• Title/Summary/Keyword: Humans and animals

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Multiple Effects of Bracken Fern under in vivo and in vitro Conditions

  • Tourchi-Roudsari, Motahhareh
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.18
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    • pp.7505-7513
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    • 2014
  • Several toxic substances have been detected in plants which are responsible for animal and human diseases. Bracken fern (Pteridium aquilinum) is one example, widely distributed in many parts of the world. It is known to cause cancer in humans and other animals. In fact, man can be directly or indirectly exposed to the danger by consuming fern, contaminated water, milk, meat, and spore inhalation. Experimental studies have shown an association between bracken exposure and gastric cancer, and research has shown genotoxic and cytotoxic effects in vitro. This paper describes and reviews toxic, carcinogenic, genotoxic/cytotoxic, and immunomodulatory effects of bracken and included possible toxic agents. The chemistry of Ptaquiloside (PT) reactions is emphasized, along with bracken problems in livestock, possible pathways of exposure in man, and control for human health.

Examining Portraits in Digital Fashion Art Non-Fungible Tokens (NFTs) through Baudrillard's Simulation

  • Yoon Kyung Lee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.47 no.5
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    • pp.929-942
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    • 2023
  • Web 3.0 enables people and machines to connect, evolve, share, and use knowledge on an unprecedented scale and in new ways, drastically improving our Internet experience. The metaverse is a collective, virtual shared space supporting all digital activities. Prompted by the rapid growth of digital art and digital fashion, this theoretical analysis explores using Jean Baudrillard's simulation concept to create unique digital art non-fungible tokens (NFTs), allowing them to express and communicate ideas like real-world art. Specifically, this study analyzes 120 digital fashion portraits of humans and animals and classifies them under three types of simulacra covering four stages of Baudrillard's simulation process. The result shows that NFT fashion artworks reflect the core features of a digital reality by connecting and transcending the boundaries of cultures, genders, and nationalities. However, in the final simulation stage (the fourth step), the simulacrum can only coexist in the virtual world as a hyperreal object (the Type III of simulacrum): an object more real than reality.

Induction of Apoptosis by N-nitrosocarbofuran, via Cytochrome c-Mediated Activation of Caspase-3 protease

  • Lee, Bang-Wool;Oh, Seon-Hee;Lee, Byung-Hoon
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.158.1-158.1
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    • 2003
  • Carbofuran(CF) is one of the most widely used carbamate pesticides in the world applied for insect and nematode control. Due to its widespread use in agriculture and households, contamination of food, water, and air has become serious, and consequently adverse health effects are inevitable in humans, animals, wildlife and fish, it has reported that CF alone or in combination with other carbamate insecticides influences the level of reproductive and metabolic hormones such as thyroxine and corticosterone, and results in impairment of endocrine, immune behavioral functions. (omitted)

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In vitro mutagenicity and genotoxicity study of PAHs and nitro-PAHs using the bacterial revertant (Ames) test and alkaline single cell gel electrophorosis (Comet) assay

  • Kim, Soung-Ho;Oh, Seung-Min;Chung, Kyu-Hyuck
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.284.1-284.1
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    • 2002
  • In previous studies, we demonstrated that ambient PM collected from urban site of Korea air could induce DNA damage, Various mutagens and carcinogens present in the urban air differ according to the source of the pollutants. Polycyclic aromatic hydrocarbons (PAHs) and their nitrated compound are produced in the combustion of fossil fuels as diesel emission exhausts. In recent, PAH and nitro-PAH have been identified in urban air particulate matter (PM). and some of them were found to be tumorigenic in experimental animals and humans. (omitted)

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Prevalence of Clostridium difficile Isolated from Beef and Chicken Meat Products in Turkey

  • Ersoz, Seyma Seniz;Cosansu, Serap
    • Food Science of Animal Resources
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    • v.38 no.4
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    • pp.759-767
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    • 2018
  • The concern about the possibility of food can be a vehicle for the transmission of Clostridium difficile to humans has been raised recently due to the similarities among the strains isolated from patients, foods and food animals. In this study, therefore, the prevalence of C. difficile was investigated in beef and chicken meat products collected from 57 different butcher shops, markets and fast food restaurants in Sakarya province of Turkey. Two out of 101 samples (1.98%) was positive for C. difficile indicating a very low prevalence. The pathogen was isolated from an uncooked meatball sample and a cooked meat $d{\ddot{o}}ner$ sample, whereas not detected in chicken meat samples. The meatball isolate was resistant to vancomycin and tetracycline, while the cooked meat $d{\ddot{o}}ner$ isolate was resistant to vancomycin and metronidazole. Both isolates were sensitive to moxifloxacin and clindamycin. Toxins A and B were not detected. This study reveals the presence of C. difficile in further processed beef products in Turkey.

Development of Apoptosis Model and Bioimmune Responses in Experimental Animal I. Induction and Indicator of Apoptosis and Hepatic Tumorigenesis (실험동물에서 Apoptosis의 모델개발과 생체면역반응 및 형태학적 특징 I. Apoptosis 및 Hepatic Tumorigenesis의 유도 및 관련지표의 검색)

  • 강정부;하우송;김지경
    • Journal of Veterinary Clinics
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    • v.16 no.1
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    • pp.100-107
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    • 1999
  • Apoptosis is now widely recognized as a common form of cell death and represents mechanism of cell clearance in many physiological situations where deletion of cells is required. In vivo administration of bacterial lipopolysaccharide (LPS) to Balb/c mice induced DNA fragmentation in the thymus. DNA fragmentation in the thymus was roughly dependent on the dose of LPS injected and reached the peak 18 hours after injection. This apoptosis in the thymus might be mediated due to LPS stimulant. DEN (diethylnitrosamine) has been shown to cause liver cancer in experimental animals and humans. The hepatic tumorigenesis was induced by ad libitum feeding of DEN only. It was suggested that DEN induced hepatic tumorgenesis in rat is a good reproducible model for studying biochemical and pathophysiological changes associated with the development of hepatic tumorigenesis and apoptosis.

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Effect of the Dietary Protein Level on Plasma Glucose, Lipids and Hormones in Streptozotocin-Diabetic Rats

  • Han Yung Joo
    • Journal of Nutrition and Health
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    • v.26 no.7
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    • pp.851-857
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    • 1993
  • Atherosclerotic vascular disease is a major cause of the increased morbidity and mortality assciated with diabetes mellitus. The prominent role of nutrition in hypercholesteolemia and atherosclerosis is generally accepted. Diet is a key element in the management of diabetes (type I-IDDM), yet the appropriate diet for patient with diabetes mellitus is not well known. Dietary protein has been shown to have a significant effect on plasma cholesterol levels in both experimental animals and humans. The present experiment was designed to determine the effect of the dietary protein level(20% vs 60%) on plasma glucose concentration, lipids profile, insulin and glucagon levels from non-diabetic and streptozotocin-induced diabetic rats. Results showed that a high protein diet decreased triglyceride concentration in diabetic rats. Also diabetic rats fed a high protein diet were hypocholesterolemic than rats fed a control diet. There were no effects by level of protein on fasting blood glucose concentration and insulin/glucagon ratio. Results from the present study suggest that a high protein diet may be beneficial to control pasma lipids in chemically-induced diabetic rats.

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Phamalogical effect and component of sea buckthorn(Hippophae rhamnoides L.) (비타민나무의 약리 효과 및 구성 성분)

  • Kim, Ju-Sung;Yu, Chang-Yeon;Kim, Myong-Jo
    • Journal of Plant Biotechnology
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    • v.37 no.1
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    • pp.47-56
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    • 2010
  • Sea buckthorn (Hippophae rhamnoides L.) is deciduous shrubs in the genus Hippophae, mainly cultivated in Europe and Asia. Sea buckthorn berries have a high vitamin C, vitamin E, carotenoids, carbohydrates, protein, organic acids, dietary minerals, triterpenoids, polyphenolic acids and amino acids. Extracts of sea buckthorn berries have anti- obesity, anti-oxidantive, anti-microbial, anti-ulcerogenic, anti-diabetic and nutritional effects. Sea buckthorn used as a traditional medicine for the treatment of cough, aid digestion, invigorate blood circulation and alleviate pain. Extracts of sea buckthorn branches and leaves was administered to humans and animals to treat gastrointestinal distress in Mongolia. This paper briefly reviews the most relevant experimental data on the pharmacological effects and isolated component of sea buckthorn. And, we also describe the importance of sea buckthorn as the environmental-friendly crops.

Application of Animal Biomodel using Poultry: A Review (가금을 이용한 동물 바이오모델: 총설)

  • Seo, Dongwon;Lee, Jun Heon
    • Korean Journal of Poultry Science
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    • v.43 no.4
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    • pp.243-251
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    • 2016
  • Chicken not only serves as a high-protein source to humans, but it is also used as a suitable biomodel for increasing livestock productivity and studying human diseases. Chickens have numerous advantages as model organisms mainly because of they are relatively convenient to manage due to their small body size and short generational interval. In addition, they have a small genome size and numerous genes have biologically similar functions to those of human and livestock animals. In this review, we investigated the chicken biomodel for human disease research and the use of this model for increasing livestock productivity. This summary could provide useful and basic information for further development of strategies for enhancing livestock production and human disease studies.

An investigation of excretion of calcium from female mice ingested with boron by using neutron activation analysis

  • Sun, Gwang Min;Lee, Jaegi;Uhm, Young Rang;Baek, Hani
    • Nuclear Engineering and Technology
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    • v.52 no.11
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    • pp.2581-2584
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    • 2020
  • Boron has been considered to play a nutritionally important role in humans and animals, but its biochemical functions are not clearly understood. Though there are signs that boron affects the mineral and hormone metabolisms, there is no comprehensive epidemiological evidence establishing a relationship between a boron intake and osteoporosis due to the excretion of calcium in the bones. In this study, we investigated the influence of boron intake on the calcium excretion of old female mice in the menopause. The concentrations of calcium in backbone, thigh bone, blood, kidney, liver, and spleen were investigated by using instrumental neutron activation analysis.