• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2003년도 춘계학술발표회
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• pp.59-67
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• 2003

오늘날 해운산업분야에서 해상의 인명 ㆍ재산, 해양환경보호에 가장 큰 관심을 기울이고 있다. 국제해사기구 (IMO)에서는 해상에서 선박운항으로 인하여 발생하는 충돌, 좌초, 침몰 등 해양사고에 대한 위험성을 정량적으로 평가하여, 그에 대한 제어방안을 마련하고 합리적인 안전규정을 제ㆍ개정하기 위한 절차적 수단으로 FSA(Formal Safety Assessment)를 도입하여 과학적이고 체계적인 대응방안을 마련하고자 노력하고 있다. 따라서 본 연구에서는 FSA평가시스템을 이용하여 사고발생빈도와 사고로 인한 인적, 물적, 환경오염 피해가 막대한 선박충돌사고의 발생위험성을 분석하였다. 또한 선박충돌사고 발생에 가장 큰 영향을 미치는 위해요소(Hazard)인 인적요소(Human Factor)에 대해서 전문가집단의 의견을 수렴하여 FSM법을 이용하여 각 위해요소를 계층화하고, 요소 상호간의 관련성을 분석하여 선박충돌사고를 예방하기 위한 적절한 제어방안을 제시하였다.

• 해양환경안전학회지
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• 제9권1호
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• pp.51-56
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• 2003

오늘날 해운산업분야에서 해상의 인명$.$재산, 해양환경보호에 가장 큰 관심을 기울이고 있다. 국제해사기구(IMO)에서는 해상에서 선박운항으로 인하여 발생하는 충돌, 좌초, 침몰 등 해양사고에 대한 위험성을 정량적으로 평가하여, 그에 대한 제어방안을 마련하고 합리적인 안전규정을 제$.$개정하기 위한 절차적 수단으로 FSA(Frnnal Safety Assessment)를 도입하여 과학적이고 체계적인 대응방안을 마련하고자 노력하고 있다. 따라서 본 연구에서는 FSA평가시스템을 이용하여 사고발생빈도와 사고로 인한 인적, 물적, 환경오염 피해가 막대한 선박충돌사고의 발생위험성을 분석하였다. 또한 선박충돌사고 발생에 가장 큰 영향을 미치는 위해요소(Hazard)인 인적요소(Human Factor)에 대해서 전문가집단의 의견을 수렴하여 FSM법을 이용하여 각 위해요소를 계층화하고, 요소 상호간의 관련성을 분석하여 선박충돌사고를 예방하기 위한 적절한 제어방안을 제시 하였다.

• Preventive Nutrition and Food Science
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• 제11권1호
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• pp.1-5
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• 2006

Conjugated linoleic acid (CLA) is a group of positional and geometric isomers of linoleic acid that have been used to reduce the incidence, growth and metastasis of breast, colon, prostate and gastric cancer in animals. CLA could reduce tumor growth by altering angiogenesis; a process requiring associated angiogenic factors such as vascular endothelial growth factor (VEGF). In this study, we determined whether CLA could modulate the expression of VEGF in murine mammary tumor cells and adipocytes. The c9, t11-CLA isomer reduced VEGF transcripts and protein when mammary tumor cells were stimulated with PMA. That isomer also reduced VEGF expression in un stimulated mouse 3T3-L1 adipocytes. Since VEGF can be regulated by cyclooxygenase-2 (COX-2), we determined whether CLA could alter COX-2 enzyme expression and $PGE_2$ production. The c9, t11-CLA isomer reduced not only COX-2 enzyme expression but also $PGE_2$ production. Thus, c9, t11-CLA could modulate neovascularization by alteration of VEGF expression from mammary tumor cells and adipocytes by reducing COX-2 metabolites.

• 한국국방경영분석학회지
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• 제24권1호
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• pp.41-57
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• 1998

Since the aircraft has a property of moving in the three-dimensional space, it may cause personally and financially critical damage in the case of an accident. Among the causes of aircraft accident, human factor has occupied about 70% of all accidents. Specially, fatigue among human's problems has been studied earlier than any other factor. Fatigue has been the cause of 75% of accidents that are related to human factor. So many studies have been conducted. But the direction of these studies mainly attach importance to the sleep loss and circadian rhythm. Limitation for flight time of ICAO is 8 hours per day, civil airlines in domestic line also adopt the limitation. But this rule is not based on human's performance but compromise between labor and management. The long-haul flight brings about a mental block to pilot. This mental block decreases performance of pilot and loses a lot of important information. So this may cause many accidents. This paper is to offer optimal flight time according to the amount of fatigue due to increasing flight time. The optimal flight time is searched through the field experiment. The experiment has adopted two methods. One is to examine pilot's objective fatigue accumulation rate through the critical fusion frequency, and another is to investigate pilot's subjective fatigue feeling through the fatigue subjective symptoms investigation table.

• 산업경영시스템학회지
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• 제32권4호
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• pp.1-8
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• 2009

The studies on semiconductor industrial accident in korea have been focused on the frequencies of each type of safety management employee, characteristics, cause and unsafe conditions, acts and so on. Those attributes of semiconductor industrial accidents were usually analyzed independently, so that it was hard to provides a wel-developed process and systematic guidelines for efficient safety management. Therefore, there were a few studies based on comprehensive survey in terms of the shape type of safe management. The questionnaire survey carried out for the 284 workers who were responsible for safety management in center with cooperation companies in semiconductor industry factor analysis showed that there were three factors of safety management. First, investment and operation and management for accident prevention, Second, unsafe act and condition, safety management Third, general human error and behavior. The industries of respondents were correlative with three groups. Three groups showed statistically significant differences on the number of cases. Actually, the group with the larger investment and the more unsafe cause, human error of accidents prevention had a smaller causes of accident cases.

• Bulletin of the Korean Chemical Society
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• 제34권4호
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• pp.1212-1220
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• 2013

The human coagulation factor XI (FXI) is a serine protease that plays a significant role in blocking of the blood coagulation cascade as an attractive antithrombotic target. Selective inhibition of FXIa (an activated form of factor XI) disrupts the intrinsic coagulation pathway without affecting the extrinsic pathway or other coagulation factors such as FXa, FIIa, FVIIa. Furthermore, targeting the FXIa might significantly reduce the bleeding side effects and improve the safety index. This paper reports on a docking-based three dimensional quantitative structure activity relationship (3D-QSAR) study of the potent FXIa inhibitors, the chloro-phenyl tetrazole scaffold series, using comparative molecular field analysis (CoMFA) and comparative molecular similarity analysis (CoMSIA) methods. Due to the characterization of FXIa binding site, we classified the alignment of the known FXIa inhibitors into two groups according to the docked pose: S1-S2-S4 and S1-S1'-S2'. Consequently, highly predictive 3D-QSAR models of our result will provide insight for designing new potent FXIa inhibitors.

• Molecules and Cells
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• 제22권3호
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• pp.291-299
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• 2006

Vitexin, a natural flavonoid compound identified as apigenin-8-C-${\beta}$-D-glucopyranoside, has been reported to exhibit antioxidative and anti-inflammatory properties. In this study, we investigated its effect on hypoxiainducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) in rat pheochromacytoma (PC12), human osteosarcoma (HOS) and human hepatoma (HepG2) cells. Vitexin inhibited HIF-$1{\alpha}$ in PC12 cells, but not in HOS or HepG2 cells. In addition, it diminished the mRNA levels of hypoxia-inducible genes such as vascular endothelial growth factor (VEGF), smad3, aldolase A, enolase 1, and collagen type III in the PC12 cells. We found that vitexin inhibited the migration of PC12 cells as well as their invasion rates, and it also inhibited tube formation by human umbilical vein endothelium cells (HUVECs). Interestingly, vitexin inhibited the hypoxia-induced activation of c-jun N-terminal kinase (JNK), but not of extracellular-signal regulated protein kinase (ERK), implying that it acts in part via the JNK pathway. Overall, these results suggest the potential use of vitexin as a treatment for diseases such as cancer.

• 한국생활과학회지
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• 제14권1호
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• pp.133-141
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• 2005

This research was designed to investigate the effect of a hand and a sensibility image on the preference to skirt textiles. 131 male and female college students were surveyed and 10 kinds of preferred fabrics were used each as a specimen for all 4 seasons. Factor analysis, t-test, Pearson's correlation, and regression were used for a statistical analysis by SPSS WIN 10.0. The results of this study are as follows: 1. In spring/fall season, 6 factors including 'elasticity/flexibility' were extracted as a hand factor, and 2 factors including 'modern elegance' were extracted as a sensibility factor in skirt textiles. 2. In summer season, 5 factors such as 'unevenness/stiffness' were extracted as a hand factor and 2 factors such as 'modern elegance romantic' as a sensibility image. 3. In winter season, 7 factors including 'elasticity' were extracted as a hand factor and 2 factors including 'modern elegance romantic' as a sensibility image. 4. Significant correlations existed between a hand and a sensibility image in spring/fall, summer, and winter. 5. A sensibility image was one of the important factors in the preference to skirt textiles in spring/fall, summer, and winter.

• 한국실내디자인학회논문집
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• 제17권2호
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• pp.102-110
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• 2008

Construction space of Japan suggests the factor of speculation to human and reveals tradition. The speculation can be embodied in the aspect of space and human's mental aspect is expressed as a main factor of tradition space of Japan. The purpose of this study is to research expression characteristic of speculation space, shown in the architecture of modem architect, Tadao Ando, who succeeds the concept. His works surveyed through research contain the emotion of nature and human, which are traditional factors of Japan. Moreover, it is reinterpreted by modem space, delivers its function of space and physical factor to user and grants value to activity and behavior of user residing in the space. Users recognize movement, create new meaning of space and accept physical barrier in the space. In conclusion, it can be said that the space of speculation is not a simple visual thing but a frame of visual structure, which is invented for embodiment. The factors show the Japanese architecture, real and contemplating one, which is positive in real life and allows experience. Through the conditions above, the researcher can find the meaning from the aspect that modem architecture of Japan is planned on the basis of concept of speculation.

• 대한안전경영과학회지
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• 제1권1호
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• pp.29-39
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• 1999

Human sensibility ergonomics is the technique that qualities man's sensibility, measures and evaluates it Quantitatively and makes man's life comfortable, safe and delightful by applying it to products or environmental projects. This study consider the sensibility factor of Sasang constitutional medicine, five elemental properties, and Biorhythm in terms of human sensibility ergonomics. And this study measure reaction-time dependent on a temperament or a state and evaluate the differences of reaction-times objectively with the comparison and analysis using the ANOVA. We can harness it for job design.