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PLCE1 Gene in Esophageal Cancer and Interaction with Environmental Factors

  • Guo, Li-Yan;Zhang, Shen;Suo, Zhen;Yang, Chang-Shuang;Zhao, Xia;Zhang, Guo-An;Hu, Die;Ji, Xing-Zhao;Zhai, Min
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.2745-2749
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    • 2015
  • Objective: To study the PLCE1 gene rs2274223 polymorphism with regard to esophageal cancer and its interaction with diet, lifestyle, psychological and environmental factors in Southwest Shandong province. Materials and Methods: A case series study (case-case) was conducted. Questionnaire data were collected and 3 ml-5ml venous blood was drawn for DNA extraction among the qualified research subjects. PLCE1 gene polymorphism was detected after PCR amplification of DNA. SPSS 13.0 software was used for statistical analysis of the data. Results: The three genotypes A/A, A/G and G/G PLCE1 gene rs2274223 was 31, 16 and 4 cases, accounting for 60.8%, 31.4%, 0.08% respectively. The difference of three genotypes (AA/GA/GG) proportion between negative and positive family history of patients was statistically significant, ${\chi}^2=6.213$, p=0.045. There was no statistically significant relationship between PLCE1 gene rs2274223 polymorphism and smoking, drinking, ${\chi}^2=0.119$, p=0.998, and ${\chi}^2=1.727$, p=0.786. There was no linkage of the three rs2274223 PLCE1 gene genotypes (AA/GA/GG) proportion with eating fried, pickled, hot, mildew, overnight, smoked, excitant food, eat speed, salt taste or not (p>0.05). or with living environment pollution and nine risk factors of occupational exposure (p>0.05). There was no statistically significant difference in TS scores between different genotype of rs2274223 PLCE1 gene. Conclusions: The PLCE1 rs2274223 polymorphism has a relationship with family history of esophageal cancer, but does not have any significant association with age, gender, smoking, alcohol drinking, food hygiene, eating habits, living around the environment and occupation in cases.

Study on the Accident of Kitchen Food Service Industry Employees in Accordance with the Safety and Environment Awareness and Accident Experience (안전 환경 인식과 사고 경험에 따른 외식산업 주방 종사원의 안전사고에 관한 연구)

  • Oh, Suk-Tae
    • Culinary science and hospitality research
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    • v.21 no.2
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    • pp.85-102
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    • 2015
  • The purpose of this study was to present the direction of the safety manual in the food service industry kitchen. The accident rate in food industry kitchens is around 87.2%, it meaning nearly 9 workers have accident among 10, considered to be very high. The most common accident is a knife cut wound (84.7%). And burns caused by hot water and oil (74.4%), then shown slip and falls (28.1%). The degree of fulfillment of kitchen safety awareness and safe environment varied based on gender, in which male are considered more likely to suffer from accidents than women. The level of safety perception varies between workers at different career points. Workers with 1~3 years of experience suffer the highest rate of accident, while workers with 7~10 years and more of experience are believed to be at lower risk of accident. Restaurant type did not exhibit a significant influence on accidents cases, although differences in the adoption of personal safety, even partially, were discovered, at significance of 0.01 < 0.027 < $0.05^*$. Based on these results, this paper has suggested preventive safety management validation model the food service industry based on kitchen management and incident management, and presented steps necessary.

Effects of UV-B and Growth Inhibitor on Physiological Changes and Antioxidat Enzyme Activities in Fruit Vegetable Plug Seedlings (UV-B와 생장억제 처리가 과채류 플러그묘의 생리 변화 및 항산화 효소의 활성에 미치는 영향)

  • Kwon, Joon-Kook;Kang, Nam-Jun;Lee, Jae-Han;Choi, Young-Ha;Yu, In-Ho;Cho, Mi-Ae;Kim, Hoe-Tae
    • Journal of Bio-Environment Control
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    • v.12 no.4
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    • pp.259-265
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    • 2003
  • The physiological changes and antioxidant enzyme activities of plug seedlings irradiated with 4 kJ${\cdot}m^{-2}{\cdot}d^{-1}$ UV-B or sprayed growth inhibitors of 50 ${\cdot}L^{-1}$ diniconazole and 500 mg${\cdot}L^{-1}$ hexaconazole for retarding the overgrowth of cucumber, tomato and hot pepper seedlings in summer season were investigated. Photosynthetic rate just after UV-B irradiation was significantly low but recovered to the level of non-treated seedlings 10 days after IV-B irradiation. And photosynthetic rate of chemical-sprayed seedlings was slightly lower in tomatoes but not different in cucumbers and peppers, compared with non-treated seedlings. Cholrophyll contens in the leaves showed no difference among treatments. Anthocyanin contents in the leaves of UV-B-irradiated seedlings were higher and no difference inchmical-sprayed seedlings, compared with non-treated seedlings. the activites of SOD(superoside dismutase), CAT )catalase), and POD(perosidase) of UV-B-irradated seedlings were higher thatn those of the non-irradiated seedlings just after UV-B irradiation. However. 10 days after UV-B irradiation, the activities were decreased to half of the value just after UV-B irradiation Whereasd the activies of chemical-sprayed seedlings were slightly higher than those of non-treated ones but lower than those of UV-B-irradiated one.

Fundamental Heat Analysis about the Thermoelectric Generation System Using the Waste Heat of Exhaust Gas from Ship (선박의 배기가스 폐열을 활용한 열전발전시스템에 관한 기초 열해석)

  • Kim, Myoung-Jun;Ga, Gwang-Jin;Chea, Gyu-Hoon;Kim, In-Seup
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.22 no.5
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    • pp.583-592
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    • 2016
  • IMO (International Maritime Organization) in the UN (United Nations) set up that aim at reducing $CO_2$ emission from ship by up to 30 percent until 2030. The final purpose of this study is the development of marine thermoelectric generation system using waste heat from vessel of internal combustion engines. Before the development of marine thermoelectric generation system, this paper carried out the fundamental heat analysis of marine thermoelectric generation system. It was able to obtain the valuable results about the efficiency improvement of the thermoelectric generation system. The results is as follows : 1) It was confirmed that the efficiency of thermoelectric generation system improves to 8.917 % with increasing the temperature difference of peltier module by reducing the temperature difference between peltier module and heat source at the hot side. 2) System efficiency according to change in the external load resistance was confirmed that the change width of about 6 % which does not significantly occur. 3) System efficiency in the case stainless steel at the same condition is 8.707 %. System efficiency could be confirmed that the stainless steel is higher than duralumin (8.605 %), copper (8.607 %).

Low Temperature Thermal Desorption (LTTD) Treatment of Contaminated Soil

  • Alistair Montgomery;Joo, Wan-Ho;Shin, Won-Sik
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • 2002.09a
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    • pp.44-52
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    • 2002
  • Low temperature thermal desorption (LTTD) has become one of the cornerstone technologies used for the treatment of contaminated soils and sediments in the United States. LTTD technology was first used in the mid-1980s for soil treatment on sites managed under the Comprehensive Environmental Respones, Compensation and Liability Act (CERCLA) or Superfund. Implementation was facilitated by CERCLA regulations that require only that spplicable regulations shall be met thus avoiding the need for protracted and expensive permit applications for thermal treatment equipment. The initial equipment designs used typically came from technology transfer sources. Asphalt manufacturing plants were converted to direct-fired LTTD systems, and conventional calciners were adapted for use as indirect-fired LTTD systems. Other innovative designs included hot sand recycle technology (initially developed for synfuels production from tar sand and oil shale), recycle sweep gas, travelling belts and batch-charged vacuum chambers, among others. These systems were used to treat soil contaminated with total petroleum hydrocarbons (TPH), polycyclic aromatic hydrocarbons (PAHs), pesticides, polychlorinated biphenyls (PCBs) and dioxin with varying degrees of success. Ultimately, performance and cost considerations established the suite of systems that are used for LTTD soil treatment applications today. This paper briefly reviews the develpoment of LTTD systems and summarizes the design, performance and cost characteristics of the equipment in use today. Designs reviewed include continuous feed direct-fired and indirect-fired equipment, batch feed systems and in-situ equipment. Performance is compared in terms of before-and-after contaminant levels in the soil and permissible emissions levels in the stack gas vented to the atmosphere. The review of air emissions standards includes a review of regulations in the U.S. and the European Union (EU). Key cost centers for the mobilization and operation of LTTD equipment are identified and compared for the different types of LTTD systems in use today. A work chart is provided for the selection of the optmum LTTD system for site-specific applications. LTTD technology continues to be a cornerstone technology for soil treatment in the U.S. and elsewhere. Examples of leading-edge LTTD technologies developed in the U.S. that are now being delivered locally in global projects are described.

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Development and Application of Real-time Measurement System of Silt Loading for Estimating the Emission Factor of Resuspended Dust from Paved Road (포장도로 재비산먼지 배출계수 산정을 위한 silt loading의 실시간 측정시스템 개발과 적용)

  • Han, Se-Hyun;Won, Kyung-Ho;Jang, Ki-Won;Son, Young-Min;Kim, Jeong-Suk;Hong, Ji-Hyung;Jung, Yong-Won
    • Journal of Korean Society for Atmospheric Environment
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    • v.23 no.5
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    • pp.596-611
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    • 2007
  • Resuspended dust from paved roads in Seoul and Incheon metropolitan areas is regarded as one of the major $PM_{10}$ sources in these areas, according to the recent emission estimates using the emission factors compiled in AP-42. It is well known that the AP-42 model for estimating $PM_{10}$ emissions from paved roads requires information on silt loadings of particular paved roads. The conventional AP-42 method (vacuum swept method) for road silt sampling, however, is expensive, time consuming, and dangerous. These drawbacks led us to develop a Mobile Dust Monitoring System (MDMS) capable of doing real time measurements of silt loading of paved roads, thereby we could get higher resolution silt loading data both in terms of time and space without too much human efforts and danger. In this study, for the real-time measurement of silt loading of paved roads, the principle used in the TRAKER method of U.S. Desert Research Institute was employed and the entire sampling systems including data acquisition system were designed for theses purpose and mounted on a SUV. The correlation between the silt loading measured by vacuum swept method and the speed corrected ${\Delta}Dust$ was derived for the vehicle-based silt loading measurements, and then the variations of silt loading on paved roads were surveyed using the MDMS in test routes of Seoul and Incheon. From the results of real-time measurements, temporal and spatial variations of silt loading data together with the existence of hot spots were observed for paved roads in Seoul and Incheon. The result of this study will be employed to estimate fugitive dust emissions from paved roads.

High-Value Materials from Microalgae (미세조류 유래 고부가 유용물질)

  • 오희목;최애란;민태익
    • Microbiology and Biotechnology Letters
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    • v.31 no.2
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    • pp.95-102
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    • 2003
  • Microalgae are a diverse group of photosynthetic organisms and abundant in every ecosystem in the biosphere. They are common in aqueous environments including marine, brackish and fresh waters and in some habitats that lack eukaryotic life such as some hot springs and highly alkaline lakes. Microalgal biotechnology that is focused on the microalgae-based production of a variety of useful materials such as pharmaceutical comfounds, health foods, natural pigments, and biofuels is considered as an important discipline with the development of biotechnology. In addition, the mass cultivation of microalgae can also contribute to improving the environmental quality by reducing the concentration of $CO_2$ which is one of major gases lead to global warming. Consequently, it seems that the microalgae can be used as an efficient, renewable, environmentally friendly source of high-value biomaterials such as chemicals, pigments, energy, etc. and the microalgal biotechnology will most likely represent a larger portion of modern biotechnology.

${\ll}$황제내경소문(黃帝內經素問).사기조신대논(四氣調神大論)${\gg}$ 주석서(注釋書)의 비교분석연구(比較分析硏究)

  • Lee Yong-Beom;Kim Seong-Hwan
    • Journal of Korean Medical classics
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    • v.13 no.1
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    • pp.184-232
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    • 2000
  • The trend of the concept for modern medicine is gradually forwarding to preventive medicine from therapeutic medical science. One of the most remarkable characteristics of oriental medicine is that it attaches greater importance to preventive medicine scientifically. The basic theory of oriental medicine principally takes roots in Huang Di Nei Jing and it is Si Qi Tian Shen Da Lun that is deep-rooted in the principle of "growing life" grounded in theory of unity of heaven and man of oriental medicine. Therefore having translated annotation of 〈Si Qi Tian Shen Da Lun·Huang Di Nei Jing Su Wen〉 which is quoted frequently and using it for appendix and comparing each views of annotators, I would like to state the results of dissertation as below. 1. Si Qi Tian Shen of title of the paper means that it keeps our health and prevent diseases in advance to control our mind and rhythm of life to the change of Yin and Yang - that is, the grower Yin, the looser Yang - following four seasons of nature environment. 2. The summary of this dissertation is that spring means things newly sprout from old ones, things become profuse, beautiful and brilliant in the summer. Autumn stands for things is harvested and allocated evenly and finally things is closed and stored. That is, in the spring and summer. If one break this principle of growth, diseases are followed after this. Therefore an excellent physician should handle diseases before they are attacked not remedy them after outbreak of diseases. It is said that a sage governs the nation before it is put into confusion. 3. These four terms standing for each season describe definitely and realistically rural life in the agricultural environment, in other words, spouting in spring, growing in summer, harvesting in autumn, storing in winter. Going with the current of the times, they have developed to theoretical concept of getting, growth, harvest, store so that implied the principle of growth for four seasons. 4. It means in a concrete way "Yang would grow in the spring and summer and Yin would grow in autumn and winter" as follow. That is, when the day is long, things act energetically and emit the warmth of life and expand the vigor of growth. On the other hand, when the night is long, things lessen their activity to protect the warmth of life and to preserve the sprit of growth. In addition, we should be concerned about the work outward and try to concretely fulfill plan of business in spring and summer. It is in autumn and winter when we should grow Yin. It does not mean that we simply grow cold yin in our body to build Yin. But according to annotators, for example, Wang Bing stated that we need to make things be cool in spring and summer, and be warm in autumn and winter for improvement. Zhang Jie Bin noted that things should not be cold in spring and summer and not be too hot to improve in autumn and winter. Those principles theorized to unify physiological status into the principle of changing of Yang and Yin in the nature and enriched the contents. In these principles, no problems are not found logically somewhat.

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Estimation of Benzene Emissions from Mobile Sources in Korea (국내 이동오염원에서 발생되는 벤젠 배출량 산정)

  • Lee, Ju-Hyoung;Cha, Jun-Seok;Hong, Ji-Hyung;Jung, Dong-Il;Kim, Ji-Young
    • Journal of Korean Society for Atmospheric Environment
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    • v.24 no.1
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    • pp.72-82
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    • 2008
  • Benzene is a very harmful and toxic compound known as human carcinogen by all routes of exposure. Owing to the risky feature of benzene, several countries such as Japan, UK and EU have established the ambient air quality standard and protect from that risk of it. Korea also has designated it as one of the criteria air pollutants and established the concentration limit ($5\;{\mu}g/m^3$) in the air and is going to apply the standard from 2010. Benzene is emitted from various sources such as combustion plants, production processes, waste treatment facilities and also automobiles. Mobile source is known as one of the major emission sources of benzene. In this study, we estimated the domestic emissions of benzene from mobile source and compared the results with those of advanced countries. Mobile source was divided into 2 categories, Le., on-road source and non-road source. The total emissions of benzene from mobile source were estimated as 3,106 tons/yr and 1,612 tons/yr was emitted from on-road source and 1,494 tons/yr was from non-road source. Emission ratio of benzene from on-road source showed that 80.0% was from passenger cars, 10.1% was from taxis, 7.2% was from light-duty vehicles, 2.5% was from heavy-duty vehicles and 0.2% was from buses. In the case of non-road source, the distribution showed that 66.3% was from construction machineries, 14.5% was from locomotives, 11.7% was from ships, 7.1% was from agriculture equipments and 0.5% was from aircrafts. The cold-start emissions were estimated as 942 tons/yr and this value was almost 1.5 times greater than that for hot engine emissions (608 tons/yr). In addition, the fuel-based distribution was 65.9%, 31.1% and 2.8% from gasoline, LPG and diesel vehicles, respectively. The emission ratio from mobile source occupied 65% and 30% of total benzene emissions in USA and UK, respectively. In case of Korea, the emission ratio of benzene from mobile source occupied 29% (15% from on-road source, 14% from non-road source) which showed similar value with UK.

Yield and Storability of Spring Transplanted Onion Cultivars in the Middle Area of the Korean Peninsula (중부지방에서 플러그 육묘에 의한 춘파 양파 품종의 생육과 저장성)

  • Lee, Jung-Soo;Park, Su-Hyung;Park, De-Young;Lee, Youn-Suk;Chun, Chang-Hoo
    • Journal of Bio-Environment Control
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    • v.18 no.1
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    • pp.51-59
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    • 2009
  • Bulb onion cultivation area has been restricted in southern part of Korea to avoid blotting and bulb division. The traditional culture method is transplanting bare-rooted plantlet into the field at the end of summer and harvesting at the beginning of next summer. The hot weather and weak plantlets occasionally causes unstable supply of onions in autumn. In order to enlarge cultivation area and to reduce culture period, long nursery system using plug tray and spring transplanting was tried. Forty cultivars collected from Korea and Japan were nursed using 200-plug tray and transplanted to the field in spring. Marketable yield was not related to the seedling size but lodging time. Cultivar of 'Hamasodachi' was lodged early and resulted low marketable yield. Cultivar of 'Cheonjudaego' was not lodged and yielded high but not in accordance with storability. Generally early lodged cultivars showed low storability. In order to avoid rainy harvesting season, cultivars requires excessive long time for lodging is not recommended for spring culture. Using plug nursery and spring transplanting, we successfully produced marketable onions in 3 months. But immediate using of the harvested onion is recommended. The storability of produced onions showed different result among cultivars, storage of spring onion was not recommended.