Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Serum Homocysteine Level and MTHFR C677T, A1298C Gene Polymorphism in Korean Schizophrenics

정신분열병 환자에서의 혈중 Homocysteine 농도와 MTHFR C677T, A1298C의 유전자 다형성

  • Lee, Young Sik (Department of Psychiatry, Chung-Ang University, College of Medicine) ;
  • Jeon, Chang Moo (Department of Psychiatry, Chung-Ang University, College of Medicine) ;
  • Na, Chul (Department of Psychiatry, Chung-Ang University, College of Medicine) ;
  • Chae, Seok Lae (Department of Labaratory Medicine, Chung-Ang University, College of Medicine)
  • 이영식 (중앙대학교 의과대학 신경정신과학교실) ;
  • 전창무 (중앙대학교 의과대학 신경정신과학교실) ;
  • 나철 (중앙대학교 의과대학 신경정신과학교실) ;
  • 채석래 (중앙대학교 의과대학 진단검사의학교실)
  • Published : 2005.11.30
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Abstract

Objectives:Recently in schizophrenia high incidence of MTHFR(methylenetetrahydrofolate reductase), which is a main relating enzyme that reduce homocysteine level, genetic variations were reported. So we examined serum homocysteine level and MTHFR gene polymorphism in Korean schizophrenics. Method:We compared serum homocysteine level and MTHFR polymorphism between 235 schizophrenics (100male, 135female) and 235 normal controls(100male, 135female). C677T and A1298C polymorphism of MTHFR gene were analyzed. Results:1) C677T genetic mutation(CT and TT) were more frequent in schizophrenia group than normal control group(p<0.01). But the difference of A1298C mutation frequency was not found between two groups. 2) In schizophrenia patients, TT genotype of C677T mutation showed significantly higher homocysteine level (29.99uM/L) than other group(CT:13.34uM/L, CC:9.34uM/L p<0.01). 3) MTHFR 677 TT homogeneous mutation genotype showed two times more risk(odds ratio=2.15) than 677CC normal genotype in schizophrenia. Conclusion:Some schizophrenia patients with high homocysteine serum level may have C677T TT genotype. In that case, folate ingestion could be a good management for clinical improvement.

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