• Toxicological Research
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• v.16 no.1
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• pp.67-71
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• 2000

It has been demonstrated that the injection of naked DNA expressing vascular endothelial growth factor 165(VEGFl165) to the affected area can provide significant therapeutic effects on peripherol artery occlusive diseases. Success with this type of gene therapy highly depends on the quality of the vector delivering the therapeutic gene, especially in terms of the level and duration of gene expression in the localized area. We have recently developed a vector expressing VEGF165(pCK-VEGF) for the treatment of peripheral artery occulsive diseases and demonstrated high level expression of VEGF165 in mouse skeletal muscle. This study was designed to assess the acute toxicity of intramuscularly injected pCK-VEGF in BALB/c mice and Sprague-Dawely rats. There was no evidence of any changes in clinical signs, body weights, or gross pathological signs. We estimate LD50 values of pCK-VEGF higher than 50mg/kg in mice and 20 mg/kg in rats by intramuscular injection.

• The Journal of Pediatrics of Korean Medicine
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• v.20 no.1
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• pp.165-180
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• 2006

Objective : This study has been carried out to understand the effect of several herbal medicine concentrated solution on the hyperglycemic mice Induced with streptozotocin(STZ). Methods : The 60 mg/kg of STZ injection into mice twice by 24 h interval and then 120 mg/kg of STZ injection again 3 days after the earlier injection. Control group was subjected to natural recovery, however, treated groups were fed 0.2 ml of several herbal medicine-concentrated solution (PA (x2, several herbal medicine-concentrated solution 1 group); PB (x4 several herbal medicine-concentrated solution 2 group) daily for 6 weeks. Result : The weight of PA was higher than that of control, but weight of PB was lower than control. The blood level of control increased continuously, reaching to 350mg/dL after 6 weeks, however, PA and PB showed a fast reduction of blood glucose. In blood glucose tolerance test, PA and PB showed better resistance than control. The GOT level in significantly(p<0.05) decreased in PA and PB compared with control group. The BUN and creatinine levels are significantly(p<0.01) decreased in PA compared with control group. Feeding of several herbal medicine-concentrated solution in a concentration of PA had an efficient effect on regeneration or recovery of Langerhans islet and ${\beta}-cell$ damaged by STZ. More Langerhans islet and high insulin-immunohistochemical resistance were observed in PA compared with control, but they were higher in PB than in PA. The number of Langerhans islet ${\beta}-cell$ and Langerhans islet. Conclusions : The result from the six weeks of observation demonstrates that the several herbal medicine concentrated solution have a positive effect of lowering the level of blood sugar and they increased insulin concentration. They have an effect for recovery of pancreas tissue and recovery of kidney, liver function from a diabetes mellitus.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09a
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• pp.399-400
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• 2006

M390 microclean(R) of $B{\ddot{o}}hler$ Edelstahl is a powder metallurgical plastic mould steel with a high level of corrosion and wear resistance and therefore often used in the plastics processing industry. But as a consequence of rapidly advancing developments in the plastics processing industry the required level of wear resistance of tool steels in this field is constantly rising. For that reason a new PM tool steel with higher hardness values and an increased amount of primary carbides has been developed to improve the resistance against abrasive and adhesive wear. The wear resistance of both steels against adhesive situations for components of the plastification unit of injection moulding machines has been tested with a novel method. In case of processing polyolefins with an injection moulding machine it was found that there is adhesive wear between the check-ring and the flights of the screw tip of the non-return valve under certain circumstances. The temperature in that region was measured with an infrared temperature sensor. The existence of significant peaks of that signal was used as an indicator for an adhesive wear situation.

• Journal of Electrical Engineering and Technology
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• v.10 no.1
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• pp.138-145
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• 2015

In this paper, a novel static overmodulation scheme (OVM) for space-vector PWM (SVPWM) is proposed. The proposed static OVM scheme uses the concept of adding offset voltages in linear region as well as overmodulation region to fully utilize DC-link voltage. By employing zero sequence voltage injection, the proposed scheme reduces procedures for achieving SVPWM such as complicated gating time calculation. In addition, this paper proposes a stepwise discontinuous angle movement in high modulation region in order to reduce Total Harmonic Distortion (THD). The validity of the proposed scheme is verified through theoretical analysis and experimental results.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.22 no.52
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• pp.9-20
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• 1999

The standard deviation is constant in the progress of Powder Injection Filling, The setting value of the filling amount can modify the numerical rate. Since high level of the numerical rate can get the effect of reducing the material cost, it improves the productivity by permitting the possibility of the economical production. Consequently, this thesis analyzed and suggests the numerical model which consider the economical factors of the Powder Injection Shaping progress, and I try to reinforce the competitive powder of the domestic medicine manufacture industry which face the wave of globalism and evolutionism.

• Proceedings of the KIEE Conference
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• 1996.11a
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• pp.471-474
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• 1996

The effects of injection angles between $0^{\circ}$ and $9^{\circ}$, mainstream turbulent intensities between 0.36 percent and 9.3 percent and embedded longitudinal vortices on jets issuing from a single film cooling hole and from a row of inclined holes are investigated. The heat transfer coefficients around film cooling holes are affected greatly by the compound injection angles. The injected jets affected weakly by the freestream turbulence at low level. However, the heat transfer coefficients near the film cooling holes have higher values at a high turbulence intensity. The vortices generated from a delta winglet change the injected jet direction and the kidney-type vortex pattern.

• Korean Journal of Veterinary Research
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• v.51 no.3
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• pp.239-241
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• 2011

In this study, we investigated the kinetics of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6 and high mobility group box 1 (HMGB1) concentrations in a 48-h model of canine endotoxemia by lipopolysaccharide (LPS) injection. Four healthy beagles were slowly administered 1 mg/kg of LPS diluted in normal saline, while two others were administered normal saline as controls. Blood collection was performed at 0 h (baseline), 1 h and 3 h (for TNF-${\alpha}$), 6 h, 12 h, 24 h and 48 h of the experiment, and cytokine levels were determined using the sandwich ELISA method. Early increments of TNF-${\alpha}$ and IL-6 were observed (< 3 h), but HMGB1 levels increased the most at 12 h of the experiment and gradually decreased until 48 h. During the whole experiment, IL-6 and HMGB1 were sustained over 12 h of LPS injection, whereas TNF-${\alpha}$ decreased within 6 h of LPS injection. Taken together, canine HMGB1 levels increase relatively late (< 12 h) and sustained longer than TNF-${\alpha}$ and IL-6 in response to endotoxin. This is the first study to evaluate canine HMGB1 cytokine from endotoxemia in dogs.

• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1563-1565
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• 2008

Hydrophobic plastic plates employing nano surface features are injection molded using thermoplastic materials. A variotherm molding process is devised for filling the nano pores and releasing the molded nano features from the master. The size of the molded nano surface features are about 100nm in diameter and 200nm in height. The size of the molded plate is about 30mm x 30mm and the thickness is 1mm. As molding materials, Polypropylene, PMMA, COC and PC are employed, which are all typical commodity thermoplastic materials. The mold temperature(stamper temperature) is investigated as a major processing parameter for molding high aspect ratio nano surface features. Almost fully molded nano features are fabricated above a certain level of mold temperature depends on the employing material. The contact angles on the injection molded plates are measured to estimate the hydrophobicity and found to have higher contact angle up to 180% compared to the blank plate with no surface features.

• Design & Manufacturing
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• v.2 no.3
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• pp.28-31
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• 2008

In recent, the demand of high-productivity injection mold is increased because of the growth of international packaging market which is induced by an increase of population. The increase of productivity leads to the large-capacity injection molding machine and peripheral devices. For solving this problem, the stack mold which is based on the exsiting machine and device has researched in advanced countries actively. In this paper, as the preliminary research of stack mold development, the stack mold which has 2 level ${\times}4$ cavity was designed and fabricated. Besides, the motion and structural analysis were performed to verify the stability of developed stack mold.

• Journal of the Korea Convergence Society
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• v.12 no.1
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• pp.127-132
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• 2021

The intravenous injection monitoring system used by medical institutions was developed to remotely provide patients with the amount of intravenous injected and the termination point of the injection. In order to measure the amount of intravenous injection input, the weight or flow rate of the level going out from the inside to outside of the intravenous injection can be observed with a measuring sensor. The criteria for devices that apply herein are accuracy and vigilance. In addition, it is compact and should be easy to use when installing intravenous injection on patients. In medical institutions, the accuracy of the measured values must be high, and economically inexpensive devices are required. In this study, low-cost small-weight-centered load cell sensors were applied, and algorithms were applied to reduce the artefact by external movement by converging with gyro sensors for accuracy of measurements. As a result, it was possible to reduce the error of measurement, thereby improving the accuracy of the intravenous injection monitoring measurement value.