• Investigative Magnetic Resonance Imaging
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• 제20권3호
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• pp.141-151
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• 2016

Purpose: Advances of magnetic resonance imaging (MRI), especially that of the Ultra-High Field (UHF) MRI will be reviewed. Materials and Methods: Diffusion MRI data was obtained from a healthy adult young male of age 30 using a 7.0T research MRI scanner (Magnetom, Siemens) with 40 mT/m maximum gradient field. The specific imaging parameters used for the data acquisition were a single shot DW echo planar imaging. Results: Three areas of the imaging experiments are focused on for the study, namely the anatomy, angiography, and tractography. Conclusion: It is envisioned that, in near future, there will be more 7.0T MRIs for brain research and explosive clinical application research will also be developed, for example in the area of connectomics in neuroscience and clinical neurology and neurosurgery.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 D
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• pp.2783-2785
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• 2003

In multi-dimensional magnetic resonance imaging, data is obtained in the spatial frequency domain. Since the signal variation in the spatial frequency domain is much larger than that in the spatial domain, analog-to-digital converts with wide conversion bits are required. In this paper, the quantization noise in magnetic resonance imaging is analyzed. The signal-to-quantization noise ratio(SQNR) in the reconstructed image is derived from the level of quantization in the data acquisition. Since the quantization noise is proportional to the signal amplitude, it becomes more dominant in high field imaging. Using the derived formula the SQNR for several MRI systems are evaluated, and it is shown that the quantization noise can be a limiting factor in high field imaging, especially in three dimensional imaging in magnetic resonance imaging.

• Investigative Magnetic Resonance Imaging
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• 제11권2호
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• pp.95-102
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• 2007

목적: 3.0 Tesla와 같은 고 자장에서 고해상도의 나선주사영상을 얻기 위해서는 주자장을 균일하게 만들어야 한다. 특히, 나선주사영상인 경우 스핀-에코펄스 시퀀스(SE)나 경사자계 에코 펄스 시퀀스(GE)에 비하여 측정 시간이 길기 때문에 주자장이 균일하지 못하다면, off-resonance 현상으로 영상의 blur가 심해진다. 본 연구에서는 빠른 시간 안에 주자장을 균일하게 할 수 있는 고차(Higher-order) shimming방법을 모색했다. 대상 및 방법: 3 Tesla 자기 공명 영상시스템에서 고해상도의 나선주사영상을 얻기에 적합할 정도의 균일한 주자장을 빠른 시간 안에 만들기 위해, 한번의 스캔으로 axial, sagittal, coronal 방향의 불균일도 map을 구할 수 있는 펄스 시퀀스를 제안하였고, 불균일도 map으로부터 spherical harmonics 분석를 통해 shim 코일에 적절한 전류를 인가하여 주자장을 균일하게 만들었다. 결과: 3 Tesla 자기 공명 영상 시스템에서 주자장의 불균일도는 주자장의 크기에 비례하게 된다. 제안한 펄스 시퀀스로 얻은 영상을 이용하여 불균일도 Map을 만들 수 있었고, 이를 spherical harmonics 분석을 하여 2-3회의 고차 shimming으로 불균일한 자장을 균일하게 만들 수 있었다. 제안된 고차 shimming 방법은 전체 영상 영역 뿐만 아니라 선택한 영역에 대해서만 적용도 가능하기 때문에 국부 영역에 대한 고차 shimming이 가능하다. 고차 shimming이 적용되어 주자장이 균일하게 개선된 상태에서 고해상도의 나선주사영상을 얻을 수 있었다. 결론: 3 Tesla 고자장 자기 공명 영상 시스템에서 주자장의 불균일도를 개선하기 위한 펄스 시퀀스와 알고리즘을 통해 주자장의 불균일도를 빠른 시간 안에 개선할 수 있었다. 주자장의 불균일도를 효과적으로 개선함으로써, 고해상도의 나선주사 영상을 얻을 수 있었다.

• Investigative Magnetic Resonance Imaging
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• 제10권2호
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• pp.108-116
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• 2006

목적 : 3.0 Tesla 고 자장에서 고 해상도 나선주사영상을 수행하였다. 나선주사영상은 초고속 영상기법의 하나로서, Echo Planar Imaging(EPI)에 비하여 eddy current 가 작게 발생하고, 경사자계 파형의 기울기가 완만하여 상대적으로 낮은 slew rate 를 가진 경사자계시스템으로 구현이 가능한 장점이 있다. 또한 고 자장 영상에서 고속스핀에코(Fast Spin Echo: FSE) 등의 rf 에코 기반의 고속영상방법에서 심각하게 대두되는 SAR 문제가 근원적으로 발생하지 않는 장점이 있어 고 자장에서의 초고속영상방법으로 주목을 받고 있다. 본 연구에서는 3.0 Tesla 에서 나선주사방식으로 고 해상도 영상을 얻어 고 자장 MRI에서 나선주사영상기법의 다양한 응용 가능성을 살펴보고자 한다. 대상 및 방법 : 3 Tesla 전신 자기 공명 영상 시스템에서 다양한 해상도의 나선주사영상 방법을 개발하였다. 고차(higher-order) shimming 을 통하여 영상의 화질을 개선하였고, 해상도에 맞게 interleaves 수를 조절하였다. 스핀에코 와 gradient에코 기반 나선주사영상방법을 구현하였고, 에코 time 과 repetition time, rf 회전 각도를 조절하여 영상의 대조도(contrast)와 신호대잡음비를 조절하였다. 결과 : 3 Tesla 전신 자기 공명 영상 시스템에서 나선 주사 방법을 이용하여 다양한 해상도의 영상을 얻었다. 고 자장에서 주 자장의 불균일도(inhomogeneity) 의 절대 크기가 커지기 때문에 이를 줄이기 위한 shimming 이 더욱 중요해진다. 한번의 스캔으로 axial, sagittal, coronal 방향의 불균일도 map을 구하여 spherical harmonics 분석으로 고차 shimming을 하였다. 팬텀과 in-vivo 두부 영상에서 single shot 나선주사 영상으로 $100{\times}100$ 정도의 영상과 6-12 정도의 interleaves 를 적용하여 $256{\times}256$ 의 고 해상도 영상을 얻을 수 있었다. 결론 : 신호대잡음비의 향상과 스펙트럼의 분리, 뇌기능영상에서 BOLD 효과 향상 등으로 고자장 영상에 대한 관심이 높아지고 있다. 그러나 고 자장 영상에서의 rf field 에 의한 SAR 증가는 중요한 제한 요소로 부각되고 있다. 나선주사영상은 SAR 문제가 근원적으로 발생하지 않고, EPI에 비하여 하드웨어 요구 조건이 낮아 고 자장에서의 고속영상방법으로 적합하다. 본 논문에서는 고차 shimming 을 통하여 불균일도를 개선하고, single shot 과 interleaving 을 적용한 multi-shot 나선주사영상 기법으로 $100{\times}100$에서 $256{\times}256$의 고해상도 영상을 얻어 고 자장에서 초고속영상기법으로 다양한 적용 가능성을 보였다.

• Current Optics and Photonics
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• 제2권6호
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• pp.568-575
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• 2018

Various techniques to measure the three-dimensional (3D) surface profile of a 3D micro- or nanostructure have been proposed. However, it is difficult to apply such techniques directly to industrial uses because most of them are relatively slow, unreliable, and expensive. The HiLo optical imaging technique, which was recently introduced in the field of fluorescence imaging, is a promising wide-field imaging technique capable of high-speed imaging with a simple optical configuration. It has not been used in measuring a 3D surface profile although confocal microscopy originally developed for fluorescence imaging has been adapted to the field of 3D optical measurement for a long time. In this paper, to the best of our knowledge, the HiLo optical imaging technique for measuring a 3D surface profile is proposed for the first time. Its optical configuration and algorithm for a precisely detecting surface position are designed, optimized, and implemented. Optical performance for several 3D microscale structures is evaluated, and it is confirmed that the capability of measuring a 3D surface profile with HiLo optical imaging technique is comparable to that with confocal microscopy.

• Journal of the Optical Society of Korea
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• 제18권2호
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• pp.151-155
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• 2014

Although various ophthalmic imaging methods, including fundus photography and optical coherence tomography, have been applied for effective diagnosis of ocular diseases with high spatial resolution, most of them are limited by shallow imaging penetration depth and a narrow field of view. Also, many of those imaging modalities are optimized to provide microscopic anatomical information, while functional or cellular information is lacking. Compared to other ocular imaging modalities, photoacoustic imaging can achieve relatively deep penetration depth and provide more detailed functional and cellular data based on photoacoustic signal generation from endogenous contrast agents such as hemoglobin and melanin. In this paper, array-based ultrasound and photoacoustic imaging was demonstrated to visualize pigmentation in the eye as well as overall ocular structure. Fresh porcine eyes were visualized using a real-time ultrasound micro-imaging system and an imaging probe supporting laser pulse delivery. In addition, limited photoacoustic imaging field of view was improved by an imaging probe tilting method, enabling visualization of most regions of the retina covered in the ultrasound imaging.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2003년도 제8차 학술대회 초록집
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• pp.109-111
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• 2003

Compared to the present clinical field strengths, MR at 47 and above promises to improve anatomic imaging quality by factors, and to bring metabolic and functional imaging to the forefront of research and diagnostic modalities. While human bore sized magnets as high as 9.4T are now installed, realization of the potential benefit of these magnets will require more of the MR system than a simple field, frequency or power scaling from technologies used at lower fields. New constraints on the high field MR studies, both physical and physiological, will require new technical developments to be considered for the highest field systems.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2010년도 추계학술대회
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• pp.103-112
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• 2010

This study was done to provide basic data on the safety of professionals in medical imaging system by measuring the electromagnetic waves generated in the medical imaging system being used in medical organization. The studied medical imaging systems were general X-ray system, computed tomography(CT), ultrasonographic system, magnetic resonance imaging(MRI), PET-CT and fluoroscopic system, and through these devices, electric field and magnetic field were measured and analyzed. As a result of the analysis, the measured values classified by the medical organizations were not much significant, but in the measurement by the medical imaging systems, there were high hazard elements in the sequential order of electric field PET-CT($17.7{\pm}22.9$)v/m, CT($10.3{\pm}8.7$)v/m, general X-ray system ($8.8{\pm}8.8$)v/m, magnetic field general X-ray system($5.06{\pm}8.26$)mG, CT($2.71{\pm}4.53$)mG and PET-CT($0.74{\pm}0.34$)mG, the systems that adopted X-ray as main ray source, and the more aged the medical imaging systems, the greater the effects of electro-magnetic waves($10.6{\pm}15.93v/m$ for 5 years or more, $6.14{\pm}5.60v/m$ for 5 years or less). The effects of electromagnetic waves on medical imaging systems or facilities were not much when the notification of ministry of knowledge economy is considered, but in the overall perspective considering all the equipments and facility of the medical organization, such effects were significant. It is determined that sustainable safety managements of electric field and magnetic field must be done during process from medical imaging system installation to maintenance to rule out such factors.

• 대한안전경영과학회지
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• 제12권4호
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• pp.67-72
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• 2010

This study was done to provide basic data on the safety of professionals in medical imaging system by measuring the electromagnetic waves generated in the medical imaging system being used in medical organization. The studied medical imaging systems were general X-ray system, computed tomography(CT), ultrasonographic(USG) system, magnetic resonance imaging(MRI), PET-CT and fluoroscopic(R/F) system, and through these devices, electric field and magnetic field were measured and analyzed. As a result of the analysis, the measured values classified by the medical organizations were not much significant, but in the measurement by the medical imaging systems, there were high hazard elements in the sequential order of electric field PET-CT($17.7{\pm}22.9$)v/m, CT($10.3{\pm}8.7$)v/m, general X-ray system($8.8{\pm}8.8$)v/m, magnetic field general X-ray system($5.06{\pm}8.26$)mG, CT($2.71{\pm}4.53$)mG and PET-CT($0.74{\pm}0.34$)mG, the systems that adopted X-ray as main ray source, and the more aged the medical imaging systems, the greater the effects of electro-magnetic waves($10.6{\pm}15.93v/m$ for 5 years or more, $6.14{\pm}5.60v/m$ for 5 years or less). The effects of electromagnetic waves on medical imaging systems or facilities were not much when the notification of ministry of knowledge economy is considered, but in the overall perspective considering all the equipments and facility of the medical organization, such effects were significant. It is determined that sustainable safety managements of electric field and magnetic field must be done during process from medical imaging system installation to maintenance to rule out such factors.

• 전자공학회논문지D
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• 제35D권2호
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• pp.1-12
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• 1998

In this paper, an incoherent imaging of a high-contrast cylindrical cavity illuminated by the time-harmonic cylindrical wave is obtained ia the back-projections of he incoherent intensity patterns, which si acquired by averaging out the multi-frequency intensities of the total electric field scattered from this object in the cross-borehole measurement configuration. Multi-freuqncy effect is shown numerically and is intepreted analytically by the mutual coherence function defined in the is frequency domain. This imaging method is validated by imaging high-contrast cylindrical cavidities and the conditions to get better image are investigated.