• The Journal of Korean Medicine
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• v.32 no.1
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• pp.151-163
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• 2011

Objective: The purpose of this study is to observe the effects of Persicae Semen herbal-acupuncture at GB34(Yangneungcheon) on hyperlipidemia of rats caused by high-fat diet. Methods: The author performed several experiments to measure the DPPH radical scavenging activity of PS-HAS,to analyze various components and enzymes in serum and liver, and to observe the histological changes of liver and aorta. Results: 1. Persicae Semen herbal-acupuncture solution increased the DPPH radical scavenging activity in rat's liver cells. 2. In the Persicae Semen herbal-acupuncture group, compared with control group, the level of total cholesterol in serum and the ratio of total cholesterol to HDL-cholesterol decreased significantly. 3. In the Persicae Semen herbal-acupuncture group, compared with the control group, the level of glutathione in liver cells increased significantly. 4. In the Persicae Semen herbal-acupuncture group, compared with the control group, the pathological changes in liver and aorta were reduced. Conclusion: The above results suggest that Persicae Semen herbal-acupuncture at GB34 has good effects on preventing and treating hyperlipidemia.

• The Journal of Korean Medicine
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• v.33 no.2
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• pp.11-24
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• 2012

Objectives: This study was designed to evaluate lipid-lowering and antioxidant effects of Artemisia capillaris(A. capillaris) using a model of hyperlipidemic rats induced by poloxamer-407. Methods: Rats were previously treated by A. capillaris water extract, and intraperitoneally injected by poloxamer-407 to induce hyperlipidemia. Parameters of serum lipid and oxidative stress biomarkers were determined. Results: 1. A. capillaris ameliorated the elevation of serum total cholesterol, triglyceride, LDL-cholesterol and MDA level. 2. A. capillaris ameliorated the reduction of serum TAC and SOD activities. 3. A. capillaris ameliorated the reduction of serum GSH and GSH-reductase level. Conclusions: According to these results, A. capillaris can be used to treat hyperlipidemia or as basis for making new drugs for treating hyperlipidemia in the future.

• The Korea Journal of Herbology
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• v.21 no.3
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• pp.47-54
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• 2006

Objectives : This study was performed to compare the preventive effect of water extracts from Injinho-tang and Haninjinho-tang on hyperlipidemia and liver damage induced by alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. We measured the serum component in rat's blood, body weight and weight of liver. Results : 1. At first, we observed effects of Injinho-tang and Haninjinho-tang on hyperlipidemia induced by alcohol. Injinho-tang group showed significant decrease of triglyceride, body weight in comparison with those of the control group. Haninjinho-tang group showed significant decrease of total cholesterol, triglyceride in comparison with those of the control group. I 2. At second, we observed effects of Injinho-tang and Haninjinho-tang on liver damage induced by alcohol. lnjinho-tang group showed significant decrease of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), liver weight in comparison with those of the control group. Haninjinho-tang group showed significant decrease of AST (aspartate aminotransferase), ALT (alanine aminotransferase) in comparison with those of the control group. Conclusion : Reviewing these experimental results, it appears that water extracts from Injinho-tang and Haninjinho-tang have pharmaceutical preventive efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.

• The Korea Journal of Herbology
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• v.23 no.4
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• pp.31-38
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• 2008

Objectives: This study was performed to investigate the effects of water extract from Cynanchi Wilfordii Radix on prevention of hyperlipidemia and liver damage induced by alcohol. Methods: Except for the normal group, we fed rat on 25% alcohol for 55 days. And water extracts from Cynanchi Wilfordii Radix were administrated for the Cynanchi Wilfordii Radix group during the same period. We measured the serum components in rat's blood, body weight and weight of liver. Results: At first, we observed effects of Cynanchi Wilfordii Radix on prevention of hyperlipidemia induced by alcohol. Cynanchi Wilfordii Radix group showed significant decrease of total cholesterol and triglyceride in comparison with those of the control group. Cynanchi Wilfordii Radix group showed significant increase of HDL-cholesterol in comparison with those of the control group. Cynanchi Wilfordii Radix group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. At second, we observed effects of Cynanchi Wilfordii Radix on prevention of liver damage induced by alcohol. Cynanchi Wilfordii Radix group showed significant decrease of GPT and ALP in comparison with those of the control group. Cynanchi Wilfordii Radix group showed significant increase of liver weight in comparison with those of the control group. Conclusions: Reviewing these experimental results, it appears that water extracts from Cynanchi Wilfordii Radix have pharmaceutical efficacy on prevention of hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.

• The Korea Journal of Herbology
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• v.30 no.3
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• pp.77-82
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• 2015

Objectives : The Korean medical doctors use PMR(Polygoni Multiflori Radix) for nourishing the liver-kidney, loosing the bowel to relieve constipation, recovering from malaria, and clearing away heat and eliminating toxin, etc. But, this study was performed to investigate the effect of water extracts from PMR on prevention of hyperlipidemia and liver damage induced by alcohol. Methods ： Except for the normal group, we fed rat on 25% alcohol for 55 days. And the extract was administrated for the same period. We measured the serum components in rat's blood, body weight and weight of liver. Results ： At first, we observed effects of PMR on prevention of hyperlipidemia induced by alcohol. PMR group showed significant decrease of total cholesterol and triglyceride in comparison with those of the control group. PMR group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. At second, we observed effects of PMR on prevention of liver damage induced by alcohol. PMR group showed significant decrease of GOT, GPT, ALP, and LDH in comparison with those of the control group. PMR group showed significant increase of liver weight in comparison with those of the control group. Conclusions ： Reviewing these experimental results, it appears that water extracts from PMR have pharmaceutical efficacy on prevention of hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.

• Toxicological Research
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• v.30 no.4
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• pp.291-296
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• 2014

Saururus chinensis has been reported to contain compounds such as lignans, alkaloids, diterpenes, flavonoids, tannins, steroids, and lipids. Fermentation is commonly used to break down certain undesirable compounds, to induce effective microbial conversion, and to improve the potential nutraceutical values. Previous studies have reported that the fermentation process could modify naturally occurring constituents, including isoflavons, saponins, phytosterols, and phenols, and could enhance biological activities, specifically antioxidant and antimicrobial properties. The probiotic strains used for fermentation exert beneficial effects and are safe. In this study, the antioxidative effects of the Bacillus subtilis fermentation of Saururus chinensis were investigated in a rat model with Triton WR-1339-induced hyperlipidemia by comparing the measured antioxidative biological parameters of fermented Saururus chinensis extract to those of nonfermented Saururus chinensis extract. Fermentation played a more excellent role than nonfermentation in ultimately protecting the body from oxidative stress in the liver of the experimental rats with Triton WR-1339-induced hyperlipidemia.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.2
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• pp.372-376
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• 2006

In order to study the effects of Cervi pantotrichum on hyperlipidemia, we divided the rats into three groups (normal group, control group & sample group) and perfomed the experimental research. Hyperlipidemia rat was induced by olive oil $1m{\ell}$(involved cholesterol 0.05g)/1200g for 10 days. The sample group was administerd the extract of Cervipantotrichum 10.8mg/200g for 5 days. and control group was administerd equal dose of saline. And then we measured the amount of serum total cholesterol, triglyceride, HDL-cholesterol, and phospholipid. Cervi pantotrichum showed decreasing effects on total cholesterol, LDL-cholesterol and phospholipid level, and increasing effects on HDL-cholesterol level in serum significantly. According to the above results, Cervi pantotrichum showed significant decreasing effects on hyperlipidemia, and it is considered that it is appropriate to apply for hyperlipidemia.

• Journal of Society of Preventive Korean Medicine
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• v.8 no.1
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• pp.33-45
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• 2004

In order to study the effects of Typha angustata on hyperlipidemia, we divided the rats into three groups(normal group, control group & sample group) and perfomed the experimental research. Hyperlipidemia rats were induced by Triton WR-1339 for 3days. The sample group was administerd the extract of Typha angustata 2ml／200g for 3 days and control group was administerd equal dose of saline. And then we measured the amount of serum Total cholesterol, Triglyceride, LDL-cholesterol, HDL-cholesterol, and Phospholipid. The results were as follows: 1. Typha angustata showed decreasing effects on Total cholesterol, Triglyceride, LDL-cholesterol, and Phospholipid levels in serum significantly(p<0.01) 2. Typha angustata showed and showed increasing effects on HDL-cholesterol level in serum significantly(p<0.05). According to the above results, Typha angustata showed significant decreasing effects on hyperlipidemia, and it is considered that it is appropriate to apply for hyperlipidemia.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.431-435
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• 2004

The purpose of this study was to examine the effects of Salviae Miltiorrhizae Radix on the high fat diet-induced hyperlipidemia in rats. Sixty male Sprague-Dawley rats, around 270g of B.W., were divided into normal, control, sample A and sample B group. Normal and control groups were orally administrated with saline during 4 weeks, sample A and sample B with 252.5mg/kg(rat) and 420.1 mg/kg(rat) of solid extract of Salviae Miltiorrhizae Radix during 4 weeks respectively. Blood samples were collected from each of animals at 4 weeks, and used for the blood chemical analysis. Animals were sacrificed at 4 weeks, and chemical analysis was performed on the collected liver samples. The serum total cholesterol, HDL-cholesterol, LDL-cholesterol levels of sample A group were significantly decreased compared with the control group. On the basis of these of results, it is confirmed that Salviae Miltiorrhizae Radix has the curative effects on the hyperlipidemia in rats induced by high fat diet

• Journal of Haehwa Medicine
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• v.13 no.2
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• pp.109-122
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• 2004

As a long-term goal for the development of new prescriptions for hyperlipidemia, Cheungsimdodamtang(CSDDT) was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. CSDDT-treated animal group showed only a 4.5% body weight increase compared to normal animal group whereas hyper- lipidemia-induced control group increased body weight by 13.6% compared to normal animals. 2. CSDDT-induced animal group showed a significant decrease in cholesterol levels beginning one week after CSDDT treatment, compared to hyperlipidemia-induced control group. 3. Total cholesterol levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 4. Glucose levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 5. Triglyceride levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 6. SGOT and SGPT levels in CSDDT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 7. HDL-cholesterol levels were significantly increased in CSDDT -treated animal group compared to the hypeiIipidemia-induced control group. 8. LDL-cholesterol levels were significantly decreased in CSDDT-treated animal group compared to the hyperlipidemia-induced control group.