• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 하계종합학술대회 논문집(3)
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• pp.37-40
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• 2002

Intelligent Wearable Module is intelligent system that arises when a human is part of the feedback loop of a computational process like a certain control system. Applied system is mobile robot. This paper represents the mobile robot control system remote controlled by Intelligent Wearable Module. So far, owing to the development of internet technologies, lots of remote control methods through internet have been proposed. To control a mobile robot through internet and guide it under unknown environment, We propose a control method activated by Intelligent Wearable Module. In a proposed system, PDA acts as a user interface to communicate with notebook as a controller of the mobile robot system using TCP/IP protocol, and the notebook controls the mobile robot system. Tlle information about the direction and velocity of the mobile robot feedbacks to the PDA and the PDA send new control method produced from the fuzzy inference engine.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3223-3228
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• 2012

HMGN5 is a typical member of the HMGN (high mobility group nucleosome-binding protein) family which may function as a nucleosomal binding and transcriptional activating protein. Overexpression of HMGN5 has been observed in several human tumors but its role in tumorigenesis has not been fully clarified. To investigate its significance for human lung cancer progression, we successfully constructed a shRNA expression lentiviral vector in which sense and antisense sequences targeting the human HMGN5 were linked with a 9-nucleotide loop. Inhibitory effects of siRNA on endogenous HMGN5 gene expression and protein synthesis were demonstrated via real-time RT-PCR and western blotting. We found HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation assessed by MTT, BrdU incorporation and colony formation assays. Furthermore, flow cytometry analysis showed that specific knockdown of HMGN5 slowed down the cell cycle at the G0/G1 phase and decreased the populations of A549 and H1299 cells at the S and G2/M phases. Taken together, these results suggest that HMGN5 is directly involved in regulation cell proliferation in A549 and H1299 cells by influencing signaling pathways involved in cell cycle progression. Thus, our finding suggests that targeting HMGN5 may be an effective strategy for human lung cancer treatment.

• 한국항공우주학회지
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• 제45권4호
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• pp.284-291
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• 2017

최근 무인기는 정찰, 수송, 통신, 항공촬영 등 다양한 분야로 급속히 확대되고 있다. 또한 무인기 자동화 기술의 발전으로 한 명의 운용자가 복수의 무인기를 동시에 감독제어할 수 있게 되었다. 하지만 운용자에게 할당된 무인기의 대수가 많아지면 처리가 필요한 정보의 양이 많아져 운용자가 감당할 수 있는 부하보다 커질 수가 있다. 이에 따라 복수무인기를 제어하는 운용자의 과부하를 효율적으로 측정할 수 있는 지표 개발의 필요한 실정이나, 이와 관련된 연구가 미흡한 실정이다. 따라서 본 논문에서는 복수무인기 운용자 임무과부하 연구의 국내외 동향을 파악하고, 복수무인기 운용 시나리오와 지상체를 설계하여, 임무과부하 지표의 효용성을 검증하는 실험환경을 구축하여 향후 임무과부하 지표 연구를 위한 기반을 마련하였다.

• Journal of Microbiology and Biotechnology
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• 제28권11호
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• pp.1928-1936
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• 2018

Recently, human infections caused by severe fever with thrombocytopenia syndrome virus (SFTSV), which can lead to fatality, have dramatically increased in East Asia. With the unavailability of vaccines or antiviral drugs to prevent and/or treat SFTSV infection, early rapid diagnosis is critical for prevention and control of the disease. Here, we report the development of a simple, rapid and sensitive portable detection method for SFTSV infection applying reverse transcription-loop mediated isothermal amplification (RT-LAMP) combined with one-pot colorimetric visualization and electro-free reaction platform. This method utilizes a pocket warmer to facilitate diagnosis in a resource-limited setting. Specific primers were designed to target the highly-conserved region of L gene of SFTSV. The detection limit of the RT-LAMP assay was approximately $10^0$ viral genome copies from three different SFTSV strains. This assay exhibited comparable sensitivity to qRT-PCR and 10-fold more sensitivity than conventional RT-PCR, with a rapid detection time of 30 to 60 minutes. The RT-LAMP assay using SFTSV clinical specimens has demonstrated a similar detection rate to qRT-PCR and a higher detection rate compared to conventional RT-PCR. Moreover, there was no observed cross-reactive amplification of other human infectious viruses including Japanese Encephalitis Virus (JEV), Dengue, Enterovirus, Zika, Influenza and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). This highly sensitive, electro- and equipment-free rapid colorimetric visualization method is feasible for resource-limited SFTSV field diagnosis.

• Journal of Microbiology and Biotechnology
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• 제31권4호
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• pp.610-620
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• 2021

There has been increasing interest in the head and neck squamous cell carcinoma (HNSCC) that is caused by high-risk human papillomavirus (HR-HPV) and has posed a significant challenge to Otolaryngologists. A rapid, sensitive, and reliable method is required for the detection of HR-HPV in clinical specimens to prevent and treat HPV-induced diseases. In this study, a multiple cross-linking spiral amplification (MCLSA) assay was developed for the visual detection of HPV-16. In the MCLSA assay, samples were incubated under optimized conditions at 62℃ for 45 min, and after mixing with the SYBR Green I (SGI) dye, the positive amplicons showed bright green fluorescence while the negative amplicons exhibited no obvious change. The specificity test revealed that the developed MCLSA technique had high specificity and could effectively distinguish all five HPV-16 strains from other pathogenic microorganisms. In terms of analytical sensitivity, the limit of detection (LoD) of MCLSA assay was approximately 5.4 × 101 copies/tube, which was 10-fold more sensitive than loop-mediated isothermal amplification (LAMP) and RT-PCR. The detection results of laryngeal cancer specimens collected from 46 patients with suspected HPV infection in the Liaoning region demonstrated that the positive detection rates of MCLSA and hybridized capture 2 kit were 32.61% (15/46). The true positive rate of the MCLSA assay was higher than that of RT-PCR (100% vs. 93.33%) and LAMP (100% vs. 86.67%). Therefore, the MCLSA assay developed in the present study could be a potentially useful tool for the point-of-care (PoC) diagnosis of HR-HPV, especially in resource-limited countries.

• 로봇학회논문지
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• 제18권3호
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• pp.299-307
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• 2023

In the midst of accelerating wars around the world, unmanned robot technology that can guarantee the safety of human life is emerging. ERP-42 is a modular platform that can be used according to the application. In the field of defense, it can be used for transporting supplies, reconnaissance and surveillance, and medical evacuation in conflict areas. Due to the nature of the military environment, atypical environments are predominant, and in such environments, the platform's path followability is an important part of mission performance. This paper focuses on reducing the minimum turning radius in terms of improving path followability. The minimum turning radius of the existing 2WS/2WD in-wheel platform was reduced by increasing the torque of the independent driving in-wheel motor on the rear wheel to generate oversteer. To determine the degree of oversteer, two GPS were attached to the center of the front and rear wheelbases and measured. A closed-loop speed control method was used to maintain a constant rotational speed of each wheel despite changes in load or torque.

• 대한기관식도과학회지
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• 제4권1호
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• pp.73-78
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• 1998

The mutation of p53 is the most common genetic alteration found in human cancers and has oncogenic properties. mdm-2 is a recently discoverd that controls the p53 activity by binding of its protein, so negative feedback loop has been suggested in which p53 induces mdm-2 expression. The purpose of this study was to analyze the expression of p53 in leukoplakias, mdm-2 in squamous cell carcinomas, and relationship between p53 and mdm-2 expression in leukoplakias and squamous cell carcinomas. The results were as follows : 1) The p53 was expressed 33.4% in leukoplakias 2) The mdm-2 was expressed 8.3% in leukoplakias and 22.7% in squamous cell carcinomas. 3) The expression rate of p53 was higher in specimens negative for mdm-2 than in specimens positive for mdm-2, but there was not significant relationship between p53 and mdm-2 expression. In conclusion p53 was thought to participate in early phase of oncogenesis, and mdm-2 was thought to have a role as a oncogene in squamous cell carcinoma of head and neck. Though there was not significant relationship between p53 and mdm-2 expression, mdm-2 was thought to inhibit p53 activity.

• 한국전자파학회논문지
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• 제20권12호
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• pp.1325-1332
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• 2009

본 논문에서는 인체의 호흡 및 심박수 측정을 위해 2.4 GHz에서 동작하는 바이오 레이더 시스템의 소형화 및 성능 개선 방안으로서 하나의 원형 편파 안테나와 PLL 회로를 갖는 시스템을 설계하고 그 측정 결과를 제시 하였다. 제작된 바이오 레이더는 $90^{\circ}$ 하이브리드를 이용하여 원형 편파 특성과 송수신 격리 특성을 갖는 마이크 로스트립 안테나, 저잡음 증폭기, 전력 증폭기, 위상 고정 루프를 갖는 전압 제어 발진기, 직교 복조기 및 아날로그 회로로 구성된다. 특히, 단일 원형 편파 안테나를 소형화하기 위하여 annular-ring 형태의 마이크로스트립 안 테나를 송수신 회로와 적층함으로써, $40\times40mm^2$의 크기로 소형화할 수 있었다. 또한, 누설 송신 신호에 인한 수신부의 위상 잡음의 영향을 최소화하기 위하여 PLL 회로를 채용함으로써, 개선된 신호대 잡음비 성능을 갖도록 하였다. 설계된 바이오 레이더 시스템은 특별한 신호 처리 없이 50 cm 떨어진 사람의 호흡 및 심박수를 측정할 수 있음을 확인하였다.

• 동의생리병리학회지
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• 제34권3호
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• pp.149-158
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• 2020

The positive margins after LEEP(loop electrosurgical excision procedure) in cervical intraepithelial neoplasia are generally considered to be a risk factor for the recurrence or persistence of CIN currently. When positive margin exists, secondary LEEP or hysterectomy is performed. The aim of this study was to observe effects of Traditional Korean Medicine treatment for patients with surgical margin positive after LEEP. It was conducted retrospective chart review for 4 patients with the surgical margin positive after LEEP, who were scheduled to have secondary LEEP 3 months later. Patients were treated with herbal medicine, pharmacopuncture and herbal liquid vaginal treatment. They were followed up by cytology, colposcopy, human papillomavirus DNA test and punch-biopsy at 1, 3 and 6 months. After 3 month of treatment, three patients did not need secondary LEEP because of normal cytology, negative HPV status and normal colposcopy, while the other patient underwent secondary LEEP because of ASCUS cytology and positive high-risk HPV. After 6 month of treatment, the other patient also had normal cytology, negative HPV status and normal colposcopy and had been in fifth week of pregnancy. This study suggest that Traditional Korean Medicine treatment may be an effective to the patients with surgical margin positive after LEEP in cervical intraepithelial neoplasia.

• 대한임베디드공학회논문지
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• 제10권4호
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• pp.189-198
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• 2015

Most IoT-related approaches have tried to establish the relation by connecting the network between things. The proposed research will present how the pervasive interaction of eco-system formed by touching the objects between humans and things can be recognized on purpose. By collecting and sharing the detected patterns among all kinds of things, we can construct the environment which enables individualized interactions of different objects. To perform the aforementioned, we are going to utilize technical procedures such as event-driven signal processing, pattern matching for signal recognition, and hardware in the loop simulation. We will also aim to implement the prototype of sensor processor based on Arduino MCU, which can be integrated with system using Arduino-Matlab/Simulink hybrid-interoperation environment. In the experiment, we use piezo transducer to detect the vibration or vibrates the surface using acoustic wave, which has specific frequency spectrum and individualized signal shape in terms of time axis. The signal distortion in time and frequency domain is recorded into memory tracer within sensor processor to extract the meaningful pattern by comparing the stored with lookup table(LUT). In this paper, we will contribute the initial prototypes for the acoustic touch processor by using off-the-shelf MCU and the integrated framework based on Matlab/Simulink model to provide the individualization of the touch-sensing for the user on purpose.