• Information Systems Review
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• v.5 no.2
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• pp.241-256
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• 2003

This empirical study is to explain critical success factors for building effective regional IT cluster from the literature reviews which have some limitations, and is to suggest new key factors from the views of Regional Innovation System and Sectoral Systems of Innovation. For building successful cluster, the new key factors not only stress on regional networks, the spill-over of tacit knowledge through learning by interacting, institutions which contain regional custom, norms, established practices, culture, and characteristics from the Regional Innovation System, but also emphasize on heterogeneous agents who are interacting by each others from Sectoral Systems of Innovation. From these factors we suggest some strategies for building effective "Daegu IT Cluster" as following; making characterized IT brands which are selected and concentrated based on regional and IT sectoral characteristics, strengthening learning competence of tacit knowledge built in multiple heterogeneous agents network, establishing strong agent networks which are composed of universities, companies, institutes and government, and sharing the institution of mind-opening culture in order to correspond with environmental changes and link to other industrial clusters. By putting above strategies in force, the compatabilities of Daegu region are reinforced. Tacit knowledges spill over and the regional innovation competence are accumulated. Also IT cluster plays core role of employment in Daegu for long term. Especially, "Daegu IT Cluster" changes city's image from medium and small manufacturing city to new industrial city based on high technologies.

• Journal of KIISE:Software and Applications
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• v.34 no.9
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• pp.817-827
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• 2007

In the age of ubiquitous environment, huge number of devices and computing services are provided to users. Personalized service, which is modeled according to the character of each and every individual is of particular need. In order to provide various dynamic services according to user's movement, service unit and operating mode should be able to operate automatically with minimum user intervention. In this paper, we discuss the steps of offering approximate service based on user's request in ubiquitous environment. First, we present our simulator designed for modeling the physical resource and computing object in smart space - the infrastructure in ubiquitous. Second, intelligent agents, which we developed based on a FIPA specification compliant multi-agent framework will be discussed. These intelligent agents are developed for achieving the service goal through cooperation between distributed agents. Third, we propose an automated service discovery and composition method in heterogeneous environment using semantic message communication between agents, according to the movement by the user interacting with the service available in the smart space. Fourth, we provide personalized service through agent monitoring anytime, anywhere from user's profile information stored on handhold device. Therefore, our research provides high quality service more than general automated service operation.

• Journal of the Korea Computer Industry Society
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• v.4 no.12
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• pp.965-974
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• 2003

Today's network consists of a large number of routers and servers running a variety of applications. In this paper, we have designed and constructed the general simulation environment of network security model composed of multiple IDSs agent and a firewall agent which coordinate by CNP (Contract Net Protocol). The CNP, the methodology for efficient integration of computer systems on heterogeneous environment such as distributed systems, is essentially a collection of agents, which cooperate to resolve a problem. Command console in the CNP is a manager who controls the execution of agents or a contractee, who performs intrusion detection. In the knowledge-based network security model, each model of simulation environment is hierarchically designed by DEVS (Discrete Event system Specification) formalism. The purpose of this simulation is the application of rete pattern-matching algorithm speeding up the inference cycle phases of the intrusion detection expert system. we evaluate the characteristics and performance of CNP architecture with rete pattern-matching algorithm.

• The KIPS Transactions:PartD
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• v.10D no.2
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• pp.327-336
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• 2003

Recently the rapid growth of Internet and the construction of high speed networks make many kinds of multimedia services possible. But most of current multimedia services are designed being by client/server model, which incurs high load of central server. In order to solve this problem, we propose a peer-to-peer network-based discovery mechanism for multimedia services. In the proposed scheme, mobile agents that have autonomy and mobility are used to search the location of resources. Use of mobile agents can solve the loss problem of the search result that occurs when the network is unsettled in pure peer-to-peer network. It also supports interoperability in heterogeneous system environments. In the proposed scheme, each host maintains the location information of resources which are locally requested or recently requested by other hosts. So, the proposed scheme has faster response time than the pre-existing mechanisms in pure peer-to-peer network environments.

• Clinical and Experimental Pediatrics
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• v.51 no.11
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• pp.1140-1146
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• 2008

Nocturnal enuresis is a heterogeneous disorder with various underlying pathophysiological mechanisms and causes a mismatch between the nocturnal bladder capacity and the amount of urine produced during sleep at night. It is associated with a simultaneous failure of conscious arousal in response to the sensation of bladder fullness. Generally, a complete history and physical examination, with a specific focus on the genitourinary, gastrointestinal, and neurologic systems, is sufficient to evaluate a patient with enuresis. The therapeutic focus is directed toward a differential approach based on the underlying mechanism and toward combination therapies such as alarm devices and desmopressin as well as anticholinergic agents and desmopressin. Children with increased nocturnal urine production usually have a good response to desmopressin therapy. Patients with a small bladder generally show a poor response to desmopressin treatment, but they would benefit more from combination therapy with enuretic alarm, urotherapy, and antimuscarinic agents in addition to desmopressin. Different types of bladder dysfunction, which result in a small nocturnal bladder capacity, probably contribute significantly to the pathogenesis of nocturnal enuresis, particularly in those with treatment failure and refractory symptoms. Because different clinical subgroups may show different responses to treatment, it is necessary to distinguish these subgroups before a decision on the specific treatment protocol can be made.

• Korean Journal of Food Science and Technology
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• v.27 no.6
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• pp.972-977
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• 1995

The induction of phase II enzymes including quinone reductase [NAD(P)H dehydrogenase(quinone): NAD(P)H : (quinone acceptor) oxidoreductase, EC 1.6.99.2] is a major mechanism of whereby a large group of heterogeneous compounds prevent the toxic, mutagenic, and neoplastic effects of carcinogen. Using murine hepatoma cells(Hepalclc7 cells), quinone reductase(QR) inducers as the possible chemopreventive agents were screened from rice bran, wheat bran, soymilk residue, defatted soybean cake, defatted sesame and perilla residues. The 80% methanol extracts of defatted sesame and perilla residues induced quinone reductase significantly while the others did have little effect on the enzyme induction. Thin layer chromatography of the extracts showed that the fastest moving band(Rf=0.70) in the developing solvent of n-butanol : n-propanol : 2N ammonia(10 : 60 : 30) was responsible for the enzyme induction by the 80% methanol extracts of defatted sesame and perilla residues. Further identification of active component(s) is in progress.

• KIISE Transactions on Computing Practices
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• v.22 no.8
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• pp.393-398
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• 2016

Collective Adaptive System is an adaptive multi-agent system which accomplishes its goal by collaborating various agents. Because the collective property of the Collective Adaptive System is accomplished by the goal of the system being based on collaboration, testing the goal accomplishment and their interactions among heterogeneous agents is important. This paper presents a feasibility study of applying a model-based testing approach using task-based test model to a Collective Adaptive System. This paper describes additional information to be applied for Collective Adaptive System for future studies. To analyze our approach, we applied the proposed approach to a smart home system as a case study; our results indicated that we can systematically derive test cases to check whether the Collective Adaptive System successfully achieved its goals by modifying and extending the existing task model.

• Advances in robotics research
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• v.2 no.3
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• pp.201-217
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• 2018

Agriculture production is a critical human intensive task, which takes place in all regions of the world. The process to grow and harvest crops is labor intensive in many countries due to the lack of automation and advanced technology. Much of the difficult, dangerous and dirty labor of crop production can be automated with intelligent and robotic platforms. We propose an intelligent, agent-oriented robotic team, which can enable the process of harvesting, gathering and collecting crops and fruits, of many types, from agricultural fields. This paper describes a novel robotic organization enabling humans, robots and agents to work together for automation of gathering and collection functions. The focus of the research is a model, called HARMS, which can enable Humans, software Agents, Robots, Machines and Sensors to work together indistinguishably. With this model, any capability-based human-like organization can be conceived and modeled, such as in manufacturing or agriculture. In this research, we model, design and implement a technology application of knowledge-based robot-to-robot and human-to-robot collaboration for an agricultural gathering and collection function. The gathering and collection functions were chosen as they are some of the most labor intensive and least automated processes in the process acquisition of agricultural products. The use of robotic organizations can reduce human labor and increase efficiency allowing people to focus on higher level tasks and minimizing the backbreaking tasks of agricultural production in the future. In this work, the HARMS model was applied to three different robotic instances and an integrated test was completed with satisfactory results that show the basic promise of this research.

• Molecules and Cells
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• v.46 no.6
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• pp.387-398
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• 2023

Microtubule acetylation has been proposed as a marker of highly heterogeneous and aggressive triple-negative breast cancer (TNBC). The novel microtubule acetylation inhibitors GM-90257 and GM-90631 (GM compounds) cause TNBC cancer cell death but the underlying mechanisms are currently unknown. In this study, we demonstrated that GM compounds function as anti-TNBC agents through activation of the JNK/AP-1 pathway. RNA-seq and biochemical analyses of GM compound-treated cells revealed that c-Jun N-terminal kinase (JNK) and members of its downstream signaling pathway are potential targets for GM compounds. Mechanistically, JNK activation by GM compounds induced an increase in c-Jun phosphorylation and c-Fos protein levels, thereby activating the activator protein-1 (AP-1) transcription factor. Notably, direct suppression of JNK with a pharmacological inhibitor alleviated Bcl2 reduction and cell death caused by GM compounds. TNBC cell death and mitotic arrest were induced by GM compounds through AP-1 activation in vitro. These results were reproduced in vivo, validating the significance of microtubule acetylation/JNK/AP-1 axis activation in the anti-cancer activity of GM compounds. Moreover, GM compounds significantly attenuated tumor growth, metastasis, and cancer-related death in mice, demonstrating strong potential as therapeutic agents for TNBC.

• Journal of KIISE:Computing Practices and Letters
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• v.13 no.1
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• pp.59-73
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• 2007

Although there exist many middlewares such as Havi, Jini, LonWorks, UPnP, and SLP, new middlewares specialized for diverse information appliances are expected to appear continuously as home networks evolve. In this paper, we examine an integrated architecture for supporting interoperability among heterogeneous middlewares under home network, we also propose and implement a scenario-based user-oriented integrated architecture for efficient home automation which is different from existing methods. HOMI(Homenetwork Middleware for Interoperability) architecture proposed in this paper provides interfaces that assist users with designing and modifying desirable scenarios using a script interpreter language HOMIL(HOMI Language). Different from an existing integrated middleware architecture, HOMI improves efficiency and convenience of interoperation between heterogeneous appliances for home automation allowing users to design and organize scenarios through these interfaces. HOMI classifies interoperation services into time contort, synchronization context, and asynchronization context and helps to execute next services considering contexts when a specific event occurs. Applying modified scenarios immediately to home network environment, HOMI provides users with seamless services without installing new applications, updating the server, or rebooting in order to adopt new scenarios. Lastly, distribution agents into several devices, we solved the overhead problem occurred in a centralized architecture for integrated middleware.