Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.357.1-357.1
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- 2002
The 3-D QSAR study of antitumor arylsulfonylimidazolidinone derivatives by CoMFA and COMSIA
- ParkChoo, Hea-Young (Ewha Womans University) ;
- Choi, Su-Young (Ewha Womans University) ;
- Jung, Sang-Hun (Ewha Womans University)
- Published : 2002.10.01
Abstract
Three-dimensional quantitative activity relationship (3D-QSAR) study for a series of arylsulfonylimidazolidinone derivatives with antitumor activity was conducted using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices anaysis (CoMSIA). The in vitro cytotoxicity against human lung carcinoma (A549) exhibited a strong correlation with steric and electrostatic factors of the molecules. (omitted)
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