• Journal of Veterinary Science
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• 제22권6호
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• pp.41.1-41.14
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• 2021

Background: Our previously prepared ceftiofur (CEF) hydrochloride oily suspension shows potential wide applications for controlling swine Streptococcus suis infections, while the irrational dose has not been formulated. Objectives: The rational dose regimens of CEF oily suspension against S. suis were systematically studied using a pharmacokinetic-pharmacodynamic model method. Methods: The healthy and infected pigs were intramuscularly administered CEF hydrochloride oily suspension at a single dose of 5 mg/kg, and then the plasma and pulmonary epithelial lining fluid (PELF) were collected at different times. The minimum inhibitory concentration (MIC), minimal bactericidal concentration, mutant prevention concentration (MPC), post-antibiotic effect (PAE), and time-killing curves were determined. Subsequently, the area under the curve by the MIC (AUC_0-24h/MIC) values of desfuroylceftiofur (DFC) in the PELF was obtained by integrating in vivo pharmacokinetic data of the infected pigs and ex vivo pharmacodynamic data using the sigmoid E_max (Hill) equation. The dose was calculated based on the AUC_0-24h/MIC values for bacteriostatic action, bactericidal action, and bacterial elimination. Results: The peak concentration, the area under the concentration-time curve, and the time to peak for PELF's DFC were 24.76 ± 0.92 ㎍/mL, 811.99 ± 54.70 ㎍·h/mL, and 8.00 h in healthy pigs, and 33.04 ± 0.99 ㎍/mL, 735.85 ± 26.20 ㎍·h/mL, and 8.00 h in infected pigs, respectively. The MIC of PELF's DFC against S. suis strain was 0.25 ㎍/mL. There was strong concentration-dependent activity as determined by MPC, PAE, and the time-killing curves. The AUC_0-24h/MIC values of PELF's DFC for bacteriostatic activity, bactericidal activity, and virtual eradication of bacteria were 6.54 h, 9.69 h, and 11.49 h, respectively. Thus, a dosage regimen of 1.94 mg/kg every 72 h could be sufficient to reach bactericidal activity. Conclusions: A rational dosage regimen was recommended, and it could assist in increasing the treatment effectiveness of CEF hydrochloride oily suspension against S. Suis infections.

• 소성∙가공
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• 제31권6호
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• pp.365-375
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• 2022

The microstructure and high-temperature plastic deformation behavior of the modified Al-0.7Mn alloy were investigated and compared with the conventional Al-0.3Mn (Al3102) alloy. α-Al (matrix) and Al₆(Mn, Fe) phases were identified in both alloys. As a result of microstructure observation, both alloys showed equiaxed grains, and Al-0.7Mn alloy showed larger grain size and higher Al₆(Mn, Fe) fraction than Al-0.3Mn alloy. High temperature compressive tests, the deformation temperatures of 410℃, 450℃, 490℃, 530℃ and strain rats of 10^-2/s, 10^-1/s, 1/s, 10/s, were conducted using Gleeble equipment. The flow stress values of Al-0.7Mn alloy were higher than that of Al-0.3Mn alloy at all strain rates and temperature conditions. Constitutive equations were presented using the flow stresses obtained from experimental results and the Zener-Hollomon parameter. In the true stress-true strain curves of the two alloys, the experimental and predicted values were in good agreement with each other. Based on the dynamic material model, eutectic deformation maps of Al-0.7Mn and Al-0.3Mn alloys were suggested, and the plastic instability region was presented. The modified Al-0.7Mn alloy showed a wider plastic instability region than that Al-0.3Mn alloy. Based on the process deformation maps, the MPE tube parts could be manufactured through the actual extrusion process using the suggested conditions.

• Wind and Structures
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• 제35권2호
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• pp.83-92
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• 2022

When the rolling stocks run on the curve, the external rail has to be lifted to a certain level to balance the centrifugal force acting on the train body. Under such a situation, passengers may feel uncomfortable, and the slanted vehicle has the potential overturning risks at high speed. This paper conducted a wind tunnel test in an annular wind tunnel with φ=3.2 m based on a 1/20^th scaled high-speed train (HST) model. The sensitivity of Reynolds effects ranging from Re = 0.37×10⁶ to Re = 1.45×106 was tested based on the incoming wind from U=30 m/s to U=113 m/s. The wind speed covers the range from incompressible to compressible. The impact of roll angle ranging from γ=0° to γ=4° on train aerodynamics was tested. In addition, the boundary layer development was also analyzed under different wind speeds. The results indicate that drag and lift aerodynamic coefficients gradually stabilized and converged over U=70 m/s, which could be regeared as the self-similarity region. Similarly, the thickness of the boundary layer on the floor gradually decreased with the wind speed increase, and little changed over U=80 m/s. The rolling moment of the head and tail cars increased with the roll angle from γ=0° to γ=4°. However, the potential overturning risks of the head car are higher than the tail car with the increase of the roll angle. This study is significant in providing a reference for the overturning assessment of HST.

• Asian-Australasian Journal of Animal Sciences
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• 제16권4호
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• pp.489-493
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• 2003

Reproductive traits of sows are determined chiefly by the genetic background of the dam herself. Whether the breed of the serviced boars also contributes is not yet clear. A total of 8,946 litters of Landrace (L) sows from 68 farms were examined. Of these, 876, 1,260, and 6,810 litters were produced from natural mating with L, Yorkshire (Y), and Duroc (D) breeds, respectively. The birth litter size (BLS), weaning litter size (WLS), live born piglets (LBP), and survival rate % (SR), of every litter were recorded. A general linear-model procedure was followed to estimate the effects of boars' breed (B), parity (P) and B${\times}$P interaction on the reproductive traits of the sows. Results show that BLS, WLS, and LBP were all significantly (p<0.001) affected by B and P. SR% was significantly influenced by B but not by P. L sows crossbred with Y or purebred with L produced litters with higher BLS, WLS, and LBP values than those bred with D. Pure L breeding yielded litters with lower SR% than did crossbreeding with D, while the difference between SR% due to LY and that due to LD crossbreeding was not significant. The interaction of B with P was significant with respect to BLS, WLS, and LBP (p<0.001), but not SR%. No significant B effect on reproductive traits was measured in sows at their first parity; but at latter parities, LL or LY produced litters with similarly high BLS, WLS and LBP, which values were all significantly greater than those of LD litters. The breed of boar evidently affected the subsequent reproductive performance of L sows and this effect may be further manipulated by the parity effect. Breed differences in semen quality and the success of fetus development with different interactions of the genetic background with the uterus function of the sow that may contribute to these effects are discussed.

• 방송공학회논문지
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• 제18권2호
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• pp.297-310
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• 2013

본 연구에서는 디지털 방송 TV, VOD 등 제한된 네트워크 대역폭에서 서비스를 제공하기 위해 비디오 콘텐츠를 부호화하는 과정에서 고정된 비트율을 이용한 화질과 비교하여 주관적 화질을 유지하면서 적절한 비트율을 찾는 방법을 제시한다. 제안하는 예측 구조는 먼저 프레임에서 비트와 연관성이 있는 파라미터를 추출하여 프레임의 복잡도를 계산한 후, 비트가 많이 할당될 것으로 예상되는 프레임을 찾아 후보 프레임으로 추출하며, 추출된 후보 프레임들에 대해 실제 부호화하는 과정으로써 목표 화질을 기준으로 수학적 모델링을 통해 최종적으로 전송될 비트율을 예측하는 구조를 설계하였다. 실험 결과, 고정 비트율에 비해 저복잡도 영상에서 평균 43%의 비트 감소율을 보였으며, 이러한 영상의 비트 감소율이 있음에도 주관적 화질을 유지함을 알 수 있었다. 비디오 콘텐츠별 적절한 비트율을 찾기 위해 기존 구조에서는 다수의 부호화를 통해 결과물들의 주관적 화질 검증을 반복적으로 거치는 반면, 제안하는 구조는 사람이 관여하여 주관적 화질 검증을 반복적으로 수행하지 않아도 되며 일부 프레임만을 부호화하여 비트율 예측이 가능하다. 따라서 전체 프레임 중 평균 4% 프레임을 부호화하여 자동적으로 비트율을 찾을 수 있다.

• Steel and Composite Structures
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• 제28권1호
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• pp.39-49
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• 2018

The concrete bridge decks are usually precast and in-situ assembled with steel girders with post-pouring joint in the construction practice of super-wide steel-concrete composite beam. But the difference of concrete age between the precast slabs and the post-pouring joint has been not yet considered for the long-term performance analysis of this kind composite beam. A simply supported precast-assembled T-shaped beam was taken as an example to analyze the long-term performance of steel-concrete composite beam with post-pouring joint. Based on the deformation coordination conditions of the old-new concrete deck and steel girder, a theoretical model for the long-term behavior of precast-assembled composite beam is proposed in this paper according to age-adjusted effective modulus method. Then, the feasibility of the proposed model is verified by the available test data from the Gilbert's composite beams. Parametric studies were preformed to evaluate the influences of the cross-sectional area ratio of the post-pouring joint to the whole bridge deck, as well as the difference of concrete age between the precast slabs and the post-pouring joint, on the long-term performance of the composite beam. The results indicate that the traditional method without considering the age difference would seriously underestimate the effect of creep and shrinkage of concrete bridge decks. The concrete age difference between the precast slabs and the post-pouring joint should be demonstrated for the life cycle design and long-term performance analysis of precast-assembled steel-concrete composite beams.

• Journal of Microbiology and Biotechnology
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• 제32권6호
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• pp.740-748
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• 2022

As circ_UBE2D2 has been confirmed to have targeted binding sites with multiple miRNAs involved in septic acute kidney injury (SAKI), efforts in this study are directed to unveiling the specific role and relevant mechanism of circ_UBE2D2 in SAKI. HK-2 cells were treated with lipopolysaccharide (LPS) to construct SAKI model in vitro. After sh-circ_UBE2D2 was transfected into cells, the transfection efficiency was detected by qRT-PCR, cell viability and apoptosis were determined by MTT assay and flow cytometry, and expressions of Bcl-2, Bax and Cleaved-caspase 3 were quantified by western blot. Target genes associated with circ_UBE2D2 were predicted using bioinformatics analysis. After the establishment of SAKI rat model, HE staining and TUNEL staining were exploited to observe the effect of circ_UBE2D2 on tissue damage and cell apoptosis. The expression of circ_UBE2D2 was overtly elevated in LPS-induced HK-2 cells. Sh-circ_UBE2D2 can offset the inhibition of cell viability and the promotion of cell apoptosis induced by LPS. Circ_UBE2D2 and miR-370-3p as well as miR-370-3p and NR4A3 have targeted binding sites. MiR-370-3p inhibitor reversed the promoting effect of circ_UB2D2 silencing on viability of LPS-treated cells, but shNR4A3 neutralized the above inhibitory effect of miR-370-3p inhibitor. MiR-370-3p inhibitor weakened the down-regulation of NR4A3, Bax and Cleaved caspase-3 and the up-regulation of Bcl-2 induced by circ_UB2D2 silencing, but these trends were reversed by shNR4A3. In addition, sh-circ_UBE2D2 could alleviate the damage of rat kidney tissue. Circ_UBE2D2 mitigates the progression of SAKI in rats by targeting miR-370-3p/NR4A3 axis.

• Steel and Composite Structures
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• 제49권4호
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• pp.457-471
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• 2023

To make up for the performance weaknesses of recycled aggregate concrete (RAC), expand the application range of RAC, and alleviate the environmental problems caused by excessive exploitation of natural coarse aggregates (NCA), this study proposes a basalt fiber-reinforced recycled aggregate concrete (BFRRAC)-filled square steel tubular columns that combines two modification methods of steel tube and fiber, which may greatly enhance the mechanical properties of RAC. The axial compression performance for BFRRAC-filled square steel tubular columns was reported during this study. Seven specimens with different replacement ratios of recycled coarse aggregate (RCA), length-diameter ratios, along with basalt fiber (BF) contents were designed as well as fabricated for performing axial compression test. For each specimen, the whole failure process as well as mode of specimen were discovered, subsequently the load-axial displacement curve has obtained, after which the mechanical properties was explained. A finite element analysis model for specimens under axial compression was then established. Subsequently, based on this model, the factors affecting axial compression performance for BFRRAC-filled square steel tubes were extended and analyzed, after which the corresponding design suggestion was proposed. The results show that in the columns with length-diameter ratios of 5 and 8, bulging failure was presented, and the RAC was severely crushed at the bulging area of the specimen. The replacement ratio of RCA as well as BF content little affected specimen's peak load (less than 5%). As the content of BF enhanced from 0 kg/m³ to 4 kg/m³, the dissipation factor and ductility coefficients increased by 10.2% and 5.6%, respectively, with a wide range.

• Nuclear Engineering and Technology
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• 제56권9호
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• pp.3884-3897
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• 2024

This study investigates the creep behavior of bentonite-sand mixtures as potential buffer materials for low-level radioactive waste (LLW) repositories, with a specific case study in Taiwan. To assess the long-term hydro-mechanical properties, constant-volume swelling pressure, hydraulic conductivity, strain-controlled shear, and stress-controlled shear tests were conducted on MX80 and KV1 bentonite-sand mixtures. The experimental results indicate that MX80-sand 70/30 mixtures are prioritized as the buffer materials with 2.10 MPa swelling pressure and 1 × 10^-13 m/s hydraulic conductivity. However, the shear strength of mixtures was reduced by almost 50 % when fully saturated. Furthermore, this study proposed a novel stress-controlled direct shear apparatus to retrieve the creep model parameters. The numerical method based on the creep model efficiently supports and simulates the saturation process and creep displacement. The finite element method (FEM) result predicts that the buffer of both bentonite-sand mixtures will achieve an average degree of saturation of 95 % at the end of three decades and full saturation in 100 years. The simulated creep displacement results at key nodes suggest that both top and bottom parts in the buffer, assembled from MX80-sand 70/30 mixtures or KV1-sand 70/30 mixtures, will have almost equivalent values of 4 mm in the horizontal and 2 mm in the vertical directions eventually.

• Geomechanics and Engineering
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• 제23권2호
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• pp.151-163
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• 2020

Grouting method is an effective way of reinforcing cracked rock masses and plugging water gushing. Current grouting diffusion models are generally developed for horizontal cracks, which is contradictory to the fact that the crack generally occurs in rock masses with irregular spatial distribution characteristics in real underground environments. To solve this problem, this study selected a cement-sodium silicate slurry (C-S slurry) generally used in engineering as a fast-curing grouting material and regarded the C-S slurry as a Bingham fluid with time-varying viscosity for analysis. Based on the theory of fluid mechanics, and by simultaneously considering the deadweight of slurry and characteristics of non-uniform spatial distribution of viscosity of fast-curing grouts, a theoretical model of slurry diffusion in an oblique crack in rock masses at constant grouting rate was established. Moreover, the viscosity and pressure distribution equations in the slurry diffusion zone were deduced, thus quantifying the relationship between grouting pressure, grouting time, and slurry diffusion distance. On this basis, by using a 3-d finite element program in multi-field coupled software Comsol, the numerical simulation results were compared with theoretical calculation values, further verifying the effectiveness of the theoretical model. In addition, through the analysis of two engineering case studies, the theoretical calculations and measured slurry diffusion radius were compared, to evaluate the application effects of the model in engineering practice. Finally, by using the established theoretical model, the influence of cracking in rock masses on the diffusion characteristics of slurry was analysed. The results demonstrate that the inclination angle of the crack in rock masses and azimuth angle of slurry diffusion affect slurry diffusion characteristics. More attention should be paid to the actual grouting process. The results can provide references for determining grouting parameters of fast-curing grouts in engineering practice.