• The KIPS Transactions:PartD
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• v.18D no.1
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• pp.1-8
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• 2011

The cache structure, which is designed for assuring fast accesses to frequently accessed data, resides on the various levels of computer system hierarchies. Many studies on this cache structure have been conducted and thus many page-replacement algorithms have been proposed. Most of page-replacement algorithms are designed on the basis of heuristic methods by using their own criteria such as how recently pages are accessed and how often they are accessed. This data-retrieval process in computer systems is analogous to human memory retrieval process since the retrieval process of human memory depends on frequency and recency of the retrieval events as well. A recent study regarding human memory cognition revealed that the possibility of the retrieval success and the retrieval latency have a strong correlation with the frequency and recency of the previous retrieval events. In this paper, we propose a novel page-replacement algorithm by utilizing the knowledge from the recent research regarding human memory cognition. Through a set of experiments, we demonstrated that our new method presents better hit-ratio than the LRFU algorithm which has been known as the best performing page-replacement algorithm for DBMS caches.

• Proceedings of the SCSK Conference
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• 2003.09a
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• pp.192-202
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• 2003

The wrinkles correspond to the most obvious expression of skin ageing and are manifested by changes on the organization and dermal structure. In the extracellular matrix, decreased quantities of collagens and glycosaminoglycans as well as a deterioration of the fibrillary network is noted, result in a reduction of dermal thickness. In addition, the activity of the collagenases increases in contrast to the synthesis of collagen fibers. Nor are cells spared during the aging process. We thus studied and compared the contractile capacity as well as the synthesis capacity of normal human fibroblasts and human fibroblasts obtained from biopsies of forehead wrinkles. The capacity of the fibroblasts to be adhered to the collagen network and to maintain a three-dimensional structure of dermis was studied on a model of equivalent dermis. The metabolic activity was studied by evaluating the capacities of synthesis of collagen I, main component of dermis. Human fibroblasts resulting from the forehead wrinkle contract less the gel of collagen than the normal human fibroblasts and present an activity of biosynthesis of collagen I less important than normal human fibroblasts. These results show that fibroblasts with aging present a deceleration of their metabolic activity and lose their capacity of adhesion to collagen fibers thus limiting the possibility of organizing the dermal tissue. We investigated the potential of an active ingredient able to compensate for the reduction of the metabolic activity and to restore the contractile capacity of fibroblasts obtained from forehead wrinkles. This effect was compared with a reference molecule: the vitamin C.

• BMB Reports
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• v.40 no.6
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• pp.1028-1038
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• 2007

Human plasma Hp is classified as 1-1, 2-1, and 2-2. They are inherited from two alleles Hp 1 and Hp 2, but there is only Hp 1 in almost all the animal species. Hp 2-2 molecule is extremely large and heterogeneous associated with the development of inflammatory-related diseases. In this study, we expressed entire bovine Hp in E. coli as a $\alpha\beta$ linear form. Interestingly, the antibodies prepared against this form could recognize the subunit of native Hp. In stead of a complicated column method, the antibody was able to isolate bovine Hp via immunoaffinity and gelfiltration columns. The isolated Hp is polymeric containing two major molecular forms (660 and 730 kDa). Their size and hemoglobin binding complex are significantly larger than that of human Hp 2-2. The amino-acid sequence deducted from the nucleotide sequence is similar to human Hp 2 containing a tandem repeat over the $\alpha$ chain. Thus, the Hp 2 allele is not unique in human. We also found that there is one additional -SH group (Cys-97) in bovine $\alpha$ chain with a total of 8 -SH groups, which may be responsible for the overall polymeric structure that is markedly different from human Hp 2-2. The significance of the finding and its relationship to structural evolution are also discussed.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.12 no.2
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• pp.121-130
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• 2012

This paper proposes an intuitive real-time robot control system using human body movement. Recently, it has been developed that motion generation for humanoid robots with reflecting human body movement, which is measured by a motion capture. However, in the existing studies about robot control system by human body movement, the detailed structure information of a robot, for example, degrees of freedom, the range of motion and forms, must be examined in order to calculate inverse kinematics. In this study, we have proposed Associative Motion Generation as humanoid robot motion generation method which does not need the detailed structure information. The associative motion generation system is composed of two neural networks: nonlinear principal component analysis and Jordan recurrent neural network, and the associative motion is generated with the following three steps. First, the system learns the correspondence relationship between an indication and a motion using training data. Second, associative values are extracted for associating a new motion from an unfamiliar indication using nonlinear principal component analysis. Last, the robot generates a new motion through calculation by Jordan recurrent neural network using the associative values. In this paper, we propose a real-time humanoid robot control system based on Associative Motion Generation, that enables user to control motion intuitively by human body movement. Through the task processing and subjective evaluation experiments, we confirmed the effective usability and affective evaluations of the proposed system.

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.6
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• pp.806-814
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• 2019

One of the future weapon systems is the individual smart weapon which has a structure mounted on the forearm of soldiers. The structure may cause injuries or affect the accuracy of fire due to its impact on joints when shooting. This paper proposes human-impact interaction modeling and a verification methodology in order to estimate the impact of fire applied to the forearm. For this purpose, a human musculoskeletal model was constructed and the joints' behavior in various shooting positions was simulated. In order to verify the simulation results, an impact testing device substituting the smart weapon was made and the experiment was performed on a real human body. This paper compares the simulation results performed under various impact conditions and the experimental values in terms of accuracy and introduces methods to complement them. The results of the study are expected to be a basis for a reliable human-impact interaction modeling, and smart individual weapon development.

• Bulletin of the Korean Chemical Society
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• v.24 no.6
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• pp.805-808
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• 2003

Fundamental ideas of the free energy gradient method are briefly reviewed with three applications: the stable structures of glycine and ammonia-water molecule pair in aqueous solution and the transition state (TS) structure of a Menshutkin reaction $NH_3 + CH_3Cl → CH_3NH_3^+ + Cl^-$ in aqueous solution, which is the first example of full TS optimization of all internal degrees of freedom.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.348.2-348.2
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• 2002

The significant antitumor activities of 3-arylisoquinolines promoted us to explore the structure-activity relationship of these compounds. A series of 3-Arylisoquinoline derivatives, which related to Benzo［c］ phenanthridine alkaloids. were evaluated for antitumor cytotoxicity against human lung tumor cell (A 549). We tried to study structure-activity relationship (SAR) of 3-Arylisoquinolines using the comparative molecular field analysis (CoMFA) method. (omitted)

• Journal of Communications and Networks
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• v.17 no.2
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• pp.100-109
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• 2015

Mobile phone carriers face challenges from three synergistic dimensions: Wireless, social, and mobile. Despite significant advances that have been made about social networks and human mobility, respectively, our knowledge about the interplay between two layers remains largely limited, partly due to the difficulty in obtaining large-scale datasets that could offer at the same time social and mobile information across a substantial population over an extended period of time. In this paper, we take advantage of a massive, longitudinal mobile phone dataset that consists of human mobility and social network information simultaneously, allowing us to explore the impact of human mobility patterns on the underlying social network. We find that human mobility plays an important role in shaping both local and global structural properties of social network. In contrast to the lack of scale in social networks and human movements, we discovered a characteristic distance in physical space between 10 and 20 km that impacts both local clustering and modular structure in social network. We also find a surprising distinction in trajectory overlap that segments social ties into two categories. Our results are of fundamental relevance to quantitative studies of human behavior, and could serve as the basis of anchoring potential theoretical models of human behavior and building and developing new applications using social and mobile technologies.

• Molecules and Cells
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• v.45 no.8
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• pp.522-530
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• 2022

Transposable elements (TEs) account for approximately 45% of the human genome. TEs have proliferated randomly and integrated into functional genes during hominoid radiation. They appear as right-handed B-DNA double helices and slightly elongated left-handed Z-DNAs. Human endogenous retrovirus (HERV) families are widely distributed in human chromosomes at a ratio of 8%. They contain a 5'-long terminal repeat (LTR)-gag-pol-env-3'-LTR structure. LTRs contain the U3 enhancer and promoter region, transcribed R region, and U5 region. LTRs can influence host gene expression by acting as regulatory elements. In this review, we describe the alternative promoters derived from LTR elements that overlap Z-DNA by comparing Z-hunt and DeepZ data for human functional genes. We also present evidence showing the regulatory activity of LTR elements containing Z-DNA in GSDML. Taken together, the regulatory activity of LTR elements with Z-DNA allows us to understand gene function in relation to various human diseases.

• Journal of Arbitration Studies
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• v.32 no.2
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• pp.85-114
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• 2022

When human rights disputes are related to the cross-border investments treaties, the investment arbitral tribunals are confronted with the question of how to adjudicate connected human rights violations. The traditional structure restricts arbitration proceedings to the parties named within an investment treaty, i.e., Investor-Claimant and State-Respondent. If human rights issues occur, States must act as proxies for citizens with human rights claims. This effectively excludes individuals or groups with human rights concerns and contradicts the premise of international human rights law that seeks to empower human rights-holders to pursue claims directly and on an international stage. The methods for intorducing human rights issues in the context of investment arbitration proceedings are suggested as follows: First, human rights arguments can be introduced into ISDS by the usual initiator of investment disputes: the investor as the complainant. Especially, if the jurisdictional and applicable law clauses of the respective international investment agreements are sufficiently broad to include human rights violations, adjudicating a pure human rights claim could be possible. Second, the host state may rely on human rights argumentation as a respondent of an investor claim. Human rights have played a role as a justification for state measures undertaken to comply with human rights laws. Third, third party interventions by NGOs and civil society groups as amici curiae may act as advocates for affected populations or communities in response to the reluctance of governments to introduce their own human rights duties into the investment dispute. Finally, arbitrators have also referred to human rights ex officio, i.e., without having a dispute party referring to the specific argument. This was mainly the case in the context of determining the scope of property rights and the existence of an expropriation. As all U.N. member states have human rights obligations, international investment laws must be presumed to be in conformity with the relevant human rights obligations.