• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.357.1-357.1
• /
• 2002

Three-dimensional quantitative activity relationship (3D-QSAR) study for a series of arylsulfonylimidazolidinone derivatives with antitumor activity was conducted using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices anaysis (CoMSIA). The in vitro cytotoxicity against human lung carcinoma (A549) exhibited a strong correlation with steric and electrostatic factors of the molecules. (omitted)

• Annual Conference of KIPS
• /
• 2010.11a
• /
• pp.474-477
• /
• 2010

본 논문에서는 패턴인식을 이용한 의류의 결함을 자동으로 탐색하는 시스템을 설계하였다. 이는 히스토그램을 기반으로 하여 영상의 특징을 추출하고 템플릿 매칭을 이용해서 패턴을 추적하도록 하였스며, 또한, SSIM(Structural Similarity) Index를 통해 추적된 패턴과 원 패턴의 유사도를 HVS(Human Vision System)을 기준으로 하여 결함을 판별할수 있도록 하였다.

• Bulletin of the Korean Chemical Society
• /
• v.35 no.11
• /
• pp.3181-3187
• /
• 2014

A series of 3,4-dihydroquinazoline derivatives with anti-cancer activities against human colon cancer HT-29 cell were subjected to three-dimensional quantitative structure-activity relationship (3D-QSAR) studies using the comparative molecular similarity indices analysis (CoMSIA) approaches. The most potent compound, BK10001 was used to align the molecules. As a result, the best prediction was obtained with CoMSIA combined electrostatic, hydrophobic, and hydrogen-bond acceptor fields ($q^2=0.648$, $r^2=0.882$). This model was validated by an external test set of six compounds giving satisfactory predictive $r^2$ values of 0.879. This model would guide the design of potent 3,4-dihydroquinazoline derivatives as anti-cancer agent for the treatment of human colon cancer.

• Journal of Korea Multimedia Society
• /
• v.24 no.5
• /
• pp.659-666
• /
• 2021

With the continuous development of deep learning, human behavior recognition algorithms have achieved good results. However, in a multi-person recognition environment, the complex behavior environment poses a great challenge to the efficiency of recognition. To this end, this paper proposes a multi-person pose estimation model. First of all, the human detectors in the top-down framework mostly use the two-stage target detection model, which runs slow down. The single-stage YOLOv3 target detection model is used to effectively improve the running speed and the generalization of the model. Depth separable convolution, which further improves the speed of target detection and improves the model's ability to extract target proposed regions; Secondly, based on the feature pyramid network combined with context semantic information in the pose estimation model, the OHEM algorithm is used to solve difficult key point detection problems, and the accuracy of multi-person pose estimation is improved; Finally, the Euclidean distance is used to calculate the spatial distance between key points, to determine the similarity of postures in the frame, and to eliminate redundant postures.

• Smart Media Journal
• /
• v.13 no.4
• /
• pp.16-22
• /
• 2024

Pitching is a major part of baseball, so much so that it can be said to be the beginning of baseball. Analysis of accurate pitching motions is very important in terms of performance improvement and injury prevention. When analyzing the correct pitching motion, the currently used motion capture method has several critical environmental drawbacks. In this paper, we propose analysis of pitching motion using the RGB-based Human Pose Estimation (HPE) model to replace motion capture, which has these shortcomings, and use motion capture data and HPE data to verify its reliability. The similarity of the two data was verified by comparing joint coordinates using the Dynamic Time Warping (DTW) algorithm.

• International Journal of Stem Cells
• /
• v.17 no.2
• /
• pp.204-211
• /
• 2024

With recent advances in adeno-associated virus (AAV)-based gene therapy, efficacy and toxicity screening have become essential for developing gene therapeutic drugs for retinal diseases. Retinal organoids from human pluripotent stem cells (hPSCs) offer a more accessible and reproducible human test platform for evaluating AAV-based gene therapy. In this study, hPSCs were differentiated into retinal organoids composed of various types of retinal cells. The transduction efficiencies of AAV2 and AAV8, which are widely used in clinical trials of inherited retinal diseases, were analyzed using retinal organoids. These results suggest that retinal organoids derived from hPSCs serve as suitable screening platforms owing to their diverse retinal cell types and similarity to the human retina. In summary, we propose an optimal stepwise protocol that includes the generation of retinal organoids and analysis of AAV transduction efficacy, providing a comprehensive approach for evaluating AAV-based gene therapy for retinal diseases.

• Science of Emotion and Sensibility
• /
• v.10 no.2
• /
• pp.209-220
• /
• 2007

The purpose of this study is to investigate the words that represent the human sensibility for the water space. The selection of certain words for human sensibility valuation is very important things because of make standard for human sensibility valuation in water bodies. At the first step of the research, 129 words were collected from the subjects by imagination in group of specialist, studies on water space, studies on landscape valuation and studies on human sensibility valuation in out door environmental. At the second step, the suitability test was done and 39 words collected over an average 3.5 point. This words test was 5 point measure to similarity water bodies. At the third step, the factor analysis, cluster analysis, Multi Dimensional Scaling was performed on data, and 9 words were selected from the analysis. Finally, selected comfortable words for human sensibility valuation in water space is hands-on experience, natural, sensibility, harmony, clear, good-feeling, dynamic, free-heart, romantic. The significance of the present study is that it contributes the progress of uncovering the axis of the human sensibility by carefully selecting the words that represent the human sensibility.

• BMB Reports
• /
• v.42 no.2
• /
• pp.72-80
• /
• 2009

In mammals, major progress has recently been made with the dissection of early embryonic cell specification, the isolation of stem cells from early embryos, and the production of embryonic-like stem cells from adult cells. These studies have overcome long-standing species barriers for stem cell isolation, have revealed a deeper than expected similarity of embryo cell types across species, and have led to a better understanding of the lineage identities of embryo-derived stem cells, most notably of mouse and human embryonic stem (ES) cells. Thus, it has now become possible to propose a species-overarching classification of embryo stem cells, which are defined here as pre- to early post-implantation conceptus-derived stem cell types that maintain embryonic lineage identities in vitro. The present article gives an overview of these cells and discusses their relationships with each other and the conceptus. Consequently, it is debated whether further embryo stem cell types await isolation, and the study of the earliest extraembryonically committed stem cells is identified as a promising new research field.

• Annual Conference on Human and Language Technology
• /
• 2017.10a
• /
• pp.190-193
• /
• 2017

'서치 방지 단어'는 SNS 상에서 사용자들이 작성한 문서의 검색 및 수집을 피하기 위하여 사용하는 변이형을 뜻한다. 하나의 검색 키워드가 있다면 그와 같은 대상을 나타내는 변이형이 여러 형태로 존재할 수 있으며, 이들 변이형에 대한 검색 결과를 함께 수집할 수 있다면 데이터 확보가 중요하게 작용하는 다양한 연구에 큰 도움이 될 것이다. 본 연구에서는 특정 단어가 주어진 키워드로부터 의미 벡터 상의 거리가 가까울수록, 그리고 주어진 키워드와 비슷한 음성적 형태 즉 발음을 가질수록, 해당 키워드의 변이형일 가능성이 높을 것이라고 가정하였다. 이에 따라 단어 임베딩을 이용한 의미 유사도와 최소 편집 거리를 응용한 음성적 유사도를 이용하여 주어진 검색 키워드와 유사한 변이형들을 제안하고자 하였다. 그 결과 구성된 변이형 후보의 목록에는 다양한 형태의 단어들이 포함되었으며, 이들 중 다수가 실제 SNS 상에서 같은 의미로 사용되고 있음이 확인되었다.

• Annual Conference on Human and Language Technology
• /
• 2017.10a
• /
• pp.276-280
• /
• 2017

현대사회에 존재하는 다양한 시스템들이 병합될 때는 병합을 위해서 여러 가지 방법을 사용해 볼 수 있다. 이때 시스템의 성격에 따라 더 적절한 병합 방법론이 존재할 수 있지만, 어떤 방법이 해당 시스템을 통합하는데 더 적절한지를 판단하기는 쉽지 않다. 본 논문에서는 서로 다른 시스템을 통합할 때, 그 상호운용성을 평가하기 위한 수단으로 트리의 유사도를 측정하는 방안을 제시한다. 이렇게 측정된 유사도는 0이상 1이하의 값을 가지며, 정확한 수치로 제시되기 때문에 서로 다른 통합 방법론을 평가하기 위한 계량적 근거로 사용될 수 있다. 다만 트리 구조로 나타낼 수 없는 일부 시스템들에 대해서는 적용할 수 없는 한계를 가진다.