• Korean Journal of Clinical Pharmacy
• /
• v.26 no.2
• /
• pp.150-162
• /
• 2016

Objective: First-in-human dose estimation is an essential approach for successful clinical trials for drug development. In this study, we systematically compared first-in-human dose and human pharmacokinetic parameter estimation approaches. Methods: First-in-human dose estimation approaches divided into similar drug comparison approaches, regulatory guidance based approaches, and pharmacokinetic based approaches. Human clearance, volume of distribution and bioavailability were classified for human pharmacokinetic parameter estimation approaches. Results: Similar drug comparison approaches is simple and appropriate me-too drug. Regulatory guidance based approaches is recommended from US Food and Drug Administration (FDA) and European Medicines Agency (EMA) regarding no-observed-adverse-effect level (NOAEL) or minimum anticipated biological effect level (MABEL). Pharmacokinetic based approaches are 8 approaches for human clearance estimation, 5 approaches for human volume of distribution, and 4 approaches for human bioavailability. Conclusion: This study introduced and compared all methods for first-in-human dose estimation. It would be useful practically to estimate first-in-human dose for drug development.

• The Journal of Asian Finance, Economics and Business
• /
• v.8 no.5
• /
• pp.29-35
• /
• 2021

This study discusses the effect of human capital and technology on economic growth in Indonesia using annual time series data over the 35-year research period (1984-2019). This study uses an autoregressive distribution gap to the cointegration approach to understanding the relationship between human capital, technology, and economic growth. Human capital is inherent in humans and becomes capital in providing the best performance that has an impact on their own income. We use the human capital framework in this study where education is one mechanism to increase human capital. Based on the results of our estimation, we find that the increase in human capital using the education mechanism affects economic growth. This shows the role of human capital investment is very important in economic growth. Technology shows a significant positive effect on economic growth. Increasing human resources and technology are important factors in efforts to increase economic growth in Indonesia. Educational development is the key to the success of increasing human capital and technological development because education plays a role in improving the quality of human resources. Increasing human resources here is in the form of increased knowledge, mastery of technology, innovation, and the ability to develop technology to encourage technology development.

• Korean Institute of Interior Design Journal
• /
• no.28
• /
• pp.51-59
• /
• 2001

This Study tried to approach with a new Point of view about Green Design that had been studied on just Aesthetics and Function and it focused on creating a pleasant environment In the Interiors combing with Horticultural therapy as advanced study in Green Design. This study is barred on understanding that nature, human and space should continue to coexist through realizing relationship between nature and human and overcoming denaturalization and dehumanization and have an opportunity to know what a pleasant space for human is. Although pleasant space can be made by many different methods, this study start from the thought that a space with plants is the best to satisfy human's basic emotion. The method of study is through research and analysis with many kinds of references and examples, and then the results were used to make design guide which introduces Green Amenity Space in residential space. The pleasant space that human pursuits should be the human-centered space as well as the space giving them mental and physical satisfaction beyond space with just function and beauty. Therefore Green Amenity Space is the best space with which human is familiar.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.46 no.2
• /
• pp.22-31
• /
• 2023

Governments around the world are enacting laws mandating explainable traceability when using AI(Artificial Intelligence) to solve real-world problems. HAI(Human-Centric Artificial Intelligence) is an approach that induces human decision-making through Human-AI collaboration. This research presents a case study that implements the Human-AI collaboration to achieve explainable traceability in governmental data analysis. The Human-AI collaboration explored in this study performs AI inferences for generating labels, followed by AI interpretation to make results more explainable and traceable. The study utilized an example dataset from the Ministry of Oceans and Fisheries to reproduce the Human-AI collaboration process used in actual policy-making, in which the Ministry of Science and ICT utilized R&D PIE(R&D Platform for Investment and Evaluation) to build a government investment portfolio.

• Journal of Information Technology Services
• /
• v.7 no.4
• /
• pp.101-117
• /
• 2008

As the rapidly changing e-business environment and development of IT, it is difficult to predict appropriate demand and supply of human resources in e-business industry. Such problem causes the imbalance of needs in demand and supply and the difficulty of proving useful information about fostering necessary e-business human resource and so forth. This study present a manpower training plan in e-business industry by investigating e-business human resource in the market and by analyzing curriculums in selected universities. To achieve this objective, we conducted a survey study of e-business companies, educational organizations and workers. From the results of this study, we present the current status of e-business human resource market and the problems of past manpower training system, and provide recommendations. This study would help policy makers, the private companies and academic institutions in developing effective strategies for the e-Biz human resource sector.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 1999.03a
• /
• pp.207-211
• /
• 1999

Nowadays human sensibility ergonomics is spotlighted as one of trends which we have pursued for improvement of humanity. Human sensibility ergonomics is a technique making human life more convenient by applying it to many kinds of products and design for environment by measuring and estimating human sensibility more qualitatively and quantitatively. The study of human sensibility can be discovered in oriental philosophy based on human being. Therefore there is an close relationship between human sensibility ergonomics and oriental philosophy. In this study, we research the sensibility factors of diagnostics by Sasang constitutional medicine, Five element properties and biorhythm by human sensibility ergonomics, and will apply the result of this study - the analyses of the difference among reaction time by using ANOVA after measuring the reaction time depending on one's individual temperament and condition- to job design.

• Journal of the Ergonomics Society of Korea
• /
• v.30 no.1
• /
• pp.169-177
• /
• 2011

The aim of this study is to review previous studies on human errors in the service delivery processes. Service industry is sharply growing in the advanced countries. Many people are looking for something to contribute to the service industry. Although there are many research topics related to service domain that human factors and ergonomics specialists can do contribute, a few researchers are studying such topics. This paper indicated how previous researches on human factors and human errors have addressed the service domain, in order to prompt human factor study on the service domain. A variety of sources were inspected for literature reviews, including books and journals of managements, medicine, psychology, consumer behavior as well as human factor and ergonomics. The characteristics of human errors in the service domain were investigated. Human error studies in several service sectors were summarized such as medical service, automotive service operation, travel agent service and call center service. Until now, human factors community was not much interested in human errors in service domain. However, there is much space to contribute to service domain; human error identification, human error analysis and control of human error. The research of human error in service domain can provide clues to improve service quality. This paper helps to guide to identify human error of service domain and to design service systems.

• Journal of the Korean Society of Industry Convergence
• /
• v.11 no.4
• /
• pp.201-208
• /
• 2008

This thesis is the result of the study about 'How we should develop the human resources program to gain human strength in the strategic environment of the future?' Once again, regional stability is interdependent with economic stability, political stability, and military stability of all the factors in the region. History shows that if a militarily capable regime lacks economic resources, then there is political pressure on the regime to use their military to acquire needed resources. The purpose of this study is to find the way that how to gain excellent human resources now and in the future. Military man power should be strong whenever. The Ministry of National Defense has "Reform Military Structure Plan". The focus of this Plan is Korean military strategy in the situation of the confrontation between South and North Korea and in the situation of the international relationship and the way of constructing the military strength for the future. To study these subjects, I reviewed the theories of "Acquisition Program of Human Strength" were developed and assessed the future strategic environment of the Korean Peninsula. From these studies, I suggest that The Ministry of National Defense should pursue preparing for the future military strategy and military structure. we should be skillful in supplementing the Human Strength. We should study about Military Revolution Plan and Human Strength structure for the future.

• The Journal of the Korea Contents Association
• /
• v.16 no.12
• /
• pp.267-280
• /
• 2016

The purpose of this study was to examine the effects of adolescent victimization on human rights consciousness and the mediating effects of depression and evaluation on their own human rights among adolescents. A total of 3,662 middle school student data from '2014 Korean Children and Youth Human Rights Survey' were used for the study. This study analysed a hypothesized research model using structural equation modeling. The main findings on structural model are as follows: First, victimization did not have a direct influence on human rights consciousness but had an indirect effect through a mediating role of evaluation on their own human rights. Secondly, victimization were related to human rights consciousness through double mediating paths of depression and evaluation on their own human right. Finally, human rights education, a control variable, had an indirect effect on human rights consciousness through self-evaluation on human rights. The results of this study suggest some implications for practical intervention and further research on the relation between adolescent victimization and human rights consciousness.

• Journal of the Korea Convergence Society
• /
• v.11 no.11
• /
• pp.81-88
• /
• 2020

In this study, an attempt was made to prepare an effective human rights sensitivity education plan for nursing students. This study was before and after a non-equal control group that identified human rights sensitivity and patient rights awareness. As a result of the study, the human rights sensitivity of the subjects averaged 40.22 out of 90 points. The effect on human rights sensitivity through case-based human rights sensitivity education showed that students who received training to improve case-based human rights sensitivity improved human rights sensitivity and patient rights awareness than those who did not(t=2.765,p=.006, t=-5.768,p=.000). As a result of this study, it is considered that the foundation of the curriculum to improve the human rights sensitivity of nursing students should be prepared. We propose a later study on the relationship between clinical practice and human rights sensitivity.