• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 2003년도 정기총회 및 학술발표회
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• pp.59-59
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• 2003

Serotonin (5-HT; 5-hydroxytryptamine) exerts multiple effects on central nervous system as well as behaviors such as mood and appetite. The signaling of serotonin is mediated by 7 families of serotonin receptors, designated 5-HT$_1$ to 5-HT$_{7}$. Six families of this receptor are G-protein coupled 7TM receptors, and the third intracellular loop of these receptors is proposed to interact with specific types of G-proteins. To investigate the specific interaction between the third intracellular loop of 5-HT$_{6}$ with G$\square$s, we have constructed a chimera protein that represent the third intracellular loop of 5-HT$_{6}$ within a leucine zipper motifs, In addition an alpha subunit of human G-protein that interact with 5-HT$_{6}$ was cloned into a bacterial expression vector. The two proteins were expressed in E. coli and purified in homogeneity. The interaction of the prepared proteins was examined by ELISA assay. The affinity between the two proteins and effect of insertion mutations were discussed.ussed.d.

• Nuclear Engineering and Technology
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• 제30권6호
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• pp.531-540
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• 1998

The DYLAM-3 code which overcomes the limitation of event tree/fault tree was applied to LOOP (Loss of Off-site Power) in the mid-loop operation employing HEPs (Human Error Probabilities) supplied by the ASEP (Accident Sequence Evaluation Program) and the SEPLOT (Systematic Evaluation Procedure for Low power/shutdown Operation Task) procedure in this study. Thus the time history of core uncovery frequency during the mid-loop operation was obtained. The sensitivity calculations in the operator's actions to prevent core uncovery under LOOP in the mid-loop operation were carried out. The analysis using the time dependent HEP was performed on the primary feed & bleed which has the most significant effect on core uncovery frequency. As the result, the increment of frequency is shown after 200 minutes duration of simulation conditions. This signifies the possibility of increment in risk after 200 minutes. The primary feed & bleed showed the greatest impact on core uncovery frequency and the recovery of the SCS (Shutdown Cooling System) showed the least impact. Therefore the efforts should be taken on the primary feed & bleed to reduce the core uncovery frequency in the mid-loop operation. And the capability of DYLAM-3 in applying to the time dependent concerns could be demonstrated.

• 대한기계학회논문집A
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• 제26권2호
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• pp.314-321
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• 2002

An endoscope is usually inserted into the human body for the inspection of the gullet, stomach, and large intestine (colon) and this may cause discomfort to patients and damage to tissues during diagnostic or therapeutic procedures. This situation necessitates a self-propelling endoscope. There are many kinds of mechanism to move in a rigid pipe. However, these methods are difficult to apply directly to the endoscope. The main reason is that human intestine cannot be considered as a uniform, straight, and rigid pipe. This paper proposes a flexible loop wheel mechanism, which is adaptable to the human intestine. This mechanism is designed and fabricated by a simple modeling, and tested by an experiment. Finally, the actuator is inserted into the pig colon.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.326-329
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• 2004

In this paper, we show a new form of blood pressure controller combined PI control with $H_{\infty}$ loop-shaping. Hypertensive patients or post-operative patients need to maintain normally blood pressure. Exact regulation of blood pressure is needed for maintaining variable blood pressure of preventing complications. The regulation of blood pressure is achieved by injecting drugs, and usually sodium nitroprusside is used as those kinds of drugs. It is necessary to control the infusion rate sodium-nitroprusside carefully to achieve the desired blood pressure. It has been known that regulation of blood pressure by automatic controller is more effective than regulation of blood pressure by human operators. The control of blood pressure has many constraints and uncertainties. Most of biological system has the time-varying variables and the side effects such as increased risk of sepsis and organ failure. To solve such a problem, we design a new robust PI controller using $H_{\infty}$ loop-shaping to decrease noise effects that come out from human body and errors for time delay. The system with designed controller shows more stable control of mean blood pressure and more robust performance for uncertainties. Validation methods for the control performance are confirmed to computer simulations.

• Smart Structures and Systems
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• 제26권6호
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• pp.797-807
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• 2020

Due to the influence of nonlinearity and time-variation, it is difficult to establish an accurate model of concrete frame structures that adopt active controllers. Fuzzy theory is a relatively appropriate method but susceptible to human subjective experience to decrease the performance. This paper proposes a novel artificial intelligence based EBA (Evolved Bat Algorithm) controller with machine learning matched membership functions in the complex nonlinear system. The proposed affine transformed membership functions are adopted and stabilization and performance criterion of the closed-loop fuzzy systems are obtained through a new parametrized linear matrix inequality which is rearranged by machine learning affine matched membership functions. The trajectory of the closed-loop dithered system and that of the closed-loop fuzzy relaxed system can be made as close as desired. This enables us to get a rigorous prediction of stability of the closed-loop dithered system by establishing that of the closed-loop fuzzy relaxed system.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집A
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• pp.646-653
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• 2001

LQG/LTR Control Methology is recently used for the analysis of multi-variable control in frequency domain. Target filter loop is designed by the demanding requirements such as cross-over frequency, disturbance rejection in low frequency domain, zero steady-state error, identification of maximum and minimum singular values and sensor noise rejection in high frequency domain. Loop transfer recovery is accomplished by solving the cheap control and then simulation close to the target filter loop. In this study, LQG/LTR Control Methodology is applied to the seat suspension system. It is found that this technique is very effective to control the system and improve the ride quality of human body.

• 한국시스템다이내믹스연구
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• 제15권1호
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• pp.5-27
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• 2014

The purpose of this study is to analyze the school autonomy policy based on the system thinking perspective using causal loop diagrams. School autonomy was the main educational policy concerning school domain during the last government and was the instrument for school-based management, but it was not implemented effectively in site. The school autonomy policy practically disappeared as an explicit policy agenda in the current government. This study displays causal loop diagrams about the policy's logic and contents of school autonomy, in terms of curriculum, human resource management, and a supportive system. The causal loop diagrams depicting the implementation of the school autonomy policy are suggested concerning excessive enforcement and the confirmative mechanism for policy implementation. The conclusion provides some research implications and future directions.

• Nuclear Engineering and Technology
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• 제55권6호
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• pp.2246-2255
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• 2023

Evacuation time estimation (ETE) is crucial for the effective implementation of resident protection measures as well as planning, owing to its applicability to nuclear emergencies. However, as confirmed in the Fukushima case, the ETE performed by nuclear operators does not reflect behavioral features, exposing thus, gaps that are likely to appear in real-world situations. Existing research methods including surveys and interviews have limitations in extracting highly feasible behavioral features. To overcome these limitations, we propose a VR-based immersive experiment system. The VR system realistically simulates nuclear emergencies by structuring existing disasters and human decision processes in response to the disasters. Evacuation behavioral features were quantitatively extracted through the proposed experiment system, and this system was systematically verified by statistical analysis and a comparative study of experimental results based on previous research. In addition, as part of future work, an application method that can simulate multi-level evacuation dynamics was proposed. The proposed experiment system is significant in presenting an innovative methodology for quantitatively extracting human behavioral features that have not been comprehensively studied in evacuation. It is expected that more realistic evacuation behavioral features can be collected through additional experiments and studies of various evacuation factors in the future.

• 청정기술
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• 제1권1호
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• pp.34-46
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• 1995

Clean Technology goes beyond Clean-UP (or "End of PiPe) Technologies to include Pollution prevention, waste minimisation, and cleaner production. However, the concept of Clean Technology goes deeper than changes in technology, to ways in which human needs can be satisfied sustainably. In other words, Clean Technology, concentrates on delivering a human benefit rather than making a product. Introducing cleaner technology may therefore involve new commercial relationships as well as new technological practices. In some economic sectors, this involves leasing or providing a service rather than selling a product. Life Cycle Assessment (LCA) is an important tool in Clean Technology. LCA involves determining all the resources used and all the wastes and emissions produced in providing the human benefit. Use of LCA ensures that improved environmental performance in one part of the Life Cycle is not achieved merely at the expense of more environmental damage elsewhere. Going beyond LCA, the concepts of Life Cycle Design and "metabolised" use of materials are approaches to obtain maximum benefit from materials as they pass through the human economy. "Closed-loop" use can be a component of clean technology. Looking beyond simple re-use and recycling, a material may pass through a "cascade of uses". typically a series of applications with progressively lower performance specifications. Closed-loop use necessarily involves a change in commercial practice, because the material or product must be recovered after use.

• 한국생활과학회지
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• 제14권4호
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• pp.665-671
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• 2005

This study aims to examine the effect of structural properties, subjective textures, sensibilities, and objective handle on the preference for weft knit fabrics, and then to provide useful information in planning and designing knit fabrics through predicting the preference. We made 20 plain knit fabrics, as specimens, with a combination of 5 kinds of wool/rayon fiber contents and 4 kinds of stitch loop length. For the subjective evaluation of textures, sensibilities, and preference, we used the questionnaire that had been developed in the previous study. The data analysis was conducted with Pearson's correlation analysis, ANOVA, Duncann multiple range test and regression analysis. The results are as follows: In relationship of structural properties and preference, we could not recognize any difference in whole ranges of wool/ rayon fiber contents and in 7.5mm and less stitch loop length. On the other hand, we could find the decrease of preference in over 7.5mm stitch loop length. As to subjective textures and sensibilities, a multiple regression analysis of preference indicated a higher determination coefficient by sensibilities than by textures. But there were little correlation between a objective handle and preference of weft knit fabrics.