• Journal of Korean Medicine for Obesity Research
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• v.23 no.1
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• pp.42-50
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• 2023

Obesity often develops to hypothyroidism patients because thyroid hormone is associated with changes in body weight, body temperature, and energy expenditure. Obesity is not only pointed out as the cause of various other diseases, but also can worsen thyroid function, so obesity treatment is essential for hypothyroidism patients. But there is lack of studies about obesity treatment for hypothyroidism patients in Korea. In this study, two obese patients who diagnosed hypothyroidism were treated by Korean medicine. We prescribed herbal medicine (Banhabakchulchunma-tang) for about 2 months. A total of 6.5 kg and 4.5 kg of weight loss were observed respectively, and there were no serious side effects. Further large-scale clinical trials are needed to evaluate the anti-obesity effect and the effect of thyroid function improvement.

• Journal of The Korean Association For Science Education
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• v.43 no.3
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• pp.225-236
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• 2023

This study investigated the characteristics of pre-service elementary teachers' TPACK in science lesson planning using VR/AR content based on epistemic network analysis (ENA). Seven TPACK coding elements were derived inductively based on the existing TPACK framework. Then, the pre-service elementary teachers' discourse in science lesson planning was coded according to the seven TPACK coding elements and analyzed using the ENA Web Tool. The discourses of the two groups were analyzed and compared, and the differences between the two groups, which the researchers analyzed qualitatively, were clearly shown on the ENA graph. Based on these findings, the researchers argued that the ENA method is a useful research tool for analyzing the complex interactions of technology knowledge (TK), content knowledge (CK), and pedagogical knowledge (PK), which is different from previous TPACK research. Also, the researchers discussed the implications for the TPACK competency development of pre-service teachers by comparing the characteristics of the two groups' discourse.

• Journal of Microbiology and Biotechnology
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• v.33 no.4
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• pp.519-526
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• 2023

Panax ginseng is one of the most important herbal medicinal plants consumed as health functional food and can be fermented to achieve better efficacy. Lacticaseibacillus, one of the representative genera among lactic acid bacteria (LAB), has also been used as a probiotic material for health functional foods due to its beneficial effects on the human body. To achieve a synergistic effect by using these excellent dietary supplement ingredients together, a novel LAB strain was isolated from the root of 6-year-old ginseng. Through similarity analysis of 16S rRNAs and whole-genome sequences, the strain was confirmed as belonging to the genus Lacticaseibacillus and was named L. casei KGC1201. KGC1201 not only met all safety standards as food, but also showed excellent probiotic properties such as acid resistance, bile salt resistance, and intestinal adhesion. In particular, KGC1201 exhibited superior acid resistance through morphological observation identifying that the cell surface damage of KGC1201 was less than that of the L. casei type strain KCTC3109. Gene expression studies were conducted to elucidate the molecular mechanisms of KGC1201's acid resistance, and the expression of the glycosyltransferase gene was found to be significantly elevated under acidic conditions. Exopolysaccharides (EPSs) biosynthesized by glycosyltransferase were also increased in KGC1201 compared to KCTC3109, which may contribute to better protection of KGC1201 cells from strong acidity. Therefore, KGC1201, with its increased acid resistance through molecular mechanisms and excellent probiotic properties, can be used in health functional foods to provide greater benefit to overall human health and well-being.

• Journal of the Korea Fashion and Costume Design Association
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• v.25 no.2
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• pp.45-59
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• 2023

This study aims to find implications for the introduction and practice of ESG by domestic fashion companies by examining the core ESG topics and strategies of Samsung C&T Fashion Division, Kolon FnC, F&F holdings, and Fila. ESG management analysis examined the importance of the criticality evaluation process, critical issues, and implementation strategies for each key topic based on the company's 2021 ESG sustainable management report, and analyzed the relationship with UN SDGs and the GRI. The analysis results are as follows: As for KCGS' ESG rating, Samsung C&T's fashion division, Kolon FnC, and Fila Holdings were rated A, while F&F Holdings was rated B+. The major issues derived from ESG's criticality assessment are environmental issues related to Samsung C&T's fashion division. Kolon FnC was found to have focused on the social sector and F&F Holdings focused on governance structure. After examining the correlation between the ESG core strategies of the investigated fashion companies and the 17 SDGs, the common areas were identified as quality employment, sustainable production and consumption, and climate changes and response. Correlation with the GRI Standards 2021 Index, (GRI 1, GRI 11, and GRI 12 created in 2021) was not reflected. In the future, it will be necessary to have a transparent governance structure that meets global standards, sets measurable goals, and continuously manages them. Other companies should also recognize ESG management processes that embrace various stakeholders and strengthens win-win cooperation to manage risks, and establish mid- to long-term response strategies.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.214-216
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• 2021

It proposes a plan to strengthen the limitations of existing corporate security systems based on Zero-Trust. With the advent of the era of the Fourth Industrial Revolution, the paradigm of security is also changing. As remote work becomes more active due to cloud computing and COVID-19, security issues arising from the changed IT environment are raised. At the same time, in the current situation where attack techniques are becoming intelligent and advanced, companies should further strengthen their current security systems by utilizing zero trust security. Zero-trust security increases security by monitoring all data communications based on the concept of doubting and trusting everything, and allowing strict authentication and minimal access to access requestors. Therefore, this paper introduces a zero trust security solution that strengthens the existing security system and presents the direction and validity that companies should introduce.

• Journal of the Korea Fashion and Costume Design Association
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• v.25 no.1
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• pp.49-63
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• 2023

The purpose of this study is to investigate the current status and motives of buying second-hand clothing among university students and to suggest a plan to activate second-hand clothing transactions. In order to discover the effect of the buying motives on the purchasing of second-hand clothing, 112 university students who have purchased second-hand clothing over the past six months were surveyed and their responses were used for analysis. As a result of the analysis, it was found that design differentiation, habitual use, and economical factors had a meaningful effect on the purchase of second-hand clothes. Second-hand clothes have a positive environmental perception, but that perception did not impact the purchasing of second-hand clothes. It is necessary to raise the awareness and social movement around second-hand clothing and teach consumers the environmental benefits and sustainability of second-hand clothing. An activation plan for the second-hand clothing market is: 1. Proposes various market subdivisions that meet the characteristics and tastes of consumers that lead to the purchase of used clothing. In this study, two economic factors were found among the buying motives. The first is purchasing second-hand clothing at a very low price, and the second is finding luxurious expensive items or unique values at a lower price. Therefore, it is necessary to find various markets segments that suit consumer tastes by checking consumer characteristics and detailed factors. 2. Nurture second-hand clothing processing brands for the diversification of the second-hand clothing market. 3. There is an urgent need for quality classification, quality assurance, and the standardization of second-hand clothing. This study is meaningful in that it explored the possibility of having a positive effect on activating the second-hand clothing market.

• Korean Journal of Pharmacognosy
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• v.54 no.2
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• pp.61-65
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• 2023

Clerodendrum trichotomum has been widely used as a traditional medicine for the treatment of numerous diseases, including pain management. However, there have been extremely limited pharmacological and phytochemical studies on Clerodendrum trichotomum up to now. In this study, we investigated the effects of the methanolic extract of Clerodendrum trichotomum (MCT) on nociceptive pain in mice. Our finding demonstrate that MCT treatment significantly extended the latency time in both the tail-immersion test and hot-plate test. Additionally, MCT treatment reduced acetic acid-induced writhing motions. These results suggest that MCT possesses strong anti-nociceptive activities against thermal and chemical nociception. In the formalin test, mice fed with MCT exhibited reduced licking time during both the early and late phases, thereby confirming the therapeutic potential of MCT in central and peripheral nociception. Furthermore, in combination tests using naloxone, the MCT-mediated anti-nociception was slightly reduced, indicating that MCT might act as a partial opioid receptor agonist. Based on these results, MCT may be a valuable candidate for the development of anti-nociceptive agents.

• Journal of Veterinary Science
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• v.24 no.4
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• pp.53.1-53.12
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• 2023

Background: Mammalian orthoreovirus type 3 (MRV3), which is responsible for gastroenteritis in many mammalian species including pigs, has been isolated from piglets with severe diarrhea. However, the use of pig-derived cells as an infection model for swine-MRV3 has rarely been studied. Objectives: This study aims to establish porcine intestinal organoids (PIOs) and examine their susceptibility as an in vitro model for intestinal MRV3 infection. Methods: PIOs were isolated and established from the jejunum of a miniature pig. Established PIOs were characterized using polymerase chain reaction (PCR) and immunofluorescence assays (IFAs) to confirm the expression of small intestine-specific genes and proteins, such as Lgr5, LYZI, Mucin-2, ChgA, and Villin. The monolayered PIOs and three-dimensional (3D) PIOs, obtained through their distribution to expose the apical surface, were infected with MRV3 for 2 h, washed with Dulbecco's phosphate-buffered saline, and observed. Viral infection was confirmed using PCR and IFA. We performed quantitative real-time reverse transcription-PCR to assess changes in viral copy numbers and gene expressions linked to intestinal epithelial genes and antiviral activity. Results: The established PIOs have molecular characteristics of intestinal organoids. Infected PIOs showed delayed proliferation with disruption of structures. In addition, infection with MRV3 altered the gene expression linked to intestinal epithelial cells and antiviral activity, and these effects were observed in both 2D and 3D models. Furthermore, viral copy numbers in the supernatant of both models increased in a time-dependent manner. Conclusions: We suggest that PIOs can be an in vitro model to study the infection mechanism of MRV3 in detail, facilitating pharmaceutical development.

• 한국노년학
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• v.29 no.3
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• pp.935-951
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• 2009

This study purposed to explain the development process on elder education policy in Korea and to find out its characteristic. As previous studies mainly described the current situation of elder education policy to make a proposal, the analysis of the development process and its characteristic was ignored. Analyzing the government documents the elder education policy was started as a part of by considering the part in saemaul(New-village) movement, the current policy support for the elderly leads to the training of human resources. In the process, characteristic of policy are as follows, first, the policy objectives and targets has changed. And in the late 1990s, most of the established elder education policy was not to run. Finally, it is not match between policy making and implementation.

• Biomolecules & Therapeutics
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• v.31 no.6
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• pp.674-681
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• 2023

Bile pigment, bilirubin, and biliverdin concentrations may change as a results of biliary tract cancer (BTC) altering the mechanisms of radical oxidation and heme breakdown. We explored whether changes in bile pigment components could help distinguish BTC from benign biliary illness by evaluating alterations in patients with BTC. We collected bile fluid from 15 patients with a common bile duct stone (CBD group) and 63 individuals with BTC (BTC group). We examined the bile fluid's bilirubin, biliverdin reductase (BVR), heme oxygenase (HO-1), and bacterial taxonomic abundance. Serum bilirubin levels had no impact on the amounts of bile HO-1, BVR, or bilirubin. In comparison to the control group, the BTC group had considerably higher amounts of HO-1, BVR, and bilirubin in the bile. The areas under the curve for the receiver operating characteristic curve analyses of the BVR and HO-1 were 0.832 (p<0.001) and 0.891 (p<0.001), respectively. Firmicutes was the most prevalent phylum in both CBD and BTC, according to a taxonomic abundance analysis, however the Firmicutes/Bacteroidetes ratio was substantially greater in the BTC group than in the CBD group. The findings of this study showed that, regardless of the existence of obstructive jaundice, biliary carcinogenesis impacts heme degradation and bile pigmentation, and that the bile pigment components HO-1, BVR, and bilirubin in bile fluid have a diagnostic significance in BTC. In tissue biopsies for the diagnosis of BTC, particularly for distinguishing BTC from benign biliary strictures, bile pigment components can be used as additional biomarkers.