• Asian-Australasian Journal of Animal Sciences
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• v.14 no.10
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• pp.1419-1424
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• 2001

Previous research in our laboratory has demonstrated the importance of lactose in phase I and II pig starter diets. Two experiments were conducted to evaluate the use of a carbohydrate by-product (food by-products) as a replacement for lactose. In Exp. I, 120 weaned pigs ($14{\pm}2d$ and 5.65kg) were allotted in a randomized complete block design (RCBD) to 10 replications with four pigs per pen. This experiment evaluated three carbohydrate sources (lactose, carbohydrate by-product, and 50-50 blend of the carbohydrate by-product and lactose). The carbohydrate sources were added at 26% in the phase I diets and 15% in the phase II diets. Phase I diets contained 7.5% spray dried plasma protein (SDP). The phase I diets were fed from d 0 to 14 and the phase II diets from d 15 to 28. There were no significant differences between carbohydrate sources on pig performance in phase I. However, during phase II pigs fed the diet with lactose had an improved gain/feed ratio (G/F) (p=0.06) compared to pigs fed the carbohydrate by-product. For the entire 28 d trial ADG, ADFI and G/F were similar for the 50-50 blend and those fed lactose. Total replacement of lactose with the carbohydrate byproduct resulted in a reduced G/F (p=0.09). Exp. 2 used 100 weaned pigs ($17{\pm}2d$ and 4.75kg) with five replications with five pigs per pen. This experiment evaluated four carbohydrate treatments (lactose, carbohydrate by-products, 50-50 blend, and corn). All phase I diets contained 3.5% SDP with the carbohydrate sources included at 15%, and were fed d 0 to 14. The phase II diets contained 7.5% of the carbohydrate sources and were fed d 15 to 27. A common phase III diet was fed d 28 to 42. During all phases pigs fed com tended to have a lower ADG than pigs fed the other carbohydrate sources with the 50-50 blend resulting in the highest ADG. The results of both experiments suggest that this carbohydrate by-product can replace at least 50% of the lactose in phase I and phase II pig starter diets.

• Korean journal of applied entomology
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• v.31 no.4
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• pp.543-550
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• 1992

Residual and biological effects of buprofezin(25% WP) on the larvae of the brown planthopper(BPH), Ni/aparvata /ugens SUlI, were studied by pot experiments. Residual lethal effects on the 2nd instar larvae lasted significantly long, and were higher with application rates. The rate of 17.50 g a.i./10a showed ca. 90% mortality even on 35 days after treatment (OAT). $RLT_{90}$ and $RLT_{50}$(residual lethal time that can show 90% and 50% mortality, respectively) with rates of 5.78-11.50 g a.i./lOa were 9.0-13.5, and 16.8-22.8 days, respectively. It was estimated that 13.00 and 4.44 g a.i./lOa were the rates of buprofezin which could show mortalities of 2nd instar BPH larvae above 95% and 50% until 15 OAT, respectively. The residual lethal effect of 7.00 g a.i./10a on the 1st instar BPH larvae was 100 % even on 17 OAT. $RLT_{50}$ was 32.5 days which was 15 days longer than $RLT_{50}$ for the 2nd instar larvae. Buprofezin with 7.0 g a.i./lOa showed 100% and 70% mortality for 1st-4th and 5th instar BPH larvae, respectively. Longevity of a female BPH which emerged from the 5th instar larvae treated by buprofezin was greatly reduced, and its fecundity was nearly zero.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.3
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• pp.343-348
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• 2004

The objective of the present study was to determine the plasma level of insulin-like growth factor-I (IGF-I) in relation to mammary blood flow and milk yield including biological variables of relevance to milk synthesis in two different types of crossbred Holstein cattle at 3 different stages of lactation. Eight heifers were 87.5% HF and eight 50% HF animals were selected for the experiments. The three stages of lactation tested were: early lactation (30 days postpartum), mid-lactation (120 days postpartum) and late lactation (210 days postpartum). Animals in each group were fed a concentrate and rice straw treated with 5% urea as the source of roughage throughout the experiments. In early lactation, mammary blood flow and milk yield of 87.5% HF animals were significantly higher than those of 50% HF animals. In mid- and late lactation, both mammary blood flow and milk yield showed a proportional decrease from the early lactating period of 87.5% HF animals. The trends for persistency were observed in 50% HF animals as for udder blood flow and milk yield throughout the experimental periods. The plasma glucose level of the 50% HF animals was significantly higher than those of 87.5% HF animals in both early and mid-lactation. The concentrations of arterial plasma free fatty acids ($C_{16}\;to\;C_{18}$) were higher in 50% HF animals as compared with 87.5% HF animals in all periods of study. In early lactation, the concentration of plasma growth hormone (GH) of 87.5% HF animals was higher than those of the 50% HF animals, thereafter the mean level of plasma growth hormone declined in both mid- and late lactation. The concentration of plasma IGF-I of 50% HF animals was significantly higher than those of 87.5% HF animals in all stages of lactation. There were no differences among stages of lactation for the levels of plasma IGF-I, insulin and growth hormone in 50% HF animals. In 87.5% HF animals, the plasma levels of both IGF-I and insulin were lower in early lactating period while it showed an increase during mid- and late lactation. The present results indicated that the regulatory role for the higher mammary blood flow and milk yield during lactation in 87.5% HF are not mediated via the higher level of circulating IGF-I. Differences in mammary blood flow and milk yield between 50% HF and 87.5% HF animals are in part due to a higher concentration of circulating growth hormone. The lower level of circulating growth hormone in 50% HF animals would be regulated by higher levels of IGF-I, free fatty acid and glucose in plasma.

• Journal of Bio-Environment Control
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• v.31 no.4
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• pp.300-310
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• 2022

The objective of this experiment was to investigate the effect of drip irrigation volume on tomatoes (Solanum lycopersicum L.) grown in a greenhouse using perlite medium. Plants were treated by three different irrigation treatment I₀, I₂₅, and I₅₀ (where irrigation volume of I₂₅ and I₅₀ was 25% and 50% higher than I₀, having limited or no leaching). Growth characteristics of plants, yield and water use efficiency were measured. The result showed that plant height, leaf length and leaf width were lowest in the I₀ treated plants. However, these parameters were not statistically significant differences between the plants that were grown in the I₂₅ and I₅₀ treatment. Soluble solids content, acidity and dry matter of 111th, 132nd, and 143rd days harvested tomato were higher in the plants irrigated with lowest volume (I₀) than the higher volume (I₂₅ or I₅₀). In addition, water content was lower in the 111th and 132nd days of harvested tomatoes from the I₀ treatment. The number of big-size tomatoes (>180 g) was significantly higher in the I₂₅ irrigated plants. There was no significant difference in the total number of harvested fruits among the treatments. The average fruit weight and total yield of harvested tomatoes were lowest in the I₀ treated plants. The water consumption of tomato was not significantly different amongst the treatments but water use efficiency was lowest in the I₀ treatment. Principal component analysis revealed that total soluble solid and acidity of tomato showed a positive correlation between each other. These results suggest that I₂₅ was the optimum irrigation treatment for tomato based on its measured growth characteristics, yield and water use efficiency.

• Natural Product Sciences
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• v.5 no.3
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• pp.113-120
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• 1999

Nitric oxide (NO) is a free radical synthesized from L-arginine by nitric oxide synthase (NOS). It is believed that NO is an important mediator in numerous physiological and inflammatory responses. Particularly, a large amount of NO released from the inducible nitric oxide synthase (iNOS) is mostly associated with inflammatory processes. Overproduction of NO in these processes including sepsis and autoimmune diseases can have deleterious consequences and pathophysiologic relevance. Therefore, for the discovery of new inhibitory agents against iNOS activity, we have evaluated about 100 kinds of natural products after partition into three layers (n-hexane, ethyl acetate and aqueous) from 100% methanol extracts to study inhibitory effects on iNOS activity induced by lipopolysaccharide (LPS) in RAW264.7 cells culture system. As a positive control, curcumin, which is known as an anti-tumor promoter, anti-inflammatory agent as an iNOS inhibitor, was used and showed the dose-dependent inhibitory effect $(IC_{50},\;2.5\;{\mu}g/ml)$. Among tested fractions, the n-hexane fraction of Cimicifuga heracleifolia $(IC_{50}:\;9.65\;{\mu}g/ml)$, Forsythiae fructus $(IC_{50}:\;6.36\;{\mu}g/ml)$, Saposhnikovia divaricata $(IC_{50}:\;5.92\;{\mu}g/ml)$, and the ethyl acetate fraction of Chrysanthemum sibiricum $(IC_{50}:\;2.56\;{\mu}g/ml)$, Gastrodia elata $(IC_{50}:\;3.46\;{\mu}g/ml)$, and the aqueous fraction of Dianthus chinensis $(IC_{50}:\;6.73\;{\mu}g/ml)$, Euonymus alatus $(IC_{50}:\;6.78\;{\mu}g/ml)$, Mechania urticifoloria $(IC_{50}:\;8.01\;{\mu}g/ml)$ showed strong inhibitory activity against LPS-stimulated iNOS. Especially, the ethyl acetate fraction of Chrysanthemum sibiricum $(IC_{50}:\;2.56\;{\mu}g/ml)$, which exhibited the strongest inhibition against iNOS, was fractionated with silica-gel column chromatography. These subfractions exhibited dose-dependent inhibition against iNOS activity in the range of $2.59-5.6\;{\mu}g/ml$ except for fraction No. 3, 4, 5, 6, 8, 9, and 16. Our study shows that Chrysanthemum sibiricum has the strongest inhibitory effect against iNOS activity and has similar effect to curcumin. Therefore, further studies for the identification of active principles from Chrysanthemum sibiricum and investigation for the mechanism of the inhibition of iNOS by active principles will be performed.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.1
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• pp.99-104
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• 2010

Purpose: Difference of refraction result from the method of autorefraction and iTrace were investigaged for the children of elementary school in Asan City. In iTrace method. exclusion of accommodation without cycloplegia was used. Methods: Manifest refractive stale of 42 eyes of 12~13 years old were measured using autorefractor and iTrace. Refractions of far (more than 5 m) and ncar (30 cm) vision were measured using iTrace. All data showed that the spherical equivalent were classified as being in the group 1 (-0.50D < ~ < +1.00D) and 2 (below -0.50D) according 10 refractive errors. Results: Mean spherical equivalent using autorefractor and iTrace (far and near vision) were -1.08D, -0.29D and -2.34D, respectively (p<0.01). Compared with the far vision using iTrace, autorefraction was measured the myopia with -0.50D ~ -1.00D in 52.4% of total eyes. Autorefraction also statistical significant were measured a more myopia than the far vision using iTrace in group I and 2. Conclusions: The difference of refractive errors between autorefraction and iTrace, objective refraction were measured with far vision of more than 5 m were -0.79D. Autoreftaction showed statistically decreased refraction errors than iTrace with far vision.

• 한국전기화학회:학술대회논문집
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• 2001.04a
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• pp.50-50
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• 2001

• Journal of Haehwa Medicine
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• v.13 no.2
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• pp.87-95
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• 2004

The medicine through I-Ching(The Book of Changes, 易經) is a field of the medical science, which studies physiology, pathology and Yin-Yang philosophy. From ancient times so many scholars have studied I Ching and they are divided into two different school. one is the school of Image and Number(象數學派), the other is the school of reason(義理學派). Da-San Jung Yak-Yong(茶山 丁若鏞) is a distinguished scholar in the I-Ching study, and he had a unique opinion in the analysis about sentences of I Ching. He has done his best to make 'Image and Number(象數)' harmonize with reason(義理). I Ching is the book about changes, which includes everything like natural phenomena, human body and mind. So we can understand human physiology and pathology through I Ching. But it's important to understand it was organized by symbols. The main symbols are Ba-Gua(八卦), 12 Bi-Gua, Zai-Ruo-zhi-Gua(再閏之卦), 50 Yan-Gua(50衍卦) and these symbols originated from the imagess of the four seasons. The image of 12 Bi-Gua coincide with 12 jing-lao(經絡), the images of Zai-Ruo-zhi-Gua(再閏之卦) coinside with Ren-mai(任脈), Du-mai(督脈). 12 Bi-Gua and Zai-Ruo-zhi-Gua(再閏之卦) are fundamental stuffs, on the other hand 50 Yan-Gua(50衍卦) is an application of every phenomenon.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2003.10b
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• pp.43-43
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• 2003

Multiple regression equations (Rehman et al. 2000) have been developed to predict the salinity tolerance of Acacia seeds, expressed as the I$\sub$50/ (the concentration of NaCl required to reduce final germination to 50% of the control value in DW). Accurate predictions can be made using one or more chemical and biological seed parameters. In this study the theoretical effect of varying final germination percentage in distilled water, germination rate in distilled water. (Rate), Ca$\^$2+/ or K$\^$+/ contents and their ratios, as independent factors or related factors, on the predicted salinity tolerance (I$\sub$50/) of Acacia species was investigated. Simulation of the effects of changing final germination, rate, calcium and potassium suggest the possibility of practical application of these results to modify the salinity tolerance of seeds. The predicted I$\sub$50/ increased with increasing final germination. Similarly, the higher the rate of germination, the higher the predicted salt tolerance of Acacia species. The Ca$\^$2+/ content of seeds was found to be positively correlated with I$\sub$50/. Species with higher Ca$\^$2+/ contents had a higher I$\sub$50/. This suggests that I$\sub$50/ might be increased by increasing the Ca$\^$2+/ contents of seeds by pretreatment with calcium salts or by supplying these to the mother plants.

• Journal of the Korean Chemical Society
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• v.53 no.1
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• pp.34-41
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• 2009

A new series of hydrazone derivatives were synthesized from 4-(2-chloroethyl)semicarbazide and their antiproliferative activity against human brain (U251) and liver (Hepg2) carcinoma cell lines were evaluated. The hydrazone compounds are benzaldehyde (2a-2g), acetophenone (3a-3f), and 3-formylindole derivatives (4a-4d). Among the acetophenone derivatives, 3e (p-methoxy substituted) and 3f (p-nitro substituted) showed the highest cytotoxic activity against Hepg2 cell line (I$C_{50}$ = 6 and 8 $\mu$g/ml, respectively). Among the 3-formylindole derivatives, 4a (hydrazone of 3-formylindole itself) showed a pronounced cytotoxic activity against both U251 (I$C_{50}$ = 21 $\mu$g/ml) and Hepg2 (I$C_{50}$ = 7 $\mu$g/ml).