• 한국주거학회논문집
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• 제18권1호
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• pp.131-139
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• 2007

The aim of this paper is to find out different preference of common spaces and shared activities in senior cohousing community between regions in Korea: Seoul and other cities. Social survey was conducted nationwide and the respondents were 50s only, since they are the generation who will face to elderly housing subject within 10 years in turbulent Korean society. Collected data, about 1000, were analyzed by SPSS program using frequency, percentage, and Chi-square test. In summary, respondents mostly would like to move to senior cohousing on circumstance when they remain alone without big difference between regions. Loneliness and housekeeping were considered as the most difficult issues for the elderly to manage by themselves. Among common spaces, exercise room was the most preferred space to meeting room and kitchen. Exercise room was more preferred in Seoul than in other cities, on the contrary meeting room was evidently less preferred in other cities than in Seoul. Regarding shared activities, resident meeting, gardening, and common meal were revealed as less preferred activities than hobby exercise and tea meeting. As a conclusion, I would like to propose that a big common living room is better to be designed for meeting room cum dining and gathering room with flexibility in order to give residents chances to know each other more often. And since common space and shared activity show different preferences by regions, those are to be designed and planned reflecting region's different circumstance.

• 천문학회보
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• 제42권2호
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• pp.85.1-85.1
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• 2017

We develop a coronagraph to measure the coronal electron density, temperature, and speed by observing the linearly polarized brightness of solar corona with 4 different wavelengths. Through the total solar eclipse on 21 August 2017, we test an operating software of a prototype coronagraph working with two sub-systems of two motorized filter wheels and a CCD camera that are controlled by a portable embedded computer. A Core Flight System (CFS) is a reusable software framework and set of reusable software applications which take advantage of a rich heritage of successful space mission of NASA. We use the CFS software framework to develop the operating software that can control the two sub-systems asynchronously in an observation scenario and communicate with a remote computer about commands, housekeeping data through Ethernet. The software works successfully and obtains about 160 images of 12 filter sets (4 bandpass filters and 3 polarization angles) during the total phase of the total solar eclipse. For the future, we can improve the software reliability by testing the software with a sufficient number of test cases using a testing framework COSMOS. The software will be integrated into the coronagraph for balloon-borne experiments in 2019.

• BMB Reports
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• 제40권6호
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• pp.1077-1082
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• 2007

Human glutamate dehydrogenase exists in hGDH1 (housekeeping isozyme) and in hGDH2 (nerve-specific isozyme), which differ markedly in their allosteric regulation. In the nervous system, GDH is enriched in astrocytes and is important for recycling glutamate, a major excitatory neurotransmitter during neurotransmission. Chloroquine has been known to be a potent inhibitor of house-keeping GDH1 in permeabilized liver and kidneycortex of rabbit. However, the effects of chloroquine on nerve-specific GDH2 have not been reported yet. In the present study, we have investigated the effects of chloroquine on hGDH2 at various conditions and showed that chloroquine could inhibit the activity of hGDH2 at dose-dependent manner. Studies of the chloroquine inhibition on enzyme activity revealed that hGDH2 was relatively less sensitive to chloroquine inhibition than house-keeping hGDH1. Incubation of hGDH2 was uncompetitive with respect of NADH and non-competitive with respect of 2-oxoglutarate. The inhibitory effect of chloroquine on hGDH2 was abolished, although in part, by the presence of ADP and L-leucine, whereas GTP did not change the sensitivity to chloroquine inhibition. Our results show a possibility that chloroquine may be used in regulating GDH activity and subsequently glutamate concentration in the central nervous system.

• 한국산업보건학회지
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• 제4권2호
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• pp.198-207
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• 1994

In order to evaluate the effectiveness of environmental intervention of work place, metal mercury concentration in air and in urine of the total 43 workers for 3years from December 1991 to October 1993 in a fluorescent lamp manufacturing industry exposed to mercury, was measured before and after implementation of controls such as establishing exhaust ventilation at the department of exhaustion, coating the floor of work place with epostane, cleaning of the floor, improved housekeeping, and etc. The results were as follows. 1. Before the intervention(December 1991) 39.0% exceeded metal mercury Threshold Limit Value(TLV, $0.05mg/m^3$). After the intervention(October 1993) 10.0% exceeded TLV and geometric mean of mercury in air was $0.1mg/m^3$, and showed effectiveness rate of intervention to be 74.4% 2. After the intervention, geometric means of mercury concentrations in air were 0.013, $0.019mg/m^3$ and showed effectiveness rate of intervention to be 76.6%, 65.5% in A factory(right tube lamp)and at exhaustion department, respectively, A follow up survey fround statistically significant reductions in mercury concetration in air three years later. 3. Mercury concentration in urine of 11 workers(29.7%) exceeded warning level of $100{\mu}l/l$ before the intervention. After the intervention, of 3workers(8.8%) exceeded warning level and geometric mean of mercury concentration($26.5{\mu}l/l$) in urine was 2.4 times than that of before the intervention. Geometric means of mercury concentrations in urine of workers at exhaustion department, at sealing and aging department were 44.0, $77.7{\mu}l/l$, respectively and they decreased 2.3, 3.2 times than that of before the intervention.

• 동의생리병리학회지
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• 제20권2호
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• pp.328-332
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• 2006

This study aims to provide definitions and standardization for necessities that elderly people can use conveniently and properly in their daily lives and classify necessities for different purposes. First, standard terminologies were defined by reviewing the literature and the relevant laws related to daily necessities for the elders. Secondly, a concept for necessities for the elders was also defined through consultation with experts. Lastly, the elderly's necessities were selected and classified. The elderly's necessities are defined as aids that ordinary elderly people in normal aging process need for the purpose of the convenience of life and aids they wear or use to maintain or improve their health. In this study, the elderly's necessities are divided into three categories: necessities of health, necessities of Oriental medical aids and necessities of daily living. Each category is further classified as follows: Necessities of health include aids for personal medical treatment, aids for personal care and protection and aids for recreation. Necessities of Oriental medical aids include aids for personal medical treatment, aids for personal care and protection and others. Necessities of daily living include aids for personal care and protection, aids for personal mobility, aids for housekeeping, furnishings, aids for communication, information and signalling, aids for handling products and goods and aids for recreation. The classification of the elderly's necessities in this study can be used as basic information for further studies of demand for necessities for the elderly. The results will lay the foundation for a standardization system for the elderly's necessities and the development of silver industry.

• 한국주거학회논문집
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• 제22권4호
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• pp.133-142
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• 2011

The purpose of this study was to gather baseline data to be used for improving housing environments and developing welfare policies for low-income groups by identifying the similarities and differences in housing environmental conditions and in the usages of community welfare services between the dwellers of Da-Ka-Gu rental housing and those of permanent rental apartment. This multifaceted diagnosis currently being undertaken can be utilized through the lowincome housing planning and welfare policies as the basis for future policy formulation. Self-administered questionnaires and interviews were carried out by 212 dwellers in Da-Ka-Gu rental housing (104) and permanent rental apartments (108) in the city of Gwangju from July to October of 2010. The main findings are as follows: 1. The dwellers living in both Da-Ka-Gu rental housing and permanent rental apartments are satisfied with their housing environment. Specifically, a higher satisfaction with transportation and a lower satisfaction with neighbor's inter-relationships were evident. The dwellers of Da-Ka-Gu rental housing appear to be more satisfied with community spaces and housing management than those of the permanent rental apartments, whereas the latter appear to be less satisfied with the noise of the housing complex than the former. 2. Of the community welfare service programs, a higher usage is shown for meals service, free health screenings, home repair, and after-school learning programs among all residents in the two housing types. In particular, for the residents of Da-Ka-Gu rental housing, the children's education and parent education programs are more popular, whereas for those of the permanent rental apartments, the housekeeping services and health services utilization are highest.

• 산업공학
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• 제18권3호
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• pp.288-296
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• 2005

Many jobs and activities in our daily lives require squatting postures. The fore part includes housekeepers, farmers, and welders and the latter includes a wide variety of activities such as housekeeping; planting, cultivating and harvesting various agricultural products; grinding, welding, etc. It is speculated that prolonged squatting postures without any supporting stool would gradually cause musculoskeletal injuries to workers. This study is conducted to examine the proper height of stools according to the position of the working materials and to develop wearable stools for workers with squatting posture. Forty male and female subjects participated in the experiment to find the proper height of stools according to the position of the working materials. Subjects were asked to squat and work with 3 different working positions: floor level; ankle level; shank level of 3 different stool height conditions: 10cm height; 15cm height; and 20cm height. After 5 minutes of maintaining a squatting work posture while sitting on the different height stools, Likert summated rating method as well as pairwise ranking test was applied to evaluate the user preferences for provided stools under the conditions of different working positions. The results of statistical analysis show that the subjects preferred 10cm height stool for floor level, 15cm height stool for ankle level, 20cm height stool for knee level. We thus strongly recommend to use appropriate height stools in accordance with the different working positions. Moreover, a prototype wearable stool was designed such that workers with squatting posture do not need to move the stool while they are moving about. The purpose of developing wearable stool was to decrease the physical stress and hence promote worker's health who work with squatting posture.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.953-958
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• 2015

Background: Expression of KRT13, FAIM2 and CYP2W1 appears to be influenced by risk habits, thus exploring the associations of these genes in oral squamous cell cancer (OSCC) with risk habits, clinico-pathological parameters and patient survival may be beneficial in identifying relevant biomarkers with different oncogenic pathways. Materials and Methods: cDNAs from 41 OSCC samples with and without risk habits were included in this study. Quantitative real-time PCR was used to analyze KRT13, FAIM2 and CYP2W1 in OSCC. The housekeeping gene (GAPDH) was used as an endogenous control. Results: Of the 41 OSCC samples, KRT13 was down-regulated in 40 samples (97.6%), while FAIM2 and CYP2W1 were down-regulated in 61.0% and 48.8%, respectively. Overall, there were no associations between KRT13, FAIM2 and CYP2W1 expression with risk habits, selected socio-demographic and clinico-pathological parameters and patient survival. Conclusions: Although this study was unable to show significance, there were some tendencies in the associations of KRT13, FAIM2 and CYP2W1 expression in OSCC with selected clinic-pathological parameters and survival.

• Clinical and Experimental Pediatrics
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• 제60권7호
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• pp.221-226
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• 2017

Purpose: Escherichia coli sequence type (ST) 131, a multidrug-resistant clone causing extraintestinal infections, has rapidly become prevalent worldwide. However, the epidemiological and clinical features of pediatric infections are poorly understood. We aimed to explore the characteristics of ST131 Escherichia coli isolated from Korean children with urinary tract infections. Methods: We examined 114 uropathogenic E. coli (UPEC) isolates from children hospitalized at Chung-Ang University Hospital between 2011 and 2014. Bacterial strains were classified into STs by partial sequencing of seven housekeeping genes (adk, fumC, gyrB, icd, mdh, purA, and recA). Clinical characteristics and antimicrobial susceptibility were compared between ST131 and non-ST131 UPEC isolates. Results: Sixteen UPEC isolates (14.0%) were extended-spectrum ${\beta}-lactamase$ (ESBL)-producers; 50.0% of ESBL-producers were ST131 isolates. Of all the isolates tested, 13.2% (15 of 114) were classified as ST131. There were no statistically significant associations between ST131 and age, sex, or clinical characteristics, including fever, white blood cell counts in urine and serum, C-reactive protein, radiologic abnormalities, and clinical outcome. However, ST131 isolates showed significantly lower rates of susceptibility to cefazolin (26.7%), cefotaxime (40.0%), cefepime (40.0%), and ciprofloxacin (53.3%) than non-ST131 isolates (65.7%, 91.9%, 92.9%, and 87.9%, respectively; P<0.001 for all). ESBL was more frequently produced in ST131 (53.3%) than in non-ST131 (8.1%) isolates (P<0.01). Conclusion: ST131 E. coli isolates were prevalent uropathogens in children at a single medical center in Korea between 2011 and 2014. Although ST131 isolates showed higher rates of antimicrobial resistance, clinical presentation and outcomes of patients were similar to those of patients infected with non-ST131 isolates.

• Asian-Australasian Journal of Animal Sciences
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• 제21권11호
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• pp.1673-1679
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• 2008

In order to study the biological function of gapdh gene in yak, and prove whether the gapdh gene was a useful intra-reference gene that can be given an important role in molecular biology research of yak, the cDNA sequence encoding glyceraldehyde-3-phosphate dehydrogenase from yak was cloned by the RT-PCR method using gene specific PCR primers. The sequence results indicated that the cloned cDNA fragment (1,008 bp) contained a 1,002 bp open reading frame, encoding 333 amino acids (AAs) with a molecular mass of 35.753 kDa. The deduced amino acids sequence showed a high level of sequence identity to Bos Taurus (99.70%), Xenopus laevis (94.29%), Homo sapiens (97.01%), Mus musculus (97.90%) and Sus scrofa (98.20%). The expression of yak's gapdh gene in heart, spleen, kidney and brain tissues was also detected; the results showed that the gapdh gene was expressed in all these tissues. Further analysis of yak GAPDH amino acid sequence implied that it contained a complete glyceraldehyde-3-phosphate dehydrogenase active site (ASCTTNCL) which ranged from 148 to 155 amino acid residues. It also contained two conserved domains, a NAD binding domain in its N-terminal and a complete catalytic domain of sugar transport in its C-terminal. The phylogenetic analysis showed that yak and Bos taurus were the closest species. The prediction of secondary structures indicated that GAPDH of yak had a similar secondary structure to other isolated GAPDH. The results of this study suggested that the gapdh gene of yak was similar to other species and could be used as the intra-reference to analyze the expression of other genes in yak.