• Title/Summary/Keyword: Hodgkin-Huxley model

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A Computational Model for a Neuronal Membrane Considering the Extremely Low Frequency and Mobile Phone Frequency Electromagnetic Field Effect (극 저주파 및 휴대전화 전자파 환경 변수를 고려한 새포막 활동 전위 모형)

  • 서영준;이은주;안재목;이용업;황태금;이재선;서정선
    • Journal of Biomedical Engineering Research
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    • v.24 no.4
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    • pp.347-354
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    • 2003
  • In this paper, a computational method of an action potential including the effect of extremely low frequency and mobile phone (external) electromagnetic fields is Proposed. The method is based on the Hodgkin and Huxley model, applies the effect of the electromagnetic fields on the action Potential in terms of a binding factor into the injection current of the model, and calculates the Strength-Duration curve from numerical experiments for a frequency range of electromagnetic fields. In the numerical experiments, the coupled ordinary differential equations of the action potential and the state variables are solved solf-consistently by using Runge-Kutta Fehlberg method. The range of the frequency considered is from 1Hz through 100Hz and of 900MHz, which is specific for a mobile Phone. The Strength-Duration curves resulted showed good agreements with the equation suggested by Hodgkin and Huxley.

Hardware implementation of a pulse-type neuron chain with a synapse function for hodgkin-huxley model (호지킨-헉슬리 모델을 위한 시냅스 기능을 지닌 신경세포 체인의 하드웨어 구현)

  • Jung, Jin-Woo;Kwon, Bo-Min;Park, Ju-Hong;Kim, Jin-Su;Lee, Je-Won;Park, Yong-Su;Song, Han-Jung
    • Journal of Sensor Science and Technology
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    • v.18 no.2
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    • pp.128-134
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    • 2009
  • Integrated circuit of a new neuron chain with a synapse function for Hodgkin-Huxley model which is a good electrical model about a real biological neuron is implemented in a $0.5{\mu}m$ 1 poly 2 metal CMOS technology. Pulse type neuron chain consist of series connected current controlled single neurons through synapses. For the realization of the single neuron, a pair of voltage mode oscillators using operational transconductance amplifiers and capacitors is used. The synapse block which is a connection element between neurons consist of a voltage-current conversion circuit using current mirror. SPICE simulation results of the proposed circuit show 160 mV amplitude pulse output and propagation of the signal through synapses. Measurements of the fabricated pulse type neuron chip in condition of ${\pm}2.5\;V$ power supply are shown and compared with the simulated results.

A Modified Hodgkin-Huxley Model (수정된 호지킨-헉슬리 모델)

  • 서병설
    • Journal of Biomedical Engineering Research
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    • v.2 no.2
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    • pp.151-158
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    • 1981
  • A modification of the Hodgkin-Huxley equations was done with the changes of the binding sitea for the sodium and potassium channels. The computer simulation results agree well with the currant experiments. Thus, the contradictory problems that Suh had indicated previously can be solved. And also, the results show that the sodium and potassium channels play an important role in the firing and the leakage channel does not.

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THRESHOLD RESULTS FOR THE MCKEAN EQUATION

  • Lee, Eui-Woo
    • Communications of the Korean Mathematical Society
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    • v.10 no.1
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    • pp.251-259
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    • 1995
  • In 1952, British physiologists Hodgkin and Huxley [4] derived a model that describes the conduction of the nervous impulse in the optical nerve of a squid. The mathematical analysis of the Hodgkin-Huxley equations is technically very difficult, because of the complicated nonlinear functions in the equations. In the early 1960's FitzHugh and Nagumo [2], [9] derived a simpler formulation which retains most of the qualitative features of the original system, and yet is more amenable to analytical manipulations.

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Integrated Circuit Implementation and Analysis of a Pulse-type Hodgkin-Huxley Neuron Model (펄스형 호지킨-혁슬리 신경세포 모델의 집적회로 구현 및 분석)

  • Kwon, Bo-Min;Jung, Jin-Woo;Park, Ju-Hong;Lee, Je-Won;Park, Yong-Su;Song, Han-Jung
    • 전자공학회논문지 IE
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    • v.46 no.1
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    • pp.16-22
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    • 2009
  • Integrated circuit of a pulse-type neuron for Hodgkin-Huxley model is implemented in a $0.5{\mu}m$ 1 poly 2 metal CMOS technology. Proposed pulse-type neuron model consist of input stage with summing function and pulse generating block which make neuron pulse above threshold value. Pulse generating circuit consist of several transistors, capacitors and negative resistor with a charge supply function. SPICE simulation results show that neuron pulse is generated above threshold current of 70 nA. Measurements of the fabricated pulse type neuron chip in condition of 5 V power supply are shown and compared with the simulated results.

A Study on the Propogation Velocity of Biological Action Potential (생체의 자극 전도속도에 관한 연구)

  • Che, Gyu-Shik;Kwon, Yong-Chan
    • Journal of Advanced Navigation Technology
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    • v.14 no.6
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    • pp.1002-1009
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    • 2010
  • I made the axon to the electrical transmission model and then constructed electrical equivalent model using Kirhhoff's current law and voltage law in this paper. I calculated various axon parameters in order to analyze the electrical potential hehavior versus minute distance chang of axon. The transmission velocity of unmyelinated nerve is proportional to square root of axon diameter, while that of myelinated nerve is directly proportional to its diameter. Because the transmission of myelin sheath is independent of voltage unlike unmyelinated sheath, the Hodgkin-Huxley model across the membrane is not so precise.

Study on Electric Stimulus Pattern in Cochlear Implant Using a Computer Model (신경모델링을 이용한 인공와우 전기자극 패턴 연구)

  • Yang, Hyejin;Woo, Jihwan
    • Journal of the Institute of Electronics and Information Engineers
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    • v.49 no.12
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    • pp.249-255
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    • 2012
  • A cochlear implant system uses charge-balanced biphasic pulses that are known to reduce tissue damage than monophasic pulses. In this study, we investigated effect of pulse pattern on neural responses using a computer model, based on the Hodgkin-Huxley equation. Electric pulse phase, pulse duration, and phase gap have been systematically varied to characterize auditory nerve responses. The results show that neural responses, dynamic range and threshold are represented as a function of stimulus patterns and duration. The results could greatly extend to develop more efficient cochlear implant stimulation.

A study on new control mechanisms of memory

  • Liu, Haibin;Kakazu, Yukinori
    • 제어로봇시스템학회:학술대회논문집
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    • 1992.10b
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    • pp.324-329
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    • 1992
  • A physical phenomenon is observed through analysis of the Hodgkin-Huxley's model that is, according to Maxwell field equations a fired neuron can yield magnetic fields. The magnetic signals are an output of the neuron as some type of information, which may be supposed to be the conscious control information. Therefore, study on neural networks should take the field effect into consideration. Accordingly, a study on the behavior of a unit neuron in the field is made and a new neuron model is proposed. A mathematical Memory-Learning Relation has been derived from these new neuron equations, some concepts of memory and learning are introduced. Two learning theorems are put forward, and the control mechanisms of memory are also discussed. Finally, a theory, i.e. Neural Electromagnetic(NEM) field theory is advanced.

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