• The Korean Journal of Physiology and Pharmacology
• /
• 제2권6호
• /
• pp.671-676
• /
• 1998

In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects of morphine in differentiated SH-SY5Y human neuroblastoma cells. The increases in CREB and AP-1 DNA binding activities were time-dependent up to 6 days of morphine treatment (1, 4, and 6 days). However, the significant reduction in the DNA binding activities of CREB and AP-1 was observed after 10 days of chronic morphine $(10\;{\mu}M)$ administration. Secondly, we examined whether the changes of CREB and AP-1 DNA binding activities could be modulated by dopamine and haloperidol. Dopamine cotreatment moderately increased the levels of the CREB and AP-1 DNA binding activities induced by 10 days of chronic morphine treatment, and haloperidol cotreatment also resulted in a moderate increase of the CREB and AP-1 DNA binding activities. However, dopamine or haloperidol only treatment showed a significant increase or decrease of the CREB and AP-1 DNA binding activities, respectively. In the case of acute morphine treatment, the CREB and AP-1 DNA binding activities were shown to decrease in a time-dependent manner (30, 60, 90, and 120 min). Taken these together, in differentiated SH-SY5Y cells, morphine tolerance seems to involve simultaneous changes of the CREB and AP-1 DNA binding activities. Our data also suggest the possible involvement of haloperidol in prevention or reversal of morphine tolerance at the transcriptional level.

• 한국생활과학회지
• /
• 제23권1호
• /
• pp.47-61
• /
• 2014

The purpose of this study was to identify the relationship among financial debt burden, psychological factors and financial stress. Data was collected by surveying 450 individuals who were over twenty years old, and 384 were used for the analysis. As the result, first, number of sources of debt, use of each debt, marital status/double income, housing, debt amount and financial stress were found to be significantly different among three groups(debt free, non risky, risky). In addition, marital status/double income, gender, housing and income were found to significantly influence to the probability of being one of the three groups. Second, level of debt burden, age, employment and income were found to significantly influence to financial stress, while psychological factors such as risk tolerance and self-control were not. It might be noteworthy that people in debt were likely to have higher level of stress, while the older, employed, and having higher income were likely to have lower level of stress. This study would provide useful information in terms of debt policy to relieve the financial stress.

• 한국생활과학회지
• /
• 제20권1호
• /
• pp.195-203
• /
• 2011

The purpose of this study was to define the effects of the finger temperature response according to the daily life of college student. For this study, 31 healthy female college students were taken as a subject group. To define the effects of the finger temperature response, housing style, subjective thermal sensations during daily life in the house and domestic working time were surveyed. The finger temperature response items were measured. The results were as follows. Strong, normal and weak group members were divided according to their cold resistance index(RI) 3, 8, 20 people, repectively. Subjective thermal sensations during daily life in the house affects the cold resistance index(p<.01). The cold resistance index(RI) got higher as domestic working time was increased(p<.05, F-value=3.927). The percentage wearing protective gloves during domestic work in the weak group was higher than the normal or strong groups. Subjective sensations during daily life and domestic working time effected the local cold tolerance, living in a comfortable environment continuously can weaken one's cold tolerance.

• Journal of Plant Biotechnology
• /
• 제37권3호
• /
• pp.283-291
• /
• 2010

Vaccine is one of the best known and most successful applications of immunological theory to human health and it protects human life through inducing the immune response in systemic compartment. However, when we consider the fact that mucosal epithelium is exposed to diverse foreign materials including viruses, bacteria, and food antigens and protects body from entry of unwanted materials using layer of tightly joined epithelial cells, establishing the immunological barrier on the lining of mucosal surfaces is believed to be an effective strategy to protect body from unwanted antigens. Unfortunately, however, oral mucosal site, which is considered as the best target to induce mucosal immune response due to application convenience, is prone to induce immune tolerance rather than immune stimulation. Since intestinal epithelium is tightly organized, a prerequisite for successful mucosal vaccination is delivery of antigen to mucosal immune induction site including a complex system of highly specialized cells such as M cells. Consequently, development of efficient mucosal adjuvant capable of introducing antigens to mucosal immune induction site and overcome oral tolerance is an important subject in oral vaccine development. In this review, various approaches on the development of oral mucosal adjuvants being suggested for effective oral mucosal immune induction.

• 항공우주시스템공학회지
• /
• 제15권1호
• /
• pp.47-55
• /
• 2021

항공기의 비정상적인 착륙 상황에서도 조종사의 생존을 보장하고 탈출에 방해되지 않도록 구조물이 설계되어야 한다. 추락 시, 화재의 원인을 찾는 연구를 시작으로 과거 수많은 고정익 항공기 추락시험이 수행되었다. 동역학적 분석을 통한 구조물의 거동특성을 이해하고, 가속도 상태에서 인체의 허용한계를 조사하여 적절한 추락하중배수가 설정되었다. 또한 화물기 사고 데이터를 확률론적 방법으로 분석하여 승객의 안전과 운용비용이 합리적으로 반영된 화물고정용 추락하중배수도 제시되었다. 과거 사례를 바탕으로 현재 적용되고 있는 추락하중배수의 물리적, 의학적, 경제적 의미를 살펴 보았다.

• Biomolecules & Therapeutics
• /
• 제7권4호
• /
• pp.342-346
• /
• 1999

This study was performed to investigate the effect of cyclosporine (CsA) on glucose tolerance and peripheral insulin sensitivity in normal Sprague-Dawley rats. After daily treament of CsA (10 mg/kg, i.p.) for two weeks, glucose tolerance tests were carried out by the treatment of glucose (Glu, 2 g/kg, i.p.) alone or in conjunction with exogenous insulin (Ins; human regular insulin, 5 U/kg, s.c.) and measured the decrement of area under the time-plasma glucose concentration curve ($AUC_{o\longrightarrow120}$; g.min/ml) by the trapezoidal rule. The rats were divided into three groups (Glu- (Control), Ins+Glu- and CsA+Ins+Glu-, n=7 in each group). The $AUC_{o\longrightarrow120}$ of the CsA+Ins+Glu-group was significantly (p<0.01) lower than that of Glu-group (61.0% of control) and significantly (p<0.05) higher than that of Ins+Glu-group (197.4% of Ins+Glu-). The CsA+Ins+Glu- grou showed higher levels of maximal blood glucose concentration and higher $AUC_{o\longrightarrow120}$ than those of Ins+Glu-group in normal rats. Besides direct pancreatic toxicity of CsA previously reported (Hahn et al., 1972), these results suggest that CsA also make the possibility to induce peripheral insulin insensitivity and glucose intolerance in normal rats.

• Current Optics and Photonics
• /
• 제1권5호
• /
• pp.538-543
• /
• 2017

Progressive addition lenses (PAL) have very wide application in the modern glasses market. The unique progressive surface can make a lens have progressive refractive power, which can meet the human eye's different needs for distance-vision and near-vision. According to the national glasses fabrication standard, the difference between actual optical power after fabrication and nominal design value should be less than 0.1D over the lens effective area. The optical power distribution of PAL is determined directly by the surface. Consequently, the surface processing accuracy requirement is proposed. Beginning from the surface expressions of progressive addition lenses, the relationship equations between the surface sag and optical power distribution are derived. They are demonstrated through tolerance analysis and test of an example progressive addition lens with addition of 2.09D (5.46D-7.55D). The example addition surface is fabricated under given accuracy by a single-point diamond ultra-precision machine. The optical power of the PAL example is tested with a focal-meter after fabrication. The optical power addition difference between test result and design nominal value is 0.09D, which is less than 0.1D. The derived relationship between the surface error and optical power is verified from the PAL example simulation and test result. It can provide theoretical tolerance analysis proof for the PAL surface fabricating process.

• 환경영향평가
• /
• 제15권6호
• /
• pp.385-394
• /
• 2006

Land resources should be managed not only for human utilizations but also for environmental preservation. Based on that, environmental capacity should be estimated in both environmental and developmental ways. This study was performed for developing an estimation model for relative environmental capacity, considering both Development Tolerance Index(DTI), which shows environmental and ecological conservation value and is based on national environmental assessment indicators of the Korea Ministry of Environment, and Development Attractiveness Index(DAI), which shows topographical characteristics and geographical accessibility. The relative environmental capacity in this study can be helpful to coping with the conflict in planning and managing the use of land resources. The relative environmental capacity in this study, however, did not include either environmental or ecological sensitivity of land resources. This limitation should be solved through further research.

• IEIE Transactions on Smart Processing and Computing
• /
• 제4권6호
• /
• pp.407-412
• /
• 2015

In model-based tracking, an accurate 3D model of a target object or scene is mostly assumed to be known or given in advance, but the accuracy of the model should be guaranteed for accurate pose estimation. In many application domains, on the other hand, end users are not highly distracted by tracking errors from certain levels of modeling errors. In this paper, we examine perceptual tracking errors, which are predominantly caused by modeling errors, on subjective evaluation and compare them to computational tracking errors. We also discuss the tolerance of modeling errors by analyzing their permissible ranges.

• 수면정신생리
• /
• 제12권1호
• /
• pp.17-22
• /
• 2005

Sleep-disordered breathing (SDB) is associated with increased cardiovascular and cerebrovascular morbidity. Epidemiological and clinic-based studies have shown that SDB is related to impaired glucose tolerance and increased insulin resistance, independent of obesity. Despite of a consistent association between SDB and impaired glucose-insulin metabolism, the mechanism underlying this relationship has not been fully elucidated. It is recognized that hypoxemia and hypercapnia that occur in SDB provoke sympathetic nervous activity and catecholamine, epinephrine and norepinephrine, and cortisol are released. Sympathetic hyperactivity and increased catecholamines can impair glucose homeostasis by increasing glycogenolysis and gluconeogenesis, which can result in increased circulating insulin levels and increased risk of insulin resistance. A prospective study is needed to investigate the causal relationship between SDB and impaired glucose-insulin metabolism in a healthy population without diabetes, hypertension and obesity as etiologic risk factors.