• Journal of Mechanical Science and Technology
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• v.18 no.1
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• pp.12-19
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• 2004

Using LSM (laser scanning method) , the radius of curvature due to thermal deformation in polyimide film coated on Si substrate is measured. Since the polyimide film shows viscoelastic behavior, i.e., the modulus and deformation of the film vary with time and temperature, we estimate the relaxation modulus and the residual stresses of the polyimide film by measuring the radius of curvature and subsequently by performing viscoelastic analysis. The residual stresses relax by an amount of 10％ at 100$^{\circ}C$ and 20% at 150$^{\circ}C$ for two hours.

• Annual Conference of KIPS
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• 2019.10a
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• pp.657-659
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• 2019

본 논문에서는 피부 이미지에서 건선 병변만을 가장 효과적으로 분할 할 수 있는 분할기법 선별을 목표로 한다. Interactive graph cuts (IGC)와 Level set method (LSM)를 사용하여 건선 영역을 분할한 후 Jaccard Index (JI)와 Dice Similarity Coefficient (DSC)을 사용하여 건선 영역에 효과적인 분할 방법을 제안한다.

• KSBB Journal
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• v.8 no.5
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• pp.478-482
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• 1993

Perfusion culture was conducted in Celligen perfusion culture system using a self-constructed hybridoma cell and low serum medium. The culture system employed hollow fiber to separate cells from the culture broth. Maximum cell density of $2.1\times10^7$ ce11s/m1, 10 times higher than in batch culture, could be achieved. Concentration of monoclonal antibody (MAb) was 4 times higher and production rate at maximum feed rate was 9 times higher than in batch culture. Glucose concentration was very important for the cell growth and MAb production. When glucose concentration was below 1g/l, i. e. 0.5~0.9g/l, specific MAb production rate decreased but cell concentration still increased. As the glucose concentration goes above 1g/l, specific MAb production rate increased and remained at maximum value at more than 1.5g glucose/l. The maximum value of the specific Mab production rate was similar to that of batch culture.

• Journal of the Korean Ceramic Society
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• v.52 no.5
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• pp.325-330
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• 2015

Performance of solid oxide fuel cells (SOFCs), in comparison with that under hydrogen fuel, were investigated under direct internal reforming conditions. Anode supported cells were fabricated with an Ni+YSZ anode, YSZ electrolyte, and LSM+YSZ cathode for the present work. Measurements of I-V curves and impedance were conducted with S/C (steam to carbon) ratio of ~ 2 at $800^{\circ}C$. The outlet gas was analyzed using gas chromatography under open circuit condition; the methane conversion rate was calculated and found to be ~ 90% in the case of low flow rate of methane and steam. Power density values were comparable for both cases (hydrogen fuel and internal steam reforming of methane), and in the latter case the cell performance was improved, with a decrease in the flow rate of methane with steam, because of the higher conversion rate. The present work indicates that the short-term performance of SOFCs with conventional Ni+YSZ anodes, in comparison with that under hydrogen fuel, is acceptable under internal reforming condition with the optimized fuel flow rate and S/C ratio.

• The Journal of Korean Physical Therapy
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• v.14 no.2
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• pp.1-15
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• 2002

Excitation-contraction coupling in skeletal muscle is process by which depolarization of the muscle fiber membrane, elicited by a nerve action potential, triggers the release of $Ca^{2+}$ from the sarcoplasmic reticulum(SR). The resulting rise in intracellular $Ca^{2+}$ concentration$([Ca^{2+}]_i)$ activates the troponin complex, thereby initiating the contraction of the muscle. The question remains as to what factors are involved in the inhibition of SR $Ca^{2+}$ release in fatigued muscle. The purpose of this study was determine whether ATP-sensitive $K^+(K_{ATP})$ channels are activated and contribute to decrease in $[Ca^{2+}]_i$ during fatigue development in the mouse skeletal muscle. To elucidate a role of $K_{ATP})$ in relation to ECC, I measured the modulation effects of $K_{ATP})$ channel blocker(glibenclamide) and opener(pinacidil) on $[Ca^{2+}]_i$ after fatiguing electrical field stimulation(FEFS). Intracellular $Ca^{2+}$ signals were recorded by conforcal laser microscopy(LSM 410) and monitored using the fluorescent $Ca^{2+}$-Sensitive indicator Fluo-3 AM. The results of this study were as followed: 1. The relative [Ca2'li after FEFS in the pre-glibenclamide-treated group was higher than the control. And relative $[Ca^{2+}]_i$ after FEFS in the pre-glibenclamide-treated group was lower than the control. 2. The relative $[Ca^{2+}]_i$ after FEFS for 3 min in the control, pre-glibenclamide-treated group and pre-pinacidil-treated group showed a similar pattern; the gradually significant decrease in $[Ca^{2+}]_i$. But, these decreasing pattern was most significant in the control. These findings suggest a tight relationship between $K_{ATP})$ and $Ca^{2+}$ in ECC during fatigue. Therefore, 1 thought that activation of $K_{ATP})$ channels may be one of mechanisms of the fatigue in skeletal muscle.

• Journal of the Korea Concrete Institute
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• v.16 no.3 s.81
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• pp.375-382
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• 2004

The compressive strength of concrete is used as the most basic and important material Property when reinforced concrete structures are designed. It has become a problem to use this value, however, because the control specimen sizes and shapes are different from every country. In this study, the effect of specimen sizes and shapes on compressive strength of concrete specimens was experimentally investigated based on fracture mechanics. Experiments for the Mode I failure was carried out by using cylinder, cube, and prism specimens. The test results are curve fitted using least square method(LSM) to obtain the new parameters for the modified size effect law(MSEL). The analysis results show that the effect of specimen sizes and shapes on ultimate strength is apparent. In addition, correlations between compressive strengths with size, shape, and casting direction of the specimen are investigated. For cubes and prisms the effect of placing direction on the compressive strength was investigated.

• Journal of the Korea Concrete Institute
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• v.13 no.2
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• pp.153-160
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• 2001

In this study, the size effect on axial compressive strength for concrete members was experimentally investigated. Experiment of mode I failure, which is one of the two representative compressive failure modes, was carried out by using double cantilever beam specimens. By varying the eccentricity of applied loads with respect to the axis on each cantilever and the initial crack length, the size effect of axial compressive strength of concrete was investigated, and new parameters for the modified size effect law (MSEL) were suggested using least square method (LSM). The test results show that size effect appears for axial compressive strength of cracked specimens. For the eccentricity of loads, the influence of tensile and compressive stress at the crack tip are significant and so that the size effect is present. In other words, if the influence of tensile stress at the crack tip grows up, the size effect of concrete increases. And the effect of initial crack length on axial compressive strength is present, however, the differences with crack length are not apparent because the size of fracture process zone (FPZ) of all specimens in the high-strength concrete is similar regardless of differences of specimen slenderness.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.2
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• pp.59-63
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• 2008

The surface runoff is one of the important components for the surface water balance. However, most Land Surface Models(LSMs), coupled to climate models at a large scale for the prediction and prevention of disasters caused by climate changes, simplistically estimate surface runoff from the soil water budget. Ignoring the role of surface flow depth on the infiltration rate causes errors in both surface and subsurface flow calculations. Therefore, for the comprehensive terrestrial water and energy cycle predictions in LSMs, a conjunctive surface-subsurface flow model at a large scale is developed by coupling a 1-D diffusion wave model for surface flow with the 3-D Volume Averaged Soil-moisture Transport(VAST) model for subsurface flow. This paper describes the new conjunctive surface-subsurface flow formulation developed for improvement of the prediction of surface runoff and spatial distribution of soil water by topography, along with basic schemes related to the terrestrial hydrologic system in Common Land Model(CLM), one of the state-of-the-art LSMs.

• KSBB Journal
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• v.7 no.2
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• pp.92-95
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• 1992

A model for the role of serum was proposed to develop a low serum medium for the large scale cu1ture of mammalian cell. The strategy of medium development adopted in this study facilitated the understanding of the role being carried out by the serum in the culture of hybridoma KAl12 cell line. In this model, the serum components were divided into two main groups : the first group encompasses the nutrient factors that determine the maximum cell density and the second group includes the growth factors that regulate the cell growth rate, The model prediction was compared with the experimental results. The model enabled us to find out several useful aspects of medium composition for cell growth. 1) One particular component in the basal medium became limiting factor when serum concentration level was more than 7%. 2) The growth regulating factors and nutrient factors limited the cell growth at 3% and 5% serum concentration levels respectively.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.332-332
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• 2022

적설은 지구 기후시스템과 수문순환 과정에서 중요한 역할을 하고 있으며, 겨울철의 적설은 봄철에 녹으면서 식생과 수자원 제공에 큰 영향을 주는 인자로 알려져 있다. 동아시아가 위치한 북반구는 적설량의 90%가 관찰되고 토지의 약 42%가 긴 시간동안 눈으로 덮여 있어 지표 에너지와 물 균형에 영향을 주고, 특히 수자원 관리를 위한 유출이나 토양수분과 같은 수문 인자에 큰 영향을 미친다. 따라서 적설을 정확하게 예측하는 것은 수자원 관리에 있어 매우 중요한 일이다. 한편, 이러한 수문 순환을 정확히 예측하기 위해 수문 분야에서는 지면모형(Land Surface Model, LSM)을 많이 사용하고 있다. 지면모형은 지표면과 대기 사이의 상호작용을 모의하기 위해 개발되었고, 에너지, 수증기, 이산화탄소 등의 다양한 인자들의 교환에 대하여 해석하며, 토양수분, 유출량 등의 수자원 분야의 주요 인자들을 산출하여 수자원 관리에 적극적으로 활용되고 있다. 이에 본 연구에서는 National Center for Atmospheric Research(NCAR)에서 개발한 Community Land Model(CLM)을 사용하여 2001년부터 2016년까지 25km의 공간해상도로 동아시아 지역의 적설 모의를 평가하였다. CLM의 적설 모의 평가 인자는 Snow depth, Snow water equivalent의 2가지 인자를 대상으로 수행하였고, 모의 성능 평가를 위한 관측 자료로 NASA Aqua와 JAXA GCOM-W1 위성에 탑재된 Advanced Microwave Scanning Radiometer(AMSR) 센서에서 제공하는 위성 관측 자료와 Defense Meteorological Satellite Program(DMSP) 위성의 Special Sensor Microwave/Imager(SSM/I) 센서와 Nimbus-7 위성의 Scanning Multichannel Microwave Radiometer(SMMR) 센서에서 제공하는 위성 관측 자료를 기반으로 지상 기상 관측소 자료와 조합하여 재생성한 European Space Agency Global Snow Monitoring for Climate Research (ESA GlobSnow)의 자료를 사용하였다. 그 결과 CLM의 적설 모의는 과대 추정하는 것을 알 수 있었으며, 본 연구의 결과는 동아시아 적설 모의 개선을 위해 자료 동화를 사용하는 후속 연구의 기초자료로 사용할 수 있다.