• 미생물학회지
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• 제30권6호
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• pp.472-478
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• 1992

HTLV-1 이 pol 유전자산물을 합성하기 위해서는 genome-size mRNA 를 번역해 나아가는 ribosome 이 -1 방향으로 두차례 frame 을 바꾸어야 한다. 우리는 단 한차계의 frameshifting 만으로도 많은 양의 Gag-Pro-Pol polyprotein 의 합성어 가능하도록 gag 와 pro 유전자의 frame 을 연결시킨 mutant RNA 를 제작하였다. 이 돌연변이를 이용하여 ribosome 의 shift site 하류영역내에 형성이 예상되는 RNA 의 이차구조 또는 삼차 구조가 -1 frameshifting 을 결정하는 인자로서 작용하는지의 여부를 조사하였다. 결손변이주의를 해석한 결과 pro-pol 중첩영역에서 효율적으로 frameshifting 이 일어나기 위해서는 stem-loop 가 필수적으로 형성되어야 하지만 pseudoknot 의 형성은 그다지 중요하지 않다는 사실을 알았다.

• 한국산학기술학회논문지
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• 제16권1호
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• pp.666-670
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• 2015

본 논문은 생체신호를 측정하는 팔목부착용 Fitbit Flex상에 구현된 방사패턴 재구성 안테나에 관련된 논문이다. 또한 본 논문에서 제안하는 루프-다이폴 방사패턴 재구성 안테나의 인체 내 부위별 전자파 흡수율 (Specific Absorption Rate; SAR)에 관한 논문이다. 본 논문의 루프-다이폴 방사패턴 재구성 안테나는 두 개의 RF 스위치를 사용하여 서로 반대방향의 두 가지 방사패턴을 구현한다. 방사패턴 재구성 안테나는 블루투스 (Bluetooth) 통신 대역 (2.4 - 2.485 GHz)을 사용하며, 최대이득은 1.96 dBi이다. SAR 시뮬레이션 결과로 블루투스 입력 평균전력 0.04 W가 팔목을 포함하는 인체 내 다섯 개 부위 (두부, 가슴, 배, 등, 팔목)에 입력되었을 때 Federal Communication Commission (FCC)의 기준인 단위 1 g 당 1.6 W/kg을 모두 만족함을 확인하였다. 또한 최대 SAR 값은 두부에서 1.12 W/kg이다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 춘계학술대회 논문집
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• pp.384-389
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• 2011

The electric railway cars are operated by high voltage supply through the catenary wire. Also, numerous electric equipments operated by electric signal are distributed in the electric railway cars. Such electric equipments are exposed to EMI/EMC problems, and there is the possibility that the magnetic field due to the catenary wire current takes effect on the electromagnetic field in the electric railway cars which move under the catenary wire. There is the possibility that the electromagnetic interference generates in view of the operation of many electric equipments in the electric railway cars. There is the possibility that the communication device faults generate, and that the hazards on the human beings generate. In this paper, we predict the magnetic field around the catenary wire, and obtain the exact magnetic field distribution by comparing the analytic results and the numerical results. Finally, we confirmed the possibility of the passive loop mitigation by comparing the analytic results and the numerical results through the passive loop mitigation technique.

• 대한의용생체공학회:의공학회지
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• 제16권4호
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• pp.481-491
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• 1995

Endovaginal and endorectal receiver only surface coils were designed for MR imaging (MRI) and $^1H$ MR spectroscopy (MRS) for the uterine cervix and the prostate. The shape of endovaginal coil wire was rectangular with round corner. Size of the coil wire was empirically determined for 7cm and 4cm along the long and short axis, respectively. The coil wire loop was supported by acryl handle and bent about $150^{\circ}$ at one side of the loop considering the average angle of the cervix to the vagina. We called this as a "spoon-type endovaginal coil". The wire of the endorectal coil was made of the flexible materials so that the wire loop became long elliptic shape by pushing the acryl handle into the plastic tube for the comfort of patients when the coil was inserted into the cervix. Then, the shape was maintained to be circle by popping out handle. Conventional spin echo (SE) and fast spin echo (FSE) sequences were used as 71 and 72 weighted imaging sequences, respectively. Matrix size was 128~$256{\times}256$. FOVs for surface coil and body coil were 14cm and 24cm, respectively. 3D volume localized in vivo $^1H$ MR spectroscopy of the human cervix and prostate was performed using PRESS or STEAM localization method with the following parameters . TR=3 sec, TE=135 msec for PRESS or 30 msec for STEAM, NEX=2, NS=48, Sl=2048, and SW=2500 Hz. Using home-built endovaginal and endorectal coils, excellent T1- and T2-images were obtained to visualize early cervical and prostate tumors. 3D volume localized in vivo IH MRS was useful to differentiate the cancerous tissue from the normal tissue.

• 한국운동역학회지
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• 제17권2호
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• pp.83-91
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• 2007

This experiment studied the change in a human's control of his or her static posture by analyzing the stabilogram diffusion and, by using the said study, evaluated the control ability of different groups with different experiences. The postures had a rising requirement of heel-rise according to three conditions: heel-toe, ball, toe; the groups were divided into dance major student and non-dance majors. The results of the critical points according to posture did not show a direct relation with the change in postures that had a rising requirement of heel-rise. The diffusion coefficient(D) had greater stochastic activity for short-term regions that utilize open-loop controls without feedback than for long-term regions that used closed-loop controls with feedback to maintain balance. The directional results of the body undergoing disturbance showed that A/P direction's diffusion coefficient (D) was larger than that of M/L direction. Both feet's planar diffusion coefficients were a linear combination of the diffusion coefficients calculated for the x and y axis. In studying the different abilities to control posture between a dance major student and a non-dance majors, a comparison of open-loop control's diffusion coefficient(D) was effective, and dance major student had superior control ability to that of non-dance majors.

• 제어로봇시스템학회논문지
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• 제3권2호
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• pp.187-196
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• 1997

This paper presents a semi-automatic methodology to synthesize executable digital controller saftware in a multi-loop control system. A digital controller is described by a task graph and end-to-end timing requirements. A task graph denotes the software structure of the controller, and the end-to-end requirements establish timing relationships between external inputs and outputs. Our approach translates the end-to-end requirements into a set of task attributes such as task periods and deadlines using nonlinear optimization techniques. Such attributes are essential for control engineers to implement control programs and schedule them in a control system with limited resources. In current engineering practice, human programmers manually derive those attributes in an ad hoc manner: they often resort to radical over-sampling to safely guarantee the given timing requirements, and thus render the resultant system poorly utilized. After task-specific attributes are derived, the tasks are scheduled on a single CPU and the compiled kernel is synthesized. We illustrate this process with a non-trivial servo motor control system.

• 대한바이러스학회지
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• 제26권2호
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• pp.251-258
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• 1996

The V3 loop, a hypervariable domain of envelope glycoprotein, has an essential role in viral infectivity and has a major epitope for type-specific neutralizing antibody. In order to investigate genetic diversity of V3 region of gp120 of human immunodeficiency virus type 1 (HIV-1) isolated from Korean patients, DNA sequences encoding the C2 to V3 region were amplified by nested polymerase chain reaction (PCR) from uncultured peripheral blood mononuclear cells obtained from 15 HIV-1 seropositive patients and nucleotide sequences were determined. All nucleotide sequences from fifteen patients were compared with 8 distinctive subtypes (A-H) and another subtype O. Phylogenetic analysis was carried out with PHYLIP ver 3.5 (Dnapars) program. Of the 15 isolates, 14 HIV-1 subjects were clustered with subtype B, while one was clustered with subtype C. Intra-subtype B distance at the nucleotide and deduced amino acid level were maximum 17.7% and 37.0%, respectively. Intra-patient distance at the nucleotide and deduced amino acid level were maximum 7.3% and 17.8%, respectively. Analysis of the nucleotide sequences revealed that Korean types have relatively well conserved sequences. These findings could be useful for assessing the source of infection and developing an AIDS vaccine.

• 한국시스템다이내믹스연구
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• 제15권1호
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• pp.51-74
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• 2014

Despite the high efficiency of nuclear power plant, people in Korea do not give approvals and supports the facilities because the risk of the accidents and incidents. In particular, the low level of safety culture is a crucial mechanism that damages the robustness of the NPP. By considering the various definitions of safety culture and analyzing the major reasons of incidents, the conceptual safety culture model is made by using Causal Loop Diagramming. For sustaining development of nuclear power, social supports, incentives and organizational learning are needed. It also requires the coordination of work schedules and the expansion of human resource for protecting the rules and procedures in NPP. Decommissioning aging nuclear power plants will prevent a serious accident. In order to promote the safety culture, Korea Hydro & Nuclear Power Corporation should disclose more information to the public and promote the internal and external communications.

• 제어로봇시스템학회논문지
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• 제20권3호
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• pp.333-344
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• 2014

This is the survey paper on the role of kinematics in robot development. The robot is considered as a form of mechanical systems which includes closed-chain loop system, open-chain loop system and closed and open switching system. To analyze these systems, kinematic notations has been developed in kinematics of mechanical theory since 1955 and has been applied in robotics. Several kinematic notations including Denavit-Hartenberg notations have been reviewed. The status of development of the spherical motor which has a great impact on the future robot advancement has reviewed, and research activity on a spherical motor and its application to 3-D spatial mechanisms at UNIST is introduced. For the open and closed switching mechanical systems, the bipedal robots' walking theories using Zero Moment Point are reviewed. And current status regarding bipedal robots based on newly developed passive dynamic walking theory is reviewed with the research activity at UNIST on this subject.

• 한국자기공명학회논문지
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• 제20권2호
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• pp.46-49
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• 2016

MiRNA-155, upregulated in various cancers, is one of the miRNAs that suppress apoptosis of human cancer. Thus, inhibition of the maturation of miRNA-155 could be an effective way to induce apoptotic cancer cell death. The apical stem-loop of the pre-miRNA-155 has been known as a Dicer biding site for RNA cleavage. Here, to understand the molecular basis of the tertiary interaction between pre-miRNA-155 with Dicer, we characterize the structure of the apical stem-loop of pre-miRNA-155 using NMR spectroscopy. The RNA has a stem-bulge-stem-loop-stem structure, which is consist of G-C Watson-Crick and G-U Wobble base pairs. The assignments of imino- protons were further confirmed by 2D $^{15}N-^1H$ HSQC NMR spectrum. The NMR parameters obtained in this study can be further used to investigate the tertiary interaction between pre-miRNA-155 and other biomolecules such as protein, nucleic acids, or small chemicals which might be used to control the apoptosis of cancer.