• Journal of Veterinary Clinics
• /
• v.29 no.5
• /
• pp.361-367
• /
• 2012

Diabetes-related complications in human and veterinary medicine have been shown to be associated with hyperglycemia-induced inflammation. It has been recently suggested that the onset of insulin resistance may be caused by over-production of inflammatory cytokines such as tumor necrosis factor (TNF)-${\alpha}$ from immune cells. Conjugated linoleic acid (CLA) regulates inflammatory response through modulation of TNF-${\alpha}$ expression. The objective of this study was to examine the effect of CLA on nuclear factor kappaB (NF-${\kappa}B$) p65 binding activity, inhibitory kappaB ($I{\kappa}B$)-${\alpha}$ expression, and TNF-${\alpha}$ production from high glucose-treated RAW 264.7 cells. CLA was added to RAW cells that had been previously cultured with low or high concentration of glucose. The levels of TNF-${\alpha}$ protein in the culture supernatant of RAW cells exposed to high concentrations of glucose were higher than those of cells exposed to low concentrations of glucose. The treatment with the high concentration of glucose in RAW cells increased levels of NF-${\kappa}B$ p65 binding activity and the decreased $I{\kappa}B-{\alpha}$ expression when compared with those of low glucose. The treatments in combination with CLA and glucose (low and high) glucose in RAW cells increased TNF-${\alpha}$ production when compared with that glucose alone. These treatments with CLA increased TNF-${\alpha}$ production in high glucose-treated RAW cells than those with low glucose. These treatments of CLA also showed higher NF-${\kappa}B$ p65 binding activity and lower $I{\kappa}B-{\alpha}$ expression in high glucose than those in low glucose condition. This suggests that CLA can increase NF-${\kappa}B$ p65 binding activity and TNF-${\alpha}$ production from high glucose-treated RAW 264.7 cells and is likely to promote hyperglycemia-induced inflammation.

• Communications of the Korean Mathematical Society
• /
• v.26 no.4
• /
• pp.623-634
• /
• 2011

The object of the present paper is to study N(${\kappa}$)-quasi Einstein manifolds. Existence of N(${\kappa}$)-quasi Einstein manifolds are proved. Physical example of N(${\kappa}$)-quasi Einstein manifold is also given. Finally, Weyl-semisymmetric N(${\kappa}$)-quasi Einstein manifolds have been considered.

• The Journal of Korean Society for School & Community Health Education
• /
• v.15 no.2
• /
• pp.91-101
• /
• 2014

Objectives: This study aimed to identify agreement between smartphone addiction (SA) and perceived SA among adolescents. Methods: This survey was done with 394 subjects conveniently sampled from elementary school (ES), middle school (MS), academic (AHS) and vocational (VHS) high school. The data were collected from June 20 to July 20, 2013 with self-administered questionnaire and analyzed by descriptive statistics, chi-square test and Cohen's kappa (${\kappa}$). Results: High risk of SA showed 2.8% in total, 1.0% in ES, 2.1% in MS, 4.1% in AHS, and 4.0% in VHS, which was statistically different by type of school (p<0.001). Perceived SA showed 22.6% in total, 9.0% in ES, 21.9% in MS, 33.7% in AHS, and 26.0% in VHS, which was statistically different by type of school (p=0.003). The agreement between SA and perceived SA was 82.0% (${\kappa}$=0.54) in total, 91.8% (${\kappa}$=0.53) in ES, 75.0% (${\kappa}$=0.33) in MS, 77.5% (${\kappa}$=0.53) in AHS, and 84.8% (${\kappa}$=0.65) in VHS. Conclusion: The agreement between SA and perceived SA showed moderate in general, but fair in MS. It is suggested to develop step-by-step activities to reduce the gap between SA and perceived SA among adolescen, in particular, middle school students.

• 한국전산유체공학회:학술대회논문집
• /
• 2003.08a
• /
• pp.158-163
• /
• 2003

This paper assesses the two-equation turbulence models available in a commercial code, FLUENT, for heat transfer in a turbulent heated pipe flow. In case of flow under $Re_D=10,000$, Standard $\kappa-\epsilon$ and Realizable $\kappa-\epsilon$ models overpredict the Nusselt number about $20\%$ compared with the experimental correlation, and RNG $\kappa-\epsilon$ model overpredicts about $30\%$ when the two-layer zonal method is employed. When wall function method is adopted, all $\kappa-\epsilon$ models show better predictions. Standard $\kappa-\omega$ and SST $\kappa-\omega$ models have the dependency on the first grid point ($0.3). As Reynolds number becomes high, the predictions of all $\kappa-\epsilon$ and $\kappa-\omega$ models are in a good agreement with the experimental correlation.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.11
• /
• pp.5511-5515
• /
• 2012

Introduction: The nuclear factor ${\kappa}B$ (NF-${\kappa}B$) is a super family of transcription factors which plays important roles in development and progression of cancer. The present investigation concerns NF-${\kappa}B$ /p65 activity in human breast cancers with overexpression of ER, PR, HER-2/neu, as well as the significance of p65 expression with regard to menopausal status, stage, grade, tumor size, nodal status, and NPI of invasive ductal carcinomas in Eastern India. Materials and Methods: In this hospital based study 57 breast cancer patients attending a Breast Clinic of a reputed institute of Eastern India were assessed for p65 protein expression in breast tumor tissue samples by Western blotting. ER, PR and HER-2/neu expression was determined by immunohistochemistry. Results: NF-${\kappa}B$/p65 was significantly associated with advanced stage, large tumor size (${\geq}5$ cm), high grade, negative ER, negative PR, and positive HER-2/neu. High NF-${\kappa}B$/p65 expression was more frequent in patients with a high NPI ($NPI{\geq}5.4$, 84.6%) compared with low NPI (<5.4, 44.4%) and this association was statistically significant (p = 0.002). Conclusion: NF-${\kappa}B$/p65 overexpression was associated with advanced stage, large tumor size, high grade, and high NPI which are poor prognostic factors linked to enhanced aggressiveness of the disease. NF-${\kappa}B$/p65 expression implies aggressive biological behavior of breast cancer and this study validates significant association of NF-${\kappa}B$ /p65 overexpression with negative estrogen and progesterone receptor status and overexpression of HER-2/neu oncoprotein. In our good clinical practice, patients with NF-${\kappa}B$ positive tumors need to be treated aggressively.

• Proceedings of the Polymer Society of Korea Conference
• /
• 2006.10a
• /
• pp.168-168
• /
• 2006

Low-operating voltage organic field-effect transistors (OFETs) have been realized with high dielectric constant (${\kappa}$) polymer such as cyanoethylated poly vinyl alcohol (CR-V, ${\kappa}=12$). Since the $high-{\kappa}$polymers are likely to contain water and ionic impurities, large hysteresis and considerable leakage current are frequently observed in OFETs. To solve these problems, we cross-linked the CR-V by using a cross-linking agent. Cross-linked CR-V dielectrics showed high dielectric constant of 11.1 and good insulating properties, resulting in a high capacitance ($81nF/cm^{2}$ at 1MHz) at 120 nm of dielectric thickness. Pentacene FETs with cross-linked CR-V dielectrics exhibited high carrier mobility ($0.72\;cm^{2}/Vs$), small subthreshold swing (185 mV/dec) and little hysteresis at low-operating voltage (${\Leq}-3V$).

• Tuberculosis and Respiratory Diseases
• /
• v.52 no.5
• /
• pp.485-496
• /
• 2002

Background : The NF-${\kappa}B$ transcription factors control various biological processes including the immune response, acute phase reaction and cell cycle regulation. NF-${\kappa}B$ complexes are retained in the cytoplasm in the basal state and various stimuli cause a translocation of the NF-${\kappa}B$ complexes into the nucleus where they bind to the ${\kappa}B$ elements and regulate the transcription of the target genes. Recent reports also suggest that NF-${\kappa}B$ proteins are involved in oncogenesis, tumor growth and metastasis. High expression of NF-${\kappa}B$ expression was reported in many cancer cell lines and tissues. The constitutive activation of NF-${\kappa}B$ was also reported in several cancer cell lines supporting its role in cancer development and survival. The anti-apoptotic action of NF-${\kappa}B$ is important for cancer survival. NF-${\kappa}B$ also controls the expression of several proteins that are important for cellular adhesion (ICAM-1, VCAM-1) suggesting a role in cancer metastasis. In lung cancer, high expression levels of the NF-${\kappa}B$ subunit p50 and c-Rel were reported. In fact, high expression does not mean a high activity, and the activation pattern of NF-${\kappa}B$ in lung cancer has not been reported. Materials and Methods : In this study, the NF-${\kappa}B$ nuclear binding activity in the basal and TNF-${\alpha}$ stimulated states were exmined in various lung cancer cell lines and compared with the normal bronchial epithelial cell line. Twelve lung cancer cell lines including the non-small cell and small cell lung cancer cell lines (A549, NCI-H358, NCI-H441, NCI-H552, NCI-H2009, NCI-H460, NCI-H1229, NCI-H1703, NCI-H157, NCI-H187, NCI-H417, NCI-H526) and BEAS-2B bronchial epithelial cell line were used. To evaluate the NF-${\kappa}B$ expression and DNA binding activity, western blot analysis and an electrophoretic mobility shift assay with the nuclear protein extracts. Results : The basal expressions of the p65 and p50 subunits were observed in the BEAS-2B cell line and all lung cancer cell lines except for NCI-H358 and NCI-H460. The expression levels of p65 and p50 were increased 30 minutes after stimulation with TNF-${\alpha}$ in BEAS-2B and in 10 lung cancer cell lines. In the NCI-H358 and NCI-H460 cell lines, p65 expression was not observed in the basal and stimulated states and the two p50 related protein levels were higher after stimulation with TNF-${\alpha}$ These new proteins were smaller than p50 and are thought to be variants of p50. In the basal state, NF-${\kappa}B$ was nearly activated in the BEAS-2B and all lung cancer cell lines. The DNA binding activity of the NF-${\kappa}B$ complexes was markedly higher after stimulation with TNF-${\alpha}$ In the BEAS-2B and all lung cancer cell line except for NCI-H358 and NCI-H460, the activated NF-${\kappa}B$ complex was a p65/p50 heterodimer. In the NCI-H358 and NCI-H460 lung cancer cell lines, the NF-${\kappa}B$ complex was variant of a p50/p50 homodimer. Conclusion : The NF-${\kappa}B$ activation pattern in the lung cancer cell lines and the normal bronchial epithelial cell lines was similar except for the activation of a variant of the p50/p50 homodimer in some lung cancer cell linse.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
• /
• 2006.06a
• /
• pp.167-172
• /
• 2006

High-yield Pinus radiate kraft pulps with various Kappa number were produced from flow-through laboratory pulping. The samples were prepared and scanned using a rapid scan photoacoustic Fourier transform infrared (PAS-FTIR) spectrometer. A partial-least-squares (PLS) model was established based on the spectral data collected at different mirror velocities. The model was used to predict the Kappa number of the pulps and its robustness was statistically evaluated. The outcomes indicate that the PLS model can be used to predict the Kappa number of Pinus radiata kraft pulps with a high degree of accuracy provided that the moving mirror velocity is ${\leq}\;0.5cm/s$.

• The Bulletin of The Korean Astronomical Society
• /
• v.43 no.1
• /
• pp.56.3-56.3
• /
• 2018

The present study formulates the theory of spontaneously emitted electromagnetic fluctuations in magnetized plasmas containing particles with an anisotropic suparthermal (bi-Kappa) velocity distribution function. The formalism is general applying for an arbitrary wave vector orientation and wave polarization, and for any wave-frequency range. As specific applications, the high-frequency electromagnetic fluctuations emitted in the upper-hybrid and multiple harmonic electron cyclotron frequency range are evaluated. The fluctuations for low-frequency are also applied, which include the kinetic $Alfv\acute{e}n$, fast magnetosonic/whistler, kinetic slow mode, ion Bernstein cyclotron modes, and higher-order modes. The model predictions are confirmed by a comparison with particle-in-cell simulations. The study describes how energetic particles described by kappa velocity distribution functions influence the spectrum of high and low frequency fluctuations in magnetized plasmas. The new formalism provides quantitative analysis of naturally occurring electromagnetic fluctuations, and contribute to an understanding of the electromagnetic fluctuations observed in space plasmas, where kappa-distributed particles are ubiquitous.

• 한국전산유체공학회:학술대회논문집
• /
• 2007.04a
• /
• pp.45-49
• /
• 2007

Asymmetric force and vibration caused by separation flow at high angle of attack affect the stability of supersonic missile. As a preliminary study we verified the effect of turbulence model through general 3-D slender body for the supersonic flow at high angle of attack. ${\kappa}-{\omega}$ Wilcox model, ${\kappa}-{\omega}$ Wilcox-Durbin+ model, ${\kappa}-{\omega}$ shear-stress transport model, and Spalart-Allmaras one equation model are used. Grid sensitivity test was performed with three different grid system. results show that all models are in good agreement with the experimental data.