• 대한한의학방제학회지
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• 제13권2호
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• pp.71-91
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• 2005

A/J mice injected with urethane(1mg/ g of body weight) develop tumors with distinct histological patterns, which are classified as solid and papillary. I divided the mice into 3 groups; control group treatment with saline, BYA group treatment with herbal formula, Bopheyangyoungjeon 0.3g/kg and BYB groups treatment with herbal formula 1.5g/kg. The administration of herbal medicine was done every day for 56 days. The experimental results from herbal medicine treatment were compared to those from a saline-treated control group. Serial sections of the whole lung(150 to 200 sections per mouse) showed solid and papillary tumors arose from the pulmonary acinus, invading the bronchioles only as the tumors grew. The number of tumor, in the 8-weeks groups, are decreased in the experimental groups compared to control group. COX-2 protein and IGF- I protein expression was more increased in lung tumors of the control group compared to BYA and BYB groups. These results suggest that Bopheyangyoungjeon extract suppress the carcinogenesis of lung in the A/J mouse.

• 대한한의학방제학회지
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• 제13권2호
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• pp.17-40
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• 2005

A/J mice injected with urethane(1mg/ g of body weight) develop tumors with distinct histological patterns, which are classified as solid and papillary. I divided the mice into 3 groups; control group treatment with saline, BA group treatment with herbal formula, Soeuminbojungikgitang 0.4g/kg and BA group treatment with herbal formula 2.0g/kg. The administration of herbal medicine was done every day for 8 weeks. The experimental results from herbal medicine treatment were compared to those from a saline-treated control group. Serial sections of the whole lung(150 to 200 sections per mouse) showed solid and papillary tumors arose from the pulmonary acinus, invading the bronchioles only as the tumors grew. The number of tumor, in the 8 weeks group, are decreased in the experimental groups compared to control group. COX-2 protein and IGF- I protein expression was more increased in lung tumors of the control group compared to BA and BB groups. These results suggest that Soeuminbojungikgitang extract suppress the carcinogenesis of lung in the A/J mouse.

• Clinics in Shoulder and Elbow
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• 제18권2호
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• pp.80-85
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• 2015

Background: This study measured the rate of adrenal insufficiency among rotator cuff tear patients, and determined the roles of steroid treatment and herbal medicine as specific risk factors of adrenal insufficiency. Methods: We prospectively evaluated the 53 patients who agreed to participate in the study and underwent arthroscopic rotator cuff repair due to a chronic full-thickness tear from March 2012 to September 2013. The diagnosis of adrenal insufficieny was made by rapid adrenocortical hormone test before the operation. We collected information regarding their history of steroid and herbal medicine treatment within the last 12 months. Results: The rate of adrenal insufficiency among the rotator cuff tear patients in our study was 18.9% (10 of 53 patients). Steroid treatment (p=0.034), frequency of local steroid injection (p=0.008), and herbal medicine treatment (p=0.02) showed significant association with the risk of adrenal insufficiency. Conclusions: In this study, careful taking of a patient's medical history, such as the use of steroids and herbal medicine, is important when investigating adrenal function before surgery.

• Journal of Acupuncture Research
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• 제25권5호
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• pp.89-95
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• 2008

Objectives : This study was aimed at comparing clinical effectiveness among dry needle, Bee Venom Acupuncture, Hwangryunhaedoktang Herbal Acupuncture for treating acute ankle sprain. Methods : The subjects in this study were sixty patients with lateral ankle pain who came to Jaseng Hospital of Oriental medicine from Oct. 28. 2007 to Jul. 14. 2008. Among them, the number of patients after 3 session of each treatment was 17 with dry needle, 18 with Bee Venom Acupuncture, 17 with Hwangryunhaedoktang Herbal Acupuncture, and they were evaluated with Numerical Rating Scale(NRS), and Ankle-Hindfoot Scale(AHS) before and after every session of treatment. Results : 1. Each group had significant decrease in NRS(P<0.05) and increase in AHS score(P>0.05) after 3 session of each treatment. 2. There was no significant difference among 3 groups after 3 session of each treatment. Conclusions : When treating patients with acute ankle pain, Acupuncture, Bee Venom Acupuncture, Hwangryunhaedoktang Herbal Acupuncture each has clinical effect.

• 대한한방소아과학회지
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• 제36권3호
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• pp.35-48
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• 2022

Objectives The purpose of this study is to review relevant clinical studies to investigate the effectiveness of herbal medicines for IgA (Immunoglobulin A) nephropathy in children. Methods Studies on herbal treatment for IgA nephropathy were searched and analyzed through electronic databases such as PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang, CiNii, J-STAGE, Oriental Medicine Advanced Searching Integrated System and Science ON. Studies included Randomized controlled trials and case series. Results We selected nine studies and analyzed the findings. In most studies, improvement of IgA nephropathy was observed after treatment, and was evaluated using factors as 24 hour urine protein, hematuria, Scr (serum creatinine) and BUN (blood urea nitrogen). The most commonly used herbs for IgA nephropathy were Poria cocos (茯苓), Astragalus membranaceus (黃芪), and Rehmannia glutinosa (生地黃). Conclusions Based on the results of the clinical studies, we identified that herbal medicine is an effective treatment for IgA nephropathy. However, additional systematic clinical studies are necessary to prove its effect and safety.

• 대한한방부인과학회지
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• 제29권3호
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• pp.35-46
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• 2016

Objectives: The aim of this study was to investigate the effect of herbal medicine on obesity and overweight female patients and to gather the information of a proper treatment goal for anti-obesity program in Korean medicine clinic.Methods: 230 subjects were recruited and those data were analyzed for body-mass index (BMI), treatment duration, weight, body fat, muscle volume and body fat/weight loss ratio. It was compared among age groups and severity of obesity.Results: It was achieved to loss 12-13 kg for 105.8 days thru obesity program of Korean medicine clinic. There were no significant differences for BMI loss, weight loss, body fat loss, muscle volume gain and treatment duration among age groups. It was found that there were significant differences among overweight, obesity and severe obesity group for BMI loss, weight loss, body fat loss and muscle volume gain except treatment duration. It was assumed the weight loss for 1 month was 3.2 kg, 4.2 kg, 4.5 kg for each severity group respectively.Conclusions: It was found herbal medicine treatment would be effective for female obesity and expected the patients could achieve 12-13 kg weight loss for 15 weeks treatment including 8-12 weeks herbal medicine administration and BMI loss per month could be 1.22 kg/m², 1.60 kg/m² and 1.70 kg/m² for severity of obesity respectively. Hereafter, further controlled study with more numbers of patients should be needed to determine the goal of medical treatment for obesity.

• 대한한의학방제학회지
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• 제21권2호
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• pp.181-186
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• 2013

Objectives : The purpose of this study is to report the clinical effect of herbal medicine on the patient considering chronic renal failure. The patient complained of hemiparesis, general weakness, anorexia, nausea and dizziness. Methods : According to the traditional Korean medicine syndrome differentiation, the patient was classified as Deficiency of Spleen Qi and prescribed Bojungikki-tang and Bojungikki-tang gamibang as well as acupuncture and moxibustion treatment. Changes of BUN, creatinine, VAS for genaral weakness, nausea, dizziness were compared before and after treatment for 2 weeks. Results : After treatment, the level of BUN and creatinine was decreased and main symptoms were improved. Conclusions : Herbal medicine Bojungikki-tang and Bojungikki-tang gamibang with acupuncture and moxibustion treatment would be efficient to the patient of chronic renal failure.

• 대한한방소아과학회지
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• 제34권4호
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• pp.77-100
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• 2020

Objectives The purpose of this study is to investigate recent clinical studies on the effect of herbal medicine for pediatric tonsillitis in China, and to seek better methods to treat and study for pediatric tonsillitis in Republic of Korea. Methods We searched clinical studies from the China National Knowledge Infrastructure (CNKI) by search formula (SU='扁桃体炎'+'扁桃炎'+'扁桃腺炎'+'乳蛾'+'喉蛾'+'蚕蛾'+'石蛾'+'珠蛾'+'肉蛾'+'乳蛾風'+爛乳風'+'tonsillitis') and (SU='中樂'+'中医樂'+'本草'+'湯'+'丸'+'散'+'方'+'顆粒'+'膠囊'+'自擬'+'herb'+'herbal'+'decoction'+'remedy'+'Chinese medicine'+'Korean medicine'+'kampo'+'formula'+'herbal drug'+'Chinese drug'+'plant'+'Chinese prescription'+'traditional medicine'+'Medicine, East Asian Traditional'+'Herbal Medicine') in professional search from January 2016 to August 2020. We analyzed the literature focusing on the treatment methods and results. Results Among 1464 searched studies, 35 randomized controlled trials were selected and analyzed. In most studies, the effectiveness of oral administration of herbal medicine on pediatric tonsillitis was significant. Most commonly used herbs were Fructus Forsythiae (連翹), Radix Glycyrrhizae (甘草), Radix Scutellariae (黃芩), Herba Menthae (薄荷), Fructus Arctii (牛蒡子), Radix Scrophulariae (玄蔘), Radix Platycodi (桔梗), Flos Lonicerae (金銀花), Radix Isatidis (板藍根), Radix Bupleuri (柴胡), Fructus Gardeniae (梔子), Rhizoma Belamcandae (射干), Radix et Rhizoma Rhei (大黃), Gypsum Fibrosum (石膏). Conclusions By analyzing the improvement of indicators such as total effective rate, cured rate, symptom disappearance time and symptom score, we found that herbal medicine treatment can help improve pediatric tonsillitis. However, additional studies are needed to solidify these findings.

• 대한한방내과학회지
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• 제21권4호
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• pp.677-682
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• 2000

Idopathic thrombocytopenic purpura(ITP) is the most common autoimmune hematologic disorder. The use of glucocorticoids and splenectomy have been the mainstays of treatment of ITP Some studies have shown that chinese herbal medicine treatment increase platelet count level of ITP patients. However, there is a lack of research considering oriental herbal medicine with ITP, in korea. A 33-year-old female who had diagnosed ITP on Mar 1999, was treated herbal medicine for decreased platelet count level$(34000/{\mu}l)$ that was identified on regular follow-up. this patient's platelet count level was get to normal$(139000/{\mu}l)$ by BuQiSheXue(補氣攝血) pattern herbal medicine that composed with Radix Astragali(黃?), Herba Agrimoniae(仙鶴草), Rhizoma Atractylodis Macrocephalae(白朮), Radix codonopsis(黨參), etc. I report the case with a review of literature.

• 대한한의학회지
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• 제43권1호
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• pp.180-189
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• 2022

Objectives: This study aims to find out the effect of herbal medicine on sleep disorder in developmental delayed children. Methods: 2 patients were treated by herbal medicine. For the progress evaluation, we used The Children's Sleep Habits Questionnaire (CSHQ). Results: The clinical symptoms were improved after the treatment. Conclusion: This study reports that the herbal medicine improved sleep disorder in developmental delayed children, but further studies are needed to clarify the effectiveness of the treatment.