• Korean Journal of Biological Psychiatry
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• v.12 no.2
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• pp.114-122
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• 2005

Objectives:Recently in schizophrenia high incidence of MTHFR(methylenetetrahydrofolate reductase), which is a main relating enzyme that reduce homocysteine level, genetic variations were reported. So we examined serum homocysteine level and MTHFR gene polymorphism in Korean schizophrenics. Method:We compared serum homocysteine level and MTHFR polymorphism between 235 schizophrenics (100male, 135female) and 235 normal controls(100male, 135female). C677T and A1298C polymorphism of MTHFR gene were analyzed. Results:1) C677T genetic mutation(CT and TT) were more frequent in schizophrenia group than normal control group(p<0.01). But the difference of A1298C mutation frequency was not found between two groups. 2) In schizophrenia patients, TT genotype of C677T mutation showed significantly higher homocysteine level (29.99uM/L) than other group(CT:13.34uM/L, CC:9.34uM/L p<0.01). 3) MTHFR 677 TT homogeneous mutation genotype showed two times more risk(odds ratio=2.15) than 677CC normal genotype in schizophrenia. Conclusion:Some schizophrenia patients with high homocysteine serum level may have C677T TT genotype. In that case, folate ingestion could be a good management for clinical improvement.

• Korean Journal of Biological Psychiatry
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• v.3 no.2
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• pp.162-169
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• 1996

An association study with korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D6S274 polymorphism and schizophrenia using polymerase chain reaction. Nine different alleles of a dinucleotide polymorphism on D6S273 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as DSM-IV diagnostic subtype, family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K). Then we compared the frequencies of alleles among subgroups of clinical phenotypes. there was only significant difference between two subgroups on soft neurologic signs(p<0.05). Although our findings fail to provide on evidence of association between schizophrenia and D6S274 locus, follow-up investigation of this locus may be needed in homogeneous subtypes of schizophrenia and schizophrenic pedigrees.

• Korean Journal of Social Welfare
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• v.66 no.3
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• pp.5-28
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• 2014

School absenteeism, one of the early warning signs of behavioral problems, has been known to be a complex and heterogeneous problem. However, much of the research assumes that school absentee adolescents comprise a homogeneous group. This study explored the heterogeneity of school absentee adolescents, based on school adaptation, to provide a more nuanced understanding of school absenteeism and examined predictive and risk factors associated with each typology of school absentee adolescents. Latent profile analysis was conducted using sample 477 middle school students who were reported absent in the previous year from the 3rd wave of Korean Children and Youth Panel Study. Multinomial logistic regression and ANOVA was also employed to examine the effects of predictive variables. As a result, three profiles were identified: low, middle, and high adaptive group. Group membership was found to be associated deferentially with gender, mental health, parenting neglect, delinquent friends, and delinquent behaviors. These findings propose more specific and targeted interventions designed to meet the needs and risk factors associated with the different typologies of school absentee adolescents.

• The Journal of Korean Association of Computer Education
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• v.8 no.4
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• pp.15-24
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• 2005

The success of cooperative learning in small groups heavily depends on how the small groups are set up. When small groups are formed, the factors such as the objectives and characteristics of the work and the capabilities and interests of the group members should be considered to maximize the interaction among the group members. However, it is not easy for teachers to manually divide their class to small groups to satisfy such conditions. In this work, we developed and implemented a student grouping system that divides the class as appropriate as possible, when given multidimensional student data and a set of conditions for forming small groups. The grouping conditions can be heterogeneous, homogeneous, and both. The grouping system can easily be used by teachers since the system can be accessed by clicking a menu button embedded into Microsoft Excel. The system has also a wide range of application areas where object grouping by various conditions is needed.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.4
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• pp.107-117
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• 2014

This study tests homogeneity and performs multiple comparison analysis among treatment levels of each factor group through t-test by materials and analysis of variance by structural type and service period. For that descriptive statistical analysis is performed for static and dynamic response characteristics and their ratios of calculated versus measured values based on a good many safety assessment reports for bridges. Homogeneity and post hoc test based on descriptive statistical analysis provide the measures for homogeneity identification among comparison groups in addition to the statistical reference values such as central tendency, variation and shape. This study is expected to be valuable for structural integrity assessment and design by comparing the measured and calculated values with the reference values for the homogeneous group identified, which can help the engineers review the adequacy of the values and put the group database to practical use.

• Korean Journal of Materials Research
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• v.18 no.4
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• pp.204-210
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• 2008

$1.5\;{\mu}m$-thick copper films deposited on silicon wafers were successfully bonded at $415^{\circ}C$/25 kN for 40 minutes in a thermo-compression bonding method that did not involve a pre-cleaning or pre-annealing process. The original copper bonding interface disappeared and showed a homogeneous microstructure with few voids at the original bonding interface. Quantitative interfacial adhesion energies were greater than $10.4\;J/m^2$ as measured via a four-point bending test. Post-bonding annealing at a temperature that was less than $300^{\circ}C$ had only a slight effect on the bonding energy, whereas an oxygen environment significantly deteriorated the bonding energy over $400^{\circ}C$. This was most likely due to the fast growth of brittle interfacial oxides. Therefore, the annealing environment and temperature conditions greatly affect the interfacial bonding energy and reliability in Cu-Cu bonded wafer stacks.

• Women's Health Nursing
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• v.12 no.3
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• pp.240-248
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• 2006

Purpose: The purpose of this study was to verify the effects of a Qigong prenatal education program on anxiety, depression and physical symptoms in pregnant women. Method: The subjects were a total of 40 pregnant women who received regular prenatal care at S hospital. Twenty people were enrolled in the Qigong prenatal education program and were assigned to the experimental group. The other 20 people who received regular prenatal care only were the control group. The Qigong prenatal education program was given to the experimental group once a week and 2 hours per session for 4 weeks. Anxiety, depression and physical symptoms were collected by a self-administered study questionnaire at the pre- and post-test. Result: There were no significant differences in subjects' general characteristics or pretest scores of study variables at the pretest indicating both groups were homogeneous. Differential t-tests were used to test the effects of the Qigong prenatal education program on study variables. Pregnant women who received the Qigong prenatal education program had a lower level of depression than those who did not attend(t=2.23, p=.03). There were no significant differences on anxiety and physical symptoms. Conclusion: The Qigong prenatal education program was effective in alleviating depression during pregnancy. However, further study is needed to replicate the results with a greater sample size and to investigate the long term effects of the program on the labor and delivery process.

• Journal of the Korean Geotechnical Society
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• v.35 no.6
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• pp.27-38
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• 2019

Bearing capacity of a pile in homogeneous soil is the sum of end bearing and skin resistance, and the skin resistance is more prominent in sandy soil. Bearing capacity of a pile in pile groups especially in sandy ground should be designed under the consideration of the influence by the adjacent piles. In this study, the end bearing capacity of a pile in pile groups was experimentally investigated. For this purpose, piles were installed in sandy ground in a circular test box, and end bearing - settlement behavior of the pile was measured while the pile was loaded. As the results, end bearing - settlement relation curves of the piles showed a distinct limit value. Limit value of the end bearing was little affected by skin friction and pile diameter, and it became a constant value as pile penetrates deeper. End bearing was not affected by the adjacent piles in a group of piles, when their clearance was larger than the pile diameter.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.2
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• pp.252-258
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• 2021

Software subjects such as programming practice and physical computing may have differences between men and women, and there may be individual differences in resilience due to errors and debugging. Therefore, in this study, we analyze gender differences in computational thinking classes by using a resilience testing tool. The results of this study showed that the two groups were homogeneous, and the male group did not show significant changes in resilience, but the female group showed significant increases in resilience. This study confirmed the possibility of reducing the gender gap of learners by allowing a group of female students who did not show strength in traditional software education to become more motivated and interested in the information and communication field through appropriate learning content and learning strategies in computational thinking classes.

• Journal of Pharmacopuncture
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• v.24 no.4
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• pp.196-205
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• 2021

Objectives: Bruising is an important side effect of enoxaparin injection. Comfrey (Symphytum officinale) is used to treat different types of wounds, bone fractures, and bruising in traditional medicine in many countries for centuries. This study aimed to determine the effects of the Comfrey ointment on the bruise size and color following enoxaparin injection. Methods: This double-blind randomized clinical trial was conducted on 80 patients with acute coronary syndrome (ACS). The participants were randomly divided into two groups of 40, namely Comfrey and Placebo. Changes in bruise size and color in both groups were assessed daily before and after the intervention. Results: The Comfrey and Placebo groups were homogeneous in demographic and clinical variables. A downward trend was observed in the bruise size in both groups throughout the study. However, the bruise size was smaller in the Comfrey group than the Placebo group on day 2-5 of the intervention. Moreover, there was a significant difference in bruise color between the groups, with a shorter healing course in the Comfrey group. Conclusion: The Comfrey ointment accelerated the healing process of enoxaparin injection-induced bruising in patients with ACS. It is recommended as a safe and simple approach for these patients.