• IMMUNE NETWORK
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• v.23 no.3
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• pp.25.1-25.15
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• 2023

Mucosal environments harbour lymphocytes, which express several adhesion molecules, including intestinal homing receptors and integrin αE/β7 (CD103). CD103 binds E-cadherin, an integrin receptor expressed in intestinal endothelial cells. Its expression not only enables homing or retention of T lymphocytes at these sites but is also associated with increased T lymphocyte activation. However, it is not yet clear how CD103 expression is related to the clinical staging of breast cancer, which is determined by factors such as the size of the tumor (T), the involvement of nearby lymph nodes (N), and presence of metastasis (M). We examined the prognostic significance of CD103 by FACS in 53 breast cancer patients and 46 healthy controls enrolled, and investigated its expression, which contributes to lymphocyte recruitment in tumor tissue. Patients with breast cancer showed increased frequencies of CD103⁺, CD4⁺CD103⁺, and CD8⁺CD103⁺ cells compared to controls. CD103 was expressed at a high level on the surfaces of tumor-infiltrating lymphocytes in patients with breast cancer. Its expression in peripheral blood was not correlated with clinical TNM stage. To determine the localisation of CD103⁺ cells in breast tissue, tissue sections of breast tumors were stained for CD103. In tissue sections of breast tumors stained for CD103, its expression in T lymphocytes was higher compared to normal breast tissue. In addition, CD103⁺ cells expressed higher levels of receptors for inflammatory chemokines, compared to CD103^- cells. CD103⁺ cells in peripheral blood and tumor tissue might be an important source of tumor-infiltrating lymphocyte trafficking, homing, and retention in cancer patients.

• Smart Structures and Systems
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• v.8 no.1
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• pp.39-52
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• 2011

We are developing a biomimetic robot based on the Sea Lamprey. The robot consists of a cylindrical electronics bay propelled by an undulatory body axis. Shape memory alloy (SMA) actuators generate propagating flexion waves in five undulatory segments of a polyurethane strip. The behavior of the robot is controlled by an electronic nervous system (ENS) composed of networks of discrete-time map-based neurons and synapses that execute on a digital signal processing chip. Motor neuron action potentials gate power transistors that apply current to the SMA actuators. The ENS consists of a set of segmental central pattern generators (CPGs), modulated by layered command and coordinating neuron networks, that integrate input from exteroceptive sensors including a compass, accelerometers, inclinometers and a short baseline sonar array (SBA). The CPGs instantiate the 3-element hemi-segmental network model established from physiological studies. Anterior and posterior propagating pathways between CPGs mediate intersegmental coordination to generate flexion waves for forward and backward swimming. The command network mediates layered exteroceptive reflexes for homing, primary orientation, and impediment compensation. The SBA allows homing on a sonar beacon by indicating deviations in azimuth and inclination. Inclinometers actuate a bending segment between the hull and undulator to allow climb and dive. Accelerometers can distinguish collisions from impediment to allow compensatory reflexes. Modulatory commands mediate speed control and turning. A SBA communications interface is being developed to allow supervised reactive autonomy.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.7
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• pp.633-639
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• 2007

This paper presents a new homing guidance law based on well-known BPN to achieve an impact time constraint as well as an impact angle constraint. The guidance commands are synthesized by introducing an additional command to control impact-time. The structure of the additional command has a BPN-based loop multiplied by time-varying gains being proportional to the time difference between the required time-to-go and the estimated time-to-go by BPN. Moreover, the proposed homing loop converges to BPN as the time-to-go error is reduced. The performance of the proposed guidance law is evaluated by the computer simulations.

• Journal of Information Technology Services
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• v.10 no.2
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• pp.75-94
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• 2011

The industrial ecosystem around the Internet services has been evolving since the Internet was first introduced. The Net Neutrality issue best represents the process of the evolution and presents an inevitable challenge that the industry should overcome. This paper deals with this structural change with the Two-Sided Market framework and provides a System Dynamics(SD) model to evaluate the economic implications of the net neutrality policy. In particular, our approach analyzes the policy impacts when two competing platforms (network providers) play a role of the platform in a typical two-sided market, which connects Content Providers(CPs) with users. Previous studies show that the indirect network externality between these two markets makes the entire system tip to one platform. When the multi-homing in the CP market is allowed as in our model, however, their argument may lose its validity. To examine the system behavior, conducted here is SD simulations of our model. The simulation results show that co-existence of the competing platforms persists with the network effects over a certain threshold. The net neutrality policy seems to lower the threshold based on our experimental outcomes.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.3
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• pp.1406-1424
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• 2017

Recent advancements in network infrastructures provide increased opportunities to support data delivery over multiple paths. Compared with multi-homing scenario, overlay network is regarded as an effective way to construct multiple paths between end devices without any change on the underlying network. Exploiting multipath characteristics has been explored for TCP with multi-homing device, but the corresponding exploration with overlay network has not been studied in detail yet. Motivated by improving quality of experience (QoE) for reliable data delivery, we propose a multipath message transport protocol based on application level relay (MPMTP-AR). MPMTP-AR proposes mechanisms and algorithms to support basic operations of multipath transmission. Dynamic feedback provides a foundation to distribute reasonable load to each path. Common source decrease (CSD) takes the load weight of the path with congestion into consideration to adjust congestion window. MPMTP-AR uses two-level sending buffer to ensure independence between paths and utilizes two-level receiving buffer to improve queuing performance. Finally, the MPMTP-AR is implemented on the Linux platform and evaluated by comprehensive experiments.

• Journal of Advanced Navigation Technology
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• v.14 no.5
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• pp.596-603
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• 2010

This paper presents a homing guidance law of anti-ship missiles using flight path angle to achieve an impact time constraint as well as an impact angle constraint. the independent variable in the nonlinear engagement model is change d from the flight time to the heading angle of the missile. The proposed guidance law can home a missile to the target with zero miss distance as well as satisfying both of the impact angle and time constraints. The performance of the proposed guidance law is evaluated by the computer simulations.

• Journal of Advanced Navigation Technology
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• v.16 no.1
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• pp.8-15
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• 2012

This paper on the assumption that the target is stationary and the velocity of missile is fixed value. In three dimensional space. Using flight path angle to simultaneous control impact-time-and-angle base on a homing guidance law. The independent variable in the nonlinear engagement model is the flight path angle of the missile. The propose homing guidance law can see the controllability of impact-time-and-angle. And also can see the processing of the missile arrive at the target. It is applied to several salvo attack scenarios. The performance of the proposed guidance law is verified by simulations.

• Journal of Digital Contents Society
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• v.18 no.5
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• pp.983-987
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• 2017

Multi-homing mobile router separates network for user connection and network for internet access using various interfaces for internet access. This paper proposes a load balancing metric in order that multi-network mobile router distributes its traffic to one of several heterogeneous network interfaces. To evaluate the performance of the load balancing metric, experiments on traffic balancing is performed on real commercial networks were used in Korea and Hong Kong.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.8
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• pp.1391-1400
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• 2008

In recent yeats, SCTP is known as the next transport layer protocol for connection-oriented and reliable data transfer after TCP/UDP. The SCTP was developed on the basis of the existing TCP and was designed to eliminate defects of TCP. SCTP has the different characteristic of multi-streaming and multi-homing from TCP. In this paper, we studied the defects of the performance of communication using the traits of multi-homing. And we evaluated the efficiency for each application services on the basis of SCTP of IPv6. Also, we analysed the delay time of a packet using SCTP and TCP. We noticed that the efficiency of SCTP is better than that of TCP.

• Smart Structures and Systems
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• v.18 no.3
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• pp.425-448
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• 2016

In this paper, a new Pigeon Colony Algorithm (PCA) based on the features of a pigeon colony flying is proposed for solving global numerical optimization problems. The algorithm mainly consists of the take-off process, flying process and homing process, in which the take-off process is employed to homogenize the initial values and look for the direction of the optimal solution; the flying process is designed to search for the local and global optimum and improve the global worst solution; and the homing process aims to avoid having the algorithm fall into a local optimum. The impact of parameters on the PCA solution quality is investigated in detail. There are low-dimensional functions, high-dimensional functions and systems of nonlinear equations that are used to test the global optimization ability of the PCA. Finally, comparative experiments between the PCA, standard genetic algorithm and particle swarm optimization were performed. The results showed that PCA has the best global convergence, smallest cycle indexes, and strongest stability when solving high-dimensional, multi-peak and complicated problems.