The Korean Journal of Physiology and Pharmacology
- Volume 2 Issue 6
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- Pages.671-676
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- 1998
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Effects of Dopamine and Haloperidol on Morphine-induced CREB and AP-1 DNA Binding Activities in Differentiated SH-SY5Y Human Neuroblastoma Cells
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Kim, Soo-Kyung
(Department of Pharmacology and Institute for Medical Science, Keimyung University School of Medicine) ;
- Kwon, Gee-Youn (Department of Pharmacology and Institute for Medical Science, Keimyung University School of Medicine)
- Published : 1998.12.21
Abstract
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects of morphine in differentiated SH-SY5Y human neuroblastoma cells. The increases in CREB and AP-1 DNA binding activities were time-dependent up to 6 days of morphine treatment (1, 4, and 6 days). However, the significant reduction in the DNA binding activities of CREB and AP-1 was observed after 10 days of chronic morphine