• Food Science and Biotechnology
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• 제14권3호
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• pp.323-327
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• 2005

The effects of commercial marinades were evaluated for their influence on heterocyclic aromatic amine (HAA) formation and overall mutagenicity in fried beef steaks. Three different commercial marinades A, B, and C tested individually reduced the total HAA formation in fried beef steaks by 44, 38, and 40%, respectively. Three different commercial marinades were also effective in reducing the overall mutagenicity in fried beef steaks. There was, however, no significant difference in the inhibition achieved with three different commercial marinades. Reduction of overall mutagenicity was related to the decrease in HAA formation in fried beef steaks.

• Bulletin of the Korean Chemical Society
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• 제18권5호
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• pp.484-488
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• 1997

The angular and planar heterocyclic compounds containing nitrogen, sulfur and oxygen were synthesized by reaction of 6,7-dichloro-5,8-quinoxalinedione with aromatic and aliphatic dinucleophiles. Nucleophilic reactivity was somewhat different between 2,3-dichloro-1,4-naphthoquinone and 6,7-dichloro-5,8-quinolinedione with dinucleophiles. The distribution of electron in heterocycle appeared to contribute to this difference. The intercalation comple of planar heterocyclic compound between GC/GC base pairs showed the optimum intercalation but the intercalation of angular heterocyclic compound was not good. Thus, the planar compound was expected to have antitumor activity.

• 한국축산식품학회지
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• 제31권4호
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• pp.563-569
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• 2011

일상 생활에서 섭취하는 가열한 생선, 육류 등의 고단백질 식품에서는 돌연변이원, 발암가능성 물질인 heterocyclic amine류가 생성된다. 안전성 측면을 고려하고자 백련 잎을 이용한 마리네이드 소스를 첨가하여 쇠고기의 HCAs의 형성억제효과와 돌연변이원성 억제효과를 알아보았다. Ames assay 결과 백련 잎 butanol fraction을 2.0 g 첨가하여 가열한 쇠고기 스테이크에서 61.5%로 높은 돌연변이원성 억제효과를 나타내었지만 용매 별 fraction 첨가군 사이에서는 유의적인 차이를 나타내지 않았다. 가열 전 쇠고기 마리네이드 소스에 식용이 가능한 백련잎 water fraction(2.0, 4.0, 8.0 g)을 첨가한 후 $190^{\circ}C$에서 가열한 결과 MeIQx(2-amino-3,8 dimethylimidazo[4,5-f]-quinoxalin)는 30.9-63.5%, PhIP(2-amino-1-methyl-6-pheny-limidazo[4,5-b]-pyridine)는 31.6-60.7% 억제되었다. $225^{\circ}C$에서의 가열된 쇠고기에서는 MeIQx가 38.1-65.3%, DiMeIQx (2-amino-3,4,8 trimethylimidazo[4,5-f]-quinoxaline)는 36.8-73.9%, PhIP는 33.9- 67.6%의 억제효과를 보였다. 따라서 백련 잎 추출물은 heterocyclic amine류 형성과 돌연변이 원성을 억제하는 효과가 있는 것으로 나타나 고단백질 식품 섭취시 안전성 측면에서 긍정적인 영향을 미칠 것으로 판단된다.

• Bulletin of the Korean Chemical Society
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• 제33권5호
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• pp.1794-1796
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• 2012

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3430-3432
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• 2012

• 대한화학회지
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• 제52권5호
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• pp.511-514
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• 2008

• Bulletin of the Korean Chemical Society
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• 제28권10호
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• pp.1877-1880
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• 2007

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.100-100
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• 2002

2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a heterocyclic amine, significantly inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophages. The decrease in NO production was found to correlate well with a decrease in iNOS mRNA expression as demonstrated by Northern blot analysis.(omitted)

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 1998년도 가을 학술발표회논문집
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• pp.37-40
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• 1998

Aromatic polybenzoxazoles have been known since 1964 as a class of aromatic heterocyclic polymers that exhibit excellent thermal stability. Polyhydroxyamides (PHA), precursor polymers to PBO, can cyclize to farm stable heterocyclic polymers with the simultaneous release of small molecules, which can be expected to act as a fire quencher. (omitted)

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.116-116
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• 1993

전 세계적으로 문제가 되고 있는 질병인 AIDS의 원인 virus인 HIV에 활성이 있는 nucleoside 유도체를 개발하기 위해, 일반적으로 HIV에 활성이 있는 3'-deoxythymidine 유도체의 일종으로써 3'-위치에 hydroxy기 대신에 heterocyclic thio기가 치환된 3'-deoxy-3' -(pyrimidin-2-yl)thio thymidine 및 3'-deoxy-3'-(1-methyltetrazol-5-yl) thiothymidine을 thymidine을 출발물질로 각각 합성하였다. 그러나 이 두 화합물은 항 HIV-1 (CEM cell line)에 대하여 활성이 없었다.