• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2000.11a
• /
• pp.39-40
• /
• 2000

Knowledge discovery has attracted increased attention in the biomedical industry in recent years is due to the increased availability of huge amount of biomedical data and the imminent need to turn such data into useful information and knowledge. In this talk, we discuss knowledge discovery techniques for gene expression analysis and MHC-peptide binding prediction in the context of discovering protein antigens and hot spots in these antigens.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.51 no.4
• /
• pp.119-119
• /
• 2023

• Journal of Haehwa Medicine
• /
• v.14 no.2
• /
• pp.219-224
• /
• 2005

Atopic Dermatitis has a number of characteristic symptoms, including itchy red spots and acute rashes that can ooze fluid and/or crust over. Currently, no cure exists as the fundamental cause of Atopic Dermatitis is not yet known. In this paper, the author reports on a case study in which Atopic Dermatitis patients are successfully treated by way of sweating. The described treatment method, called Poison Extraction Method, takes advantage of medical benefits of perspiring in hot bath or sauna. It assumes that the chronic symptoms suffered by Atopic Dermatitis patients are largely due to overuse of steroid-based ointments and attempts to extract resulting toxic elements by having patients sweat in either a hot bath or sauna or both. The exact prescription for sweating depends on the severity of the symptoms of individual patients. The described treatment has been successfully tested in a clinical trial, which we report in this paper.

• Proceedings of the KSME Conference
• /
• 2008.11a
• /
• pp.144-149
• /
• 2008

A transient finite element simulation is developed for the two-dimensional stationary elastoplastic layer between sliding layers, to investigate thermoelastoplastic instability(TEPI) due to frictional heating in the material. The analysis will show some differences between the case of thermoelastic instability and TEPI, especially according to the contact pressure above yield stress. A transient behavior of contact pressure is captured to explain the behavior of thermoplasticity of contact with different sliding velocity. The instability of contact pressure in the long range of braking time will be explored to understand the generation mechanism of hot spots.

• International Journal of Automotive Technology
• /
• v.7 no.6
• /
• pp.697-702
• /
• 2006

The change in the critical speed due to surface temperature of automotive disk brakes may be analyzed both theoretically as well as experimentally. Juddering of disk brakes is closely related to its critical speed. In analyzing the critical speed, if $\sigma$ is positive, Disk develops TEI(Thermo-Elastic Instability) resulting in juddering in disk brakes. And $\sigma$ is affected not only by the critical speed but also by the initial temperature of disk surface. As the initial temperature of the disk surface rises, the critical speed decreases and juddering is developed more easily. Also, when hot spots are developed by TEI, they show large temperature difference in small local range.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.39B no.1
• /
• pp.17-28
• /
• 2014

The increase of smartphone users have made mobile carriers offload increasingly congested traffic of 3/4G by providing Wi-Fi hot-spots in the public places such as coffee shops and subway stations. In the traditional authentication in WLAN, the users should convince the service providers that they are valid customers before they use WLAN services. Since the authentication protocol is designed for service providers. Even with the mutual authentication based on the IEEE 802.1X, which is supported by IEEE 802.11 standard, it is difficult to be convinced of that the service providers really have installed the WLAN APs, which users are confronted with. An attacker can install rogue APs that masquerade as legitimate APs by copying the SSID, MAC address, etc. in order to obtain users' private information. In this paper, we introduce a method of authenticating legitimate APs for smartphone users. And we show our proposal can be well utilized for the current Wi-Fi hot-spots as a security plug-in and prove it through our experiments.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.35 no.12
• /
• pp.1635-1640
• /
• 2011

The objective of this study is to design of a cooling system of the over-molding mold for a socket component of an automobile wiper by performing numerical analyses. Hot spots in which the temperature distributions are higher than those of other region, were estimated by an initial over-molding analysis for the initial design of the mold. On the basis of the initial over-molding analysis, two types of cooling system designs with a linear cooling channel and a volumetric heat sink, were considered to improve the cooling characteristics of hot spots. To obtain an appropriate cooling system design, the effects of the diameter and the position of the linear cooling channels on the cooling characteristics and the product qualities were quantitatively examined. In addition, the effects of the design of the volumetric heat sink on the cooling characteristics and deformation distributions in the molded product were investigated. The results of the over-molding analysis of the two types of cooling systems showed that the multi-sliced over-molding mold with a volumetric heat sink can improve both the product quality and the cooling characteristics of the mold.

• The Journal of Natural Sciences
• /
• v.9 no.1
• /
• pp.31-37
• /
• 1997

Apoptosis is an important event in the anticancer drug therapy. p53 was demonstrated to serve a key component to lead tumor cell death by inducing apoptosis. However, recent study showed the presence of p53 independent apoptotic pathway (Gaftenhaus et al., 1996). We were curious to know it apoptosis induced by adriamycin, a genotoxic anticancer agent, involved p53 gene mutation. Thus this study investigated the p53 gene mutation status among HeLa cell population during apoptosis induced by adriamycin. Under our experimental condition, 12 hour treatment of 1 ${\mu}m$ adriamycin caused apoptosis which was monitored by DNA fragmentation assay. In order to see the p53 gene mutation status, exons of 5, 7 and 8 of p53 gene, where previously reported p53 mutation hot spots reside, were amplified by PCR and nucleotide sequence change was scanned. However, no nucleotide change was observed among apoptotic HeLa cell population. Therefore this study demonstrated that adriamycin induced apoptosis without causing p53 gene damage.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.32 no.6
• /
• pp.790-794
• /
• 2003

This study was carried out to investigate the morphological properties and pyrrolizidine alkaloids of comfrey cultivating in Korea. 12 comfrey samples cultivation in Korea was selected and their appearance (whole plant, leaves, root etc.) were observed by expert and microscopy for morphological analysis. It is confirmed that their species are Symphytum officinale Linnaeus. Samples were extracted by hot MeOH and ultra-sonification. Their extracts contained pyrrolizidine alkaloids, which was identified by TLC analysis. By spraying thin-layer chromatograms of pyrrolizidine alkaloids stable purple spots were developed. But the extracts of chicory, pumpkin and sesame leaves did not show any purple spots. Same HPLC pattern were displayed at about 30 min of retention show peaks an one and the same time.

• BMB Reports
• /
• v.41 no.8
• /
• pp.604-608
• /
• 2008

1-Nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide are oxidative metabolites that are responsible for the mutagenicity of 1-nitropyrene. In this study, the mutation spectra induced by oxidative metabolites in human cells were determined using a shuttle vector assay. The mutation frequencies induced by 1-nitropyrene 9,10-oxide were 2-3 times higher than those induced by 1-nitropyrene 4,5-oxide. The base substitutions induced by 1-nitropyrene 4,5-oxide were $G{\rightarrow}A$ transitions, $G{\rightarrow}C$ transversions, and $G{\rightarrow}T$ transversions. In the case of 1-nitropyrene 9,10-oxide, $G{\rightarrow}A$ transitions, $G{\rightarrow}T$ transversions, $A{\rightarrow}G$ transitions and $G{\rightarrow}C$ transversions were observed. Most base substitution mutations induced by oxidative metabolites occurred at the guanine sites in the supF gene. These sequence-specific hot spots were commonly identified as 5'-GA sequences for both metabolites. On the other hand, the sequence-specific hot spots at the adenine sites were identified as 5'-CAC sequences for 1-nitropyrene 9,10-oxide. These results suggest that the oxidative metabolites of 1-nitropyrene induce sequence-specific DNA mutations at the guanine and adenine sites at high frequency.