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Pallidotomy Guided by MRI and Microrecording for Parkinson's Disease (파킨슨환자의 자기공명영상과 미세전극기록을 이용한 담창구 파괴술)

  • Lee, Kyung Jin;Son, Hyung Sun;Park, Sung Chan;Cho, Kyung Keun;Park, Hae Kwan;Choi, Chang Rak
    • Journal of Korean Neurosurgical Society
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    • v.30 no.1
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    • pp.41-46
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    • 2001
  • Objective : The exact position of the lesion during the pallidotomy is critical to obtain the clinical improvement of parkinson's disease without damage to surrounding structure. Ventriculogrphy, CT(computed tomograpy) or MRI(magnetic resonance imaging) have been used to determine the initial coordinates of stereotactic target for pallidotomy. The goal of this study was to determine whether microelectrode recording significantly improves the neurophysiologic localization of the target obtained from MRI. Methods : Twenty patients were studied. They underwent a unilateral pallidotomy. Leksell frame was applied and T1 axial images parallel to the AC-PC(anterior commissure-posterior commissure) plane using a 1.5 Tesla MRI with 3mm slice thickness were obtained. Anteroposterior coordinate of target was chosen at 2mm in front of the midcommissural point and lateral coordinate between 19 and 22mm from the midline. The vertical coordinate was calculated on coronal slice using a fast spin echo inversion recovery sequence(FSEIR) related to the position of the choroidal fissure and ranged over 4-5mm below the AC-PC plane. Confirmation of the anatomical target was done on axial slices using the same FSEIR sequence . Microrecording was done at the pallidum contralateral to the symptomatic side using an electrode with a tip diameter of $1{{\mu}m}$ diameter tip and 1.1-1.4 mOhm impedance at 1000Hz. Electrophysiologic localization of the target was also confirmed intraoperatively by macrostimulation. Results : Microrecording techniques were reliable to define the transition from the base of the pallidum which was characterized by the disappearance of spike activity and by the change of the audible background activity. Signals from high amplitude neurons firing at 200-400Hz were recorded in the pallidal base. X, Y and Z coordinates of target obtained from the MRI were within 1mm from the X, Y, Z coordinates obtained with microrecording in 16 patients (80%), 15 patients(75%), 10 patients(50%) respectively. The difference of Y coordinate between on MRI and on microrecording was 4mm in only one patient. Conclusion : The MRI was accurate to localize the target within 1mm of the error from microrecording target in 70% of the patients. 4mm discrepancy was observed only once. We conclude that MRI alone can be used to determine the target for pallidotomy in most patients. However, microrecording technique can still be extremely valuable in patents with aberrant anatomy or unusual MRI coordinates. We also consider physiologic confirmation of the target using macrostimulation to be mandatory in all cases.

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Optical Property of Zinc Oxide Thin Films Prepared by Using a Metal Naphthenate Precursor (금속 나프텐산염을 이용하여 제조한 ZnO 박막의 광학적 특성)

  • Lim, Y.M.;Jung, J.H.;Jeon, K.O.;Jeon, Y.S.;Hwang, K.S.
    • Journal of Korean Ophthalmic Optics Society
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    • v.10 no.3
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    • pp.193-203
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    • 2005
  • Highly c-axis oriented nanocrystalline ZnO thin films on silica glass substrates were prepared by spin coating-pyrolysis process with a zinc naphthenate precursor. Only the XRD intensity peak of (002) phase was observed for all samples. With an increase in heat treatment temperature, the peak intensity of (002) phase increases. No significant aggregation of particle was present. From scanning probe microscopy analyses, three-dimensional grain growth, which was thought to be due to inhomogeneous substrate surface and c-axis oriented grain growth of the ZnO phase, was independent on heal-treatment temperature. Highly homogeneous surface of the highly-oriented ZnO film was observed at $800^{\circ}C$. All the films exhibited a high transmittance (above 80%) in visible region except film heat treated at $1000^{\circ}C$, and showed a sharp fundamental absorption edge at about $0.38{\sim}0.40{\mu}m$. The estimated energy band gap for all the films were within the range previously reported for films and single crystal. ZnO films, consisting of densely packed grains with smooth surface morphology were obtained by heat treatment at $600^{\circ}C{\sim}800^{\circ}C$, expected to be ideal for practical application, such as transparent conductive film and optical device.

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A Study on Clinical Findings about Vertebral Disease Diagnosed with MRI (MRI로 진단된 척추질환의 임상적 소견)

  • Kim, Ham-Gyum
    • Journal of radiological science and technology
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    • v.29 no.3
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    • pp.157-165
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    • 2006
  • In order to analyze clinical characteristics like sex- and age-based onset frequency and onset region from vertebral disease cases, this study investigated total 1,291 cases of vertebral disease that were diagnosed via magnetic resonance imaging(MRI) from January to December 2004 at B University Hospital in metropolitan area. For higher diagnostic accuracy in cases of spinal disorder diagnosed, this study analyzed findings from data reading conducted by veteran specialists in diagnostic radiology. But this study excluded uncertain lesion cases, the cases requiring differential diagnosis from other disorders and so on from subjects under analysis. This study employed superconductive 1.5 Tesla SIGNA MR/i for MRI test and basically received resulting images via FSE(fast spin echo). In particular, this study obtained T1 and T2 myelogram with regard to regional characteristics(such as cervical vertebrae, thoracic vertebrae and lumbar vertebra) and imaging characteristics for sagittal and transverse section. As a result, this study came to the following conclusions : 1. In terms of general characteristics of subjects under analysis, male group comprised 53.5% and female 46.5% out of total 1,291 subjects. 2. The regional onset frequency of spinal disorders was converged primarily on lumbar vertebra(65.5%), which was followed by cervical vertebrae(27.3%) and thoracic vertebrae(7.0%) respectively. 3. Top 10 cases with high onset frequency of spinal disorders can be listed as follows : 1) posterior bulging disc 65.8% 2) narrowing of neural foramen 23.8% 3) herniated intervertebral disc (HIVD) 22.4% 4) spinal stenosis 16.7% 5) osteochondrosis 6.4% 6) compression fracture 6.4% 7) facet joint arthropathy 6.2% 8) spondylolisthesis 6.0% 9) spinal cord tumor 3.5% 10) inter body fusion 2.6%

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A study on the plan for the reduction of NSD noise according to path control method (패스(Path)제어 방법을 통한 NSD 소음 저감 방안에 관한 연구)

  • Kim, Seon-Jin;Kim, Sung-Gon;Kang, Tae-Woo;Shin, Cheol-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.10
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    • pp.401-409
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    • 2018
  • This paper presents means of reducing noise in NSD using path control methods for Light Tactical Vehicles (LTV). NSD is applied to the rear axle of LTVs for enhancing mobility. NSD can improve mobility of vehicles with a high locking ratio but causes noise under certain conditions due to its mechanical structure. This noise results from contact between gears due to the differential role of NSD. The noise affects users, so users have continually requested noise reductions. Though the noise doesn't affect product performance and durability, and satisfies the National Defense's noise condition standards, users request for noise reduction is the focus of this research. Eliminating the source of sound for LTVs is realistically limited, so this research applies a path control method to reduce noise by controlling the path which transmits the noise. This study improves the structural delivery system and examines methods of reducing noise in LTV systems.

Effects of the Introduction of UV Irradiation and Rapid Thermal Annealing Process to Sol-Gel Method Derived Ferroelectric Sr0.9Bi2.1Ta1.8Nb0.2O9 Thin Films on Crystallization and Dielectric/Electrical Properties (UV 노광과 RTA 공정의 도입이 Sol-Gel 법으로 제조한 강유전성 Sr0.9Bi2.1Ta1.8Nb0.2O9 박막의 결정성 및 유전/전기적 특성에 미치는 영향)

  • 김영준;강동균;김병호
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.17 no.1
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    • pp.7-15
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    • 2004
  • The ferroelectric SBT thin films as a material of capacitors for non-volatile FRAMs have some problems that its remanent polarization value is relatively low and the crystallization temperature is quite high abovc 80$0^{\circ}C$. Therefore, in this paper, SBTN solution with S $r_{0.9}$B $i_{2.1}$T $a_{1.8}$N $b_{0.2}$$O_{9}$ composition was synthesized by sol-gel method. Sr(O $C_2$ $H_{5}$)$_2$, Bi(TMHD)$_3$, Ta(O $C_2$ $H_{5}$)$_{5}$and Nb(O $C_2$ $H_{5}$)$_{5}$ were used as precursors, which were dissolved in 2-methoxyethanol. SBTN thin films with 200 nm thickness were deposited on Pt/Ti $O_2$/ $SiO_2$/Si substrates by spin-coating. UV-irradiation in a power of 200 W for 10 min and rapid thermal annealing in a 5-Torr-oxygen ambient at 76$0^{\circ}C$ for 60 sec were used to promote crystallization. The films were well crystallized and fine-grained after annealing at $650^{\circ}C$ in oxygen ambient. The electrical characteristics of 2Pr=11.94 $\mu$C/$\textrm{cm}^2$, Ps+/Pr+=0.54 at the applied voltage of 5 V were obtained for a 200-nm-thick SBTN films. This results show that 2Pr values of the UV irradiated and rapid thermal annealed SBTN thin films at the applied voltage of 5 V were about 57% higher than those of no additional processed SBTN thin films. thin films.lms.s.s.

Solution Processed Porous Fe2O3 Thin Films for Solar-Driven Water Splitting

  • Suryawanshi, Mahesh P.;Kim, Seonghyeop;Ghorpade, Uma V.;Suryawanshi, Umesh P.;Jang, Jun Sung;Gang, Myeng Gil;Kim, Jin Hyeok;Moon, Jong Ha
    • Korean Journal of Materials Research
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    • v.27 no.11
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    • pp.631-635
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    • 2017
  • We report facile solution processing of mesoporous hematite (${\alpha}-Fe_2O_3$) thin films for high efficiency solar-driven water splitting. $Fe_2O_3$ thin films were prepared on fluorine doped tin oxide(FTO) conducting substrates by spin coating of a precursor solution followed by annealing at $550^{\circ}C$ for 30 min. in air ambient. Specifically, the precursor solution was prepared by dissolving non-toxic $FeCl_3$ as an Fe source in highly versatile dimethyl sulfoxide(DMSO) as a solvent. The as-deposited and annealed thin films were characterized for their morphological, structural and optical properties using field-emission scanning electron microscopy(FE-SEM), X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS) and UV-Vis absorption spectroscopy. The photoelectrochemical performance of the precursor (${\alpha}-FeOOH$) and annealed (${\alpha}-Fe_2O_3$) films were characterized and it was found that the ${\alpha}-Fe_2O_3$ film exhibited an increased photocurrent density of ${\sim}0.78mA/cm^2$ at 1.23 V vs. RHE, which is about 3.4 times higher than that of the ${\alpha}-FeOOH$ films ($0.23mA/cm^2$ at 1.23 V vs. RHE). The improved performance can be attributed to the improved crystallinity and porosity of ${\alpha}-Fe_2O_3$ thin films after annealing treatment at higher temperatures. Detailed electrical characterization was further carried out to elucidate the enhanced PEC performance of ${\alpha}-Fe_2O_3$ thin films.

Ferromagnetic Resonance of Amorphous $Co_{1-\chi}Hf_\chi$ Thin Films (비정질 $Co_{1-x}Hf_x$ 박막의 강자성 공명)

  • 백종성;김약연;이성재;임우영;이수형
    • Journal of the Korean Magnetics Society
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    • v.7 no.3
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    • pp.129-133
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    • 1997
  • To investigate the influence of the Hf concentration and the annealing effect in $Co_{1-x}Hf_x$(X=0.16, 0.24 at.%) systems, ferromagnetic resonance experiments have been carried out. Spin wave resonance spectra for all samples consist of several volume modes and one (or two) surface mode. It is suggested that both surfaces of the film have a perpendicular hard axis to the film plane (negative surface anisotropy). The surface anisotropy $K_{s2}$ at substrate-film interface is varied slowly from -0.07 to -0.32 erg/$\textrm{cm}^2$ and the surface anisotropy $K_{s1}$ at film-air interface is varied from 0.18 to -0.47 erg/ $\textrm{cm}^2$ with increasing annealing temperature in the amorphous $Co_{84}Hf_{16}$ thin films. Also, the surface anisotropy $K_{s2}$ is varied slowly from -0.31 to -0.41 erg/$\textrm{cm}^2$ and the surface anisotropy $K_{s1}$is varied from -0.19 to -0.60 erg/$\textrm{cm}^2$ with increasing annealing temperature in the amporphous $Co_{84}Hf_{16}$ thin films. We conjecture that the variation of surface anisotropy $K_{s1}$ is due to the increase of Co concentration resulted from Hf oxidation for low temperature annealing(150~175 $^{\circ}C$) and the diffusion of Co atoms near the film surfaces for high temperature annealing (200~225 $^{\circ}C$).

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Optical Properties of $ZnIn_2S_4/GaAs$ Epilayer Grown by Hot Wall Epitaxy method (Hot Wall Epitaxy (HWE)에 의한 성장된 $ZnIn_2S_4/GaAs$ 에피레이어의 광학적 특성)

  • Hong, Gwang-Jun;Lee, Gwan-Gyo
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2004.11a
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    • pp.175-178
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    • 2004
  • The stochiometric mixture of evaporating materials for the $ZnIn_2S_4$ single crystal thin film was prepared from horizontal furnace. To obtain the $ZnIn_2S_4$ single crystal thin film, $ZnIn_2S_4$ mixed crystal was deposited on throughly etched semi-insulating GaAs(100) in the Hot Wall Epitaxy(HWE) system. The source and substrate temperature were $610^{\circ}C$ and $450^{\circ}C$, respectively and the growth rate of the $ZnIn_2S_4$ sing1e crystal thin film was about $0.5\;{\mu}m/hr$. The crystalline structure of $ZnIn_2S_4$ single crystal thin film was investigated by photoluminescence and double crystal X-ray diffraction(DCXD) measurement. The carrier density and mobility of $ZnIn_2S_4$ single crystal thin film measured from Hall effect by van der Pauw method are $8.51{\times}10^{17}\;cm^{-3}$, $291\;cm^2/V{\cdot}s$ at $293_{\circ}\;K$, respectively. From the photocurrent spectrum by illumination of perpendicular light on the c - axis of the $ZnIn_2S_4$ single crystal thin film, we have found that the values of spin orbit splitting ${\Delta}S_O$ and the crystal field splitting ${\Delta}Cr$ were 0.0148 eV and 0.1678 eV at $10_{\circ}\; K$, respectively. From the photoluminescence measurement of $ZnIn_2S_4$ single crystal thin film, we observed free excition $(E_X)$ typically observed only in high quality crystal and neutral donor bound exciton $(D^{o},X)$ having very strong peak intensity The full width at half maximum and binding energy of neutral donor bound excition were 9 meV and 26 meV, respectively, The activation energy of impurity measured by Haynes rule was 130 meV.

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A Study on the Development of an Automated Freeform Fabrication System and Construction Materials (자동화 적층 시공 시스템 및 재료 개발에 관한 연구)

  • Jeon, Kwang Hyun;Park, Min-Beom;Kang, Min-Kyung;Kim, Jung-Hoon
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.33 no.4
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    • pp.1665-1673
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    • 2013
  • Recently, the interest and demand on free formed structure providing aesthetic value as well as functionality has been increasing. Formwork has numerous advantages such as high strength, convenience, accuracy and good quality of surface roughness. Nevertheless, it increases construction cost and period to build complex shapes. For these purpose, deposition construction systems such as Contour Crafting and Concrete Printing have been developed with active collaboration between university and industry by applying the rapid prototyping technology to the construction industry in USA and England. Since there has been no related research in Korea, the possibility of spin-off technology and its fusion cannot be expected. In this paper, design elements including mechanical system and control system related to automatic deposition construction system prototype for constructing a free curved structure without mold are described. As for an appropriate material for the system, fiber reinforced mortar was selected by experiments on compressive strength, fluidity, viscosity and setting time. By performing transfer and extrusion experiments, the possibility of the development of deposition construction system was demonstrated. Based on this research results, it is required to keep the automatic deposition construction system improve and extend it into the new application area in construction industry.

Design of MRI Spectrometer Using 1 Giga-FLOPS DSP (1-GFLOPS DSP를 이용한 자기공명영상 스펙트로미터 설계)

  • 김휴정;고광혁;이상철;정민영;장경섭;이동훈;이흥규;안창범
    • Investigative Magnetic Resonance Imaging
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    • v.7 no.1
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    • pp.12-21
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    • 2003
  • Purpose : In order to overcome limitations in the existing conventional spectrometer, a new spectrometer with advanced functionalities is designed and implemented. Materials and Methods : We designed a spectrometer using the TMS320C6701 DSP capable of 1 giga floating point operations per second (GFLOPS). The spectrometer can generate continuously varying complicate gradient waveforms by real-time calculation, and select image plane interactively. The designed spectrometer is composed of two parts: one is DSP-based digital control part, and the other is analog part generating gradient and RF waveforms, and performing demodulation of the received RF signal. Each recover board can measure 4 channel FID signals simultaneously for parallel imaging, and provides fast reconstruction using the high speed DSP. Results : The developed spectrometer was installed on a 1.5 Tesla whole body MRI system, and performance was tested by various methods. The accurate phase control required in digital modulation and demodulation was tested, and multi-channel acquisition was examined with phase-array coil imaging. Superior image quality is obtained by the developed spectrometer compared to existing commercial spectrometer especially in the fast spin echo images. Conclusion : Interactive control of the selection planes and real-time generation of gradient waveforms are important functions required for advanced imaging such as spiral scan cardiac imaging. Multi-channel acquisition is also highly demanding for parallel imaging. In this paper a spectrometer having such functionalities is designed and developed using the TMS320C6701 DSP having 1 GFLOPS computational power. Accurate phase control was achieved by the digital modulation and demodulation techniques. Superior image qualities are obtained by the developed spectrometer for various imaging techniques including FSE, GE, and angiography compared to those obtained by the existing commercial spectrometer.

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