteristics and Action Pattern of Polygalacturonase from Penicillium sp.CB-20 (Penicillium sp. CB-20이 생성하는 Polygalacturonase의 특성 및 작용양상)

  • Cho, Young-Je;Ahn, Bong-Jeon;Lim, Seong-Il;Lee, Woo-Je;Choi, Cheong
    • Microbiology and Biotechnology Letters
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    • v.17 no.6
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    • pp.580-586
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    • 1989
  • Penicillium sp. CB-20 was selected for strong polygalacturonase activity among various strains of molds found in soil. The optimum pH for the enzyme activity was 5.0 and optimum temperature was 4$0^{\circ}C$. The enzyme was relatively stable in acidic condition and unstable by heat treatment. The activation energy, Km and V$_{max}$ for the polygalacturonase were 2.499 Kcal/mol, 2.13$\times$10$^{-2}$mol/l, and 104.17 $\mu$mol/min. The activity of polygalacturonase was inhibited by Ag$^{+}$, Cu$^{++}$, Pb$^{++}$, Fe$^{+++}$, $Ca^{++}$, Na$^+$, Mn$^{++}$. The enzyme can be inactivated by the treatment ethylenediamintetra acetic acid, 2,4-dinitrophenol and $H_2O$$_2$. The results indicate the possible involvement of histidine, chelate and terminal amino group as active site. The enzyme was endo-type polygalacturonase.

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