• Title/Summary/Keyword: Human consumption

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A 13 Week Subcutaneous Toxicity Study of Recombinant Human Epidermal Growth Factor (DWP401) in Mice (Recombinant Human Epidermal Growth Factor (DWP401)의 마우스를 이용한 피하투여 아급성독성시험)

  • 송시환;강부현;신천철;김희연;강진석;심점순;한상섭;노정구
    • Biomolecules & Therapeutics
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    • v.4 no.2
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    • pp.138-147
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    • 1996
  • DWP401, a recombinant human epidermal growth factor, was subcutaneously administered to ICR mice at the dose levels of 0, 0.04, 0.2 and 1.0 mg/kg/day (15rats/sex/group) in order to evaluate the subchronic toxicity. General observations, examinations for food and water consumption, ophthalmoscopy and urinalysis were carried out during the study. For the complete gross and microscopic examinations, 10 mice/ sex/group were sacrificed at the ends of the dosing period, and the remaining animals were sacrificed with a 5 week recovery period. Examinations for hematology and blood biochemistry were also carried out at the time of recovery period. Based on the results, it was thought that the target tissue or organs were mesothelial cell, injection site, spleen, adrenal gland, ovary and transitional epithelial cell of urinary tract, and no observed toxic level of DWP401 was 0.04 mg/kg while definite toxic dose level might be 0.2 mg/kg.

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Evolution of Human Locomotion: A Computer Simulation Study (인류 보행의 진화: 컴퓨터 시뮬레이션 연구)

  • 엄광문;하세카즈노리
    • Journal of the Korean Society for Precision Engineering
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    • v.21 no.5
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    • pp.188-202
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    • 2004
  • This research was designed to investigate biomechanical aspects of the evolution based on the hypothesis of dynamic cooperative interactions between the locomotion pattern and the body shape in the evolution of human bipedal walking The musculoskeletal model used in the computer simulation consisted of 12 rigid segments and 26 muscles. The nervous system was represented by 18 rhythmic pattern generators. The genetic algorithm was employed based on the natural selection theory to represent the evolutionary mechanism. Evolutionary strategy was assumed to minimize the cost function that is weighted sum of the energy consumption, the muscular fatigue and the load on the skeletal system. The simulation results showed that repeated manipulations of the genetic algorithm resulted in the change of body shape and locomotion pattern from those of chimpanzee to those of human. It was suggested that improving locomotive efficiency and the load on the musculoskeletal system are feasible factors driving the evolution of the human body shape and the bipedal locomotion pattern. The hypothetical evolution method employed in this study can be a new powerful tool for investigation of the evolution process.

Ecological and human health risk from polychlorinated biphenyls and organochlorine pesticides in bivalves of Cheonsu Bay, Korea

  • Choi, Jin Young;Yang, Dong Beom;Hong, Gi Hoon;Kim, Kyoungrean;Shin, Kyung-Hoon
    • Environmental Engineering Research
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    • v.21 no.4
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    • pp.373-383
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    • 2016
  • Cheonsu Bay, one of the most important in Korea as a coastal fishery is a semi-enclosed bay that is surrounded by large farmlands and industrial areas. This coastal environment has been affected by anthropogenic pollutants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs). The objectives of this study were to investigate the distribution of PCBs and OCPs in sediment, Manila clams, and mussels from Cheonsu Bay; the accumulation pattern of these chemicals in these bivalves in relation to seasonal changes; and the ecological risk from sediments and the risk to the Korean population from the consumption of these bivalves. The levels of ${\Sigma}PCBs$, ${\Sigma}DDT$, and ${\Sigma}HCHs$ were 69.3-109, 40.3-49.3 and 6.25-17.8 ng/g lipid in Manila clams, and 70.6-159, 38.6-102 and 9.00-13.5 ng/g lipid in Mussels. Significant seasonal variations in PCBs and OCPs concentrations were observed in the two bivalves, suggesting that the accumulation of PCBs and OCPs in these species is related to their spawning times. The dietary intake of these two bivalves and the resulting lifetime cancer risk (LCR) and non-cancer risk were calculated for the human population. The consumption of these bivalves seemed to be safe in relation to human health with negligible LCR and non-cancer risk.

20s-30s Men's Cosmetics Purchase Decision Factors (20-30대 남성의 화장품 구매결정요인)

  • Jeon, Hyang-Ran;Jae, Mie-Kyung
    • Korean Journal of Human Ecology
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    • v.18 no.6
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    • pp.1237-1246
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    • 2009
  • This study was designed to identify and compare the consumption value and interest in appearance with regard to the comparison of men's cosmetics purchase decision factors. We conducted a survey among 259 men who have experienced the re-purchase of men's cosmetics. All data was analyzed with the SPSS Windows 17.0 program in terms of frequency, percentage, means, standard deviations, paired-t test, Cronbach $\alpha$, factor analyses, and multiple regression. In summary, three findings emerged from this study. First, men's cosmetics purchase decision factors included two subfactors: product quality factors (price, quality, skin compatibility, fragrance) and image factors (trend, brand image, consciousness of others, diversion). Second, a paired-t test revealed that the consideration toward the image factors of a first time purchase decision was lower than the re-purchase decision factors. However the consideration toward the product quality factors of a first time purchase decision was not different from the re-purchase decision factors. Third, the product quality factors were positively influenced by distinction factors of appearance and functional value. And social value, emotional value, and curiosity value were found to be effective in the image factors at the first time of purchase and re-purchase. Also, the product quality factors of re-purchase decisions were influenced by the satisfaction of the first time purchase. This study will contribute to provide some information for marketers in understanding men's cosmetics purchase decisions and to offer basic data for marketing strategies and product development.

Determinants of the Social Capital Awareness of the Elderly with a Focus on Social Participation Awareness (노인의 사회적 자본 의식에 영향을 미치는 요인: 사회참여의식을 중심으로)

  • Hong, Sung-Hee
    • Journal of Family Resource Management and Policy Review
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    • v.20 no.2
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    • pp.19-41
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    • 2016
  • This study examines the human capital, economic capital, and psychological factors that influence social participation among the elderly in the future. The data, 'Survey on the Elderly in 2014', were collected from 'The Ministry of Health & Welfare' and the 'Korea Institute for Health and Social Affairs'. The samples included 10,279 elderly people who were over 65 years of age. Multiple regression analysis was used to analyze the research model. The findings are as follows. First, the highest participation awareness level of all was for the hobbies and leisure activities, and the lowest participation awareness level was for volunteer activities. Second, human capital factors such as age, education level, and health status, and economic capital factors such as household consumption expenditure and standard of living signigicant affected social participation awareness among the elderly. Psychological factors such as self-esteem, depression, and the subjective age of becoming elderly, also affected the social participation awareness. Third, awareness differed by sex. In particular, age and depression were restrictions of social participation awareness that were more common among elderly women than among elderly men, although single women were more likely to participate in religious, learning, and hobby and leisure activities. In contrast, chronic diseases and household consumption expenditures were more restrictive of social participation awareness among elderly men compared to elderly women. These results show that human capital, economic capital, and psychological factors heavily influence the social participation awareness of the elderly, although the degree of influence of these factors differs by sex.

A study on Mongol women's imported apparel selection behavior according to their conspicuous consumption orientation (몽골 여성들의 과시적 소비성향에 따른 수입의류 선택행동)

  • Munkhtuya, Bavuudorj;Kim, Yongsook
    • The Research Journal of the Costume Culture
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    • v.20 no.6
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    • pp.811-825
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    • 2012
  • The purpose of this study was to identify imported apparel selection behavior according to Mongol women's conspicuous consumption orientation. A self-administered questionnaire was used for data collection. First, factors of conspicuous consumption orientation were high price and luxury brand, fashion style, altruism, prestige, and brand. Mongol women were segmented into the price and prestige pursuit group, the fashion and brand pursuit group, the altruism pursuit group, and the conspicuous consumption retard group. Second, factors of motivating the selection of imported apparel were value, symbolism, and aesthetics, and Mongol women considered the aesthetics of imported apparel important. Married Mongol women in their 30's chose imported apparel because of its symbolism. More married women selected imported apparel because of its value and more educated women selected imported apparel because of its aesthetics. Women with higher apparel expenditure selected imported apparel because of its value and symbolism. Quality, diversity, and the fit of imported apparel were the selection criteria for Mongol women and they were satisfied with the quality, diversity, and fit of the imported apparel. Brand awareness was very important when selecting imported apparel but the women's satisfaction level was significantly low. Third, more women in their 30's, unmarried, or with a lower educational level were found in the price and the prestige pursuit group, and the price and prestige pursuit group and the altruism pursuit group selected imported apparel for its aesthetics. More unmarried women in their 30's with a higher educational level were found in the fashion and brand pursuit group and selected imported apparel for its value, symbolism, and aesthetics. More unmarried women in their 20's with a higher educational level were found in the altruism pursuit group, but unmarried women in their 20's with a lower educational level were found in the conspicuous consumption retard group.

The Roles of Benefit and Risk Perception in Ethical Fashion Consumption (윤리적 패션소비에 대한 혜택 및 위험지각이 소비자 태도와 행동의도에 미치는 영향)

  • Moon, Heekang;Choo, Ho Jung;Park, Hye Sun;Baek, Eunsoo
    • Journal of the Korean Society of Clothing and Textiles
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    • v.37 no.2
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    • pp.159-173
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    • 2013
  • This research investigates the mechanism of ethical fashion consumption by examining the effects of benefit and risk perception on ethical fashion consumption attitudes and behavioral intention. To test the hypotheses, 300 female consumers between the ages of 20 and 49 were invited as study participants. The reliability and the validity of multi-item constructs were tested by Confirmatory Factor Analysis. The hypotheses were tested by utilizing Structural Equation Analysis and hierarchical multiple regression analysis. The benefit perception of ethical consumption was composed of three benefit types, which were altruistic benefit, social image benefit, and self-oriented benefit. Benefit perception, except social image benefit, had significant effects on consumer attitudes towards ethical fashion consumption; similarly, benefit perception had significant effects on behavioral intention (except self-oriented benefit) which had an effect on behavioral intention only when it was mediated by attitudes. Further analysis was conducted to understand the reason for the weak relationship between attitudes and behavioral intention. Financial and performance risk perceptions were tested for the moderating roles of attitudes and behavioral intention; subsequently, only financial risk interacted with attitudes and showed that the positive effects of attitudes on behavioral intention were weakened by a high financial risk perception. Performance risk had a main effect on behavioral intention independent of attitudes. Managerial implication and future study directions are also discussed.

The Effects of Clothing Consumption Value and Demographic Features on Clothing Disposal Behaviors (의복소비가치와 인구통계적 특성에 따른 의복처분행동)

  • Ahn, Soo-kyoung;Ryou, Eunjeong
    • Fashion & Textile Research Journal
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    • v.17 no.6
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    • pp.956-964
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    • 2015
  • This study aims to investigate the relationship between consumers’ clothing consumption values, demographic features, and clothing disposal behaviors. The data were collected from 300 women aged between 20 and 59 through the online survey with the self-administered questionnaire. A series of exploratory and confirmative factor analysis was conducted to identify the dimensions of clothing consumption values and clothing disposition behaviors. Clothing consumption values consisted of six dimensions including conditional value, individuality value, fashion value, social value, practical value, and self-expression value. Clothing disposition behaviors were discovered as four dimensions such as discarding, giving, selling, and donating. A structural equation modeling analysis was employed to examine the relationship between clothing consumption values and disposition behaviors. While individuality value, fashion value, and practical value had a significantly positive impact on donating, giving, and discarding behaviors, both practical value and self-expression value negatively influenced discarding behavior. Fashion value negatively affected giving behavior. Employing a series of MANOVA, one-way ANOVA and sheffe's multiple range test, this study found that there were significant effects of age, marital status, monthly income, and monthly clothing expenses on giving and donating behaviors. This study suggests that fashion firms should be aware of clothing disposition in terms of social and environmental concerns and understand diverse consumer disposal behaviors and utilize them as a social marketing strategy.

Linkages of Financial Efficacy, Demographics, Risks Preference and Consumption Behavior in Malaysia

  • KUSAIRI, Suhal;SANUSI, Nur Azura;MUHAMAD, Suriyani;SHUKRI, Madihah;ZAMRI, Nadia
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.9
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    • pp.673-685
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    • 2020
  • Financial literacy is one of the sustainable development goals of huge concern of governments. Governments explore solutions addressing policies to improve financial literacy. Nevertheless, financial management has such a broad scope and is not just limited to knowledge. As human nature, individuals are born with different confidence levels that include various financial abilities. This study aims to investigate the household-financial efficacy through the application of psychometric instruments, risk preference, and demographic characteristics toward consumption decision behavior. The research is based on a survey 479 households in the peninsular Malaysia, and utilizes the structural equation model, cluster proportional and systematic random sampling, and two measurements - composite reliability and average variance extracted. Results show that households' financial efficacy is one of the critical factors that explain the households' consumption decision behavior. Also, risk preference, gender and area location (rural or urban) of the household determined the consumption decision behavior of the household. The effectiveness of consumption decision is not only determined by financial literacy, but also financial efficacy. The implications of this paper may help to design policies in narrowing the broad gap between the rural and urban level of financial efficacy. The government needs to take appropriate actions to fix it.