• The Korean Journal of Physiology and Pharmacology
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• 제24권3호
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• pp.193-201
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• 2020

Chromosomal region maintenance 1 (CRM1) is associated with an adverse prognosis in glioma. We previously reported that CRM1 inhibition suppressed glioma cell proliferation both in vitro and in vivo. In this study, we investigated the role of CRM1 in the migration and invasion of glioma cells. S109, a novel reversible selective inhibitor of CRM1, was used to treat Human glioma U87 and U251 cells. Cell migration and invasion were evaluated by wound-healing and transwell invasion assays. The results showed that S109 significantly inhibited the migration and invasion of U87 and U251 cells. However, mutation of Cys528 in CRM1 abolished the inhibitory activity of S109 in glioma cells. Furthermore, we found that S109 treatment decreased the expression level and activity of MMP2 and reduced the level of phosphorylated STAT3 but not total STAT3. Therefore, the inhibition of migration and invasion induced by S109 may be associated with the downregulation of MMP2 activity and expression, and inactivation of the STAT3 signaling pathway. These results support our previous conclusion that inhibition of CRM1 is an attractive strategy for the treatment of glioma.

• 보건의료산업학회지
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• 제3권2호
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• pp.29-43
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• 2009

The purpose of this study is to provide basic material about the improvement method of the hospital evaluation system by grasping recognition, corresponding behavior to evaluation, influence and problems about the hospital evaluation system with respect to the employee of mid sized hospitals having relatively poorer environment. In this study were used 518 questionnaires to hospital employee working at 20 general hospitals in Pusan, Kyungnam with less than 500 beds and having experience of the hospital evaluation during 2005~2007. As a result of the research, they felt the investigation tool used for the hospital evaluation has too many items and it could be difficult to reflect characteristics of each hospital. It appeared that utilization of the report result after the hospital evaluation was helpful for grasping a part necessary for hospital improvement and the present level of hospitals and increase of interest about medical service quality improvement of the a hospital director or hospital employee. They trusted the result of the hospital evaluation to some degree, and recognized it helps the patients to select a hospital and increase rights-to-know. Hospital employee recognized the necessity and showed high interest and participation, but they didn't sympathize in the propriety and the feasibility of the hospital evaluation items. High degree evaluated hospital employee receive hospital evaluation system positively and think hospital services to be improve after taking hospital evaluation. The hospital evaluation should make the hospital to effort to achieve medical quality improvement to its purpose. Also, systematic reformation will be necessary to reflect characteristics of the hospital that has relatively small scale or locates in poor environment.

• 보건의료산업학회지
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• 제9권1호
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• pp.1-16
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• 2015

This study intended to measures for high performance and for identifying competitive advantages by examining the relation between the competence and performance of the first special hospitals for which the law has now been in effect for 3 years. Furthermore, the members of special hospitals were also surveyed on measures to improve the special hospital system in order to activate it. A total of 80 special hospitals participated in this study, and 171 people responded to a survey on the special hospital system. According to the results of the multiple regression analysis the relation between the competence and performance after establishing a hypothesis that special hospital competence would have an effect on organizational performance, member competence and hospital business management competence significantly had a positive (+) effect on internal performance, and marketing management competence significantly had a positive (+) effect on external performance, which partially supported this research hypothesis. Moreover, according to the results of survey on the special hospital system, the policy thought to be the most important by special hospitals was reasonable fee system reform, followed by granting incentives.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.255-256
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• 1998

In this paper, we propose the multi-axial classification system using parallel coding method that is systemic and flexible properties for representing dental clinical behavior. The methodology and organization of this thesis as follows. First, an analysis of other classification systems. Second, the domain of medical behavior and axises using selected elements was were determined. Third, the new code system is constructed of these common factors in properties of prediction of hierarchy, brevity, simplicity, flexibility and mnemonic usage. Finally, the framework of classification system for dental was made using multi-axial code system. The result of the this study, the eight bases axis of multi-axial code system is composed and can be basic information of research for construction of classification system of all medical domain.

• 한국병원경영학회지
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• 제3권1호
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• pp.238-260
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• 1998

This article describes the theoretical foundations of government policy for hospitals in terms of correcting market failure and enhancing equity. It then discusses the characteristics that desirable payment systems should have, and the effects of the DRG-based prospective payment system on hospital behavior, its financial performance, hospital industry, and health care expenditure. The rationales and impacts of other public policies for hospitals such as antitrust and fair trade regulation, dissemination of practice guidelines and hospital mortality information, regulation of hospital capital investment, and tax policy are also discussed.

• 한국융합학회논문지
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• 제8권12호
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• pp.77-84
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• 2017

초고령화 사회로의 진입으로 인해 웰니스에 대한 관심이 높아지면서, 인공지능 의사를 통한 개인 맞춤형 의료서비스가 확대되고 있는 추세이다. 개인 맞춤형 의료서비스를 위해서는 기존의 병원시스템 구성요소인 PM/PA, OCS, EMR, PACS, LIS 만으로는 정확한 의료분석 서비스를 제공하기 어려운 문제점이 발생된다. 따라서 개인 맞춤형 의료서비스에 적합한 병원시스템 모델 및 구축방안에 대한 제시가 필요한 실정이다. 현재 국내에서도 의료 클라우드 서비스, 왓슨을 도입한 인공지능 진료서비스 등이 일부 시행되고 있지만, 아직 체계적인 병원시스템 구축을 통한 사례는 많지 않다. 따라서 이 논문에서는 개인 맞춤형 의료서비스에 적합한 병원시스템 모델을 제안한다. 이를 위해 기존의 병원시스템 구성요소에 의료 빅데이터 구축 및 AI 의료 분석시스템을 하나로 통합한 모델을 설계하고 모듈별 구축방안을 제시한다. 제안 모델은 향후 새로운 병원시스템 도입 및 구축을 위한 포괄적인 가이드 라인을 제공하는 기반연구로서 의미를 가진다.

• 한국병원경영학회지
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• 제8권1호
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• pp.42-63
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• 2003

There is a rapidly growing expansion of internet-based infrastructure throughout industries in Korea. The internet-based Electronic Purchase and Supply System(EPSS) is being considered a supportive tool to increase the economic efficiency of hospital management. In this study, we conducted an economic evaluation of the system, analyzing data on four hospitals in Korea. According to the results, four hospitals was estimated to make net benefit of about 611 million Won in one year and about 2,809 million Won in the next five years. Further, the adoption of all hospitals in Korea to the system may generate net benefit of about 31,575 million Won in one year and about 166,938 million Won in the next five years. Furthermore, we expect that as the system covered many kinds of inputs in hospitals like pharmaceuticals, the benefit of the system would go up by a considerable degree.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2008년도 춘계학술대회논문집
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• pp.458-461
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• 2008

The primary objective of this study is to provide simple analytical tools to estimate dynamic characteristics of steel framed floor system in hospital building for vibration serviceability due to human activities, bogie, medical equipment. and so on. In order to evaluate the dynamic characteristics and vibration levels according to steel framed floor system, we had executed impact test and measurement on steel structure floor system in various hospital buildings. But perhaps most importantly, how to make the most of deduced design factor for design of hospital building. therefore we presented the access method such as the three-dimensional F.E. numerical analysis on the basis of the design drawing, and the properties of all floors for estimation of vibration level in hospital building.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2006년도 추계학술대회
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• pp.240-247
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• 2006

We assess service delivery system for outpatients of general hospital(A) using. service blueprint. Service blueprint for outpatients' service process currently being implemented in general hospital(A) is analysed to improve hospital services and define hospital service delivery system more accurately. In addition, comparative analysis of service blueprint before and after improvement was conducted to find that health care services is now more customer-oriented and hospital employees can link their duties with service delivery system. The analysis of service blueprint of outpatients' service process suggested in this study are useful for setting strategies for health care service. It also helps service process design and service digitalization of other general hospitals in the future.

• Annals of Clinical Neurophysiology
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• 제24권2호
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• pp.63-67
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• 2022

Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma confined to the central nervous system. Its diagnosis requires a stereotactic biopsy, which is an invasive procedure. Cerebrospinal fluid (CSF) analysis is less invasive and easier to perform than a stereotactic biopsy. We hereby report a PCNSL case diagnosed using CSF analysis and treated with systemic chemotherapy.