• Journal of the Korean Society of Food Culture
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• v.22 no.1
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• pp.140-148
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• 2007

Diabetic nephropathy has been increasing, although blood glucose and blood pressure can be controlled by angiotensin converting enzyme(ACE) or advanced glycosylation end products(AGE) inhibitors in the diabetic patients. We investigated the effect of dietary supplementation of sea tangle on the blood glucose, and pathological scoring of diabetic kidneys in the streptozotocin(STZ) induced diabetic rats. Male Sprague-Dawley rats were divided into normal rats fed control diet and diabetic rats fed control diet or control diet supplemented with powder or oater extract of sea tangle. Diabetes was induced by a single injection of STZ(60mg/kg, ip) in citrate buffer. The animals were fed the experimental diet and water for 13 weeks. Dietary supplementation of sea tangle decreased blood glucose in the diabetic rats. However, dietary supplementation of sea tangle did not affect the antioxidant enzyme activities, MDA content and pathology of diabetic kidneys. These results indicate that decreased blood glucose by sea tangle could not delay the progression of diabetic kidney disease.

• Journal of Microbiology and Biotechnology
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• v.33 no.10
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• pp.1317-1328
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• 2023

Green tea (GT) polyphenols undergo extensive metabolism within gastrointestinal tract (GIT), where their derivatives compounds potentially modulate the gut microbiome. This biotransformation process involves a cascade of exclusive gut microbial enzymes which chemically modify the GT polyphenols influencing both their bioactivity and bioavailability in host. Herein, we examined the in vitro interactions between 37 different human gut microbiota and the GT polyphenols. UHPLC-LTQ-Orbitrap-MS/MS analysis of the culture broth extracts unravel that genera Adlercreutzia, Eggerthella and Lactiplantibacillus plantarum KACC11451 promoted C-ring opening reaction in GT catechins. In addition, L. plantarum also hydrolyzed catechin galloyl esters to produce gallic acid and pyrogallol, and also converted flavonoid glycosides to their aglycone derivatives. Biotransformation of GT polyphenols into derivative compounds enhanced their antioxidant bioactivities in culture broth extracts. Considering the effects of GT polyphenols on specific growth rates of gut bacteria, we noted that GT polyphenols and their derivate compounds inhibited most species in phylum Actinobacteria, Bacteroides, and Firmicutes except genus Lactobacillus. The present study delineates the likely mechanisms involved in the metabolism and bioavailability of GT polyphenols upon exposure to gut microbiota. Further, widening this workflow to understand the metabolism of various other dietary polyphenols can unravel their biotransformation mechanisms and associated functions in human GIT.

• The Journal of the Convergence on Culture Technology
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• v.9 no.5
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• pp.299-310
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• 2023

According to Jacques Lacan, human desire stems from a primitive lack, This lack acts as a driving force, propelling humans to continually seek pleasure and satisfaction. Given its intricacies, the interplay between the subject's and the overall human desire is intricate, making complete realization of desire unattainable. Through Jacques Lacan's theory of desire, the researcher aims to explore the balance achieved as the subject in the movie navigates ideals, frustrations, and growth. This paper focuses on the analysis of the movie 'Parasite' using Amedeo Giorgi's phenomenological method. By doing so, the researcher seeks to uncover the essence of human desire, offering insights and a theoretical framework for cinematic creation.

• International Journal of Advanced Culture Technology
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• v.11 no.4
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• pp.302-309
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• 2023

Wearable devices, attached to the human body, track and enhance users' activities, health, and communication. Therefore, considering ergonomic factors in product design is crucial. However, previous research has somewhat overlooked the importance of integrating ergonomic design elements into a broad spectrum of design factors. This study aims to examine the impact of physical attributes inherent in smart wristbands and smartwatches on the perceived functional value, specifically, perceived usefulness, ease of use, and fit. A survey was conducted among 289 US adults who had experience using smart wristbands or smartwatches. The collected data were analyzed using descriptive statistics, factor analysis, Cronbach's alpha, t-test, MANOVA, and regression analysis in SPSS version 29. The results showed that the shape of the front display significantly influenced perceived ease of use, and the product's weight had a substantial impact on both perceived ease of use and fit. Furthermore, distinct technical features on the front display had varied effects on perceived usefulness, ease of use, and fit. Notably, the presence of activity tracking, alarm, and calendar functionalities led to distinct differences in ease of use and fit. Features such as distance tracking, phone call, social media notifications, text messaging, and time display functions showed significant influences on the perception of fit. These findings provide insights into the physical values of smart wristbands and smartwatches as perceived by users.

• International Journal of Advanced Culture Technology
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• v.12 no.1
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• pp.299-304
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• 2024

Human rights problem of refugee is the most important task to be solved in the international society. The United Nations High Commissioner for Refugees (UNHCR) was established in 1950, with the need for cooperation in the face of the European refugee crisis. In 1951, 'The 1951 refugee convention' was signed for the protection of all refugees. Since the 1951 Refugee Convention, a legal framework has been established for responding to refugees. However, the discrimination and persecution of refugees are still lingering. The interest and the political will of many people in the world are needed to solve this problem. This article analyzes what efforts should be made with respect to human rights issues. This article concludes that, when comparing refugee acceptance and Korea, Korea needs to look at the common denominator of refugee law, human rights law, and international humanitarian law while looking at the treatment of refugees and displaced people from an inclusive approach, and reorganize law and policy. Since Korea is expected to gradually require inclusive policies, Korea should also supplement the legal system and take an inclusive approach. Although Korea as a member of the Refugee Convention, the Geneva Convention, and the Supplementary Protocol, has an obligation to enact domestic implementation laws, it does not reflect all of the obligations required by these conventions, so reorganization is needed.

• International Journal of Stem Cells
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• v.17 no.1
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• pp.91-98
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• 2024

The development of in vitro models is essential in modern science due to the need for experiments using human material and the reduction in the number of laboratory animals. The complexity of the interactions that occur in living organisms requires improvements in the monolayer cultures. In the work presented here, neuroepithelial stem (NES) cells were differentiated into peripheral-like neurons (PLN) and the phenotype of the cells was confirmed at the genetic and protein levels. Then RNA-seq method was used to investigate how stimulation with pro-inflammatory factors such as LPS and IFN𝛾 affects the expression of genes involved in the immune response in human fibroblast-like synoviocytes (HFLS). HFLS were then cultured on semi-permeable membrane inserts, and after 24 hours of pro-inflammatory stimulation, the levels of cytokines secretion into the medium were checked. Inserts with stimulated HFLS were introduced into the PLN culture, and by measuring secreted ATP, an increase in cell activity was found in the system. The method used mimics the condition that occurs in the joint during inflammation, as observed in the development of diseases such as rheumatoid arthritis (RA) or osteoarthritis (OA). In addition, the system used can be easily modified to simulate the interaction of peripheral neurons with other cell types.

• Journal of the Korea Safety Management & Science
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• v.16 no.2
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• pp.19-29
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• 2014

Korean societal concern for the train accidents is fast and widely increasing with an ever-increasing demand and use for KTX. Most of these train accidents are inclined to be caused by human error. Experts used to attribute the causes of human error to the defects in various aspects such as technology, organizational system, practices, corporate culture, and/or human resource itself. Among the diverse causes of human error, an important one, even though it was rarely focused, may be the issue of impact of rule or procedure change on human error. Giving attention to the implicit importance of this issue, this study intends to highlight the theme of frequent procedure change in railway driving manual as a critical factor of human error. To attain this purpose mentioned above, dual methodologies were adopted. One is to qualitatively analyze the real cases of procedure change in relevant manuals followed by the incident case(passing the station scheduled to stop) happened lately. Another is to quantitatively perform statistical analysis based on questionnaires received from 224 train drivers. Results show that frequent changes in internal affairs procedure is or may be an important factor causing stress and human error from train drivers.

• 한국생물공학회:학술대회논문집
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• 2005.04a
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• pp.80-80
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• 2005

• Proceedings of the Microbiological Society of Korea Conference
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• 2007.05a
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• pp.95-96
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• 2007

• Journal of Periodontal and Implant Science
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• v.21 no.1
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• pp.179.2-179.2
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• 1991