Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
- /
- Pages.235.2-235.2
- /
- 2003
Synthesis and Inhibitory Activity against COX-2 Catalyzed Prostaglandin Production of Flavone Analogs
- Tran, Thanh-Dao (College of Pharmacy, Kangwon National University) ;
- Chi, Yeon-Sook (College of Pharmacy, Seoul National University) ;
- Kim, Jeong-Soo (College of Pharmacy, Seoul National University) ;
- Kim, Hyun-Pyo (College of Pharmacy, Seoul National University) ;
- Kim, Sang-Hee (College of Pharmacy, Seoul National University) ;
- Park, Hae-Il (College of Pharmacy, Seoul National University)
- Published : 2003.04.01
Abstract
To decipher the structure-activity relationships of flavones for the inhibition of cyclooxygenase-2 catalyzed prostaglandin production, we synthesized 7-methxoyflavones, 7-hydroxyflavones, 5-methxoyflavones, 5-hydroxyflavones and flavones without any phenol group on A ring. Methoxyflavones were prepared from 2.6- and 2,4-dihydroxyacetophenones in 3 steps. Most of the methxoyflavones were converted to the corresponding hydroxyflavones by the reaction with BBr3 in good yields. (omitted)
Keywords