• Journal of Pharmaceutical Investigation
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• v.35 no.3
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• pp.143-150
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• 2005

Solid lipid nanoparticles(SLNs) are particulate systems for parenteral drug administration and have good biocompatibility and stability. SLNs were prepared with lauric acid, as the lipid core. Tween 20 and tween 80 were used as surfactant. 5-fluorouracil and l-benzoyl-5-fluorouracil were used as model drugs. Drug-loaded SLNs were prepared by the hot homogenization technique in order to evaluate the physical stability, entrapment efficiency of drugs as well as release profile. The particle size of SLNs was $40{\sim}600$ nm. By increasing speed, the mean particle size of SLNs was decreased. And entrapment efficiency in the case of using 1-Benzoyl-5-fluorouracil was higher than using 5-Fluorouracil. The higher surfactant concentration, the faster release rate at the range of $1.5{\sim}2.5%$.

• Structural Engineering and Mechanics
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• v.61 no.2
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• pp.209-220
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• 2017

The purpose of this paper is to study the geometrically nonlinear free vibration of functionally graded nano/micro beams (FGNBs) based on the modified couple stress theory. For practical applications, some analytical expressions of nonlinear frequencies for FGNBs on a nonlinear Pasternak foundation are developed. Hamilton's principle is employed to obtain nonlinear governing differential equations in the context of both Euler-Bernoulli and Timoshenko beam theories for a comprehensive investigation. The modified continuum theory contains one material length scale parameter to capture the size effect. The variation of two-constituent material along the thickness is modeled using Reddy's power-law. Also, the Mori-Tanaka method as an accurate homogenization technique is implemented to estimate the effective material properties of the FGNBs. The results are presented for both hinged-hinged and clamped-clamped boundary conditions. The nonlinear partial differential equations are reduced to ordinary differential equations using Galerkin method and then the powerful method of homotopy analysis is utilized to obtain the semi-analytical solutions. Eventually, the presented analytical expressions are used to examine the influences of the length scale parameter, material gradient index, and elastic foundation on the nonlinear free vibration of FGNBs.

• Journal of the Korean Society of Marine Environment & Safety
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• v.19 no.5
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• pp.545-551
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• 2013

In this study, shot peening technique was employed with shot peening time for durability improvement and surface modification of copper alloy to investigate the electrochemical characteristics and microstructural variations. As a result of shot peening, roughness was distributed over the surface, and homogenization phenomenon was observed with increasing shot peening time due to the enhancement of coverage. The results revealed that hardness increased for shot peened specimens and particularly 3.5 mins of shot-peening time represented a hardness improvement of 52 %, showing similar electrochemical characteristics to that of the un-peened surface.

• Journal of agriculture & life science
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• v.44 no.5
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• pp.75-79
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• 2010

Apple, one of the most important fruit crops world-widely, is required for rapid, cost-effective and sensitive virus detection for its better productivity. RT-PCR is extensively employed for apple virus diagnosis, but the technique requires complete tissue homogenization which is time consuming and laborious. In this study, heating-based RNA extraction method was developed and proven to effectively work for stem tissues slightly better than for leaf tissues. In RT-PCR, almost identical results were generated from the use of RNA extracts from both tissues.

• Steel and Composite Structures
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• v.43 no.1
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• pp.1-17
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• 2022

The free and forced nonlinear dynamic behaviors of Porous Functionally Graded Material (PFGM) plates are examined by means of a High-Order Implicit Algorithm (HOIA). The formulation is developed using the Third-order Shear Deformation Theory (TSDT). Unlike previous works, the formulation is written without resorting to any homogenization technique neither rule of mixture nor considering FGM as a laminated composite, and the distribution of the porosity is assumed to be gradually variable through the thickness of the PFGM plates. Using the Hamilton principle, we establish the governing equations of motion. The Finite Element Method (FEM) is used to compute approximations of the resulting equations; FEM is adopted using a four-node quadrilateral finite element with seven Degrees Of Freedom (DOF) per node. Nonlinear equations are solved by a HOIA. The accuracy and the performance of the proposed approach are verified by presenting comparisons with literature results for vibration natural frequencies and dynamic response of PFGM plates under external loading. The influences of porosity volume fraction, porosity distribution, slenderness ratio and other parameters on the vibrations of PFGM plate are explored. The results demonstrate the significant impact of different physical and geometrical parameters on the vibration behavior of the PFGM plate.

• Structural Engineering and Mechanics
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• v.85 no.1
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• pp.89-104
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• 2023

This work presents a proposal for employing reduced numerical integration in the formulation of the 4-node quadrilateral solid finite element. The use of these low-order integration rules leads to numerical instabilities such as those producing the hourglass effect. The proposed procedure allows evaluating a given constitutive model only in one integration point, achieving an attractive computational cost reduction and, also, successfully controls the hourglass effect. A validation of the proposal is included and discussed throughout the paper. To show the efficiency of the proposal, several application examples of masonry structures are studied and discussed. To represent the non-linear mechanical behaviour of masonry a plastic-damage model is implemented within the application of this sub-integration scheme. Also, in order to have a full and computationally efficient strategy to determine the behaviour of masonry structures, involving its evolution to collapse, a homogenization technique with a macro-modeling approach is used. The methodology discussed throughout this paper demonstrates a substantial computational cost reduction and an improved approximation of the non-linear problem evidenced by a reduction of up to 85% of the computational time for some cases.

• Journal of Microbiology and Biotechnology
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• v.33 no.4
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• pp.419-429
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• 2023

Ultraviolet C (UV-C, 200-280 nm) light has germicidal properties that inactivate a wide range of pathogenic and spoilage microorganisms. UV-C has been extensively studied as an alternative to thermal decontamination of fruit juices. Recent studies suggest that the efficacy of UV-C irradiation in reducing microorganisms in fruit juices is greatly dependent on the characteristics of the target microorganisms, juice matrices, and parameters of the UV-C treatment procedure, such as equipment and processing. Based on evidence from recent studies, this review describes how the characteristics of target microorganisms (e.g., type of microorganism/strain, acid adaptation, physiological states, single/composite inoculum, spore, etc.) and fruit juice matrices (e.g., UV absorbance, UV transmittance, turbidity, soluble solid content, pH, color, etc.) affect the efficacy of UV-C. We also discuss the influences on UV-C treatment efficacy of parameters, including UV-C light source, reactor conditions (e.g., continuous/batch, size, thickness, volume, diameter, outer case, configuration/arrangement), pumping/flow system conditions (e.g., sample flow rate and pattern, sample residence time, number of cycles), homogenization conditions (e.g., continuous flow/recirculation, stirring, mixing), and cleaning capability of the reactor. The collective facts indicate the immense potential of UV-C irradiation in the fruit juice industry. Existing drawbacks need to be addressed in future studies before the technique is applicable at the industrial scale.

• Journal of the Korean Geotechnical Society
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• v.19 no.6
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• pp.245-259
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• 2003

This paper deals with an Umbrealla Arch Reinforcement Method (UARM) in tunnelling. It is known that the mechanism of the reinforcement system is too complex to be simulated in existent finite element (FE) frameworks when considering its complex geometry of pipe arrangements and contribution of each component of the reinforcement to reinforcing effect. In this study a 3-D elastoplastic FE procedure is, therefore, proposed by introducing homogenisation technique, which is used to define mathematically elastic as well as elastoplastic characteristics of a reinforced ground material as a composite. A number of practical suggestions are addressed considering staged constructions of tunnels. For illustrative purposes, a series of parametric studies are undertaken and anisotropic characteristics of the reinforced ground as well as effects of the reinforcement on tunnel convergences are investigated. It is found that the reinforced ground material defined in homogenisation framework has its mechanical characteristics reasonably representing inherent geometrical and quantitative characteristics of each of constituents.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.9
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• pp.663-670
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• 2020

A study on mechanical property characterization and modeling technique was carried out to approximate the behaviour of structures with 2.5D C/SiC material. Several tensile tests were performed to analyze the behaviour characteristics of the 2.5D C/SiC material and elastic property was characterized by applying a mathematical homogenization and a modified rule of mixture. SiC matrix representing the elasto-plastic behavior approximates as a bilinear function. Then the equivalent yield strength and equivalent plastic stiffness were calculated by minimizing errors in experiment and approximation. RVE(Representative Volume Element)was defined from the fiber and matrix configuration of 2.5D C/SiC and a process of calculating the effective stiffness matrix by applying the modified rule of mixture to RVE was implemented in the ABAQUS User-defined subroutine. Finite element analysis was performed by applying the mechanical properties of fiber and matrix calculated based on the proposed process, and the results were in good agreement with the experimental results.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.4
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• pp.173-181
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• 2018

Recently composite materials have dominated most engineering fields, owing to their better performance, increased durability and flexibility to be customized and designed for a specific required property. This has given them unprecedented superiority over conventional materials. With the help of the ever increasing computational capabilities of computers, researchers have been trying to develop accurate material models for the complex and integrated properties of these composites. This has led to advances in virtual testing of composite materials as a supplement or a possible replacement of laboratory experiments to predict the properties and responses of composite materials and structures. This paper presents a review on the complex multi-scale modelling framework of the virtual testing machines, which involve computational mechanics at various length-scales starting with nano-mechanics and ending in structure level computational mechanics, with a homogenization technique used to link the different length scales. In addition, the paper presents the features of some of the biggest integrated virtual testing machines developed for study of concrete, including a multiscale modeling scheme for the simulation of the constitutive properties of nanocomposites. Finally, the current challenges and future development potentials for virtual test machines are discussed.