• Journal of Society of Preventive Korean Medicine
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• v.27 no.1
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• pp.1-16
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• 2023

Objective : To investigate syndrome identification, herbal prescriptions, acupuncture point and other treatment, this study systematically reviewed case studies on Korean medicine (KM) treatment for urticaria. Method : Literature searches were performed on four Korean database; OASIS, RISS, KTKP and NDSL. Studies published before December 2022 were categorized and analyzed according to the herbal prescriptions. Results : Thirty-three studies including 16 case series and 17 single case reports were included in our review and the total number of patients was 523. Ancient prescriptions (古方) were used in 7 studies and prescriptions of Sasang constitutions were used in 8 studies and 18 studies used prescriptions of posterity (後世方). Wind-Heat (風熱) and syndrome identifications associated with digestive function were used frequently. Nineteen studies used acupuncture combined with herbal medicine and mainly used acupoints were ST36 (足三里), LI4 (合谷), LI11 (曲池), LR3 (太衝), SP6 (三陰交), CV12 (中脘), SP10 (血海). External herbal medicine was used in only 3 studies. Conclusion : To increase the cure rate of KM, various prescriptions should be used according to the symptom and stage of urticaria. Diversification of herbal formulations and the development of new external medicines are also necessary to conduct additional clinical studies with a high level of evidence.

• Herbal Formula Science
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• v.15 no.1
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• pp.117-128
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• 2007

We re-classified traditional medicinal prescriptions in Dong-Eui-Bo-Gam for the modern application using Tradimed database. They could be devided into 6 categories by the definitions of the related laws. Herbal ethical drugs are the majority, 3926 items, account for 60.21% of total items. Herbal Health Functional Foods stands second, 1480 items, 22.70%, Herbal over the counter drugs are 893 items, 13.69%. These three categories are about 83% of total items. Herbal medical supplies are 158 items, 2.42%, Herbal medical tools are 44 items, 0.67%, Herbal cosmetics are 20 items, occupied 0.31 %. Therefore we have known that traditional medicinal prescriptions can be used not only as drugs, but also as funtional foods, cosmetics, and tools. So they should be developed as modern products to make best use of them. And we suggested that we need official criteria of herbs of careful use and higher standards for herbs which can be used as foods.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.2
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• pp.40-51
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• 2022

Objective This study identified useful herbal medicines and prescriptions for obesity treatment by analyzing herbal medicines and prescriptions that showed meaningful results in weight loss by changing the gut microbiota. Methods Using PubMed, we selected and studied 23 papers showing meaningful results on weight loss through changes in the gut microbiota using herbal medicines. Result Of the 23 selected papers, 17 were of studies using herbal medicines, and 6 of studies using prescriptions. Pomegranate peel, Flos Lonicera, Rehmannia glutinosa, Rhein, Coix seed, Platycodon grandiflorus, mulberry leaves, Poria cocos, asperuloside, Bupleuri radix, Astragalus polysaccharides, Ephedra sinica, Ganoderma lucidum, Hirsutella sinensis, Caulis spatholobi, aconite, and Bletilla striata were used as herbal medicine. Linggui zhugan-tang, Bofutsushosan, Shenling baizhu powder, Chowiseungcheng-tang, Daesiho-tang, and Yijin-tang were used as prescription. Conclusion Seventeen herbal medicines and six prescriptions associated with meaningful results in weight loss through changes in the gut microbiota, suggest the possibility of treatment and prevention of obesity through herbal medicine.

• Herbal Formula Science
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• v.9 no.1
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• pp.207-214
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• 2001

For the purpose of developing KOREA herbalogy and prescription therapeutics I study the prescriptions among the DONG-UE-BO-GAM. The conclusions are as fallows; 1. There were total 97 prescriptions contended the Bupleurum as gunyak among the DONG-UE-BO-GAM. 2. The currental prescriptions contended the Bupleurum as gunyak were HAN period :1 disease 1 prescription, SONG period :6 diseases 6 prescriptions, GUEM and WON period: 14 diseases 23 prescriptions, MYONG period: 30 diseases 63 prescriptions. 3. The most high frequency of currental effect of the Bupleurum were HAN period: sang-han(傷寒), GUEM and WON period: hak(?), sang-han(傷寒) and gol-gueng-yel(骨蒸熱), MYONG period: sang-han(傷寒), hak(?), on-yek(溫疫), juek-chui(積聚) and an(眼). 4. The most high frequency effect of the Bupleurum as gunyak were sang-han(傷寒): 15 prescriptions, hak(?): 12 prescriptions, on-yek(溫疫) 7 prescriptions etc.

• The Journal of Korean Medicine
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• v.34 no.2
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• pp.20-28
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• 2013

Objectives: This study examined the effects of 8 types of herbal prescriptions prescribed to alleviate dementia symptoms in a rat model of arterial thrombosis induced by ferric chloride ($FeCl_3$). Methods: Thirty minutes before 35% $FeCl_3$ treatment, SD rats were intraperitoneally injected with the 8 types of herbal prescriptions, respectively. We tested the effects of the herbal prescriptions on time to occlusion (TTO) in an arterial thrombosis model using a laser Doppler flow meter. In addition, thrombus weight (TW) and collagen fiber damages were evaluated in the same condition. Results: Herbal prescriptions showed the following rank-order based on their TTO: Chong-myung-tang (CMT) > modified Jangwonhan 02 (LMK02) > Toki-shakuyaku-san (TSS) ${\geq}$ Oren-gedoku-to (OGT) ${\geq}$ Yokukansan (YKS). In particular, CMT (100 mg/kg, i.p.) and LMK02 (100 mg/kg, i.p.) delayed the TTO the most ($14.83{\pm}0.98$ and $13.67{\pm}1.03$ min, respectively) compared with the vehicle group ($7.95{\pm}0.78$ min, P<0.001). In addition, CMT, LMK02, and OGT treatment ($0.63{\pm}0.01$, $0.66{\pm}0.02$ and $0.67{\pm}0.01$ mg/mm, respectively) significantly reduced thrombus weight compared with the vehicle treatment ($0.78{\pm}0.03$, P<0.001) and also alleviated collagen fiber damage (CMT; $28.40{\pm}2.22$%, LMK02; $30.79 {\pm} 4.07$%, OGT; $26.20{\pm}1.48$%) in the vessels injured by $FeCl_3$. Therefore, CMT and LMK02 showed the greatest preventive activity in rat model of arterial thrombosis induced by $FeCl_3$. Conclusions: These results provide experimental evidence for traditional use of herbal prescriptions, suggesting that CMT and LMK02 extracts could be used to prevent vascular injury and thrombosis in the early stages of dementia.

• Journal of Society of Preventive Korean Medicine
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• v.11 no.2
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• pp.87-99
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• 2007

Background : Most traditional Korean doctors use "Packed Herbal Medicine", which is made from boiling various herbs together. However, the current insurance system doesn't cover the act of making packed herbal medicine. Therefore it is urgent for these doctors to study and find the best and most logical insurance program to cover the Packed Herbal Medicine system. Objectives : The purposes of this study were to investigate whether Announced System of Herb Price is proper for stability of medical herbs's price. Methods : This study made these following results by studying medical herbs's price of KOMD(The korea oriental medicine distribution company) from 2004 March to 2007 March The results are summarized as follows ; The 50 most frequently used herbs were chosen from the 831 standard prescriptions according to 26 pre-determined specific diseases. These prescriptions are considered the most important for this study and insurance purposes. fluctuations of fifty medical herbs which were used much about a predetermined list of 831 prescriptions are multiple function not linear equation. fluctuations of fifty medical herbs which were used much about a predetermined list of 831 prescriptions are different according to time. Therefore, to notify medical herbs's price is valid method for stability of medical herbs's price.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.2
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• pp.38-52
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• 2021

Objectives : The purpose of this study is to analyze the use of insured herbal extracts and Korean medicinal treatments, which are mainly used to treat allergic rhinitis in Korean medicine. Methods : Among all HIRA(Health Insurance Review and Assessment Service) claims data in 2016, we included all statements that included J30(vasomotor and allergic rhinitis) or a subcategory of J30(J30.0, J30.1, J30.2, J30.3, or J30.4) as the main disease, using the Korean Standard Classification of Diseases(KCD-7). This study analyzed the most frequently used insured herbal extracts and Korean medicinal treatments for allergic rhinitis in Korean medicine. We performed a frequency analysis on subgroups based on treatment type(inpatient or outpatient), sex, age, insurance type, and medical institution type. Results : The result shows the 10 most frequently used insured herbal extracts and Korean medicinal treatments for allergic rhinitis. The total number of insured herbal extracts prescriptions was 82,533, and the most commonly prescribed insured herbal extracts was socheongryong-tang(35,131 prescriptions), followed by hyeonggaeyeongyo-tang(18,157 prescriptions), samsoeum(6,257 prescriptions), and galgeun-tang(4,465 prescriptions). The total number of Korean medicinal treatments prescriptions was 1,878,541, of which the most common Korean medicinal treatments was acupuncture(922,977 prescriptions), followed by moxibustion(372,120 prescriptions), cupping(242,094 prescriptions), and segmental acupuncture(161,553 prescriptions). Conclusions : It is expected that the results of this study can be used as a basis for establishing the priorities of evidence-based clinical research topics in the field of Korean medicine and making health care policy decisions to strengthen coverage in the future.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.2
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• pp.56-63
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• 2021

This study was conducted to find a candidate prescription with anti-inflammatory efficacy of 7 herbal prescriptions known to be effective in atopic dermatitis and sleep disorders in Korean medicine. The anti-inflammatory of the 7 herbal prescriptions extracts were evaluated by ELISA assay and Western blot assay. 7 herbal prescriptions, Seongyutang(SU), Danseontoetang(DST), Sotosajahwan(ST), Jisiljagyagsan(JJ), Seokchangpo(SCP), Wiryeongseon(WLS), Gogojohwan(GGJ) 30 % EtoH extract was used for in vitro experiments. In TNF-α + IFN-γ(TI) stimulated HaCaT cells, all 7 herbal prescriptions reduced TARC and MDC production, and JJ strongly reduced TARC and MDC production at 100 ㎍/ml concentration. SCP strongly reduced MDC production at 10 ㎍/ml and 100 ㎍/ml concentration. In addition, in substance P(SP)/CRH stimulated HMC-1 cells, JJ strongly inhibited VEGF production at both 10 and 100 ㎍/ml concentrations. In LPS/CRH stimulated Raw264.7 cells, all 7 herbal prescriptions significantly inhibited TNF-α. PMA + Ionomycin(PI)/CRH stimulated EL4 cells, SU significantly reduced IL-4 production at both concentrations of 10 and 100 ㎍/ml. WLS significantly reduced IL-17 production at both concentrations of 10 and 100㎍/ml. This suggests that 7 herbal prescriptions have anti-inflammatory effects by reducing inflammatory cytokines in keratinocytes, mast cells and macrophages caused by inflammation. Therefore, it is expected that 7 herbal prescriptions that are effective for sleep disorders and atopic dermatitis can be used as therapeutic materials for sleep disorders and diseases associated with atopic dermatitis.

• Herbal Formula Science
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• v.10 no.1
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• pp.41-55
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• 2002

There are total 403 prescriptions containing Radix Scutellariae in Donguibogam and among them, 106 prescriptions treat Radix Scutellariae as a principal medicine. This report describes the study on therapeutic range, symptom, pathology and composition of 106 Radix Scutellariae-main blended Prescriptions from Donguibogam. The frequency and percentage of Radix Scutellariae-main blended prescriptions for the therapeutic range are as follows; cold symptom-complex is the most frequent(11 prescriptions, 10.37%) and gynecology is second(10 prescriptions, 9.43%). The symptoms that Radix Scutellariae-main blended prescriptions are made out for are 70 prescriptions of 28 therapeutic ranges, for example, minor Eum physical appearance, fire of triple burners jaundice, etc. The main pathologies that Radix Scutellariae-main blended prescriptions are being affected by cold, fire triple burners, dampness and heat, wind and heat, heat of heart and lung, heat of liver, heat of spleen, etc. Through the research into the composition of Radix Scutellariae-main blended prescriptions, the kind of medicines and certain rules of compounding medicines centering on Radix Scutellariae are deduced as follows: The main combinations of herbal medicines are Radix Scutellariae and Fructus Gardeniae, Radix Scutellariae and Rhizona Rhei, and Radix Scutellariae, Rhizona coptidis and Fructus Gardeniae. The main combinations of prescriptions are Yihwanghwan(Radix Scutellariae, Rhizoma Cotidis, Radix Glycyrrhizae), Boanbaekchulsan(Radix Scutellariae. Rhizoma Atractylodis macrocephalae), Sambohwan(Radix Scutellariae, Rhizoma Cotidis, Cortex Phellodendrj), Samhwangwon(Radix Scutellariae, Rhizoma Cotidis, Rhizoma Rhei), Hwangryeonhaedoktang(Radix Scutellariae, Cortex Phellodendri, Rhizoma Cotidis. Fructus Gardeniae), Daegumhwahwan(Radix Scutellariae, Rhizoma Cotidis, Cortex Phellodendri. Rhizoma Rhei). Sanyeolumja(Radix Scutellariae. Rhizoma Cotidis. Radix Osterici koreani. Radix Ledebouriellae), etc.

• Herbal Formula Science
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• v.17 no.1
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• pp.1-16
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• 2009

This report describes the studies as follows through the research of Basic-prescriptions about 123 prescriptions in high-chepter(上統) from Bang-Yak-Hap-Pyun(方藥合編). There are 24 Basic-prescriptions including Sagunja-tang(四君子湯), Samul-tang(四物湯), Sogeonjung-tang(小建中湯), lijung-tang(理中湯), Dangguibohyul-tang(當歸補血湯), Yijin-tang(二陳湯), Gauwon-chun(擧元煎), Jeongweon-eum(貞元飮), and Yukmichiwhang-won(六味地黃元), etc. about 123 prescriptions in high-chepter(上統) from Bang-Yak-Hap-Pyun(方藥合編). There were many cases compounding the Basic-prescriptions each other. So I investigated those cases. The results were the other typed (blended) Basic-prescriptions including Palmul-tang(八物湯), Sipjeondaebo-tang(十全大補湯), Yukgunja-tang(六君子湯), Bojungyikkee-tang(補中益氣湯), SsangHwa-tang(雙和湯), and Gwibitang(歸脾湯). And I investigated about pathologies in connection with these Basic-prescriptions. Oriental Medical Pathology applied with these Basic-prescriptions were Giheo(氣虛), hyulheo(血虛), Gihyulguheo(氣血俱虛), Biheohan(脾虛寒), Giheo-dameum(氣虛痰飮), Giheohaham(氣虛下陷), Sineumheo(腎陰虛), etc. These results indicated that 123 prescriptions in high-chepter from Bang-Yak-Hap-Pyun are composed of Bojei(補劑) to treatment against many kinds of Infirmity and promote physiological function.