• The Journal of Korean Medicine
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• v.30 no.5
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• pp.42-49
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• 2009

Objectives: To summarize and make a reference number of herbal plant-derived antioxidant researches worldwide. Methods: We surveyed all papers of antioxidant-focused studies using plants in PubMed database as "herbal plant AND antioxidant" of Default Tag "Title". The type of materials used in the studies, formation of experiments, frequency of herbal plants studied and their actions, and main study subjects were analyzed. Results: The number of studies on herbal plant-related antioxidant effects have increased worldwide since 2000. Studies have been performed using mainly single plant and single compounds for medical disorders such as immunity, heart/blood, liver, and central nerve functions. The list of plants frequently includes SalviamiltiorrhizaBge.,GinkgobilobaL., ScutellabaicalensisGeorgi.,and so on. Most of these plants have strong effects against oxidative stress and also against free radicals and increase the activities of antioxidant enzymes. Conclusion: This study produced an overview of previous research on antioxidant-focused herbal plants. This result will provide useful information for the field of Korean traditional medicine for the development of drugs related to antioxidants.

• Journal of Acupuncture Research
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• v.31 no.1
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• pp.139-148
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• 2014

Objectives : The aim of this study was to review the effect of herbal medicine on hair growth in animal models reported in Korean domestic journals. Methods : Korean core databases were searched with terms alopecia and hair, and animal study reports on hair growth with herbal medicine were reviewed. Animal model, intervention, and hair growth measure data were extracted. Results : A total of 28 reports were reviewed. C57BL/6 mice with depilation was the most frequent animal models used. Polygoni multiflori radix, Cnidii rhizoma and Biotae Folium were frequently used herbal medicine. Positive effects were reported. Conclusions : Herbal medicines may be promising resource for pharmacopuncture materials for positive effects on hair growth.

• The Journal of Korean Medicine
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• v.31 no.4
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• pp.9-19
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• 2010

Objective: To compare the contents and transfer rate of hazardous substances in crude, washing solution, crude after washing, decoction and remnant after boiling. Methods: The heavy metal contents of each step were measured by inductively coupled plasma mass spectrometer (ICP-MS) and mercury analyzer (SP-3DS). In order to analyze pesticides in each sample we used simultaneous multi-residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide ($SO_2$) were performed by Monier-Williams distillation method. Results: 1. Contents (mg/kg) of heavy metals were not detected in decoctions of any tested herbal medicine prescriptions. 2. Transfer rates (%) of heavy metals from crude to remnant were as follows: Yijin-tang (As: 46.9, Cd: 50.0 and Pb: 100.0), Oryung-san (As: 80.0, Cd: 100.0 and Pb: 73.8), Hwangryunhaedok-tang (As: 88.9, Cd: 71.4 and Pb: 92.7), Bangpungtongseong-san (As: 100.0, Cd: 17.3 and Pb: 56.1), Oyaksungi-san (As: 47.4, Cd: 175.0 and Pb: 142.4). 3. Contents (mg/kg) of residual pesticides were not detected in any samples. 4. Transfer rate (%) of sulfur dioxide ($SO_2$) from crude to remnant in all samples were as follows: Yijin-tang (25.0), Oryung-san (166.7), Hwangryunhaedok-tang (50.0), Bangpungtongseong-san (181.8), Oyaksungi-san (50.0). Conclusion: Our results showed that the boiled herbal medicine prescriptions which we take are safe from the hazardous substances.

• Korean Journal of Acupuncture
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• v.38 no.4
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• pp.250-266
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• 2021

Objectives : This study was conducted to suggest new alternative methods to improve pharmacopuncture and Korean medicine research by analyzing the injection route, pharmacological effect, and status studies of Chinese herbal injections. Methods : 130 types of marketed and licensed Chinese herbal injection were searched from National Medical Products Administration (NMPA) of China. CNKI, PubMed, EMBASE, and the 2020 edition of the Chinese Pharmacopoeia were used to collect additional information. 'Herbal injection' and 'Chinese herbal injection' were used as keywords. All data were collected mainly on the treatment of Chinese herbal injection. But data which were not related to the relevant research or Chinese herbal injection were excluded. Results : Intramuscular injection accounted for more than half of the single injection route (51%). Acupoint and intramuscular injections accounted for 55% of dual injection routes. Acupoint, intravenous, and intramuscular injections accounted for the largest proportion (76%) of the multiple routes of injections. As for the pharmacological effect, injection for cardiovascular diseases accounted for 29%. About the number of raw herbal materials, single herbal material was the most common. Twelve intervention studies all tested intravenous injections, and half of them investigated cardiocerebrovascular diseases. All were given by intravenous injection. In the side effect section, the most common symptoms were nausea and vomiting. Conclusions : Through the results, it is expected to be used for research and development of new pharmacopuncture and herbal medicine.

• Korean Journal of Medicinal Crop Science
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• v.16 no.3
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• pp.188-191
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• 2008

Poncirus trifoliata Rafinesque has been used as the immature fruit of the trifoliate orange tree. This study was carried out to investigate the quality change of Poncirus trifoliata Rafinesque depending on packing materials (vacuum packing, PP (polypropylene) packing, gunny sack packing), storage places and storage periods up to 12 months. The change of loss on drying content, content of poncirin were measured during the 12 months. As a result, the loss on drying content was decreased rapidly in gunny sack packing after storage of 12 months at room temperature. The content of poncirin was decreased generally according to storage conditions and its average loss percent was 38.8%.

• The Journal of Pediatrics of Korean Medicine
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• v.22 no.3
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• pp.83-94
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• 2008

Objectives : The purpose of this study is to confirm severe problem caused by using a modified RUCAM scale than that officially recognized to diagnose liver injury induced by herbal medicine. Materials and Methods : Cases with liver injury induced by herbal medicine received to a related institute from January 2004 to December 2007 were collected and evaluated by the original scale and modified scale. Results : 1. Based on this study, we couldn't clinicaly confirm that the case was not excluded by the relieved first item basis of modified RUCAM scale which has to be excluded by the first item basis of orginal RUCAM scale. 2. By modified 6th item, one score was added to the total score. 3. By adding 8th item, it gaind one point to the whole the total score. Conclusions : In this study, we can clinically confirm that the modified RUCAM　application to case with liver injury induced by herbal medicine is a severe problem.

• The Korea Journal of Herbology
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• v.28 no.5
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• pp.103-111
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• 2013

Objectives : Herbal medicines were used a lot in the Northeast Asia, traditionally. However, the pharmacopoeia standards in South Korea, China, Japan, Taiwan, and North Korea including many other Asia are different and cause confusion. If the origins are not belonging to same genus, it should be careful to distinguish. In this study, herbal medicines in the pharmacopoeia were analyzed for different genus of origins in order to identify the disruptive items for each country. Methods : The scientific names of herbal medicines (plant based) was analyzed origins from Pharmacopoeias of Republic of Korea, People's Republic of China, Japan, Taiwan, and Democratic People's Republic of Korea. The origins specified differently were examined. Especially, the items which have different genus were analyzed in detail and confirmed for correct scientific name. Results : The analyzed herbal medicines in Pharmacopoeia were all 753 items. 320 items were in only one country's Pharmacopoeia. 237 items were in more than two countries' Pharmacopoeia, but their origins were same on each other. The items which have different genus were 35 items. Conclusions : In general, species belonging to the same genus have similar ecological, morphological, and pharmacological activity. However, species with different genus may have different medicinal ingredients and pharmacological activity. Thus, the items which have same name but different genus are required to analyze for comparison of pharmacological activity. Also, other species belonging to the different genus should be used for different items.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.1
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• pp.43-56
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• 2018

Objectives: This study was designed to investigate the basis for developing the herbal decoction that may help promote healthy blood vessels in accordance with the basic principles of Korean medicinal materials. Methods: In this study, we investigated the vascular relaxation effects of fifty herbal decoctions on vascular response in isolated thoracic aorta of phenylephrine-preconracted rats. Results: The results of identify the vascular relaxation effect of fifty herbal decoctions provided by Korea Institute of Korean Medicine, twenty-one herbal decoctions showed vascular relaxation effects. Among them, four herbal decoctions, Mahwang-tang (麻黃湯), Samchulgeonbi-tang (參朮健脾湯), Cheonwangbosim-dan (天王補心丹), and Socheonglyong-tang (小靑龍湯), with showed significantly concentration-dependent vasodilation was examined. Vascular relaxation level are $84.02{\pm}4.70$, $79.39{\pm}13.9$, $51.26{\pm}12.56$, and $54.73{\pm}15.8%$, respectively (P<0.05, 0.01, and 0.001). Conclusions: Thus these results provide a basic data for the treatment of the impairment of vascular function and blood pressure in traditional Oriental medicine.

• Plant Resources
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• v.5 no.1
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• pp.70-73
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• 2002

To develop an optimal storage method of root of Angelica acutiloba Radix, which has been grown as major herbal medicine material to be cultivated, root of Angelica acutiloba Radix, was stored for 10 months with different packing materials and sealing methods. The loss in dry weight as influenced by packing materials and sealing methods was the lowest at vacuum packing and followed by complete sealing methods with transparent polyethylene film. The ratio of root rot during the storage period was not significantly different between packing materials but was significantly different between sealing conditions. In conclusion, vacuum packing and complete sealing with polyethylene film appears to be most optimal for storage of Angelica acutiloba Radix.

• Journal of Sasang Constitutional Medicine
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• v.22 no.2
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• pp.93-100
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• 2010

1. Objectives: To compare the contents of hazardous substances such as crude, washing solution, crude after washing, decoction and remnant. 2. Methods: The heavy metal contents of each step were measured by inductively coupled plasma (ICP) spectrometer and mercury analyzer (MA-2). In order to analyze pesticides in Yanggyeoksanhwa-tang we used simultaneous multi- residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide (SO2) were performed by Monier-Williams distillation method. 3. Results: 1) The mean values of heavy metal contents (mg/kg) for each steps in Yanggeoksanhwa-tang were as follows: crude (Pb; 1.87, As; 1.29, Cd; 0.28 and Hg; N.D.), washing solution (Pb; 1.98, As; 1.13, Cd; 0.10 and Hg; N.D.), crude after washing (Pb; 1.90, As; 1.40, Cd; 0.22 and Hg; N.D.), decoction (Pb; 1.90, As; 1.14, Cd; 0.11 and Hg; N.D.) and remnant (Pb; 2.39, As; 1.29, Cd; 0.25 and Hg; 0.01). 2) Contents (mg/kg) of residual pesticides in crude and decoction were not detected. 3) Contents (mg/kg) of sulfur dioxide (SO2) in crude, crude after washing and remnant exhibited 3.00, 2.00 and 2.00 mg/kg, respectively. However, contents of sulfur dioxide in washing solution and decoction were not detected. 4. Conclusions: These Results: will be used to establish a criterion of heavy metals, residual pesticides and sulfur dioxide of each step in Yanggeoksanhwa-tang.