• Herbal Formula Science
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• v.13 no.2
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• pp.125-140
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• 2005

This report describes 48 studies related to the use of Bulbus Fritillariae main blended prescriptions from Donguibogam. The following conclusions were reached through investigations on the prescriptions that use Bulbus Fritillariae as a key ingredient. All kinds of infection in a cough and the malignant tumor recorded the largest number of clinical frequency of the prescriptions in therapeutic use when Bulbus Fritillariae was taken as a principle medicine. The Prescriptions are compounded with Bulbus Fritillariae as a principle medicine can aplly to respiratory disease, eye disease, nose and ear disease, throat disease, a boil. Various pathogenic factors such as consumptive disease, phlegm, phlegm-fire, invasion by wind, affective by cold, fire, dyspepsia-fire are put to practical use. The dosage of Bulbus Fritillariae is 5 bun (about 1.88g) to 1 lyang(about 37.5g), however 1 jeon(about 3.75g) has been taken the most for clinical application. With examination the formulae of presciptions containing Bulbus Fritillariae, I found the basic prescriptions as well as the medicines are in conjunction with Bulbus Fritillariae and the theoretic grounds of formula in combining Bulbus Fritillariae as a group of medicine for presciption through this reseach.

• Herbal Formula Science
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• v.28 no.2
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• pp.211-242
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• 2020

Objectives : This report describes 142 prescriptions related to the use of Astragalus mainly blended from Dongeuibogam. Methods : The following conclusions were drawn through investigations on the pre-scriptions that use Astragalus as a key component. Results : Prescriptions that Radix Aconiti Lateralis Preparata was taken as a monarch drug are utilized for 31 therapeutic purposes, for example, cold disease, stool disease, child disease. In particular, 17.3% of prescriptions appear in the chapter of cold. Prescriptions that utilize Radix Aconiti Lateralis Preparata as the main component are used in the treatment of cold, diarrhea and child disease, Bi syndrome due to pathogenic wind, cold and damp and they are also used for treating 55 different types of disease. Radix Aconiti Lateralis Preparata is used in pathogenic factors such as wind, cold and dampness and used in pathology related to the kidney and spleen and stomach system. The dosage of Radix Aconiti Lateralis Preparata is 2pun(about 0.75g) to 5don(about 18.8g), however 1don(about 3.75g)~1don 5pun(about 5.63g) has been taken the most for clinical application. Conclusions : Gangbutang and Ijungtang are the most useful base prescriptions which use the Radix Aconiti Lateralis Preparata as the main ingredient.

• The Korea Journal of Herbology
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• v.21 no.4
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• pp.1-10
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• 2006

Objectives : Recently, the total medical expenses of the korean oriental medical service in national health insurance is on the increase every year. Herbal medicines are one of the major methods of the medical treatment. But the expenses of these herbal preparations that can receive benefits from insurance system are decreasing. Methods : In this research, we obtained statistical data of the benefit states of herbal preparations in herbal heath insurance during year 2001-2003 from Health Insurance Review Agency. We analyzed top twenty main diseases in herbal health insurance and mainly used prescription in these diseases. Results : There were wide differences in the application of prescriptions among diseases. For example, musculoskeletal diseases occupied an important position and Ojucksan took more than 50 percentage. Conclusion : We hope that this study could be a basic data for improving the benefit system of herbal health insurance and further studies should be carried out subsequently.

• Herbal Formula Science
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• v.15 no.2
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• pp.47-64
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• 2007

This report describes 94 prescriptions related to the use of Radix Angelicae Dahuricae main bl ended from Donguibogam. The following conclusions were reached through investigations on the prescriptions that use Radix Angelicae Dahuricae as a key component. 11.7% of wind. 10.6% of carbuncle and deep-rooted carbuncle. recorded the largest number of clinical frequency of the prescriptions in therapeutic use when Radix Angelicae Dahuricae was ta ken as a monarch drug in prescriptions, Prescriptions that utilize Radix Angelicae Dahuricae as t he main component are used in the treatment of apoplexy and carbuncle and deep-rooted carbuncle. headache. wound and they are also used for treating 26 different types of diseases. The prescriptions are compounded with Radix Angelicae Dahuricae as a monarch drug can ap ply to apoplexy, exogenous febrile disease, invasion by wind. wind-cold pathogen, wind-heat path ogen. epidemic disease, pestilence. bruise, bites, deficiency of liver and kidney, deficiency, phlegm-fire, phlegm-heat. The dosage of Radix Angelicae Dahuricae is 0.37g to 7.5g, however 3.75g has be en taken the most for clinical application. The function of Radix Angelicae Dahuricae is to expelling Wind and relieving pain, to expelling wound and forming muscle. to astrict and neutralizing poison. to expelling wind and to getting through body hole. to emit and relieving pain from the combination of drugs and prescriptions.

• Herbal Formula Science
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• v.20 no.2
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• pp.117-136
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• 2012

This thesis is the study on GuiLinGuBen "ShangHanZaBingLun"'s prescriptions which are totally 324, and unique 91 which are not written in current "ShangHanZaBingLun" and "JinKuiYaoLue", only in GuiLinGuBen "ShangHanZaBingLun". For modern clinacal effectiveness of GuiLinGuBen "ShangHanZaBingLun", this thesis clarifies the prescriptions' distinction between GuiLinGuBen, "ShangHanZaBingLun" and "JinKuiYaoLue". First it classifies prescriptions into 4 groups, which are only in GuiLinGuBen, in "ShangHanZaBingLun", in "JinKuiYaoLue", and in both "ShangHanZaBingLun" and "JinKuiYaoLue". Second it tabulates and describes in detail GuiLinGuBen's prescriptions about title, prescription composition, prescription volumetrin, decotion, and dosage. Third it catches distinctive characteristic of GuiLinGuBen's prescriptions by a comparative study which clarifies the differences of prescriptions between GuiLinGuBen, "ShangHanZaBingLun" and "JinKuiYaoLue". Current "ShangHanZaBingLun" and "JinKuiYaoLue"'s remedy focus on Shanghan and Jabbyong, so it has no choice but to have large remedy vaccum. The prescriptions only in GuiLinGuBen have same system with "ShangHanZaBingLun" and "JinKuiYaoLue"'s prescriptions, and contain unique Fever remover(淸熱劑) and Counterbalancer (補劑), so they could give more clinacal practice over "ShangHanZaBingLun" and "JinKuiYaoLue".

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1646-1654
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• 2007

The aim of this study was to investigate the effects of several herbal prescriptions in patients with allergy or atopic disease, such as atopic dermatitis, asthma and allergy rhinitis and others, on the blood immunological parameters and to verify the safety of long-term use of herbal medicine. Eighty one patients with allergy or atopy disease who taken herbal medicine at least for 2 months were compared with patients who taken same medicine with no allergy & atopy disease (n=14) and normal healthy subjects (n=22). According to the comparison of immunological parameters change, the data showed that herbal medicine decreased IgE (P=0.003), Eosinophil ratio (P<0.001) and count (P<0.001) of White Blood Cell (WBC) and did not affect to the liver cell enzymes in blood. This results indicated that herbal medicine decreased immune hypersensitivity and improved chronic inflammation related to blood immunological parameters of allergy or atopy diseases. In addition, herbal medicine seemed to be safe to the liver function for long-term use.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.4
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• pp.29-40
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• 2014

Objectives This study was designed to collect basic information about the herbal medicine used for dementia through analysis on Korean medicine prescriptions used in dissertations for a degree of Korean medicine related dementia (experimental study). Methods We searched dissertations in the National Assembly Library and oriental medicine advanced searching integrated system web DB by using keyword '치매' and 'dementia'. We reviewed and analyzed dissertations for the degree of Korean medicine, published from 2000 to 2013. Results As a result, We found 36 dissertations about Korean herbal medicines used for Dementia Yukmijihwang-tang, Chenwangbosim-dan were used much more than other prescriptions and Panax ginseng, Glycyrrhiza uralensis, Acorus gramineus, Polygala tenuifolia, Pachyma hoelen were used more than 10 times in these dissertations. Conclusions In relieving symptoms and the treatment of dementia, it is difficult to find tendency. Because the purpose and perspective of using each Korean medicine prescriptions and their herbs are various. However, as referred to outcome of preceding researches, Yukmijihwang-tang is considered as a potential dementia medicine.

• The Korea Journal of Herbology
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• v.39 no.2
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• pp.11-18
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• 2024

Objectives : High blood pressure (also called Hypertension), which is the blood pressure that is higher than normal, is a chronic disease and causes various complications. Historically, Traditional Herbal Prescriptions (THP) have treated many diseases. However, there are not many studies on the treatment of hypertension with THP, very few studies have investigated the interactions between the co-administration of synthetic anti-hypertensives and THP. Therefore, the objective of the present study was to investigate the vasorelaxant activities of 10 THP in rat thoracic aortas pre-contracted with potassium chloride (KCl). Methods : An electric extractor was used to extract THP in distilled water for 2h. Rat thoracic aortas were isolated and pre-contracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. THP extracts were added in increasing concentrations (10-1000 ㎍/mL) to investigate vasorelaxant activities. The vasorelaxant activities induced by THP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 THP, Dangguisu-san, Mahwang-tang, Bulwhangeumjeonggi-san, Jakyakgamcho-tang, and Hyangsapyeongwi-san showed significant vasorelaxant activities. Maekmundong-tang, Bojungikgi-tang, Samryeongbaekchul-san, Yukmijihwang-tang, and Insampaedok-san showed no significant effect. Also, in co-administration with amlodipine, Mahwang-tang showed higher vasorelaxant activities than amlodipine alone, and Hyangsapyeongwi-san showed greater vasorelaxant activities at low concentrations but inhibited amlodipine's vasorelaxant activities at high concentrations. Conclusion : The results of these experiments are expected to provide useful data to establish guidelines for THPs and co-administration with western antihypertensive drugs to treat hypertension.

• The Journal of Korean Medical History
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• v.31 no.1
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• pp.105-122
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• 2018

Most of the prescriptions currently used by Korean medicine institutions to treat patients are delivered in the form of decoctions. The author reviewed the five-viscera section (五臟門) of Euibangyoochui (醫方類聚), which is composed of theory, medicinals, diet, taboo, acupuncture and moxibustion, and exercises. The medicinals cover a total of 1,144 prescriptions cited from 14 medical books, and provides a wide range of prescriptions and delivery options, including decoctions, powders and pills. Of the 1,144 prescriptions, the author notes that among them, 577 prescriptions which use powders (41%) are the most popular; 444 are pills (31%) and are the second most popular; 329 decoctions (23%) are the third most popular, and 64 other prescriptions are 5 percent. Expanding treatment options and delivery of medicinal prescriptions presented in the five-viscera section (五臟門) of Euibangyoochui (醫方類聚), is beneficial to both patients and doctors. The author suggests that expansion of herbal treatment options will provide opportunities to overcome current treatment limitations in the Korean medical service industry.

• Journal of Sasang Constitutional Medicine
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• v.35 no.4
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• pp.10-22
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• 2023

Objectives The aim of this study is to explore the mechanism of action and target diseases of Sasang constitutional prescriptions using a multiscale interactome approach. Methods The compound and target information of Sasang constitutional prescriptions were retrieved from various databases such as the TM-MC, STITCH, and TTD. Key targets for Sasang constitutional prescriptions were identified by selecting the top 100 targets based on the number of simple paths within the constructed network. Diffusion profiles for Sasang constitutional prescriptions and diseases were calculated based on a biased random walk algorithm. Potential diseases and key mechanisms of Sasang constitutional prescriptions were identified by analyzing diffusion profiles. Results We identified 144 Sasang constitutional prescriptions and their targets, finding 80 herbs with effective biological targets. A cluster analysis based on selecting up to 100 key targets for each prescription revealed a more cohesive grouping of prescriptions according to Sasang constitution. We then predicted potential diseases for 62 Sasang constitutional prescriptions using diffusion profiles calculated on a multiscale interactome. Finally, our analysis of diffusion profiles revealed key targets and biological functions of prescriptions in obesity and diabetes. Conclusions This study demonstrates the effectiveness of a multiscale interactome approach in elucidating the complex mechanisms and potential therapeutic applications of prescriptions in Sasang constitutional medicine.