• Journal of the Korean Institute of Oriental Medical Informatics
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• v.15 no.2
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• pp.7-56
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• 2009

Objective: The purpose of this study is to compare the original texts with quotations in 16 Kinds of Cough Part in Haesu Chapter of Dong-Yi-Bo-Gam and to find out the ideas of Huh Jun(許浚, 1546-1615; the author of Dong-Yi-Bo-Gam) in there. Methods: I compared the original texts with quotations in 16 Kinds of Cough Part in Haesu Chapter of Dong-Yi-Bo-Gam. Results: 1. There is only one quoted sentence which perfectly matches with original text in 16 Kinds of Cough Part in Haesu Chapter of Dong-Yi-Bo-Gam. The other sentences are all modified while they are quoted by Huh Jun, at least one word. 2. The arrangement order of 'medical effect', 'consisting medicines and their dosages' and 'doctrine in application' were rearranged following the form of Dong-Yi-Bo-Gam when being quoted. 3. In cases of reciting the text, Huh Jun tries to clarify the original source of the context. However, instead of using original quotations he recited rephrased quotes from other sources. 4. Huh Jun cites from not only cough parts of other texts but also asthma(喘症) or heat(積熱) parts. 5. Titles of original text books are recorded in the end of all sentences of Dong-Yi-Bo-Gam, but there are a few wrong titles recorded. Conclusion: In consideration of the above-mentioned, the Dong-Yi-Bo-Gam is not the mere collection of various Oriental Medical books, but the Classic of Oriental Medicine to hold Huh Jun's own opinion.

• The Journal of Dong Guk Oriental Medicine
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• v.1
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• pp.1-13
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• 1992

Practical science means open and objective attitude as a new scholarly tone which gets out of Confucianism tradition and its closeness. It is concerned about practical aspect and its thought prevailed from the mid-16th century to the mid-19th century in feudal system. It is, also, the attitude seeking truth based on the facts, which is removed from the falsehood in politics, economics and social life. It is regarded as a social revolution which governs tile country economically and is utilized to stabilize and enrich a human living life. The new academic tradition appeared in the process of development of modernization proclaimed it to be utilized in modern-oriented independency. Modern historians have greatly studied the knowledge of early philosophy, while Korean oriental medicine has developed, basing on the cultivation of the mind, virtue, and benevolence through Han Bak-Keun(who showed much interest in realistic, economic and social system) and Jung Yak-Youg(who compiled all available data into one book). From Ko-Ryo dynasty to the mid-Yi dynasty Korean oriental medicine scholars struggled to develop oriental medicine in an attitude searching truth based on the facts. Among them Huh Jun's achievements and the content of his writings suggest any things with a view of practical science. These are neglected by most scholars so far, but I have surveyed as follows : 1) the revolution in oriental medical science system 2) the standardization of pharmacy appliance 3) the popularization of medicine supplies 4) cooperation of industry and academy in medical science field From the above I concluded as follows : practical science in Korean medical science began from Ko-Ryo dynasty and compiled in Ku Am Huh Jun in the period of King Sun-Jo of Li dynasty. With this repect, the pioneer in practical science in Korea is Ku Am Huh Jun. To search tile pioneer in practical science rightly we should study the history of Korean medical science.

• Journal of Sasang Constitutional Medicine
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• v.16 no.3
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• pp.1-7
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• 2004

1. Objectives This research is purposed to present developmental direction of traditional Korean medicine, through summarizing original medical mind of traditional Korean medicine. 2. Methods It was researched as bibliographic study with chief writings of traditional Korean medicine such as "DongEuiBoGam(東醫寶鑑)" and "Dongyi Suse Bowon(東醫壽世保元)" 3. Results and Conclusions (1) Huh Jun regarded Three Precious(三要: 精, 氣, 神) as important factors in Morpho-imaginary viewpoints. So he suggested finding out the pathological states according to the states of Three Precious. (2) As Huh Jun recognized that the essence(精) is the origin of the body, he suggested the medical mind of laying emphasis on the essence. And he suggested that circulating of the essence is important to health and longevity, which is different from previous trational medicne laying emphasis on the tonifying of five organs(五臟). (3) Dong-mu suggested diagnostic method that is to find out "Natural Principle of Organ(臟腑性理)" by observation of "Knowing-Acting(知行)" and "Morphological aspect and Temper(體形氣像)". And he suggested finding out pathological states according to states of "Good Qi of each constitution(體質正氣)". (4) Dong-mu recognized that the disease should be treated by recovering "Good Qi of each constitution" with both pharmacotherapy and non-pharmacotherapy. So he uggested the medical mind of laying emphasis on "Good Qi of each constitution", which is different from previous trational medicne laying emphasis on the tonifying of five organs. (5) To be brief, Huh Jun layed emphasis on the essence and Dong-mu layed emphasis on "Good Qi of each constitution". Emphasizing internal vitality which is applyed to treatment and prevention of disease is the original medical mind of traditional Korean medicine.

• BMB Reports
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• v.48 no.10
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• pp.565-570
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• 2015

In several reports, the respiratory syncytial virus (RSV) was identified as an oncolytic virus in cancer cells (e.g., lung and prostate cancer). However, the effects of RSV in hepatocellular carcinoma (HCC) cells have not yet been investigated. Here, we observed the inhibitory effects of RSV infection in HCC cell-lines. Cell growth was significantly decreased by RSV infection in BNL-HCC, Hep3B, Huh-7 and SNU-739 cells. After RSV infection, plaque formation and syncytial formation were observed in affected Hep3B and Huh-7 cells. RSV protein-expression was also detected in Hep3B and Huh-7 cells; however, only Huh-7 cells showed apoptosis after RSV infection. Furthermore, inhibition of cell migration by RSV infection was observed in BNL-HCC, Hep3B, Huh-7 and SNU-739 cells. Therefore, further investigation is required to clarify the molecular mechanism of RSV-mediated inhibition of HCC cell growth, and to develop potential RSV oncolytic viro-therapeutics.

• Proceedings of the Korean Society of Radiological Science
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• 1992.05a
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• pp.13.2-13.2
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• 1992

• Explosives and Blasting
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• v.19 no.2
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• pp.27-34
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• 2001

• Journal of Drive and Control
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• v.15 no.4
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• pp.125-130
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• 2018

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6433-6438
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• 2013

In hepatocellular cancer (HCC), lack of response to chemotherapy and radiation treatment can be caused by a loss of epigenetic modifications of cancer cells. Methionine adenosyltransferase 1A is inactivated in HCC and may be stimulated by an epigenetic change involving promoter hypermethylation. Therefore, drugs releasing epigenetic repression have been proposed to reverse this process. We studied the effect of the demethylating reagent 5-aza-2'-deoxycitidine (5-Aza-CdR) on MAT1A gene expression, DNA methylation and S-adenosylmethionine (SAMe) production in the HCC cell line Huh7. We found that MAT1A mRNA and protein expression were activated in Huh7 cells with the treatment of 5-Aza-CdR; the status of promoter hypermethylation was reversed. At the same time, MAT2A mRNA and protein expression was significantly reduced in Huh7 cells treated with 5-Aza-CdR, while SAMe production was significantly induced. However, 5-Aza-CdR showed no effects on MAT2A methylation. Furthermore, 5-Aza-CdR inhibited the growth of Huh7 cells and induced apoptosis and through down-regulation of Bcl-2, up-regulation of Bax and caspase-3. Our observations suggest that 5-Aza-CdR exerts its anti-tumor effects in Huh7 cells through an epigenetic change involving increased expression of the methionine adenosyltransferase 1A gene and induction of S-adenosylmethionine production.

• Journal of Multimedia Information System
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• v.4 no.4
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• pp.307-310
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• 2017

In the recent world of soccer, fostering of youth soccer players is considered as one of the most important issues so that many educational training programs are being prepared in the soccer-advanced countries. Amid the growing number of system management programs available for practical life due to the development of computer technology, an algorithm for youth soccer players management system has been proposed in this study for the improvement of Korean soccer skills.

• Bulletin of the Korean Chemical Society
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• v.26 no.7
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• pp.1031-1032
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• 2005