• 대한한의학원전학회지
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• 제29권1호
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• pp.17-41
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• 2016

Subjects : A literature research on the constitution and medicinal effect & adaptation diseases of "Bullsusan". "Bullsusan" is a herbal prescription composed of Angelicae Gigantis Radix(當歸) and Cnidii Rhizoma(川芎). Objectives : Through the researching on the records of "Bullsusan" in Korean Traditional Medical Books, gain the literature evidence for adaptation to these days child labor as a pre-labor keeping herbal medicine. And have detailed consideration on the constitution of prescription and medicinal effect & adaptation diseases of "Bullsusan". Methods : First, researched the records of "Bullsusan" in Korean Traditional Medical Books which were included at A Series of Korean Medicine(韓國醫學大系) and analysed component ratio, nickname, herbal manufacture and drug processing method, medicinal effect and adaptation diseases. Second, referred related Korean and Chinese researches that examined the medicinal effect and adaptation diseases of "Bullsusan" by scientific experimentation. Conclusions : We found total 46 records of "Bullsusan" from 20 kinds of Korean Traditional Medical Books included at A Series of Korean Medicine. Prescription component ratio of Angelicae Gigantis Radix and Cnidii Rhizoma were 3:2, 1:1, 2:1, 1:1. 3:2 had most 20 records and 1:1 had second 14 records. Especially 1:1 had a tendency of having nickname "Goonguitang", but not must had. First herbal manufacture was powder, it had 8 records. First drug processing method was decocting with water and alcohol, had 19 records. Medical Effects of "Bullsusan" can be induced to next 8, that were "remove get bad blood, give birth new blood", "easy labor by reducing fetal volume", "acceleration of labor", "test of fetal survival, elimination of dead embryo", "elimination of placenta", "revive", "allaying pain", "nourish the blood". From these medical effects, 9 adaptation diseases can be induced. That were "threatened abortion", "womb ache and vaginal bleeding by spontaneous abortion", "pre-labor keeping(prevention of hard labor)", "acceleration of labor", "hard labor", "missed abortion", "postnatal vaginal bleeding, dizziness, asthma, headache, womb ache", "postnatal mastoptosis and mastodynia", "first aid symptom like as dizziness, unconsciousness, stroke caused by excessive bleeding". The medical effect of "acceleration of labor" and "elimination of placenta" have been examined by modern clinical research. The effect of "remove get bad blood, give birth new blood", "allaying pain" and "nourish the blood" have been examined by modern experimental study. But overdosing on "Bullsusan" to pregnant mouse can cause natural abortion, so the proper dose of "Bullsusan" in pregnant period is very important.

• 의료법학
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• 제17권1호
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• pp.139-168
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• 2016

독일은 의료분쟁에 대하여 주의사협회를 중심으로 설립된 두 가지 방식의 대체적 분쟁해결방식을 두고 있는데, 첫째는 하노버를 중심으로 한 북독일 지역의 의료조정원이고, 다른 하나는 노트라인 지역을 중심으로 한 감정위원회 방식이다. 두 조직은 의사협회를 중심으로 구성되어 있지만, 북독일의료조정원은 법조인과 의사가 각각 1인 포함된 조정위원회를 구성하고, 감정위원회는 법조인 1인을 감정위원장으로 임명하고 그 이하에 4명의 의사 감정위원을 둠으로써, 조정위원 또는 감정위원들이 가진 고도의 의학적 지식에 법률적 중립성을 부여하려고 노력하고 있다. 현재 우리나라에서 의료사고 피해 구제 및 의료분쟁 조정 등에 관한 법률에 의하여 설립된 한국의료분쟁조정중재원에 의한 대체적 분쟁 해결 방식은 감정과 조정 중재라는 두 단계를 거쳐야 하기 때문에 독일의 감정위원회 절차와 조정위원회 절차가 참고가 될 수 있다. 의료 분쟁 조정제도가 의료인 중심으로 운영되면, 환자 측으로부터 불신을 받을 것이지만, 현재 우리의 제도는 의사측이 의료중재원 절차에서 소외될 수 있다는 우려 역시 주요한 문제점으로 나타나고 있다. 또한 법 개정에 의하여 사망자와 중상자에 대한 조정 자동개시가 도입되면서, 의료분쟁조정중재원의 중립성과 효율적 운영이 중요한 문제점이 되었다. 독일의 조정원과 감정위원회의 구성에 비추어 보면, 조정원 구성은 법조인과 의사가 동등하게 참여하여 구성하는 것과 감정위원회 구성은 위원장을 법조인이 하고, 감정 위원들을 의사들로 구성하는 것과 같이 전문가들의 협조와 견제를 고려하고 있다. 현재 의료분쟁 조정법에서 조정과 감정은 하나의 절차처럼 운영되고 있는데, 적절한 협력을 고려하면서 의료인 중심의 감정 분야와 법조인 중심의 조정 분야를 독립적으로 운영 발전할 필요가 있다.

• 한국의료질향상학회지
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• 제26권1호
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• pp.23-34
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• 2020

Purpose: This qualitative study was conducted to examine the current status and problems concerning the collection of present on admission (POA) indicators and determine how to use these indicators for evaluating the quality of care and degree of patient safety. Methods: A total of 11 health information managers were divided into two groups according to the size of their hospitals. Two focus group discussions (FGDs) were conducted, one for each group, which followed a pre-developed semi-structured guideline. The verbatim transcriptions of the FGDs were analyzed. Results: The majority of participants were concerned about entering POA flags honestly because they did not know how future POA indicators would be used. In particular, for some participants, POA N was a burden that could imply a signal of mismanagement within the medical institution. In addition, the lack of awareness and indifference of physicians regarding POA indicators were some of the difficulties for POA flag entry. Although medical institutions are making efforts to improve the accuracy of POA flagging, many participants mentioned the need to develop real case-oriented POA entry guidelines to improve the accuracy of POA flagging. Conclusion: To increase the validity of POA indicators, it is necessary to increase the level of awareness of POA indicators in physicians and other medical professionals. Furthermore, efforts related to POA indicators by individual medical institutions need to be reflected in the process evaluation.

• Nutrition Research and Practice
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• 제6권6호
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• pp.513-519
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• 2012

Aged garlic extract (AGE) is known to have a protective effect against immune system, endothelial function, oxidative stress and inflammation. We examined the effects of exercise with and without aged garlic extract administration on body weight, lipid profiles, inflammatory cytokines, and oxidative stress marker in high-fat diet (HFD)-induced obese rats. Forty-five Sprague-Dawley rats were fed either a HFD (HFD, n = 40) or a normal diet (ND, n = 5) for 6 weeks and thereafter randomized into ND (n = 5), HFD (n = 10), HFD with AGE (n = 10), HFD with Exercise (n = 10), or HFD with Exercise+AGE (n = 10) for 4 weeks. AGE groups were administered at a dose of 2.86 g/kg body weight, orally. Exercise consisted of running 15-60 min 5 days/week with gradually increasing intensity. AGE (P<0.01), Exercise, and Exercise+AGE (P<0.001) attenuated body weight gain and food efficiency ratio compared to HFD. Visceral fat and liver weight gain were attenuated (P<0.05) with all three interventions with a greater effect on visceral fat in the Exercise+AGE than AGE (P<0.001). In reducing visceral fat (P<0.001), epididymal fat (P<0.01) and liver weight (P<0.001), Exercise+AGE was effective, but exercise showed a stronger suppressive effect than AGE. Exercise+AGE showed further additive effects on reducing visceral fat and liver weight (P<0.001). AGE significantly attenuated the increase in total cholesterol and low-density lipoprotein-cholesterol compared with HFD (P<0.05). Exercise+AGE attenuated the increase in triglycerides compared with HFD (P<0.05). Exercise group significantly decrease in C-reactive protein (P<0.001). These results suggest that AGE supplementation and exercise alone have anti-obesity, cholesterol lowering, and anti-inflammatory effects, but the combined intervention is more effective in reducing weight gain and triglycerides levels than either intervention alone.

• 한국임상수의학회지
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• 제30권5호
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• pp.353-358
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• 2013

본 연구는 오배자(Galla Rhois, GR)가 이유자돈의 성장과 설사발생에 미치는 영향을 조사하였다. 100두의 28일령 이유자돈을 무작위적으로 5개의 실험군(NC, 대조군; PC, chlortetracycline 0.3 g/kg feed; GR 1, GR 1.0 g/kg feed; GR 2, GR 2.0 g/kg feed; GR 3, GR 4.0 g/kg feed3)으로 나누어 실험을 수행하였다. 28일 동안 실험군별로 처리한 후, PC, GR 2 그리고 GR 3의 최종 체중과 사료요구율은 NC와 비교하여 통계적으로 유의성 있게 증가하였다(p < 0.05). 또한, PC와 GR를 급여한 모든 군의 일평균증체량과 일평균사료섭취량도 NC와 비교하여 통계적으로 유의한 차이를 보였다(p < 0.05). 특히, GR 2와 GR 3의 최종 체중, 일일평균증체량, 일평균사료섭취량 그리고 사료요구율은 PC와 비교하여 유의한 차이를 보이지 않았다. 분변지수와 설사지속시간에 있어서, PC와 GR를 급여한 모든 군이 NC와 비교하여 통계적으로 유의한 차이를 나타내었다(p < 0.05). 혈액학적 그리고 혈액생화학적 분석 결과, NC와 GR를 급여한 모든 군들 사이에서 혈액학적 그리고 혈액생화학적 지표값들의 통계학적 유의한 차이가 보이지 않았다. 본 연구결과로부터, GR은 자돈에 있어서 설사발생과 성장증체를 개선시키기 위한 강력한 사료첨가제로 사료된다.

• 한국식품위생안전성학회지
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• 제31권4호
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• pp.299-303
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• 2016

살모넬라증과 부루셀라증은 가축 및 사람에 심각한 피해를 유발하는 질병으로, 축산업과 식품산업에 많은 경제적 손실을 초래하고 있다. 본 연구에서는, 자몽종자추출물, 구연산, 사과산 그리고 염화벤잘코늄을 주성분으로 하는 스프레이형 소독제의 Salmonella Typhimurium과 Brucella ovis에 대한 효력시험을 수행하였다. 살균효력시험은 배지희석법에 따라 수행하였으며, 스프레이형 소독제와 시험 세균들을 처리조건에 따라 경수와 유기물로 희석하여 반응을 시켰다. 유기물 조건에서, Salmonella Typhimurium과 Brucella ovis에 대한 스프레이형 소독제의 살균력은 경수조건에서의 살균력과 비교하여 낮게 나타났는데, 이는 유기물들에 의한 소독제의 살균 유효성분에 대한 저해작용에 따른 것으로 사료된다. 스프레이형 소독제는 Salmonella Typhimurium과 Brucella ovis와 같은 인수공통전염병 유발 병원균들에 대해 살균효과를 나타내어, 살모넬라증과 브루셀라증과 같은 세균성 질병의 확산을 제어하는데 효과적으로 이용될 수 있을 것으로 사료된다.

• 한국환경보건학회지
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• 제42권4호
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• pp.266-273
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• 2016

Objectives: This study evaluated the virucidal efficacy against avian influenza virus (AIV) of a disinfectant spray containing 0.25% grapefruit seed extract, 0.2% citric acid, 0.0625% malic acid and 0.0125% benzalkonium chloride. Methods: The disinfectant spray was diluted several times with hard water (HW) and organic matter (OM). Two point five mL of each diluent was added into each test tube, and 2.5 mL of AIV suspension was inserted into each test tube. After 30 minutes of virus-disinfectant contact reaction at $4^{\circ}C$, 2.5 mL of 10% inactivated fetal bovine serum was added into each test tube to neutralize the sanitizer efficacy. The neutralized solutions were serial 10-fold dilutions with phosphate buffer solution, and 0.2 mL of the diluents was injected into the allantoic cavity of five ten-day-old-chickens per dilution time. After incubation of the embryos for five days, the viability of the AIV was examined by hemagglutination titer. The valid dilution of the disinfectant spray was estimated according to the dilution time that the virus titer was inactivated more than $10^4$ 50% egg-infective dose (EID50)/mL compared with pathogen control. Results: In HW and OM conditions, the valid dilutions of the disinfectant spray against AIV were seven- and three-fold dilutions, respectively. The AIV titer of the pathogen control was more than 6.1 log10EID50/mL, and there was no embryonic toxicity. Conclusion: The present study showed that this disinfectant spray has effective virucidal activity against AIV.

• 한국식품위생안전성학회지
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• 제34권1호
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• pp.73-86
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• 2019

본 연구는 선박이라는 특수한 환경에서 생활하는 선원을 대상으로 손위생 수행도에 영향을 미치는 요인들을 파악하여 선원 승선 생활에서의 기본적인 감염관리 활동을 독려하여 건강한 승선생활에 도움이 되고자 하였다. 본 조사는 선원교육기관에 교육을 받고 있는 선원 222명을 대상으로 2017년 7월부터 8월까지 설문조사를 실시하였다. 연구대상자의 승선 중 손위생 수행도는 75점 만점에 전체 평균 $47.97{\pm}11.62$으로 나타났으며, 항목별로는, 5점 만점기준으로 '업무나 작업을 마친 후'가 $4.04{\pm}1.03$으로 가장 높은 점수를 보였고 연구대상자의 손위생 수행도에 선박의 총 톤수, 승선 중 운동여부, 선내 비누비치여부가 다중회귀분석으로 영향을 미치는 요인으로 확인되었다. 본 연구의 결과에 기초하여 향후 선원들의 손위생 수행도와 이에 영향을 미치는 요인을 파악하는 후속연구가 필요하며, 일반적 특성, 직무특성, 건강관련 특성, 손위생 환경뿐만 아니라 다양한 변수들을 고려하여 선원의 손위생 수행에 영향을 미치는 요인들에 대한 세밀한 연구가 필요할 것으로 사료된다. 또한, 승선 중에 있는 선원들에 대한 손위생 수행에 대한 지속적인 관심이 필요하고 손위생 수행을 향상 시킬 수 있는 체계적인 방안이 구체적으로 마련되어야 할 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.719-722
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• 2016

Background: Cholangiocarcinoma (CCA) is a serious health problem in Thailand, particularly in northeastern and northern regions, but epidemiological studies are scarce and the spatial distribution of CCA remains to be determined. A database for the population at risk is required for monitoring, surveillance and organization of home health care. This study aim was to geo-visually display the distribution of CCA in northeast Thailand, using a geographic information system and Google Earth. Materials and Methods: A cross-sectional survey was carried out in 9 sub-districts and 133 villages in Chum Phuang district, Nakhon Ratchasima province during June and October 2015. Data on demography, and the population at risk for CCA were combined with the points of villages, sub-district boundaries, district boundaries, and points of hospitals in districts, then fed into a geographical information system. After the conversion, all of the data were imported into Google Earth for geo-visualization. Results: A total of 11,960 from 83,096 population were included in this study. Females and male were 52.5%, and 47.8%, the age group 41-50 years old 33.3%. Individual risk for CCA was identifed and classified by using the Korat CCA verbal screening test as low (92.8%), followed by high risk (6.74%), and no (0.49%), respectively. Gender ($X^2$-test=1143.63, p-value= 0.001), age group ($X^2$-test==211.36, p-value=0.0001), and sub-district ($X^2$-test=1471.858, p-value=0.0001) were significantly associated with CCA risk. Spatial distribution of the population at risk for CCA in Chum Phuang district was viewed with Google Earth. Geo-visual display followed Layer 1: District, Layer 2: Sub-district, Layer 3: Number of low risk in village, Layer 4: Number of high risk in village, and Layer 5: Hospital in Chum Phuang District and their related catchment areas. Conclusions: We present the first risk geo-visual display of CCA in this rural community, which is important for spatial targeting of control efforts. Risk appears to be strongly associated with gender, age group, and sub-district. Therefor, spatial distribution is suitable for the use in the further monitoring, surveillance, and home health care for CCA.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1293-1297
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• 2016

Cholangiocarcinoma (CCA) is a serious problem in Thailand, particularly in the northeastern and northern regions. Database of population at risk are need required for monitoring, surveillance, home health care, and home visit. Therefore, this study aimed to develop a geographic information system (GIS) database and Google map of the population at risk of CCA in Mueang Yang district, Nakhon Ratchasima province, northeastern Thailand during June to October 2015. Populations at risk were screened using the Korat CCA verbal screening test (KCVST). Software included Microsoft Excel, ArcGIS, and Google Maps. The secondary data included the point of villages, sub-district boundaries, district boundaries, point of hospital in Mueang Yang district, used for created the spatial databese. The populations at risk for CCA and opisthorchiasis were used to create an arttribute database. Data were tranfered to WGS84 UTM ZONE 48. After the conversion, all of the data were imported into Google Earth using online web pages www.earthpoint.us. Some 222 from a 4,800 population at risk for CCA constituted a high risk group. Geo-visual display available at following www.google.com/maps/d/u/0/edit?mid=zPxtcHv_iDLo.kvPpxl5mAs90&hl=th. Geo-visual display 5 layers including: layer 1, village location and number of the population at risk for CCA; layer 2, sub-district health promotion hospital in Mueang Yang district and number of opisthorchiasis; layer 3, sub-district district and the number of population at risk for CCA; layer 4, district hospital and the number of population at risk for CCA and number of opisthorchiasis; and layer 5, district and the number of population at risk for CCA and number of opisthorchiasis. This GIS database and Google map production process is suitable for further monitoring, surveillance, and home health care for CCA sufferers.