• Title/Summary/Keyword: Hydroxyflavones

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Synthesis and Inhibitory Activity against COX-2 Catalyzed Prostaglandin Production of Flavone Analogs

  • Tran, Thanh-Dao;Chi, Yeon-Sook;Kim, Jeong-Soo;Kim, Hyun-Pyo;Kim, Sang-Hee;Park, Hae-Il
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.235.2-235.2
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    • 2003

  • To decipher the structure-activity relationships of flavones for the inhibition of cyclooxygenase-2 catalyzed prostaglandin production, we synthesized 7-methxoyflavones, 7-hydroxyflavones, 5-methxoyflavones, 5-hydroxyflavones and flavones without any phenol group on A ring. Methoxyflavones were prepared from 2.6- and 2,4-dihydroxyacetophenones in 3 steps. Most of the methxoyflavones were converted to the corresponding hydroxyflavones by the reaction with BBr3 in good yields. (omitted)

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