• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.5
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• pp.385-399
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• 2005

The phenotypic response of a cell results from a well orchestrated web of complex interactions which propagate from the genetic architecture through the metabolic flux network. To rationally design cell factories which carry out specific functional objectives by controlling this hierarchical system is a challenge. Transcriptome analysis, the most mature high-throughput measurement technology, has been readily applied In strain improvement programs in an attempt to Identify genes involved in expressing a given phenotype. Unfortunately, while differentially expressed genes may provide targets for metabolic engineering, phenotypic responses are often not directly linked to transcriptional patterns, This limits the application of genome-wide transcriptional analysis for the design of cell factories. However, improved tools for integrating transcriptional data with other high-throughput measurements and known biological interactions are emerging. These tools hold significant promise for providing the framework to comprehensively dissect the regulatory mechanisms that identify the cellular control mechanisms and lead to more effective strategies to rewire the cellular control elements for metabolic engineering.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.5
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• pp.1002-1011
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• 2005

In this paper. we design and implement a bi-directional broadcasting system, so called return channel server, to allow users to participate in a broadcasting program by using a hi-directional interaction channel. To provide user participation in a program and reflect the user's opinions or responses in real time, the return channel server can be viewed as consisting of four major functional modules: a control module, network interface module, DBMS module, and real-time content authoring module. To construct a return channel server that has a service independent architecture, we designed a return channel server to include the hierarchical structure. The presented return channel server consists of two parts: an RCSAE(return channel server application environment) and RCSA(return channel server application). An RCSA is composed of an execution code and a parameter for executing the execution code. RCSA defines the procedures for providing a specific broadcasting program using the return channel server. On the other hand, an RCSAE provides the environment for the execution of RCSAS. By adopting RCSAE and RCSA, we construct the return channel server that has a service-independent architecture which are shown by the test.

• Journal of architectural history
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• v.16 no.2
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• pp.79-98
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• 2007

The building site was presumed as the Howonjeokwon or the Dasiwonji established at the traffic route among western inland areas in old Pyeonghaegun. The groundwork was composed inclination terrace of two steps. The upper step was the territory of the main house of ceremony symbolic+lodging function and the down step was divided in the territory of both Ikrang-chae of boarding and lodging management function and the territory of Haengrang-chae pavilion of rest reception management. The building composition by each territory formed space differentiation with the line of flow according to the thorough rule of court rank. The arrangement composition set the strong center axis in tandem, and it was the building arrangement interpreting the territory and the rule of court rank by function as the relationship of master and servant and was the building type emphasizing on the whole unity with the geometric symmetry structure. The Dasiwonji and the Hyeeumwonji had the common point which is the traffic architecture of semi governmental management reinforcing the boarding lodging function in the place which a visitor stayed. The Haeeumwonji and Dasiwonji had the difference in the size, but was the same in the composition system of construction. The external space and the system of the line of flow decided from the functional territory separation and the hierarchical rank as thorough as the geometric arrangement focusing on the whole unity. Namely, it was the strict and unusual system of the line of flow depended on the thorough rule of court rank than the efficient approach or arrangement of the line of flow. After being established to be the Howonjeokwon at the end of Koryeo, it disappeared at the time of the invasion of Japanese pirates when it was the time of the King Woo in Koryeo. It is presumed that it was continued until both wars, Imjin Byeongja, ago after changing its name to the Dasiwon, being restored to the small size at the end of Koryeo at the early of Choseon.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.39.1-39.1
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• 2021

The Local Volume Mapper(LVM) project in the fifth iteration of the Sloan Digital Sky Survey (SDSS-V) will produce large integral-field spectroscopic survey data to understand the physical conditions of the interstellar medium in the Milky Way, the Magellanic Clouds, and other local-volume galaxies. We are developing the LVM Instrument control software. The architecture design of the software follows a hierarchical structure in which the high-level software packages interact with the low-level and mid-level software and hardware components. We adopt the spiral software development model in which the software evolves by iteration of sequential processes, i.e., software requirement analysis, design, code generation, and testing. This spiral model ensures that even after being commissioned, the software can be revised according to new operational requirements. We designed the software by using the Unified Modeling Language, which can visualize functional interactions in structure diagrams. We plan to use the SDSS software framework CLU for the interaction between components, based on the RabbitMQ that implemented the Advanced Message Queuing Protocol (AMQP).