• Tuberculosis and Respiratory Diseases
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• 제43권2호
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• pp.280-284
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• 1996

본 증례는 일본에서 과민성 폐장염의 원인 중 가장 높은 비율을 차지하고 있는 T. cutaneum에 의한 summer-type hypersensitivity pneumonitis가 우리나라에서 밝혀진 첫번째 예로서, 가정에 있을 때만 증상이 나타난 점, T. cutaneum에 대한 침전 항체가 양성으로 나온 점, 스테로이드 투여 후 증상 및 폐기능, 방사선 소견 등이 회복된 점 등을 볼 때 이 질환으로 진단할 수 있었다. 일본과 유사한 기후가 있는 우리나라에 있어 이 질환의 존재 가능성은 높을 것으로 생각되는데 앞으로 이 질환에 대한 연구가 요망된다.

• Tuberculosis and Respiratory Diseases
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• 제54권3호
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• pp.338-345
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• 2003

과민성 폐장염은 원인 물질들이 호흡기로 반복적으로 흡입되어 이들 감작된 항원에 의한 면역학적 반응이 일어나 폐실질에 염증성 또는 육아종성 병변이 초래되는 면역학적 염증 질환이다. 저자들은 호흡 곤란을 주소로 내원한 남자 환자에서, 주거지의 실내 벽지에 기생한 진균인 Alternaria가 원인으로 추정된 과민성 폐장염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제83권2호
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• pp.122-131
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• 2020

Hypersensitivity Pneumonitis (HP) one of the most common interstitial lung diseases (ILDs) is characterized by exposure to an inhaled inciting antigen that leads to a host immunologic reaction determining interstitial inflammation and architectural distortion. The underlying pathogenetic mechanisms are unclear. The absence of international shared diagnostic guidelines and the lack of a "gold-standard" test for HP combined with the presence of several clinical and radiologic overlapping features makes it particularly challenging to differentiate HP from other ILDs, also in expert contests. Radiology is playing a more crucial role in this process; recently the headcheese sign was recognized as a more specific for chronic-HP than the extensive mosaic attenuation. Several classification proposals and diagnostic models have been advanced by different groups, with no prospective validation. Therapeutic options for HP have been limited to antigen avoidance and immunosuppressant drugs over the last decades. Several questions about this condition remain unanswered and there is a need for more studies.

• Tuberculosis and Respiratory Diseases
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• 제41권5호
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• pp.546-551
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• 1994

금치료는 류마티스 관절염에서 고식적인 치료에 반응하지 않는 경우 유용하게 사용되고 있고, 드물게 금제에 의한 과민성 폐렴을 유발하는 것으로 알려져 있다. 저자등은 6년간 혈청반응검사 양성 류마티스 관절염을 앓아 왔던 26세 여자환자에서 Gold sodium thiomalate 300 mg을 사용후 발생원 과민성 폐렴 1예를 림프구 자극 시험으로 확인하여 문헌고찰과 함께 보고한다.

• Safety and Health at Work
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• 제10권4호
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• pp.428-436
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• 2019

Background: Metalworking fluids (MWFs) are mixtures with inhalation exposures as mists, dusts, and vapors, and dermal exposure in the dispersed and bulk liquid phase. A quantitative risk assessment was performed for exposure to MWF and respiratory disease. Methods: Risks associated with MWF were derived from published studies and NIOSH Health Hazard Evaluations, and lifetime risks were calculated. The outcomes analyzed included adult onset asthma, hypersensitivity pneumonitis, pulmonary function impairment, and reported symptoms. Incidence rates were compiled or estimated, and annual proportional loss of respiratory capacity was derived from cross-sectional assessments. Results: A strong healthy worker survivor effect was present. New-onset asthma and hypersensitivity pneumonitis, at 0.1 mg/㎥ MWF under continuous outbreak conditions, had a lifetime risk of 45%; if the associated microbiological conditions occur with only 5% prevalence, then the lifetime risk would be about 3%. At 0.1 mg/㎥, the estimate of excess lifetime risk of attributable pulmonary impairment was 0.25%, which may have been underestimated by a factor of 5 or more by a strong healthy worker survivor effect. The symptom prevalence associated with respiratory impairment at 0.1 mg/㎥ MWF was estimated to be 5% (published studies) and 21% (Health Hazard Evaluations). Conclusion: Significant risks of impairment and chronic disease occurred at 0.1 mg/㎥ for MWFs in use mostly before 2000. Evolving MWFs contain new ingredients with uncharacterized long-term hazards.

• Tuberculosis and Respiratory Diseases
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• 제65권6호
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• pp.541-545
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• 2008

페인트, 가구 도장제 등에 포함된 Isocyanate는 직업성 천식의 흔한 원인물질로 알려져 있고, 과민성 폐렴을 일으키기도 한다. 저자들은 6개월간 자동차 공장 페인트 도장공으로 일한 중국인 노동자에서 isocyanate에 의한 것으로 추정되는 과민성 폐렴 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제66권6호
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• pp.471-476
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• 2009

과민성 폐장염은 감수성 있는 사람이 특정 유발물질에 노출됨으로써 폐실질과 말초 기관지에 육아종성 염증을 일으키는 면역질환이다. 과민성 폐장염은 동물성 및 식물성 항원, 저분자 화학 물질, 세균 및 곰팡이 등의 미생물 흡인에 의해 유발 될 수 있으나 본 증례처럼 주사제에 의한 사례는 매우 드물다. 저자들은 특별한 노출력 없는 건강한 여성에서 태반 추출물 주사 후 발생한 과민성 폐장염의 첫 사례를 경험하여 보고하는 바이다.

• 한국환경보건학회지
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• 제39권2호
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• pp.105-116
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• 2013

Background: In Korea, there is low awareness of the respiratory health problems caused by the use of humidifiers, leading to a lack of governmental measures. Objectives: The objectives of this study were to review cases of varying degrees of humidifier lung and fever in connection with the use of humidifiers and to summarize the probable environmental agents causing these cases. Methods: We searched all articles reporting on humidifier lung, humidifier fever, and humidifier diseases caused by the use of a humidifier both at home and in the workplace. Results: We summarized a number of cases of varying degrees of respiratory diseases resulting from inhalation of water mist of humidifiers containing various species of bacteria and fungi and their toxins. Type of respiratory disease connected with humidifier lung includes interstitial pneumonitis, hypersensitivity pneumonitis, fever and several respiratory symptoms. Non-tuberculous mycobacteria (NTM), Actinomycetes, endotoxins and contaminated humidifier water were the most commonly suspected probable environmental agents causing humidifier lung. In Korea, the use of humidifier biocide is suspected as a likely cause of fatal lung injury including death and lung transplantation. Conclusion: Governmental policy should be devised and measures including a national surveillance system should be taken to prevent humidifier lung caused by the use of humidifiers.

• Tuberculosis and Respiratory Diseases
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• 제40권1호
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• pp.1-5
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• 1993

• IMMUNE NETWORK
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• 제10권1호
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• pp.26-34
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• 2010

Background: Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to inhaled particulate antigens. The family of $Fc{\gamma}$ receptors ($Fc{\gamma}Rs$) has emerged as central regulators for modulating both pro-and anti-inflammatory responses. However, the role of $Fc{\gamma}Rs$ in the development of HP has not been investigated yet. Methods: To explore the functional roles of $Fc{\gamma}Rs$ in HP, $Fc{\gamma}R^{-/-}$ and B6 mice were challenged with Saccharopolyspora rectivirgula (SR) antigen intranasally, and compared these mice in terms of the histological change, infiltrated immune cells in BALF and in vitro immune responses. Results: $Fc{\gamma}R^{-/-}$ mice exhibited attenuation of HP in terms of histological alterations, and reduced numbers of neutrophils and macrophages in and the increased CD4 : CD8 ratio of bronchoalveolar lavage fluid. The lungs of $Fc{\gamma}R^{-/-}$ mice showed high production of Th2 cytokine such as IL-4 and slightly low production of Th1 cytokine, INF-${\gamma}$ compared to those of B6 mice. However, SR-specific adaptive immune responses of $Fc{\gamma}R^{-/-}$ mice were similar to those of B6 mice. Conclusion: These results demonstrate that activating $Fc{\gamma}$ receptors play an important role in activating neutrophils and macrophages in pulmonary inflammation and inducing Th1 differentiation by regulating cytokine expression in SR-induced HP.