• Journal of Pharmacopuncture
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• v.17 no.3
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• pp.70-73
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• 2014

Sexual dysfunction (SD) is a health problem which occurs during any phase of the sexual response cycle that keeps the individual or couple from experiencing satisfaction from the sexual activity. SD covers a wide variety of symptoms like in men, erectile dysfunction and premature or delayed ejaculation, in women, spasms of the vagina and pain with sexual intercourse, in both sexes, sexual desire and response. And pharmacopuncture, i.e. injection of subclinical doses of drugs, mostly herb medicine, in acupoints, has been adopted with successful results. This case report showed the effect of bee venom on SD. A 51-year-old male patient with SD, who had a past history of taking Western medication to treat his SD and who had previously undergone surgery on his lower back due to a herniated disc, received treatments using pharmacopuncture of sweet bee venom (SBV) at Gwanwon (CV4), Hoeeum (CV1), Sinsu (BL23), and Gihaesu (BL24) for 20 days. Objectively, the patient showed improvement on most items on the International Index for Erectile Dysfunction (IIEF) like 28 to 29 out of perfect score 30 for erectile function, 10 to 10 out of perfect score 10 for orgasmic function, 6 to 8 out of perfect score 10 for sexual desire, 10 to 13 out of perfect score 15 for satisfaction with intercourse, and 6 to 8 out of perfect score 10 for overall satisfaction; subjectively, his words, the tone of his voice and the look of confidence in his eyes all indicated improvement. Among the variety of effects of SBV pharmacopuncture, urogenital problems such as SD may be health problems that pharmacopuncture can treat effectively.

• Korean Institute of Interior Design Journal
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• v.25 no.4
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• pp.51-59
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• 2016

Recent modern architecture shows a lot of cases that introduce natural light in indoor space, arousing diverse emotions within a minimal space by means of changes in the light. There are various causes for the background of these streams of times, and it may be said that pursuing the relationship between natural phenomena and space, using changes in light, is an important factor among them. This is closely linked to the raise of phenomenological architecture. In the case of Japan, there are many cases where the architectural language connected to the traditional architecture has been restructured to fit to modern architectural technique. The modern reinterpretation and development of the Japanese traditional effect of light and its meaning can be seen in cases of Kuma Kengo and Tadao Anndo. Of the modern architects that have used the appearance of spatial concept of light in Japanese architectural space, Kengo Kuma shows his attempt at finding identity in his designs through the acceptance and modern reinterpretation of orientalism of nature, along with the traditional and regional interpretation through materials and ways construction. It is his use oh light input used in traditional Japanese settings that have differentiated his work. On this, the present thesis intends to analyze and synthesize what impressions Kengo Kuma's unique methods of light production create in the formation of users' spatial perception, how the unique encounter of light and materials seems to perceivers, and the characteristics of his light production and expression that harmonize space, human, and nature in the visual and perceptual experience of space;

• Journal of Genetic Medicine
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• v.19 no.2
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• pp.94-99
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• 2022

Lesch-Nyhan disease (LND) is a rare X-linked recessive inherited purine metabolic disorder that accompanies neurodevelopmental problems. Neurofibromatosis type 1 (NF1) is a relatively common autosomal dominant inherited genetic disorder characterized by tumors in various systems. Some children with NF1 also accompanies neurodevelopmental problems. Here, we describe a 5-year-old boy with a maternally inherited pathogenic variant in NF1 and hypoxanthine-guanine phosphoribosyltransferase (HPRT). He was referred for severe neurodevelopmental impairment and hyperuricemia. His mother was diagnosed with NF1 and the patient was also suspected of having NF1 because of cafe au lait macules. He had dystonia, rigidity, cognitive deficit, and speech/language impairment. Serum and urine uric acid concentrations were elevated. He had more severe neurodevelopmental delay than patients with only NF1, so his clinical symptoms could not be fully understood by the disease alone. To find the cause of his neurologic symptoms and hyperuricemia, the patient and his mother underwent a whole-exome sequencing test. As a result, the pathogenic variant c.151C>T (p.Arg51Ter) in HPRT1 was identified as hemizygote in the patient and heterozygote in his mother. The pathogenic variant c.7682C>G (p.Ser2561Ter) in NF-1 was identified as heterozygotes in both of them. Although the clinical symptoms of both diseases were overlapping and complicated, genetic testing was helpful for accurate diagnosis and treatment. Therefore, we suggest to consider preemptive genetic evaluation if there are symptoms not sufficiently explained by known existing diseases. And it is considered valuable to review this rare case to understand the clinical course and possible synergic effects of these diseases.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.51 no.12
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• pp.597-602
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• 2002

The restructuring of power industry is still going on all over the world for last several decades. Many kinds of restructuring model have been studied, proposed, and applied. Among those models, power pool is more popular than other. This paper assumes the power pool market structure having competitive generation sector, and a new method is presented to build a bidding strategy in that market. The utilities participating in the market have the perfect information of their cost and price functions, but they don't know which strategy to be chosen by others. To define one's strategy as a vector, we make utility's cost/price functions into discrete step functions. An utility knows only his own strategy, so he estimates the other's cost/price functions into discrete step functions. An utility knows only his own strategy, so he estimates the other's strategy using Nash equilibrium or stochastic methods. And he also has to forecast the system demand. According to this forecasting result, his payoffs can be changed. Considering these all conditions, we formulate a bidding game problem and apply noncooperative game theory to that problem for the optimal strategy or solution. Some restrictive assumption are added for simplification of solving process. A numerical example is given in Case Study to show essential features and concrete results of this approach.

• Journal of the Korean Society of Costume
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• v.51 no.8
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• pp.43-49
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• 2001

Galliano's works showed at Dior Collection in 1997 which was held for the 50th anniversary of New Look got a good evaluation in the sense of expressing the modern taste as well as reflecting the spirit of Dior. The purpose of this study is focused on observing how to adapt the Dior's spirit. to Galliano's own design and what is the factor to let us feel his works modern. Galliano's fifty works in that Collection are analyzed by content analysis. The result is as followed : Galliano created his fabulous and modern works by four ways such as using various ethnic details, new way of fabric usage, new construction. and differentiated color harmony from Dior's. This result also includes the methodological model to adapt to design process.

• Hwankyungkyoyuk
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• v.15 no.1
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• pp.51-67
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• 2002

There are some critiques of Hungerford's "responsible environmental behavior" for misinterpreting or misunderstanding the term of "behavior". Most critics such as Wals and van der Leij, Jae-Young Lee misunderstood that Hungeford and his colleagues' approach to environmental education is a sort of behaviorism which is not correct. The writer corrected them by showing the successful story of the IEEIA program from the teachers, the children, and the community members digging by the foot. The IEEIA program represents his philosophy of education which can be characterized a non-behaviorist by Wals and van der Leij, if we attempt to classify all educators as behaviorist and non-behaviorist. And the writer also criticized the critiques with the well known "professional environmental educators" in the North America who have known Hungerford's ideas in environmental education well such as Roth, McClaren, Ramsey and Hungeford himself. Ramsey and Hungeford himself.

• Journal of The Korean Society of Clinical Toxicology
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• v.17 no.1
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• pp.28-31
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• 2019

Glyphosate herbicides, which are widely used worldwide, are known to have low toxicity. However, excessive intake may cause serious life-threatening complications; therefore, caution is needed when using them. A 51-year-old man visited the hospital after ingesting glyphosate herbicide. At the time of admission, his vital signs were 80/60 mmHg-115/min-20/min-$37.3^{\circ}C$. Electrocardiogram (ECG) showed QRS widening and corrected QT (QTc) prolongation, and blood tests showed metabolic acidosis. Treatment with gastric lavage, activated charcoal, sodium bicarbonate and intravenous lipid emulsion therapy was performed. After 2 hours, his blood pressure increased to 130/90 mg, and no QRS widening was observed on ECG.

• Korean Institute of Interior Design Journal
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• v.23 no.6
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• pp.51-59
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• 2014

Rem Koolhaas has pursued new architectural approaches breaking with conventional ones. Around the 1990s when large-scale projects occurred with the union of Europe ahead, Koolhaas recognized the limits to the existing methods for responding to such changes. Accordingly, he came to use design methods based on 'congestion' and 'void' as strategical alternatives, which became the moment for him to leap forward from the previous working sphere based in Europe to becoming an architect who would be commissioned a number of large-scale global projects. Therefore, this study intends to investigate his design methods which utilized congestion and void, and to derive spatial characteristics from the projects based on such methods. First of all, the study looked into the historical background, definition and process of congestion and the void as design methods, and analyzed his projects to which such methods were applied by classifying them into the following categories: 1) the void that removes a space of singularity; 2) the void that penetrates space while making a flow; and 3) the void that is formed by vertical extrusion. Then, the characteristics of architectural spaces made in this way were identified as 1)the single-body appearance made by congestion and the following types of space made by the void: 2) the non-uniformly shaped space that looks like floating; 3) the flexible space with various flows and directions; and 4) the space with virtual possibilities that embrace contingent events. This understanding of Rem Koolhaas's design methods which were attempted in various ways at his critical turning point will be the foundation to understand the overall world of his works.

• Journal of the Korean Chemical Society
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• v.46 no.1
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• pp.46-51
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• 2002

The recognition and cleavage of 5S rRNA from P. alcaligenes by metallopeptides to the form $Ni(II){\cdot}Gly$-Gly-His(Arg)COOH and $Cu(II){\cdot}Gly$-Gly-His(Arg)COOH were investigated. The results of RNA cleavage analyses suggest that metallopeptides selectively target the unpaired or unstably paired bases of stem-loop structure of 5S rRNA. The selectivity of metallopeptides was little affected by the species of metal ion, Ni(II) or Cu(II). When the result of cleavage by metallopeptides was compared with that of by metal complexes M(II)CR, the recognition by metallopeptides was more selective and structure specific. The cleavage data by metallopeptides and other metal complexes were used to probe the secondary structure of 5S rRNA from P. alcaligenes.

• The Plant Pathology Journal
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• v.23 no.2
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• pp.51-56
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• 2007

A plant pathogenic fungus, Gibberella zeae (anamorph: Fusarium graminearum), not only generates economic losses by causing disease on cereal grains, but also leads to severe toxicosis in human and animals through the production of mycotoxins in infected plants. Here, we characterized a histidine auxotrophic mutant of G. zeae, designated Z43R1092, which was generated using a restriction enzyme-mediated integration (REMI) procedure. The mutant exhibited pleiotropic phenotypic changes, including a reduction in mycelial growth and virulence and loss of sexual reproduction. Outcrossing analysis confirmed that the histidine auxotrophy is linked to the insertional vector in Z43R1092. Molecular analysis showed that the histidine requirement of Z43R1092 is caused by a disruption of an open reading frame, designated GzHIS7. The deduced product of GzHIS7 encodes a putative enzyme with an N-terminal glutamine amidotransferase and a C-terminal cyclase domain, similar to the Saccharomyces cerevisiae HIS7 required for histidine biosynthesis. The subsequent gene deletion and complementation analyses confirmed the functions of GzHIS7 in G. zeae. This is the first report of the molecular characterization of histidine auxotrophy in G. zeae, and our results demonstrate that correct histidine biosynthesis is essential for virulence, as well as sexual development, in G. zeae. In addition, our results could provide a G. zeae histidine auxotroph as a recipient strain for genetic transformation using this new selectable marker.