• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.3
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• pp.178-187
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• 2009

Background : Atopic dermatitis is chronic exzemaous dermatitis and the recurrence rate of atopic dermatitis is high. Many patients are suffering from pruritus. Objective : This study compared ambulatory care with hospitalization for atopic dermatitis treatment of one patient, and investigated the effect of Oriental medicine program for atopic dermatitis patients during short term hospitalization. Method : We treated a 5 year-old boy with uncontrollable atopic dermatitis by ambulatory care and hospitalizaion. Herbal medication and herbal dressing was done samely during ambulatory care and hospitalization. Intensive life management, education for compliance was done only during hospitalization. Results : Even though he had been treated for 5 months by ambulatory care, he still suffered from severe itching, erythema, oozing and insomnia. Admission duration was 10 days. During admission, the SCORAD scores and subjective scores were decreased rapidly. Conclusion : We concluded that effects of the treatments can be different due to compliance of the patient and in that view the short term hospitalization program could be more helpful than ambulatory care for uncontrollable atopic dermatitis patients.

• The Korean Journal of Physiology
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• v.27 no.1
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• pp.27-35
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• 1993

Effects of the endothelium on the contractile responses to norepinephrine (NE) were investigated in isolated helical strips of the proximal and distal coronaries artery of pigs. The helical strips were immersed in Tris-buffered Tyrode's solution equilibrated with 100% $O_2$ at $35^{\circ}C$ and its isometric tension was measured. NE relaxed the strips precontracted with acetylcholine from both the proximal and distal coronary artery. NE-induced relaxation, which might be induced mainly by $\beta$-adrenoceptor function was dominant in the distal coronary arteries. NE-induced relaxation was converted to a contraction after $\beta$-adrenoceptor blockade with propranolol $(3{\times}10^{-6}M)$. ${\alpha}$-adrenoceptor-mediated contraction by NE was greater in the proximal coronary artery than the distal coronary artery. Quantitatively, ${\alpha}_1$-adrenoceptor mediated contraction by NE was greater than ${\alpha}_2$-adrenoceptor mediated contraction by NE in both arteries. NE-induced relaxation was decreased by rubbing of endothelium in both arteries. ${\alpha}_1-and\;{\alpha}_2$-adrenoceptor mediated contraction by NE were potentiated by rubbing of endothelium in both arteries. Pretreatment with methylene blue, an inhibitor of soluble guanylate cyclase, increased ${\alpha}_1-\;and\;{\alpha}_2$-adrenoceptor mediated contraction by NE in both arteries with endothelium. From the above results, we suggest that the effect of activation of $\alpha$-adrenoceptors by NE may be modulated by endothelium in the proximal and distal coronary arteries of pigs. This effect may be mediated via endothelium derived relaxing factor.

• Korean Journal of Clinical Pharmacy
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• v.21 no.1
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• pp.22-29
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• 2011

Purpose: This study aims to investigate how gender-based differences are actually reflected on drug approval. Methods: Data on gender-based differences of drugs were analyzed by searching PDR (Physician's Desk Reference) with the keyword, "GENDER". Results: There were descriptions related to gender in product directions of 361 drugs in 2009 PDR, out of which 63 items actually showed gender-related differences. Drug categories showing comparatively high gender-based differences were nervous system, cardiovascular system, and alimentary tract and metabolism. Pharmacokinetic differences between genders were observed most frequently; compared to men, 32 drugs showed higher absorption while 18 drugs revealed lower clearance in women. There were 2 drugs which gender should be considered before prescribing, and 5 drugs which showed different severity of adverse effects according to gender. Conclusions: It is necessary to establish domestic policies for drug approval and use which reflects gender-based differences through sufficient researches.

• Journal of the Korean Institute of Telematics and Electronics
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• v.19 no.3
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• pp.19-27
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• 1982

Minimization of total routing and number of cuts has been adopted for the placement problem in LSI and printed wire board as the object function, recently. Although it is considered that in the general situation this object function reflects the final goal which is wiring of 100% of layout, it often seems to be insufficient because it does not exhibit partial wire congestion. This paper introduces a new concept called the wire congestion of segestion to get the partial wire congestion and proposes the object function to minimize the wire congestion of segmests. In order to optimize this object function, an effective heuristic algorithm is also suggestsl Experimental results show that this algorithm sustains its efficiency. The experimental consequences point out that if the total routing length is short, maximum wire congestion of segment is small and vice versa. Therefore control parameter, that is, congestion parameter, which mintnizes total length and concurrently reduces maximal wire congestion of segment, is obtained by experiment.

• Korean Journal of Soil Science and Fertilizer
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• v.46 no.5
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• pp.333-342
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• 2013

Soil compaction is affected by soil texture, organic matter (OM), strength (ST) and soil moisture, which is difficult to understand the degree and effects of related factors. The purpose of the study is to assess the impact of them on the compaction with bulk density (BD). The analysis was conducted with data collected from national-wide monitoring sites including 105 upland soils, 246 orchard soils, and 408 paddy soils between 2009 and 2012. The distributions of soil physical properties were measured. The correlation and multi linear regression analysis were performed between soil physical properties using SAS. The regression equation of BD(y) includes ST, gravitational water contents (GWC), and OM as variables commonly, having additional factors, clay content and sand content in paddy soil and upland soil for only subsoil (p<0.001). Our results show that the BD could be explained about 40~50% by various physical properties. The regression was mainly determined by ST in orchard and upland soil and by the GWC in paddy soil. To mitigate soil compaction, it is important to maintain the proper level of OM in upland soil and to consider the moisture condition with soil texture in paddy soil when making work plan. Furthermore, it would be recommended the management criteria classified by soil texture for the paddy soils.

• Food Science of Animal Resources
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• v.35 no.4
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• pp.502-506
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• 2015

The aim of this study was to investigate the antimicrobial resistance profiles of and the enterotoxin gene distribution in 4 strains of Staphylococcus aureus (S10-2, S10-3, S12-2, and S13-2) isolated from 90 bulgogi samples. The S. aureus enterotoxin H gene (seh) was found in all the strains, while the S. aureus enterotoxin A gene (sea) was found only in 3 of the 4 strains. The S10-2 strain expressed a combination of enterotoxin genes - seg, seh, sei, sej, selm, and seln. The strains S10-2 and S13-2 were resistant to ampicillin and penicillin G, and all the isolated strains were resistant to tetracycline. The S10-2 strain was the only mecA-positive strain; it was also resistant to β-lactam antibiotics. Thus, genes encoding enterotoxin as well as those conferring antibiotic resistance were identified in the S. aureus strains isolated from pork bulgogi. These results represents the potential occurrence of MRSA in pork bulgogi, and the need for a monitoring system for pork bulgogi in order to prevent an outbreak of staphylococcal food poisoning.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.4
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• pp.223-229
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• 2003

Using phospholipase D1 (PLD1)-overexpressing PC12 (PLD1-PC12) cells, the regulatory roles of PLD1 on ATP-induced currents were investigated. In control and PLD1-PC12 cells, ATP increased PLD activity in an external $Ca^{2+}$ dependent manner. PLD activity stimulated by ATP was substantially larger in PLD1-PC12 cells than in control cells. In whole-cell voltage-clamp mode, ATP induced transient inward and outward currents. The outward currents inhibited by TEA or charybdotoxin were significantly larger in PLD1-PC12 cells than in control cells. The inward currents known as $Ca^{2+}$ permeable nonselective cation currents were also larger in PLD1-PC12 cells than in control cells. However, the difference between the two groups of cells disappeared in $Ca^{2+}$-free external solution, where ATP did not activate PLD. Finally, ATP-induced $^{45}Ca$ uptakes were also larger in PLD1-PC12 cells than in control cells. These results suggest that PLD enhances ATP-induced $Ca^{2+}$ influx via $Ca^{2+}$ permeable nonselective cation channels and increases subsequent $Ca^{2+}$-activated $K^+$ currents in PC12 cells.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.85.1-85.1
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• 2013

GMT(Giant Magellan Telescope)는 25.4m의 주경과 3.2m의 부경으로 이루어진 거대망원경이다. 3.2m의 부경은 빠른 tip-tilt로 망원경을 제어하는 Fast Steering Mirror(FSM)와 적응광학계로 이루어진 Adaptive Secondary Mirror (ASM)로 구분된다. 한국천문연구원은 국내외 협력기관들과 함께 부경 FSM의 시험모델개발을 수행하고 있다. 부경은 1.06m의 반사경 일곱 개로 이루어져 있는데, 한 개의 광축 반사경 주위로 여섯개의 비축 반사경이 둘러싸여서 하나의 3.2m 반사경과 같은 기능을 하고 있다. 비축 비구면 반사경에 대한 시험모델의 반사면을 가공한 결과 표면가공 정밀도가 11.7nm rms의 정밀도를 갖는 반사경을 가공하였다(target : <20nm rms). 또한 test-bed를 제작하여 tip-tilt 정밀도를 제어한 결과 성능요구 조건 값인 0.03arcsec 제어에 성공하였고, 더 나아가 0.01arcsec의 tip-tilt 제어도 가능한 것으로 판단된다.

• Journal of the Korea Institute of Building Construction
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• v.10 no.4
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• pp.21-29
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• 2010

International construction contractors are often faced with the situation of working in an unfamiliar construction environment. Under FIDIC rules, the contractor has the right to make a claim requesting the consulting engineer for an adjustment to the contract price or the time for completion when a part or parts of the works have changed, or in the event of unforeseeable conditions. Contractors generally have more access to the costs and time implications of such a change or unforeseeable conditions than the consulting engineer or outside neutrals. Due to such an asymmetry of information, the contractor may be motivated to dispute frivolous claims of less merit, expecting erroneous judgments by the consulting engineer or the neutrals. In this paper, a claiming behavior model is presented by using game theory and experience data to study the manner in which frivolous claims develop into disputes. The model also analyzes the impacts of DAB/DRB upon the frivolous claims.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.5A
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• pp.289-297
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• 2012

This study proposes an experimental formula that can estimate the applied tensile stress of a bonded PSC by measuring a longitudinal stress wave velocity of tendon. To develop practical formula, the various bonded PSC specimens are constructed with different levels of prestresses. For all the bonded PSC specimens, the longitudinal impact-echo tests are repeated with various experimental conditions. Considering a few influence factors such as temperature, length and the number of strands, the application of the law of similarity results in a nondemensional experimental formula that could estimate existing tensile stress on tendon by measuring its longitudinal stress wave velocity. Next, a feasibility study of proposed approach has been conducted for a real reactor building containment. The estimated stress levels of two vertical tendons embedded in the nuclear plant are close to their design values.