• Journal of Digital Convergence
• /
• v.12 no.12
• /
• pp.371-379
• /
• 2014

In this study, we conducted a survey on the limited examinations of the DR system to the 30 radiologic technologists engaging in the clinical sites and university hospitals in Daejeon metropolitan city from Oct. 15, 2012 to Nov. 15, 2012. Based on the survey results, we propose the conceptual design of a supplementary table for the conventional DR system to extend the examination capability and overcome the limitation of DR system. And, we evaluated the convenience and usefulness of the proposed table by applying it to five subjects. Ten experts were involved to evaluate the clinical usefulness of the obtained images. In this study, the experimental results show the feasibility to overcome the limited examination of the conventional DR system, and the proposed supplementary table may be beneficial to patients and hospitals.

• Journal of fish pathology
• /
• v.20 no.1
• /
• pp.61-70
• /
• 2007

The epidemiological study was performed to survey the prevalence of bacterial disease of cultured olive flounder, Paralichthys olivaceus from October, 2004 to August, 2006 in Korea. A total of 1,271 of fish samples were collected at random includes fish exhibiting clinical signs of the disease in question. The total 331 samples among 738 cases of infectious diseases were infected with 366 bacteria isolates including Vibrio spp. (42.1%), Streptococcus spp. (16.9%), Edwardsiella tarda (12.3%), Photobacterium damselae subsp. damselae (8.2%), Pseudomonas spp. (2.2%) or others (18.3%). Vibrio spp. and P. damselae subsp. damselae were continually isolated through all seasons but Streptococcus spp. and E. tarda were mainly isolated from May to November. The 206 cases were showed mixed infection with other bacteria (3.6%), parasites (31.4%) or virus (41.7%); Vibrio spp. (n=21), Streptococcus spp. (n=13), Trichodina (n=76), Scutica (n=31), VNNV (n=112), VHSV (n=46).

• Korean Journal of Food Science and Technology
• /
• v.31 no.4
• /
• pp.957-963
• /
• 1999

Effects of cryoprotectants on protein denaturation of soybean curd, tofu, during frozen storage were examined. A whole-coagulated non-press tofu was prepared by adding 2% of isolated soybean protein to soy milk in order to prevent loss of added cryoprotectants. The cryoprotectants added were glocose, glycerol, sorbitol, propylene glycol, and tripolyphosphate. The texture characteristics of soybean curds before and after frozen storage were measured by sensory evaluation and Texture analyzer, and the results were evaluated by response surface methodology (RSM). Glucose, glycerol, sorbitol, and sodium tripolyphosphate were effective as single cryoprotectant, and the mixtures of glucose and sodium tripolyphosphate, and sorbitol and propylene glycol were also effective in minimizing textural change during freezing. Overall, the mixture of cryoprotectants were more effective than single cryoprotectant. According to the RSM, the maximum effect of cryoprotectants in minimizing textural changes during freezing was obtained with the mixture of 2.1% glucose, 6.7% glycerol, 2.1% sorbitol, 0.4% propylene glycol, and 0.3% sodium tripolyphosphate. However, considering the sensory acceptability, the optimum use of cryoprotectants in frozen tofu was 1% glucose, 2% glycerol, 1% sorbitol, 0.2% propylene glycol, and 0.5% sodium tripolyphosphate.

• Journal of The Korean Association For Science Education
• /
• v.37 no.2
• /
• pp.239-252
• /
• 2017

The purpose of this study is to examine metamodeling knowledge and its components, which means knowledge about model and modeling required for students and teachers for successful application of modeling in the field of science education based on research literature. For this, we analyzed and categorized major previous studies on modeling and modeling through research literature methods. Metamodeling knowledge aims to recognize models and modeling and is the most crucial element to create a scientific model in scientific modeling practice. The point of view of metamodeling knowledge proposed in this study is categorize nature of model, multiplicity of model, purpose of model, modeling process, and evaluation and revision of model. Students should be able to achieve more in-depth understanding through the awareness of the nature of the model. The development of metamodeling knowledge can facilitate students' science learning.

• Tuberculosis and Respiratory Diseases
• /
• v.80 no.3
• /
• pp.247-254
• /
• 2017

Background: Airway epithelial cells are the first line of defense, against pathogens and environmental pollutants, in the lungs. Cellular stress by cadmium (Cd), resulting in airway inflammation, is assumed to be directly involved in tissue injury, linked to the development of lung cancer, and chronic obstructive pulmonary disease (COPD). We had earlier shown that ACN9 (chromosome 7q21), is a potential candidate gene for COPD, and identified significant interaction with smoking, based on genetic studies. However, the role of ACN9 in the inflammatory response, in the airway cells, has not yet been reported. Methods: We first checked the anatomical distribution of ACN9 in lung tissues, using mRNA in situ hybridization, and immunohistochemistry. Gene expression profiling in bronchial epithelial cells (BEAS-2B), was performed, after silencing ACN9. We further tested the roles of ACN9, in the intracellular mechanism, leading to Cd-induced production, of proinflammatory cytokines in BEAS-2B. Results: ACN9 was localized in lymphoid, and epithelial cells, of human lung tissues. ACN9 silencing, led to differential expression of 216 genes. Pathways of sensory perception to chemical stimuli, and cell surface receptor-linked signal transduction, were significantly enriched. ACN9 silencing, further increased the expression of proinflammatory cytokines, in BEAS-2B after Cd exposure. Conclusion: Our findings suggest, that ACN9 may have a role, in the inflammatory response in the airway.

• Journal of the Korea Convergence Society
• /
• v.1 no.1
• /
• pp.31-39
• /
• 2010

The purpose of this study was to find related factors to success of smoking-cessation in according to general characteristic, smoking, smoking-cessation and mediation factors in participants of smoking-cessation clinic on public health center in Daejeon metropolitan city. We analyzed 2,125 participants registered in smoking-cessation clinic in 2007. We carried out frequency analysis to understand character of participants, $X^2$-test to verify significance between smoking-cessation success rate and character, and logistic regression analysis to understand significance between smoking-cessation success rate and each character. The smoking-cessation success rate during 6 month was 39.8%. In group of smoking-cessation success, male had higher success rate than female. And over 65 years old group had higher success rate than under 40 years old group. Jung gu public health center had higher success rate than other centers. Logistic regression analysis of the factor associated with smoking-cessation success rate showed statistical significance of age, public health center, 2 stage nicotine patch, total consultation times with smoking-cessation success rate. Total consultation times showed highest odd ratios than other significant factors. Therefore, we suggested that total consultation times has most significance with smoking-cessation success rate, and the consultation may be the most effective method in smoking-cessation clinic.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• v.29 no.1
• /
• pp.311-316
• /
• 2005

A laboratory study on the adsorption of nitrate contaminated in nearshore water using various materials including several types of dredged sediments(ST) and yellow clays(YC), which are activated by hear(HT), bioleaching for heavy metal removal(BL) and neutralization(NR) was performed. The equilibrium time of the adsorption for the sediment bioleached and treated by heat(BL-HT-ST) was only 17min. which was faster than the sediment bioleached, neutralized and treated by heat(BL-NR-HT-S) (25min) or the sediment treated by the bioleaching process(BL-ST)(27min), but longer equilibrium times for yellow clay(YC) or heat treated yello clay(HT-YC) were required. The adsorption processes of nitrate in sea water for tested material could be described by Freundlich isotherm, but were significantly affected by surface characteristics of the materials. The adsorption capacities for raw sediment and heat treated sediment were 2.12, 2.19mg $NO_{3}$-N/g, respectively, which were higher than others, indicating that the sediment activated by heat could be used as a material for the improvement of nearshore water quality.

• KSBB Journal
• /
• v.28 no.6
• /
• pp.339-348
• /
• 2013

Translational research (TR) as high quality research can accelerate collaboration strongly between biotechnology-based researchers and clinical-research experts for overcoming diseases. TR facilitates basic science translated to clinical efficacy and effectiveness from bench (basic science) to bedside (clinical practice) for the enhancement of human health. Disease-oriented TR programs were defined as unilateral, bilateral and multilateral TR in this patent performance analysis. Patent performance was measured in a R&D project on Health and Medical Technology to enhance the productivity of R&D investment on disease-oriented TR in Health Technology (HT). Patent Map (PM) analysis and Bibliometrics were conducted to collect information for the assessment of research patents of TR programs. Futhermore, PIAS (Patent Information Analysis System) and Thinklear programs were applied for quantitative and qualitative analysis successfully. These indicate that multi-dimensional analysis of patent performance for disease-oriented TR could promote the connection of R&D-IP (Research and Development-Intellectural Property) and R&BD (Research and Business Development) supporting system significantly.

• Environmental Mutagens and Carcinogens
• /
• v.26 no.2
• /
• pp.53-58
• /
• 2006

Normally, environmental toxicants are classified as endocrine disruptors if they interfere with regulation of cellular function by endogeneous steroids through inhibition of receptor binding and/or transcriptional activation. So, many studies have been performed about agonist/antagonist of hormone receptor to study mechanisms of endocrine disruptors. If toxicants affect steroid biosynthesis and/or degradation and alter hormone homeostasis, these also are classified as endocrine disruptors. But there are not many studies of the mechanisms of endocrine disruptors on the basis of alteration of steroid biosynthesis and/or degradation. Isolation and culture of Leydig cells from testis is one of methods for the steroidogenesis screening assays to evaluate a substance for altering steroidogenesis. Leydig cells were harvested using the method described by Klinefelter with modifications. Leydig cells were purified by perfusion of testis and incubation ($34^{\circ}C$, 80cycles/minute, 20 minutes) with collagenase (0.25 mg/kg), centrifugal elutriation, percoll gradient centrifugation and BSA multidensity gradient centrifugation. To confirm if this method is one of appropriate tools to evaluate a substance for altering steroidogenesis, ketoconazole, positive control was administered to purified Leydig cells. Ketoconazole ($10^{-8}M$ and above) significantly reduced testosterone production in purified Leydig cells. From above results, we suggest that this method for steroidogenesis screening assay appears to be a appropriate tool to detect suspected compounds for altering steroidogenesis.

• Journal of Korea Game Society
• /
• v.15 no.5
• /
• pp.57-78
• /
• 2015

This Study is the effect of the inclusive institution on a nation's economic development. Therefore, we focused on the gaming industry as an index that can drive the economic growth in the future. The reason to compare the game institution in South Korea and Germany is that both countries began to develop the game by the State, but the game institution in South Korea and Germany at the present time are sharply opposed, because the institutions can focus on the main points that are experiencing this difference. The results of this study, first, open/closed network in institutionalized aspect affects the social status of the game. This second, game workers in the legal institution has been classified as artists in Germany, as addicts in South Korea. And, Germany also has incentives to creators protected profits reinvested in the gaming industry, Korea leads to punitive exploitation is being transferred to the group for addiction treatment that revenue. Third, this exclusive and inclusive institutional system could affect the stable growth of the game market. As a result, South Korea's state institutions will notice that you get a result away from opportunities for economic development due to the loss of inclusiveness.