• BMB Reports
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• v.49 no.2
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• pp.81-92
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• 2016

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and their effects on human disease models focusing on C. elegans studies. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging.

• 한국전산유체공학회:학술대회논문집
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• 2008.08a
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• pp.60.5-60.5
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• 2008

• Proceedings of the Korea Information Processing Society Conference
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• 2002.11c
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• pp.1677-1680
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• 2002

홈 네트워크에 대한 관심이 높아지면서 각 정보가전들이 점점 지능화 되어가고, 정보가전의 데이터 서비스에 대한 욕구가 증가하면서 정보가전용 데이터들을 위한 규격이 필요하게 되었다. 규격화가 됨으로써 정보가전용 데이터들의 효율적인 관리와 적은 비용의 유지보수가 가능하게 된다. 데이터 표준화 도구로 주목을 받는 XML을 기반으로 정보가전용 데이터를 규격화하면 개발의 확장성 측면에서 바람직하며, 이를 통해 앞으로 개발될 새로운 관련기술들을 보다 쉽게 적용할 수 있다. 본 논문에서는 정보가전용 데이터 응용 프로그램의 요구 사항을 분석하고 이를 토대로 댁내의 정보가전 및 각 정보가전에 대한 데이터와 메시지들을 추출하고, 이를 이용하여 인터넷 정보가전용 규격에 대한 두 가지 방법을 제안한다. 첫 번째 제안의 내용은 추출한 데이터 대한 XML 규격화이고, 두 번째는 HDAL(Home Data Access Library)을 이용한 클라이언트와 서버 사이의 주고받는 SOAP 메시지들에 대한 XML 규격화이다. 이 두 가지 제안에 대해 구체적으로 기술하고, 이 제안이 홈 네트워크 환경에서 사용되는 예를 직접 제시한다.

• Journal of Convergence for Information Technology
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• v.11 no.8
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• pp.29-35
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• 2021

Since a sufficient condition on the larger rate volume of 3-user correlated information sources (CIS)/non-successive interference cancellation (SIC) non-orthogonal multiple access (NOMA) over independent information sources (IIS)/SIC NOMA has not been investigated, this paper analyzes such a sufficient condition. First, we demonstrates that the rate volume of 3-user CIS/SIC NOMA is the same as a portion of the rate volume of 3-user IIS/SIC NOMA. Then, by identifying a dominant rate region, we calculate the sufficient condition on the larger rate volume of 3-user CIS/non-SIC NOMA over 3-user IIS/SIC NOMA. We also show that with such condition, the rate volume of 3-user CIS/non-SIC NOMA can be larger than that of 3-user IIS/SIC NOMA.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.1127-1127
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• 2003

• BMB Reports
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• v.50 no.4
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• pp.160-161
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• 2017

Proper maintenance of biological components is crucial for longevity and healthy aging. Although the role of homeostatic maintenance systems for DNA and protein in longevity is established, it remains largely unknown for RNA. In our recent work, we show that nonsense-mediated mRNA decay (NMD) promotes longevity in the roundworm C. elegans by enhancing RNA quality control. We find that the activity of NMD decreases during aging, raising the possibility that RNA quality declines in old animals. We then show that key components of NMD complex are required for prolonged lifespan in C. elegans. In addition, animals with reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS), a representative longevity model, display increased NMD activity. Thus, up-regulation of NMD appears to play crucial roles in longevity conferred by reduced IIS via enhancing mRNA quality control. As both IIS and NMD pathways are evolutionarily conserved, mammals including humans may be equipped with similar RNA quality control systems to achieve longevity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.2
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• pp.421-429
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• 2010

In this paper we researched the development methods and design of the Ubiquitous Integrated Information System (u-IIS) that makes efficiently access the experts and various kinds of intellectual and material information of the universities. And u-IIS supports various communication and cooperation tools such as VoIP, Email, Unified Messaging, Instant Messaging, Web Conferencing, Audio/Video Communication etc. We gave our focus to the methods and design that makes it possible to effectively implement the u-IIS with the least costs based on the available databases and infrastructures.

• Proceedings of the Korea Information Processing Society Conference
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• 2004.05a
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• pp.1023-1026
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• 2004

최근 소프트웨어 보안취약성 분석의 일환으로 프로그램 소스가 없고 기계어 프로그램만 제공되는 소프트웨어의 보안 취약점을 분석하는 연구가 많이 수행되고 있다. 본 논문에서는 MS 윈도우 2000 운영체제의 IIS 웹서버를 대상으로, WebDAV의 한 버퍼 오버플로우 취약점을 공격하여 취약성을 재현한 후, 디버거 및 역공학 도구를 사용하여 해당 보안 취약점을 가진 코드를 분석하는 방법을 제시하였다. 본 연구 결과는 취약성분석 절차 방법 및 신뢰성 있는 소프트웨어 개발에 기여할 수 있을 것으로 기대된다.

• Molecules and Cells
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• v.45 no.11
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• pp.763-770
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• 2022

Caenorhabditis elegans has been used as a major model organism to identify genetic factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) regulates aging in many species, ranging from nematodes to humans. C. elegans is a nonpathogenic genetic nematode model, which has been extensively utilized to identify molecular and cellular components that function in organismal aging and longevity. Here, we review the recent progress in the role of IIS in aging and longevity, which involves direct regulation of protein and RNA homeostasis, stress resistance, metabolism and the activities of the endocrine system. We also discuss recently identified genetic factors that interact with canonical IIS components to regulate aging and health span in C. elegans. We expect this review to provide valuable insights into understanding animal aging, which could eventually help develop anti-aging drugs for humans.

• IE interfaces
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• v.17 no.4
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• pp.397-406
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• 2004

It is widely known that labor costs are continuously and rapidly growing in terms of the raw cost of products in Korea. The increased labor costs are degrading the competitiveness of dairy industry sector as in the other major industrial fields. Furthermore, the number of dairy farms is constantly decreasing while that of dairy cattle is increasing. Thus, mechanized and/or automated stockbreeding management systems are crucially required to support professional stockbreeding management, as well as to enhance the productivity of the sector. Hence this paper develops an IIS (Integrated Information System) for dairy cattle stockbreeding management. IIS is composed of five application modules and associated utility programs. The five modules are individual stock management, milking management, feeding management, propagation management, and disease management. The utility programs are involved in stock farm accounting, and handy unloading of individual stock data into a personal data acquisition device. Compared with existing foreign products, the developed system takes advantages of various stock body measurement data such as body weight, body temperature, milk conductivity, milking amount, and the number of walking steps. All the measured data are transmitted into a programmable logic controller that monitors and controls measurement devices. The transmitted data are finally aggregated into an integrated database located in the main personal computer. The integrated data are analyzed and reformed in the five modules of IIS, then, used for providing farmers with various farm states and information through application module scenes. Hence, IIS keeps the each module work in a systematic and compatible manner, while supervising the whole stockbreeding management system.