The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Screening Herbal Decoction of the Vascular Relaxation in Korean Medicine

한의학(韓醫學)에서 사용되는 한약제제(韓藥製劑)의 혈관이완 효능검색

  • Kim, Hye-Yoom (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Seo, Chang-Seob (K-herb Research Center, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (K-herb Research Center, Korea Institute of Oriental Medicine) ;
  • Hong, Mi-Hyeon (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Yoon, Jung-Joo (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Ahn, You-Mee (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Eun, So-Young (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Yun-Jung (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Dept. of Phygiology, College of Oriental Medicine, Wonkwang University)
  • 김혜윰 (원광대학교 한의과대학 생리학교실) ;
  • 서창섭 (한국한의학연구원 K-herb연구단) ;
  • 신현규 (한국한의학연구원 K-herb연구단) ;
  • 홍미현 (원광대학교 한의과대학 생리학교실) ;
  • 윤정주 (원광대학교 한의과대학 생리학교실) ;
  • 안유미 (원광대학교 한의과대학 생리학교실) ;
  • 은소영 (원광대학교 한의과대학 생리학교실) ;
  • 이윤정 (원광대학교 한의과대학 생리학교실) ;
  • 이호섭 (원광대학교 한의과대학 생리학교실) ;
  • 강대길 (원광대학교 한의과대학 생리학교실)
  • Received : 2018.01.24
  • Accepted : 2018.02.14
  • Published : 2018.02.23
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Abstract

Objectives: This study was designed to investigate the basis for developing the herbal decoction that may help promote healthy blood vessels in accordance with the basic principles of Korean medicinal materials. Methods: In this study, we investigated the vascular relaxation effects of fifty herbal decoctions on vascular response in isolated thoracic aorta of phenylephrine-preconracted rats. Results: The results of identify the vascular relaxation effect of fifty herbal decoctions provided by Korea Institute of Korean Medicine, twenty-one herbal decoctions showed vascular relaxation effects. Among them, four herbal decoctions, Mahwang-tang (麻黃湯), Samchulgeonbi-tang (參朮健脾湯), Cheonwangbosim-dan (天王補心丹), and Socheonglyong-tang (小靑龍湯), with showed significantly concentration-dependent vasodilation was examined. Vascular relaxation level are $84.02{\pm}4.70$, $79.39{\pm}13.9$, $51.26{\pm}12.56$, and $54.73{\pm}15.8%$, respectively (P<0.05, 0.01, and 0.001). Conclusions: Thus these results provide a basic data for the treatment of the impairment of vascular function and blood pressure in traditional Oriental medicine.

Keywords

References

  1. Contreras F, et al. Role of angiotensin II AT1 receptor blockers in the treatment of arterial hypertension. Am J Ther. 2003;10(6):401-8. https://doi.org/10.1097/00045391-200311000-00005
  2. Yu MH, et al. Anti-hypertensive activities of Lactobacillus isolated from Kimchi. Korean J Food Sci Technol. 2009;41(4):428-34.
  3. National Statistical Office. Statistics on the causes of death in 2016. Dae-jeon:Statistics Korea. 2016:1-56.
  4. Song L, et al. Age at natural menopause and hypertension among middle-aged and older Chinese women. J Hypertension. 2018;36(3):594-600. https://doi.org/10.1097/HJH.0000000000001585
  5. Cho KH. Korean University of Medicine and Heart Studies. Oriental medicine of the circulation nerves. Seoul:Gunja Publishing Co. 2010:171-2.
  6. Zheng X. Traditional Chinese medicine clinical research guidelines. Beijing: China Medical Science and Technology Press. 2002:73-4.
  7. Lee HY, Park JB. The Korean Society of Hypertension Guidelines for the Management of Hypertension in 2013: Its Essentials and Key Points. Pulse (Basel). 2015;3(1):21-8. https://doi.org/10.1159/000381994
  8. Leung AA, et al. Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults. Can J Cardiol. 2017;33(5):557-76. https://doi.org/10.1016/j.cjca.2017.03.005
  9. Baek DH, et al. Acute Renal Failure with Pulmonary Edema Induced by the Treatment of Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker in a Patient with Congenital Solitary Kidney. Ewha Med J. 2010;33(1):29-33. https://doi.org/10.12771/emj.2010.33.1.29
  10. Kim HJ, et al. Effects of Herb Medication on Dry Cough, a Common Side Effect Caused by Angiotensin Converting Enzyme (ACE) Inhibitor. Journal of Korean Oriental Medicine. 2010;31(1):162-73.
  11. Kim JD, et al. Experimental Studies on the interaction of Kangsimsan and Hydralazine, Verapamil, Clonidine, Hydrochlorothiazide and Furosemide. Journal of Korean Oriental Medicine. 1994;15(2):198-211.
  12. KimNJ, et al. Effects of CHUNGHYULDAN on the Pharmacokinetics and Pharmacodydnamics of Nicardipine in Rats = Studies on Interactions between Western and Traditional Heral Medicines(I). Journal of Korean society of hospital pharmacists. 2002;19(4):1-26.
  13. KimSW, Lee TH. Effect of samchulkunbitang on the gastric secretion and intestinal transport in the rat. Korean J Oriental Med Pathol. 1988;3:84-90.
  14. Ju MS. Uimunbogam. Seoul:Haenglimseowon. 1975:110-1.
  15. Lin WY. Seui-deuk Hyo Bang. Seoul: Eui seong dang publishing co. 1990:217.
  16. Lee JY, Jeong IC, Lee SR. Professor of Oriental Medicine. Herbal Formula Study. Seoul:Yeonglimsa. 1999:329-30.
  17. Kim CD, Shu SH, Kim SU. Professor of the National Academy of Oriental Medicine. Association of herbiology. Seoul:Yeonglimsa. 2000:489-90.
  18. KimSH, et al. The effects of Chenwangbosim-Dan and herbs on Mouse neuroblastoma 2a cells damaged by hypoxia-reoxygenation. J of Oriental Neuropsychiatry. 2006;17(2):15-36.
  19. Kim NJ, Kong SY, Jang SW. The effects of Chunwangboshimdan on the entral nervous system and cardio-vascular system. Kor J Phamacology. 1988;19(3):208-15.
  20. Kim JH, Whang WW. An Experimental Study on the Anti-Stress Effect by Modified Prescription of Chunwangbosimdan. K.H.M. 1988;4(4):453-66.
  21. Park JH, et al. Antidepressant effect of chunwangboshimdan and its influence on monoamines. The Journal of Herbal Formula Science. 2004;12(2):77-93.
  22. Lee DG, Lee BK. Effects of gwibitang -gasugjihwang on sedation time and analgesia in mice. The Journal of East-West Medicines. 1987;12(2):5-16.
  23. Ko SB. Research of clinical use of Herbal Medications based on mahwang-tang. Korean Journal of Oriental Medicine. 1999;7(2):361-84.
  24. Bae JY, et al. Inhibitory Effect of ten kinds of herbal medicine including ephedrae herba on nitric oxide in LPS-induced murine peritoneal macrophage. J Korean Orient Med Ophthalmol Otolaryngol Dermatol. 2009;22(2):19-38.
  25. Jin RC, Loscalzo J. Vascular nitric oxide: formation and function. J Blood Med. 2010;2010(1):147-62. https://doi.org/10.2147/JBM.S7000
  26. Francis SH, et al. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev. 2010;62(3):525-63. https://doi.org/10.1124/pr.110.002907
  27. Jung S, et al. Effects of Socheongryong-Tang on Immunoglobulin Production in Asthmatic Mice. Kor J Herbology. 2002;3(1):23-8.
  28. Ikeda Y, et al. Possible involvement of suppression of Th2 differentiation in the anti-allergic effect of Sho-seiryu-to in mice. Jpn J Pharmacol. 2002;90(4):328-36. https://doi.org/10.1254/jjp.90.328
  29. Makino T, et al. Pharmacological properties of traditional medicine: effects of Gyokuheifusan on murine antigen-specific antibody production. Biol Pharm Bull. 2005;28(1):110-3. https://doi.org/10.1248/bpb.28.110
  30. Xiong X, et al. Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science. Hypertens Res. 2013;36(7):570-9. https://doi.org/10.1038/hr.2013.18
  31. Kao ST, et al. Effects of xiao-qing-long-tang(XQLT) on bronchoconstriction and airway eosinophil infiltration in ovalbumin-sensitized guinea pigs:in vivo and in vitro studies. Allergy. 2001;56(12):1164-71. https://doi.org/10.1034/j.1398-9995.2001.00982.x
  32. Kim KS, et al. Practical East-West Medicine Clinical Series. Seoul:Jeongdam. 2001:172.
  33. Shin MK. Clinical herbal medicine. Seoul:Namsandang. 1986:172-7, 250-1, 518-9.
  34. Gong JS, Jin JP. Rejuvenation of all diseases(manbyeonghoechun). Seoul: Beobinmunhwasa. 2007:242-714.
  35. Ha JY, Jo YH, Lee JS. Antitumor and immunomodulator effects of hyangsapyungwisan in ICR-mice. J Korean Orient Oncology. 2000;6(1):47-65.
  36. Chen SW. Taepyeonghyeminhwajegukbang. Chinese medicine major volume 9. Seoul:Ryeonggang. 1987:538.
  37. Yeo DW, et al. Experimental studies on antitumor effect and immune responses of bunsimgieum. Korean J Orient Int Med. 2003;24(2):315-28.
  38. Jeon YY, et al. An experimental study of effect on ECV 304 cells, platelet rich plasma and rats treated with L-NAME by boonsimgieum extract. Korean J Orient Int Med. 2005;26(1):182-98.
  39. Lee SG, et al. The Effects of punsimgi-eum(fenxinqi-yin) in the chronic mild stress model of depression in Rats. J Korean Oriental Med. 2001;22(3):129-40.
  40. Ji SY, Jeong DK. An experimental study on the change of stress-related hormone contents by prescription of bunsimgieum. J of Oriental Neuropsychiatry. 1992;3(2):49-63.
  41. Kim JW, et al. The Effect of Punsimgieumgamibang on sleep disorder and emotionality in animals. J of Oriental Neuropsychiatry. 2000;11(2):43-52.
  42. Kim KW, et al. The Effects of Punsimgieumgamibang on Insomnia and Anxiety in Rat. J of Oriental Neuropsychiatry. 2000;11(2):53-62.