• Archives of Pharmacal Research
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• v.10 no.1
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• pp.67-68
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• 1987

1-eicosanoyl cafferate, mp 109-$110^{\circ}$ was isolated from the underground parts of Echinosophora koreenis together with hexacosanol, mp 75-$110^{\circ}$ 1-Eicosanoyl cafferate was isolated for the first time from plant source.

• Korean Journal of Pharmacognosy
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• v.30 no.3
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• pp.290-294
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• 1999

From the legumes of Albizzia julibrissin Durazzini (Leguminosae), a mixture of long-chain alcohols, ${\alpha}-spinasterol$, a mixture of acylated sterol glycosides and ${\alpha}-spinasteryl$ $3-O-{\beta}-D-glucoside$ were isolated. Two mixtures of long-chain alcohols and acylated sterol glycosides were characterized as 1-hexacosanol (major) and 1-tetracosanol, and $3-O-[6'-O-palmitoyl-{\beta}-D-glucosyl]-{\alpha}-spinasterol$ (major) and its 6'-O-stearoyl ester. All compounds were identified on the basis of spectral data and chemical reactions.

• Korean Journal of Pharmacognosy
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• v.38 no.3 s.150
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• pp.254-257
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• 2007

The aerial parts of Brassica juncea (Cruciferae) called by brown or oriental mustard have been widely used as a spice in food and also traditional folk medicine as stimulant, diuretic and expectorant agent. And Gatkimchi made of the aerial parts of this plant are very popular in Korea. The aerial parts of this plant was refluxed with MeOH and then fractionationed with $CH_2Cl_2$, EtOAc, n-BuOH and $H_2O$, successively. One higher alcohol compound and three flavonoids were isolated from the EtOAc fraction through silica gel and Sephadex LH-20 column chromatographies. Their structures were elucidated as n-hexacosanol(1), kaempferol(2), isorhamnetin $3-O-{\beta}-D-glucopyranoside(3)$ and isorhamnetin $3-O-(6'-O-acetyl)-{\beta}-D-glucopyranoside(4)$ by comparison of spectral data with those in references. And compounds 1 and 4 were firstly isolated from this plant.

• Korean Journal of Medicinal Crop Science
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• v.3 no.2
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• pp.151-155
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• 1995

Chromatographic separation of Laduca raddeana extract afforded a mixture of fatty acyl triterpene, triterpene acetates and primary long chain alcohol. The kind of triterpene moieties in these two triter­penoids was six, i.e., ${\beta}-amyrin,\;{\alpha}-amyrin$, lupeol, pseudotaraxasterol, taraxasterol and germanicol on the basis of chemical and spectroscopic methods. The acyl moieties in the corresponding acyl mixture were characterized as acetates, myristate, palmitate, stearate and arachidate. And a mixture of primary long chain alcohol were composed of teracosanol and hexacosanol.

• Natural Product Sciences
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• v.13 no.4
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• pp.394-397
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• 2007

Investigation of the chemical constituents of the dichloromethane extract from the moss Hylocomium splendens has led to the isolation of $5{\alpha},8{\alpha}$-epidioxy-24(S)-ethylcholesta-6,22-dien-$3{\beta}$-ol (1), diploptene (2), ${\beta}-sitosterol$ (3), and 1-hexacosanol (4). The chemical structures of 1 - 4 were established by spectroscopic methods including extensive 1D and 2D NMR analysis. This is the first isolation of compound 1 from the mosses, although it has been isolated from marine sponge.

• Korean Journal of Pharmacognosy
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• v.33 no.2 s.129
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• pp.105-109
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• 2002

Besides chrysophanol and friedelin, mixtures of n-hydrocarbons [pentacosane (72.6%), heptacosane (14.6%), tetracosane (5.8%), nonacosane (4.1 %) and hexacosane (2.9%)], n-hydrocarbon alcohols [octacosanol (70.5%) and hexacosanol (29.5%)], l-monoacyl glycerols [acyl part; behenic acid (43.5%), lignoceric acid (32.4%), cerotic acid (9.3%), tricosanoic acid (8.9%), pentacosanoic acid (2.6%), octacosanoic acid (2.3%), heneicosanoic acid (1.0%)], wax esters [behenic acid (56.3%), lignoceric acid (23.0%), cerotic acid (19.8%), tricosanoic acid (4.6%), octacosanoic acid (4.0%), pentacosanoic acid (1.7%), triacontanoic acid (0.6%)/ octacosanol (33.7%), hexacosanol (21.0%), tetracosanol (15.6%), triacontanol (10.5%), docosanol (6.0%), tricosanol (6.0%), heptacosanol (4.2%), nonacosanol (3.0%)] and sterols [${\beta}-sitosterol$ (73.2%), stigmasterol (14.6%), campesterol (12.2%)] were isolated from the roots of Hemerocallis fulva. The acid : alcohol combinations of the major wax esters were $C_{48}$: 22 : 26, 24 : 24, $C_{46}$: 22 : 24, and $C_{44}$: 22 : 22. This is the first report of l-monoacyl glycerols and friedelin from this plant. All isolates were identified on the basis of spectral data and chemical reactions.

• Natural Product Sciences
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• v.28 no.2
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• pp.45-52
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• 2022

The identification of Plasmodium falciparum enoyl acyl-carrier protein reductase (pfENR) is considered as a potential biological target against malaria. Trema orientalis is considered a rich source of phytochemicals useful in malaria treatment. This study evaluated the in-vitro inhibitory activity of the extract and isolated compounds of T. orientalis leaf; the isolated compounds and the analogues of the most active compound were subjected to in-silico molecular docking studies on pfENR. The methanolic extract of T. orientalis was subjected to repeated chromatographic separation which led to the isolation of some compounds. The isolated compounds from the plant were examined for their antimalarial activity using β-hematin inhibition assay. Virtual screening via molecular docking and ADMET studies were conducted to gain insight into the mechanism of binding of ligand and to identify effective pfENR inhibitors. The isolated compounds and the analogues of the most active isolates were gotten from PubChem library for use in docking study. Hexacosanol and β-sitosterol showed inhibition of the β-hematin formation. The docking results showed that hexacosanol, β-sitosterol and the analogues of β-sitosterol displayed binding energy ranging between -6.1 kcal/mol and -11.6 kcal/mol. Sitosterol glucoside has the highest docking score. Some of the ligands showed more binding affinity than known bioactive compounds used as reference. Analogues of β-sitosterol has been shown to be potential inhibitors of pfENR, therefore, the findings from this study suggest that sitosterol glucoside and ergosterol peroxide could act as antimalarial agents after further lead optimisation investigations.

• Journal of Sericultural and Entomological Science
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• v.34 no.2
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• pp.59-66
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• 1992

1-4령 저염인공사료 공동육＋5령 뽕잎육(농가개별육)$\longrightarrow$일주일 양잠에 적합한 광식성 누에품종육성에 필요한 기초지식을 얻기 위해 광식성유전자의 검색, 유전현상, 특성, 광식성계통 작출, 실용광식성 누에 품종육성방법 등에 대하여 소고하였다. 1. 광식성 유전자의 검색은 의잠을 사용하는 것이 가장 성력적이고 편리하며, 또한 섭식성을 정확히 파악할 수 있다. 2. 광식성 누에의 LP-1 사료에 대한 섭식성은 사육온도, 광조건, 발육단계 및 절식에 의하여 크게 영향 받지 않는다. 3. 광식성 유전자는 열성형질이며 1개의 주유전자와 수개의 수식유전자로 구성되어 있는 것으로 추찰된다. 4. LP-1 인공사료에 첨가한 morin 및 n-hexacosanol의 누에 섭식촉진효과는 미소하였으나, 상엽분말 첨가로 인한 누에 섭식촉진효과는 매우 양호하였다. 5. 광식성누에의 섭식성은 어분 및 효모에 의해 영향받지 않았다. 6. 섭식저해물질인 brucin 및 salicine은 정도의 차는 있으나 광식성누에의 섭식성을 저해하였다. 7. 광식성 및 비광광성누에의 LP-1 인공사료에 대한 섭식성의 차이는 누에의 두부에 있는 감각기관의 형태적 차이 때문이 아니라 기능적 차이에 기인하는 것으로 추찰된다. 8. 광식성 육성소재창출은 광식성유전자의 도입육종에 의해 가능하다. 9. 실용 광식성 누에품종육성을 위해 광식성검정에 적합한 인공사료를 사용하고, 실용형질이 우수하면서도 광식성유전자를 가진 계통을 선발, 교잡 또는 계통육성법에 의해 실용형질 및 섭식성을 개량하여 육종 목표를 달성하는 것이 최선책으로 생각된다.

• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.326-333
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• 2009

Fourteen compounds were isolated from the 70% ethanol extract of Lonicera Caulis (Caprifoliaceae) and their structures were identified as seven aliphatic compounds [long-chain alcohols (1, 2), trilinolein (3), hexacosanol (4), fatty acids (6), 9,12,13-trihydroxyoctadeca-10(E),15(Z)-dienoic acid (10), and pinellic acid (11)] and seven phenolics [bis(2-ethylhexyl) phthalate (dioctylphthalate, DOP) (5), coniferaldehyde (7), caffeic acid docosanoyl ester (8), caffeic acid (9), coniferyl aldehyde 4-O-glucoside (12), linarin (13), and coniferin (14)]. The chemical structures of these compounds were identified on the basis of spectroscopic methods and comparison with literature values. All the compounds except for caffeic acid (9) were isolated from this plant parts for the first time.

• Natural Product Sciences
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• v.14 no.4
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• pp.281-288
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• 2008

From the MeOH extract of the whole plants of Lathyrus davidii (Fabaceae), thirteen constituents were isolated and identified as the flavonoids astragalin, isoquercitrin, nicotiflorin, and rutin, as the saponins soyasapogenol B 3-O-${\beta}$-D-glucuronopyranoside, azukisaponins II and V, soyasaponins II and V and as 4-O-${\beta}$-Dglucopyranosyl syringic acid, uracil and n-hexacosanol. Five saponins and 4-O-${\beta}$-D-glucopyranosyl syringic acid were isolated from the BuOH fraction as their methyl esters. Ombuoside (rutin 7,4'-di-O-methyl ether) was also isolated from the methylated BuOH-soluble fraction. However, no ombuoside was detected in the HPLC analysis of the nonmethylated BuOH fraction. Therefore, ombuoside is an artifact derived from methylation of rutin. All of these compounds were isolated for the first time from this plant.